RAMPs: accessory proteins for seven transmembrane domain receptors

Article Abstract:

Cyclic RNA from cells that express calcitonin-gene-related peptide (CGRP) receptors induce novel CGRP responses in Xenopus oocytes. This protein is cloned and called receptor activity modifying protein (RAMP). It has 148 amino acids, a signal sequence and a single transmembrane protein. Expression of RAMPs 1, 2 and 3, leads to its expression as an adrenomedullin receptor. The RAMPs serve as transporters of calcitonin receptor-like receptor (CRLR) to the cell surface. They also participate in ligand binding directly or indirectly by inducing conformational change in CRLR.

Analysis, Carrier proteins, Transport proteins, Proteins, Ligand binding (Biochemistry)

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Calcitonin gene-related peptide - a new concept in receptor-ligand specificity?

Article Abstract:

Past gene cloning and expression studies revealed that a number of cloned seven-membrane-domain receptors are receptors for calcitonin gene-related peptide (CGRP)-related peptides. CRGP, which is released from primary afferent neurones, can have both protective and pathophysiological effects. Its receptor-recognition properties are dependent on the level of expression of receptor activity modifying proteins. Selective ligands were developed to gain better understanding on the study of CGRP and related peptides.

Calcitonin

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Urotensin II: fish neuropeptide catches orphan receptor

Article Abstract:

Researchers have identified a receptor for urotensin II, a peptide that may be involved in heart failure. This receptor could be a target for drugs to treat heart failure.

Heart failure

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