Developmental pathways: sonic hedgehog-patched-GLI

Article Abstract:

Research presented concerns the effects of an environmental disruption of genes in a developmental pathway on the likelihood of deformity or cancer. To understand the networks of genes that are critical in development, the scientists study the impact of exposures to toxins on the Hedgehog-Patched-GLI pathway.

Genetic aspects, Developmental genetics, Environmental health, Genetics, Genetic toxicology

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Meta-analysis of rat lung tumors from lifetime inhalation of diesel exhaust

Article Abstract:

Research presented concerns the effects of inhalation of diesel exhaust particulates (DEPs) on the formation of lung tumors in laboratory rats. The study examines DEP carcinogenicity, comparisons between low and high-exposure rats, and the threshold of lung tumor response.

Health aspects, Methods, Diesel motor exhaust gas, Diesel emissions, Respiratory tract diseases, Lung tumors, Carcinogenicity testing, Ames test

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