Conspiracy theory: RAS and RAF do not act alone

Article Abstract:

RAS and RAF signaling and its regulation should be reconsidered despite studies that have added new proteins that conspire with RAS, RAF, and receptors to transfer signals. To prove their findings, these new studies should explain the biochemical function of such proteins as well as include into functional models those proteins defined by in vitro properties, such as binding other identified proteins. Research on these new proteins may shed light on the function of RAS and RAF and provide answer to basic questions offered by the complex processes of signal transduction.

United States, Analysis, Evaluation, Proteins, Protein kinases, Ras genes

---

RalB signaling: A bridge between inflammation and cancer

Article Abstract:

Studies were conducted to show that the RalB GTPase regulates the IKK family member TBK1, providing an unexpected link between the signaling pathways that promote inflammation and cancer. The findings show that in tumor cells the RalB/TBK1 pathway inhibits apoptosis and in nontumorigenic cells it stimulates an innate immune response.

Cancer cells, Apoptosis

---

C. elegans LIN-18 is a Ryk ortholog and functions in parallel to LIN-17/frizzled in Wnt signaling

Article Abstract:

Wnt proteins are intercellular signals that regulate various aspects of animal development. It is studied that two independent Wnt signaling pathways, one employing a Ryk receptor and the other Frizzled receptor, function in parallel to regulate cell fate patterning in the C. elegans vulva.

Cell aggregation

Similar abstracts:

• Abstracts: Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation
• Abstracts: Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Canonical Wnt signals are essential for homeostasis of the intestinal epithelium
• Abstracts: Chromatin structure and RNA polymerase II connection: implications for transcription. Unbiased mapping of transcription factor binding site along human chromosomes 21 and 22 points to widespread regulation of noncoding RNA's
• Abstracts: Chloroplast DNA inheritance in the Orchid Anacamptis palustris using single-seed polymerase chain reaction . Recent trends in population genetics: More data! More Math! Simple models?
• Abstracts: Contribution of fungi and bacteria to leaf litter decomposition in a polluted river. Competition between ammonia-oxidizing bacteria and benthic microalgae

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.