In vivo effects of HIV-1 exposure in the presence and absence of single-dose nevirapine on cellular plasma activation markers of infants born to HIV-1-seropositive mothers

Article Abstract:

The impact of HIV-1 exposure to a single-dose nevirapine (NVP) and short-course antiretroviral prophylaxis on the developing immune system is studied. Results reveal that short-course NVP exposure might be beneficial with respect to driving immune activation before the establishment of an infection in an infant exposed to HIV-1, but might have detrimental consequences in the case of existing infection acquired in utero.

Health aspects, Antiviral agents, Antiretroviral agents

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Therapeutic drug monitoring of nevirapine reduces pharmacokinetic variability but does not affect toxicity or virologic success in the ATHENA study

Article Abstract:

The therapeutic drug monitoring (TDM) implies individualized dosing of a drug by analysis and interpretation of the plasma drug concentrations. It is investigated whether routine TDM of nevirapine in treatment-naive HIV infected patients has an effect on its pharmacokinetics, and thus on the occurrence of toxicity and the virologic response to treatment, within the framework of the ATHENA study.

Analysis, Drug utilization, Drug monitoring, Pharmacokinetics

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Nevirapine plasma concentrations are still detectable after more than 2 weeks in the majority of women receiving single-dose nevirapine

Article Abstract:

The intersubject variability and potential influencing factors in the decay of plasma nevirapine concentrations after a single 200-mg dose are investigated. Most women who received a single 200-mg nevirapine dose still have detectable plasma concentration of nevirapine after more than 2 weeks.

Women, Women's health

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