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A short primer on RNAi: RNA-directed RNA polymerase acts as a key catalyst

Article Abstract:

Research has been conducted on the gene silenced by the RNA interference. The review of the articles on the biochemical and genetic evidence demonstrating that the RNA-directed RNA polymerase chain reaction amplifies interference caused by the trigger dsRNA is presented.

Author: Nishikura, Kazuko
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
Catalysts, RNA polymerases, Genetic research

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Mutations in the RNA component of RNase MRP cause a pleiotropic human disease, cartilage-hair hypoplasia

Article Abstract:

Research has been conducted on the cartilage-hair hypoplasia, an inherited developmental disorder with the predesposition to cancer. The results of the several mutations carried in the untranslated RMRP gene which cosegragate with this disorder are described.

Author: Chapelle, Albert de la, Kaitila, Ilkka, Ridanpaa, Maaret, Eenennaam, Hans van, Pelin, Katarina, Chadwick, Robert, Johnson, Cheryl, Yuan, Bo, VanVenrooij, Walther, Pruijn, Ger, Salmela, Riika, Rockas, Susanna, Makitie, Outi
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
Finland, Gene mutations, Gene mutation, Cartilage

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Loading Rho to terminate transcription

Article Abstract:

The author reviews the publications on hexameric RNA/DNA helicase Rho required for transcriptional termination mechanisms in bacteria. The topics of interest include the analysis of organization of individual RNA-binding domains.

Author: Richardson, John P.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
Biological Product (except Diagnostic) Manufacturing, Drugs, Nucleic Acids, Deoxyribonucleic Acid, DNA, Genetic regulation, Genetic transcription, Transcription (Genetics)

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Subjects list: Statistical Data Included, United States, Analysis, Physiological aspects, Genetic aspects, RNA, Cell research, Cytological research
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