Snail blocks the cell cycle and confers resistance to cell death

Article Abstract:

Snail attenuates the cell cycle and confers resistance to cell death induced by the withdrawal of survival factors and by pro-apoptotic signals in addition to inducing dramatic phenotypic alterations. It is found that the resistance to cell death conferred by Snail provides a selective advantage to embryonic cells to migrate and colonize distant territories, and to malignant cells to separate from the primary tumor, invade and form metastasis.

Genetic aspects, Snails

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Mitochondrial fission proteins regulate programmed cell death in yeast

Article Abstract:

The link between mitochondrial fission and programmed cell death is used to investigate the possibility that the yeast mitochondrial fission machinery could regulate programmed cell death in yeast, The results provide evidence for a conserved cell death mechanism mediated by yeast Dnm1 and human Drp1 homologs and that yeast Fis1 inhibits rather than induces cell death in yeast.

Mitochondria, Yeast fungi, Yeasts (Fungi)

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Skp2-dependent degradation of p27kip1 is essential for cell cycle progression

Article Abstract:

The loss of a single skp2 substrate namely the cyclin kinase inhibitor p27kip1 reverts the phenotype of skp2 knockout hepatocytes to normal. A short period in G1 in which p27 is able to block the cell cycle after the exit from quiescence is defined by comparing the kinetics of p27 turnover and cell cycle progression in skp2 knockout and p27T187 A knock-in mice.

Cell cycle

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