Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity

Article Abstract:

A new anti-human DR5 monoclonal antibody, TRA-8, includes apoptosis of most tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-sensitive tumor cells both in vitro and in vivo. It is suggested that selective, and specific targeting of DR5 with an agonistic antibody might be a safe and effective strategy for cancer therapy.

Monoclonal antibodies, Tumor necrosis factor, Tumour necrosis factor

---

Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell mediated autoimmune diseases

Article Abstract:

The authors address apoptosis, or cell death, a necessary process which, if malfunctioning, can be harmful to health. They present a method of stimulating various processes to allow maximum function while preventing the autoimmune diseases which otherwise might occur.

Prevention, Physiological aspects, Autoimmune diseases, Cell death

---

Signaling through 0X40 (CD134) breaks peripheral T-cell tolerance

Article Abstract:

0X40 signals promote T-cell expansion after the hypo-responsive phenotype is induced and restore normal functionality. Peripheral T-cell tolerance is a mechanism to limit autoimmunity, but represents a major obstacle in diseases such as cancer.

Antigen receptors, T cell, T cell antigen receptors

Similar abstracts:

• Abstracts: Impaired activity of protease inhibitors towards neutrophil elastase bound to human articular cartilage. Cyclopentenone prostaglandins -- new allies in the war on inflammation
• Abstracts: Clinical success of class V composite resin restorations without mechanical retention. The physical properties of packable and conventional posterior ersin-based composites: a comparison
• Abstracts: Comparative efficacy of an antiseptic mouthrinse and an antiplaque/antigingivitis dentifrice. Anticalculus efficacy of an antiseptic mouthrinse containing zinc chloride
• Abstracts: Trust and the acceptance of and adherence to antiretroviral therapy. Maternal characteristics associated with antenatal, intrapartum, and neonatal zidovudine use in four U.S. cities, 1994-1998
• Abstracts: First molecular characterization of HIV-1 Tunisian strains. HHV-8 shedding among HIV-infected women. Relationship between antiretroviral drug plasma concentrations and viral load in children

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.