Commentary: survival of C. elegans in axenic culture

Article Abstract:

Jacques R. Vanfleteren and colleagues' study of the kinetics of survival of the Caenorhabditis elegans provides an interesting addition to previous studies that shed light on the dynamics of aging in the nematode. Vanfleteren and associates used axenic culture conditions instead of the more widely used abundant bacteria which substantially changed the aging kinetics for a variety of nematode strains. Their results showed that nematode growth in a reduced concentration of bacteria prolonged the life span of the C elegans while reducing egg production.

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Authors' response to commentaries on "two-parameter logistic and Weibull equations provide better fits to survival data from isogenic populations of Caenorhabditis elegans in axenic culture than does the Gompertz model."

Article Abstract:

Research conducted on the survival dynamics of the Caenorhabditis elegans in axenic culture provided evidence that the Weibull function is a better descriptor for survival than the classical Gompertz model. It was the theory that environmental conditions alter survival curves which led to the use of axenic culture conditions to reduce environmental influence on senescence. Results demonstrated that the Weibull model provides better fits to the survival dynamics of C. elegans in axenic culture.

Analysis, Weibull distribution

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Commentary

Article Abstract:

Jacques R. Vanfleteren and colleagues based their statistical analyses of the survival of Caenorhabditis elegans on experimental information that evidently lacked the biology of aging studies. Vanfleteren used 77 experiments to assess model parameter estimates instead of assuming that a Gopertz model can explain the mechanism involved in biological senescence. Therefore, they came up with the conclusion that revealed that mortality in old age hits constant levels in a wide variety of species.

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