Adaptive roles of programmed cell death during nervous system development

Article Abstract:

The putative adaptive functions of the programmed cell death (PCD) in the animal kingdom are analyzed with a major focus on PCD in the developing nervous system. The genetic regulation of PCD has made it possible to inhibit PCD and determine the possible repercussions for nervous system development and function.

Cell death, Genetic regulation

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The hedgehog pathway and neurological disorders

Article Abstract:

The hedgehog (Hh) signaling and neural diseases, including neurodegenerative disorders and brain tumors, particularly medulloblastoma, are discussed. The discovery and utility of small molecule agonists and antagonists of this pathway and their potential as novel types of therapeutics are described.

Stem cells, Medulloblastoma, Disease/Disorder overview

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Adhesion molecules in the nervous system: structural insights into function and diversity

Article Abstract:

The article describes the molecular mechanisms and the structure comprising of adhesive binding, specificity and diversity for families of adhesion molecules in the nervous system.

Nervous system, Immunoglobulin genes, Clinical report

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