Cdc13 both positively and negatively regulates telomere replication

Article Abstract:

Research shows that the single-strand telomeric DNA-binding protein Cdc13 exhibits two regulatory roles, positively influencing telomere replication by binding of telomerase and negatively by binding of Cdc13-interacting protein Stn1 to Cdc13 sites.

---

A model for the abrogation of the SOS response by an SOS protein: a negatively charged helix in DinI mimics DNA in its interaction with RecA

Article Abstract:

Research indicates that the C-terminal alpha-helix is the active site of the SOS negative regulator protein DinI in Escherichia coli. Data further reveal that the alpha-helix is negatively charged and interferes in the RecA activation by interacting with the homologous pairing region of RecA.

Research, Escherichia coli, Protein binding

---

Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends

Article Abstract:

Results demonstrate that the DNA end-binding protein Ku binds the RNA component of telomerase, TLC1, and disruption of the binding leads to 10- to 100-fold reduction in the telomere-mediated DNA repair. Data suggest that the interaction between Ku and TLC1 RNA aids telomerase activity at both broken and normal chromosome ends.

DNA repair, Chromosomes, Structure

Similar abstracts:

• Abstracts: Negative regulation of male development in Caenorhabditis elegans by a protein-protein interaction between TRA-2A and FEM-3
• Abstracts: Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts
• Abstracts: Rapid method for coextraction of DNA and RNA from natural environments for analysis of ribosomal DNA- and rRNA-based microbial community composition
• Abstracts: The neuron-specific RNA-binding protein ELAV regulates neuroglian alternative splicing in neurons and binds directly to its pre-mRNA
• Abstracts: CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.