Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module (low-density lipoprotein receptor in patients with the disease familial hypercholesterolemia)

Article Abstract:

The LDL receptor (LDLR) in patients with the disease familial hypercholesterolemia (FH) was investigated. The molecular basis of FH was studied by determining the structure of one of seven ligand-binding repeats of the LDLR, called LR5, through X-ray crystallography. Many point mutations that cause FH can be traced to LR5. X-ray crystallography shows that the LR5 structure is organized around one calcium ion. Acidic residues directly coordinate and form the scaffolding of the LR5 calcium ion. The FH point mutations found in patients with the disease alter the residues that directly coordinate the LR5 calcium ion.

Cholesterol, LDL, VLDL cholesterol lipoproteins, Hypercholesterolemia

---

Structural basis for gate-DNA recognition and bending by type IIA topoisomerases

Article Abstract:

The analysis of the structure of a complex between the DNA-binding and cleavage core of Saccharomyces cerevisiae Topo II and a prospective gate-DNA segment is described. The linking of DNA aids the opening of an enzyme dimerization interface, highlighting visual proofs for a main conformational intermediate stage necessary in DNA transport and a strong evolutionary correlation between type II and IA topoisomerases are shown.

Science & research, Food preparations, not elsewhere classified, All Other Miscellaneous Food Manufacturing, Brewers' Yeast, Genetic aspects, DNA damage, DNA-ligand interactions, DNA binding, Brewer's yeast, Saccharomyces cerevisiae, DNA topoisomerase I

---

A kinetic proofreading mechanism for disentanglement of DNA by topoisomerases

Article Abstract:

Cells need to remove entanglements between their replicated chromosomal DNAs during cell division. Some type II topoisomerases can reduce entanglements in vitro, more than expected, using ATP hydrolysis. A mechanism for this is proposed, based on a higher rate of collisions amongst entangled DNA strands, relative to collision rates of disentangled DNA strands.

Cell division, Chromosomal proteins

Similar abstracts:

• Abstracts: Molecular basis of triclosan activity. Drought sensitivity shapes species distribution patterns in tropical forests
• Abstracts: Predicting endemism from population structure of a widespread species: case study in Centaurea maculosa Lam. (Asteraceae)
• Abstracts: Induction of an illusionary shadow person. Exploitation of structural and regulatory diversity in glutamate racemases
• Abstracts: Population dynamics of a recolonizing wolf population. Calf harvest and reproductive rate of reindeer in Finland
• Abstracts: Bed site characteristics of pronghorn fawns. Whole genome amplification for sequencing and applications in conservation genetics

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.