| Nature Biotechnology 2001 |
| Title | Subject | Authors |
|---|
| A biodegradable polymer as a cytokine delivery system for inducing bone formation. | Business | et al, Naoto Saito |
| A clearer vision for in vivo imaging.(Progress continues in the development of smaller, more penetrable probes for biological imaging.) | Business | Ralph Weissleder |
| Adding new meanings to the genetic code.(Two New Approaches Offer the Means to Expand the Repertoire of Amino Acids Available for Protein Engioneering) | Business | Nina Mejhede |
| A DNA computing readout operation based on structure-specific cleavage.(Research article)(Illustration) | Business | Liman et al Wang |
| Affinity capture of proteins from solution and their dissociation by contact printing. | Business | Peter Sonderegger, Andre Bernard, Dora Fitzli, Emmanuel Delamarche, Bruno Michel, Hans Rudolf Bosshard, Hans Biebuyck |
| A high signal-to-noise Ca2 probe composed of a single green fluorescent protein. | Business | Junichi Nakai, Masamichi Ohkura, Keiji Imoto |
| A high-throughput alphavirus-based expression cloning system for mammalian cells. | Business | Daniel et al Koller |
| Alteration of Cre recombinase site specificity by substrate-linked protein evolution.(Research article)(Illustration) | Business | Frank and Stewart Buchholz A. Francis |
| A method for the amidation of recombinant peptides expressed as intein fusion proteins in Escherichia coli.(Illustration)(Statistical Data Included) | Business | Alan Colman, Ian R. Cottingham, Alan Millar, Elisabeth Emslie, Angelika E. Schnieke, Colin McKee |
| A motif-based profile scanning approach for genome-wide prediction of signaling pathways. | Business | et al, Michael B. Yaffe |
| An industry imperiled by regulatory bottlenecks.(stem and immune cell treatments) | Business | Gail Naughton |
| An infectious transfer and expression system for genomic DNA loci in human and mouse cells.(Technical report)(Illustration) | Business | Richard et al Wade-Martins |
| An intellectual property clearinghouse for agricultural biotechnology.(proposing a means for sharing intellectual property while preserving patent rights) | Business | David Zilberman, Gregory Graff |
| Antigen-specific downregulation of T cells by doxorubicin delivered through a recombinant MHC II-peptide chimera. | Business | Sofia Casares, Alexandru C. Stan, Constantin A. Bona |
| A peptide carrier for the delivery of biologically active proteins into mammalian cells. | Business | May C. et al Morris |
| A RACHITT for our toolbox.(A new twist on DNA suffling increases recombination frequency and expands access to sequence space, facilitating the engineering of new protein activities.) | Business | Joelle N. Pelletier |
| A sensitive transgenic plant system to detect toxic inorganic compounds in the environment. | Business | Olga et al Kovalalchuk |
| A systemic approach to the analysis of protein phosphorylation. | Business | Ruedi Aebersold, Julian D. Watts, Luilin Zhou |
| Aurora throws light on Vertex's aspirations.(Vertex Pharmaceuticals)(Aurora Biosciences) | Business | |
| A yeast sensor of ligand binding.(Research article)(Illustration) | Business | Chandra L. and Fields ucker Stanley |
| Bactericidal antisense effects of peptide-PNA conjugates. | Business | et al, Liam Good |
| Bar-coding ciomolecules with fluorescent nanocrystals.(Microbeads embedded w/ quantum dots) | Business | Sandra J. Rosenthal |
| Beyond comparison - antibiotics from genome data? Microbial genomics is producing a plethora of candidate targets for developing new classes of antimicrobial agents. | Business | Michael N. Alekshun |
| Big pharmas seek biotechs that deliver. | Business | |
| Bioassay of prostate-specific antigen (PSA) using microcantilevers. | Business | Guanghua Wu, Ram H. Datar, Karolyn M. Hansen, Thomas Thundat, Richard J. Cote, Arun Majumdar |
| Bioethics programs evolve as they grow. | Business | David Magnus |
| Biotech industry faces new bottleneck. | Business | Ken Garber |
| Biotechnology in the Baltic.(Estonia is Using its Genes as Bait for Foreign Investments to Support its Embryonic Biotechnology Industry) | Business | Frank Lone |
| Biotechnology patents in the food sectors.(A closer look at the field, the players, and their strategies reveals a game of follow the leader.) | Business | Shyana V. Ramani |
