Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity
Article Abstract:
It has been established that ectopic expression of the murine NKG2D ligands Rae1-beta or H60 in a number of tumour cell lines leads to strong rejection of the tumour cells in syngeneic mice. This shows that NKG2D ligand expression and resulting activation of natural killer cells and CD8+ T cells can create a strong barrier to the establishment of tumours in vivo.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
Tails of histones lost
Article Abstract:
The modifications around the double-stranded break in DNA site help to coordinate DNA repair with cell-cycle checkpoints. The addition and removal of the phosphate group on the tail of a histone protein known as H2AX creates a molecular switch that helps to maintain genomic stability.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
Article Abstract:
Mouse and human NKG2D ligands are upregulated in non-tumor cell lines by genotoxic stress and stalled DNA replication. The DNA damage response might also participate in alerting the immune system to the presence of potentially dangerous cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Cellular and genetic mechanisms of self tolerance and autoimmunity. Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA
- Abstracts: Safe and sound? A firm response to AIDS. Silicon down to the wire
- Abstracts: Doubling the estimate of invertebrate biomass in a rainforest canopy. FKF1 is essential for photoperiodic-specific light signalling in Arabidopsis
- Abstracts: Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel. Chloride/proton antiporter activity of mammalian CLC proteins CIC-4 and CIC-5
- Abstracts: Trade, Tenure, and Tradition: Influence of Sociocultural Factors on Resource Use in Melanesia. New Tools for Marine Conservation: the Leasing and Ownership of Submerged Lands