Eph receptor tyrosine kinases, axon repulsion, and the development of topographic maps

Article Abstract:

Graded spatial distributions of the factors on the optic tectum provide positional information that is detected by receptor tyrosine kinases on axons to direct topographic map formation. The Eph family of receptor tyrosine kinases mediates contact repulsion of axons and provides the diversity of signals necessary to mediate distinct and specific recognition events throughout the nervous system. The Eph family provides one of the long-sought keys to understand topographic map formation.

Topographic maps

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T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases

Article Abstract:

The mechanisms by which protein-tyrosine kinase (PTK) is activated by the T cell antigen receptor (TCR) are reviewed. TCR has alpha, beta, CD3 and zeta chains, wherein the last two are responsible for signal transduction. Three distinct PTKs implicated in TCR function are Fyn, Lck and ZAP-70. A model of TCR-mediated PTK activation suggests that antigen recognition activation motifs couple the TCR to intracellular PTKs with Lck or Fyn required for ZAP-70 activation.

Antigen receptors, T cell, T cell antigen receptors, Cellular signal transduction

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Neuropilin is a receptor for the axonal chemorepellent Semophorin III

Article Abstract:

Expression cloning was conducted to identify the Collapsin-1/Semaphorin III/D (Sema III)-binding proteins in embryonic rat sensory neurons and determine the axonal chemorepellent mechanisms of Sema III. Results show that Sema III's chemorepellent ability is inhibited by neuropilin antibodies. Results reveal that neuropilin is a receptor or a receptor complex component that degrades Sema III's effects on axons.

Research, Carrier proteins, Transport proteins, Axons, Cell receptors

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