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Chemistry

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Useful designs in the synthesis of trans-fused polyether toxins

Article Abstract:

Polycyclic ethers can be formed by the cyclization of ring ether systems or the modification of oxygen heterocyclic compounds. Cyclization involves the formation of either a C-O bond or a C-C bond. The C-O bond is formed by the nucleophilic reaction between an oxygen atom and an activated carbon center. C-C bonds formation may involve the de novo formation of cyclic systems or may expand the rings of an existing cyclic framework. Methods used for the formation of the C-O and C-C bonds are given. The polycyclic ethers are the lipid-soluble brevetoxins and ciguatoxins produced by marine dinoflagellates.

Research, Ethers, Ethers (Class of compounds), Polycyclic compounds

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Studies of total synthesis of the cylindricine/fasicularin/lepadiformine family of tricyclic marine alkaloids

Article Abstract:

In three papers that appeared in the early 1990s, Blackman and co-workers described the isolation of a family of eleven structurally related tricyclic alkaloids produced by the marine ascidian (sea squirt) Clavelina cylindrical, collected off the east coast of Tasmania. Based on these papers and subsequent studies, a total synthesis of the cylindricine/fasicularin/lepadiformine family of tricyclic marine alkaloids is presented.

Pyrroles, Alkaloids

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Total synthesis of ingenol

Article Abstract:

Several methods for total synthesis of ingenol are described. Ingenol, a highly oxygenated tetracyclic diterpene were found to exhibit antitumor, antileukemic and anti-HIV properties, hence their chemical synthesis as well as isolation from natural sources would help in development of new therapeutic agents.

Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Tetracycline Preparations, Observations, Tetracycline, Tetracyclines, Structure

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