Modulating substrate choice: The SspB adaptor delivers a regulator of the extracytoplasmic-stress response to the AAA+ protease ClpXP for degradation

Article Abstract:

Proteins captured by ClpXP(super trap) in sspB+ but not sspB(super -) strains are examined to identify new sspB(super -)regulated substrates. RseA(super 1-108), a fragment of a transmembrane protein that regulates the extracytoplasmic-stress response, fits this criterion and in response to stress. RseA is cleaved on each side of the membrane and is released as a cytoplasmic fragment that remains bound in an inhibitory complex with the sigma(super E) transcription factor.

Membrane proteins, Decomposition (Chemistry), Chemical properties

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C1pS modulates but is not essential for bacterial N-end rule degradation

Article Abstract:

A genetic screen for N-terminal sequences that direct degradation of a conditionally toxic Escherichia coli protein was developed to explore the bacterial degradation of N-end rule substrates by the [AAA.sup.+] protease C1pAP. The results indicate that C1pA has an intrinsic ability to recognize and degrade N-end rule substrates whereas C1pS modulates substrate recognition and turnover.

Protein research

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Latent ClpX-recognition signals ensure LexA destruction after DNA damage

Article Abstract:

Research has been conducted on DNA-damage response gene upregulation when LexA repressor undergoes autocatalytic cleavage. The authors demonstrate the LexA fragments are the substrates for ClpXP protease.

United States, Genetic aspects, DNA damage, Peptides, Genetic regulation, Genetic research

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