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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

Article Abstract:

Familial amyotrophic lateral sclerosis (FALS) may result from mutations of the gene that encodes a cytosolic, copper/zinc-binding superoxide dismutase, which is also a metalloenzyme that inhibits the toxic effect of superoxide anions or free oxygen radicals. FALS is the inherited form of ALS, in which motor neurons in the cortex, brainstem and spinal cord degenerate. The association of FALS with free oxygen radicals may lead to new treatments that target the radicals.

Author: Horvitz, H. Robert, Pericak-Vance, Margaret A., Siddique, Teepu, McKenna-Yasek, Diane, Tanzi, Rudolph E., Laing, Nigel G., Brown, Robert H., Jr., Figlewicz, Denise A., Sapp, Peter, Patterson, David, Rosen, Daniel R., Hentati, Afif, Donaldson, Deirdre, Goto, Jun, O'Regan, Jeremiah P., Han-Xiang Deng, Rahmani, Zohra, Krizus, Aldis, Cayabyab, Annarueber, Gaston, Sandra M., Berger, Ralph, Halperin, John J., Herzfeldt, Brian, Van den Bergh, Raymond, Wu-Yen Hung, Bird, Thomas, Gang Deng, Mulder, Donald W., Smyth, Celestine, Soriano, Edwin, Haines, Jonathan, Rouleau, Guy A., Gusella, James S.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
Health aspects, Abnormalities, Physiological aspects, Genetic aspects, Motor neurons, Free radicals (Chemistry), Free radicals, Superoxide dismutase, Amyotrophic lateral sclerosis, Active oxygen, Active oxygen in the body

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MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans

Article Abstract:

The molecular characterization of the gene MOD-1 demonstrates the existence of a 5-HT-gated chloride channel that modulates locomotory behaviour in the nematode Caenorhabditis elegans.

Author: Horvitz, H. Robert, Ranganathan, Rajesh, Cannon, Stephen C.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
Neurobiology

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Phagocytosis promotes programmed cell death in C. elegans

Article Abstract:

Research describing programmed cell death in the nematode Caenorhabditis elegans is presented. In particular the role of engulfment genes is investigated.

Author: Horvitz, H. Robert, Reddein, Peter W., Cameron, Scott
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
Cell death, Nematoda, Nematodes

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