Cyclopentenone prostaglandins -- new allies in the war on inflammation

Article Abstract:

Research on cyclopentenone prostaglandins shows that COX enzymes can be anti-inflammatory as well as pro-inflammatory. Cyclopentenone prostaglandins inhibit the activity of I(sub)kappaB kinase.

Prostaglandins, Inflammation mediators

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Possible new role for NF-kB in the resolution of inflammation

Article Abstract:

Research has been conducted on the role of the nuclear factor-kB, a dimeric transcription factor formed by protein hetero- and homodimerization, in inflammatory resolution regulation. Results indicate that activation of nuclear factor-kB in recruited during the inflammation onset leukocytes is associated with the pro-inflammatory gene expression.

United Kingdom, Causes of, Genetic aspects, Proteins, Gene expression, Biomedical engineering, Leukocytes, White blood cells

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Impaired activity of protease inhibitors towards neutrophil elastase bound to human articular cartilage

Article Abstract:

Protease inhibitors may be less effective in preventing the breakdown of tissue and cartilage when the enzyme neutrophil elastase has attached to cartilage cells. Researchers tested the effects of knee joint fluid from six patients with rheumatoid arthritis (RA) and differing weights of protease inhibitors on healthy cartilage samples either exposed to or allowed to attach to neutrophil elastase. Cartilage damage steadily increased over time after exposure to or attachment with neutrophil elastase. Synthetic lower weight protease inhibitors were better able to control cartilage damage than the naturally occurring higher weight protease inhibitors. The synthetic protease inhibitor best able to control cartilage damage was N-methoxysuccinyl-Ala-Ala-Pro-Val chloromethyl ketone. Exposure to full strength joint fluid from the patients with RA only partially prevented cartilage damage in the cartilage samples containing bound neutrophil elastase.

Protease inhibitors, Neutrophils, Articular cartilage

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