Mostly dead

Article Abstract:

Developments in cell suicide or apoptosis research are discussed. In particular the view that cells in which caspases have been activated have reached a point of no return is challenged.

Discovery and exploration, Cell research, Cytological research

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Apoptotic cell death induced by c-myc is inhibited by bcl-2

Article Abstract:

The gene bcl-2 stops the apoptosis of cells caused by the proto-oncogene c-myc. Apoptosis is a type of cell death involving chromatin condensation, cytoplasmic blebbing and DNA fragmentation. C-myc can initiate both cell growth and apoptotic cell death; bcl-2 tilts the balance in favor of growth by inhibiting apoptosis. Bcl-2 probably accomplishes this by taking on the role of survival signal that stimulates c-myc to continue spurring cell growth.

Proto-oncogenes

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CD4(super +) T-cell help controls CD8(super +) T-cell memory via TRAIL-mediated activation-induced cell death

Article Abstract:

The instructional program that governs the secondary response of CD8(super +) T cells is explored and fit is found that helpless cells undergo death by activation-induced cell death upon secondary simulation. Regulation of tumor-necrosis factor (TNF)-related apoptosis-inducing ligand (Trail) expression can account for the role of CD4(super +) T cells in the generation of CD8(super +) T cell memory and represents a novel mechanism for controlling adaptive immune responses.

United States, Science & research, T cells, Tumor antigens, Tumour antigens

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