Tyrosine kinase receptor RET is a key regulator of Peyer's Patch organogenesis
Article Abstract:
A study was conducted to show that the haematopoietic cells in the gut exhibit a random pattern of motility before aggregation into the primordia of Peyer's patches, a major component of the gut-associated lymphoid tissue. The findings suggests that the RET signaling pathway by regulating the development of both the nervous and lymphoid system in the gut, has a key role in the molecular mechanisms that orchestrate intestine organogenesis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
Article Abstract:
A reporter construct composed of the 1.6-kb IL-2 promoter, containing the three AML1-binding sites fused to a luciferase reporter gene is prepared to examine the functional responsiveness of the IL-2 promoter to AML1. The interaction between AML1 and Foxp3 might be a potential therapeutic target for controlling physiological and pathological immune responses.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
Kissing chromosomes
Article Abstract:
Spilianakis reveal a novel mechanism of gene regulation showing how cells organize their genome to respond efficiently to stimuli. They further show gene on different chromosomes that are destined to be expressed within a common lineage and are brought together in the nucleus.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. WAVE2 is required for directed cell migration and cardiovascular development
- Abstracts: Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor
- Abstracts: Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. A blank canvas no more
- Abstracts: Opponent recognition in male green anoles, Anolis carolinensis. Assessment in contests of male lizards (Anolis carolinensis): How should smaller males respond when size matters?
- Abstracts: Lost in translation. The secret life of sperm. Parasite infiltrates fruitfly research