Useful designs in the synthesis of trans-fused polyether toxins
Article Abstract:
Polycyclic ethers can be formed by the cyclization of ring ether systems or the modification of oxygen heterocyclic compounds. Cyclization involves the formation of either a C-O bond or a C-C bond. The C-O bond is formed by the nucleophilic reaction between an oxygen atom and an activated carbon center. C-C bonds formation may involve the de novo formation of cyclic systems or may expand the rings of an existing cyclic framework. Methods used for the formation of the C-O and C-C bonds are given. The polycyclic ethers are the lipid-soluble brevetoxins and ciguatoxins produced by marine dinoflagellates.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
Studies of total synthesis of the cylindricine/fasicularin/lepadiformine family of tricyclic marine alkaloids
Article Abstract:
In three papers that appeared in the early 1990s, Blackman and co-workers described the isolation of a family of eleven structurally related tricyclic alkaloids produced by the marine ascidian (sea squirt) Clavelina cylindrical, collected off the east coast of Tasmania. Based on these papers and subsequent studies, a total synthesis of the cylindricine/fasicularin/lepadiformine family of tricyclic marine alkaloids is presented.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Total synthesis of ingenol
Article Abstract:
Several methods for total synthesis of ingenol are described. Ingenol, a highly oxygenated tetracyclic diterpene were found to exhibit antitumor, antileukemic and anti-HIV properties, hence their chemical synthesis as well as isolation from natural sources would help in development of new therapeutic agents.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Domino reactions in organic synthesis. Stereocontrolled synthesis of tetrasubstituted olefins. Enantioselective palladium-catalyzed transformations
- Abstracts: Metal-free methods in the synthesis of macrocyclic Schiff bases. Structural biology and chemistry of the terpenoid cyclases
- Abstracts: Molecular modelling studies of a nerve growth factor receptor
- Abstracts: Synthesis of therapeutically useful prostaglandin and prostacyclin analogs. Solvent-free organic synthesis
- Abstracts: Molecules in optical, electric and magnetic fields: a personal perspective. Optically detected magnetic resonance studies of colloidal semiconductor nanocrystals