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Persistence of episomal HIV-1 infection intermediates in patients on highly active anti-retroviral therapy

Article Abstract:

Research presented concerns the suppression of HIV-1 replication in HIV-1 infected patients on a highly active anti-retroviral therapy. Findings suggest there is often viral persistence and replication in patients who have gone through anti-retroviral therapy, despite continued undetectable amounts of plasma viral RNA.

Author: Moyle, Graeme, Sharkey, Mark E., Teo, Ian, Greenough, Thomas, Sharova, Natalia, Luzuriaga, Katherine, Sullivan, John Lawrence, Bucy, R. Pat, Kostrikis, Leondios G., Haase, Ashley, Veryard, Claire, Davaro, Raul E., Cheeseman, Sarah H., Daly, Jennifer S., Bova, Carol, Ellison, Richard T. III, Mady, Brian, Lai, Kwan Kew, Nelson, Mark, Gazzard, Brian, Shaunak, Sunil, Stevenson, Mario
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
Statistical Data Included, HIV patients, Antiviral agents

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Tat's seductive side

Article Abstract:

Research indicates that the trancription activator of HIV, Tat, is involved in the viral gene expression and in addition, regulates the expression of chemokines in dendritic cells. Data suggest that Tat recruits susceptible host cells to infected dendritic cells, which leads to dissemination of HIV infection.

Author: Stevenson, Mario
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
Genetic aspects, Genetic regulation, Genetic transcription, Transcription (Genetics), Viral genetics

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Renal dysfunction with tenofovir disoproxil fumarate-containing highly active antiretroviral therapy regimens is not observed more frequently

Article Abstract:

The overall incidence and risk of renal dysfunction in individuals receiving tenofovir disoproxil fumarate (DF) is investigated and compared with other antiretrovirals. The data reveals that tenofovir DF is not associated with renal dysfunction more frequently than other antiretroviral drugs, and the occurrence of renal dysfunction in this context is usually attributable to other causes.

Author: Moyle, Graeme, Nelson, Mark, Gazzard, Brian, Mandalia, Sundhiya, Stebbing, Justin, Bower, Mark, Jones, Rachael
Publisher: Lippincott Williams & Wilkins, WK Health
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2004
Health aspects, Usage, Risk factors, Drug therapy, Kidney diseases, Highly active antiretroviral therapy, Tenofovir

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Subjects list: United States, Physiological aspects, HIV infection, HIV infections, Research
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