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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response

Article Abstract:

[E.sub.[mu]]-myc transgenic mice that are heterozygous for a Tip60 gene knockout allele are used for showing that Tip60 counteracts Myc-induced lymphomagenesis in a haplo-insufficient manner and in a time window that is restricted to a pre- or early-tumoral stage. It is shown that in both mouse and human, Tip60 has a haplo-insufficient tumour suppressor activity that is independent from its role within the ARF-p53 pathway.

Author: Amati, Bruno, Lough, John, Gorrini, Chiara, Marchesi, Francesco, Capra, Maria, Syed, Nelofer, Gasco, Milena, Crook, Tim, Nuciforo, Paolo, Mai, Sabine, Scanziani, Eugenio, Cesaroni, Matteo, Squatrito, Massimo, Verrecchia, Alessandro, Confalonieri, Bennett, Samantha, Wark, Landon, Martinato, Francesca, Sardella, Domenico, Luise, Chiara, Perna, Daniele
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
DNA damage, Tumor suppressor genes, Tumour suppressor genes

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Induction of epithelial tubules by growth factor HGF depends on the STAT pathway

Article Abstract:

Hepatocyte growth factor (HGF) mediates a three-stage response, which results in the formation of branched tubular structures in epithelial cells. Tyrosine kinase, an HGF receptor, operates via a Src homology (SH2) docking site which activates signalling pathways. It is show that the third phase depends on the STAT pathway, with HGF stimulating recruitment of Stat-3 to the receptor.

Author: Comoglio, Paolo M., Bardelli, Alberto, Boccaccio, Carla, Ando, Margherita, Tamagnone, Luca, Michieli, Paolo, Battistini, Carlo
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
Epithelial cells, Liver cells, Hepatocytes

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The MET oncogene drives a genetic programme linking cancer to haemostasis

Article Abstract:

A mouse model of sporadic tumorigenesis based on genetic manipulation of somatic cells is developed. An activated, human MET oncogene is targeted to adult liver and it was found to cause slowly progressing hepatocarcinogenesis.

Author: Naldini, Luigi, Comoglio, Paolo M., Boccaccio, Carla, Sabatino, Gabriella, Medico, Enzo, Girolami, Flavia, Follenzi, Antonia, Reato, Gigliola, Sottile, Antonino
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
Liver cancer, Somatic cells

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Subjects list: Research, Genetic engineering, Observations
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