Structure of the S-adenosylmethionine riboswitch regulatory mRNA element

Article Abstract:

The 2.9-Angstrom resolution crystal structure of an S-adenosylmethionine (SAM)-responsive riboswitch from Thermoanaerobacter tengcongensis complexed with S_adenosylmethionine, an RNA element is described that controls the expression of several genes involved in sulphur and methionine metabolism. Ligand binding induces the formation of a series of tertiary interactions with one of the helices, serving as a communication link between the aptamer and expression platform domains.

Colorado, Ligand binding (Biochemistry), Crystals, Crystal structure, Chemical properties

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Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF

Article Abstract:

A molecular basis is demonstrated for specific recognition of H3(1-15)K4me3 by a plant homeodomain (PHD) finger of human bromodomain and PHD domain tanscription factor (BPTF), the largest subunit of the ATP-dependent chromatin-remodeling complex nucleosome remodeling factor (NURF). Binding studies establish that the BPTF PHD finger exhibits a preference for K4me3-containing H3 peptides, and key specificity-determining residues are identified.

New York, Physiological aspects, Drosophila, Nuclear magnetic resonance, Nucleosomes

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Structural basis for gene regulation by a thiamine pyrophosphate-sensing riboswitch

Article Abstract:

Riboswitches are metabolite-sensing RNAs, typically located in the-coding portions of messenger RNAs that control the synthesis of metabolite-related proteins. A 2.05-Angstrom crystal structure of a riboswitch domain from the Escherichia coli thiM mRNA is described that responds to the coenzyme thiamine pyrophosphate (TPP).

Connecticut, Properties, Thiamine pyrophosphate

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