Cancer Risk in Women Exposed to Diethylstilbestrol In Utero

Article Abstract:

Women who were exposed to diethylstilbestrol (DES) as fetuses do not appear to have a higher risk of cancer in general with the exception of clear cell adenocarcinoma (CCA) of the vagina and cervix. Researchers compared the incidence of cancer in 4,536 DES-exposed daughters and 1,544 unexposed daughters. The rate of cancer in general was no higher in the exposed daughters as the unexposed daughters with the exception of CCA. Exposed women had a CCA rate 41 times higher than women in the general population. An extended follow-up is needed as the average age of these women was only 38.

Complications and side effects, Adenocarcinoma, Diethylstilbestrol

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Cancer incidence before and after kidney transplantation

Article Abstract:

The incidence of cancer in patients receiving immune suppression after kidney transplantation was compared to cancer incidence during end-stage kidney disease before commencement of renal replacement therapy (RRT) and during dialysis in a population-based cohort study. Results revealed that cancer incidence is increased across a number of organ systems after kidney transplantation, suggesting an important role for the interaction between common viral infections and the immune system in the etiology of cancer.

Patient outcomes, Diagnosis, Renal replacement therapy

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Smokers and breast cancer: 'chemical individuality' and cancer predisposition

Article Abstract:

Research showing an increased susceptibility to cancer in people who are fast or slow acetylators needs to be confirmed in larger studies. Many chemicals in the body are acetylated during their metabolism, which means that an enzyme adds an acetyl group to the chemical. People who have a mutation in the gene for this enzyme are called slow acetylators, which may predispose them to certain kinds of cancer. Fast acetylators can also be at increased risk because acetylation can turn a chemical into a carcinogen.

Health aspects, Editorial, Genetic aspects, Disease susceptibility, Acetylator status (Pharmacology)

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