| Breaking the code of resistance.(insect pests' resistance to Bacillus thuringiensis)(Illustration) | Business | Bruce E. Tabashnik |
| Bungled law threatens Italian tech transfer.(New legislation from the Italian goverment)(Statistical Data Included) | Business | Anna Meldolesi |
| Canadian farmer found guilty of Monsanto canola patent infringement. | Business | |
| Can bioremediation bounce back? As the market for bioremediation using genetically modified microorganisms is eroded by controversy over the technology, transgenic plants may take center stage for environmental cleanup. | Business | Myrna E. Watanabe |
| Cell factories for fighting cancer. | Business | Douglas Hanahan, Gabriele Bergers |
| Combined transductional and transcriptional targeting improves the specificity of transgene expression "in vivo." | Business | Paul N. et al Reynolds |
| Comples biology with no parameters.(Human genome sequence) | Business | James E. Bailey |
| Crafting crop resistance to corn rootworms.(Transgenic corn) | Business | Ken Ostlie |
| CREating breakthroughs.(utilizing a recombinant Cre recombinase)(Illustration) | Business | Chun-Ming Chen, Richard C. Behringer |
| Designing an optimal intellectual property system for plants: a US Supreme Court debate.(Illustration) | Business | Mark D. Janis, Jay P. Kesan |
| Designing a polyvalent inhibitor of anthrax toxin.(Illustration)(Statistical Data Included) | Business | George M. Whitesides, Michael Mourez, Ravi S. Kane, Jeremy Mogridge, Steve Metallo, Pascal Deschatelets, Bret R. Sellman, R. John Collier |
| Differentiation and integration.(Mergers and acquisitions likened to the product of incremental quantities)(Brief Article) | Business | |
| Direct and sensitive detection of a human virus by rupture event scanning. | Business | Matthew A. et al Cooper |
| Disease genes less elusive than once thought, say researchers. | Business | Christopher Morrison |
| DNA shuffling method for generating highly recombined genes and evolved enzymes. | Business | et al, Wayne M. Coco |
| Drug discovery--an operating model for a new era. | Business | Scott Myers, Ann Baker |
| Efficient metaphase II transgenesis with different transgene archetypes.(Technical report)(Illustration) | Business | Anthony C.F. et al Perry |
| Enrichment analysis of phosphorylated proteins as a tool for probing the phosphoproteome. | Business | Yoshida Oda, Takeshi Nagasu, Brian T. Chait |
| Epigenetic regulation of gene structure and function with a cell-permeable Cre recombinase.(Illustration) | Business | Daewoong Jo, Abudi Nashabi, Christie Doxsee, Qing Lin, Derya Unutmaz, Jin Chen, H. Earl Ruley |
| Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer. | Business | et al, Timothy R. Hughes |
| Feeder-free growth of undifferentiated human embryonic stem cells.(Illustration)(Statistical Data Included) | Business | Chunhui Xu, Margaret S. Inokuma, Jerrod Denham, Kathaleen Golds, Pratima Kundu, Joseph D. Gold, Melissa K. Carpenter |
| Genetic rescue of an endangered mammal by cross-species nuclear transfer using post-mortem somatic cells.(Illustration) | Business | Michael Clinton, Pasqualino Loi, Grazyna Ptak, Barbara Barboni, Josef Fulka Jr., Pietro Cappai |
| Genetic selection and the lure of SIN.(A rapid method for exploring gene function uses alphavirus expression cloning) | Business | Garry P. Nolan |
| Genotyping of dinucleotide tandem repeats by MALDI mass spectrometry of ribozyme-cleaved RNA transcripts. | Business | Martin Forster, Stefan Krebs, Doris Seichter |
| GlaxoSmithKline presents a biotech facade. | Business | Dorey. Emma |
| Going for the big one: blockbuster patents enrich university coffers, but can also affect future patenting and research divisions. | Business | |
| Group II introns as controllable gene targeting vectors for genetic manipulation of bacteria. | Business | Michael et al Karlberg |
| Growing better blod vessels.(Methods for engineering mature blood vessels) | Business | Peter and Conway Carmeliet Edward M. |
| Growing pains for biopharmaceuticals. Biopharmaceuticals have provided a swift means of swelling pharmaceutical company pipelines, but they may not be such a fast "fix" for the industry in the future. | Business | Gabby Ashton |
| High-yield selection and extraction of two promoter-defined phenotypes of neural stem cells from the fetal human brain. | Business | H. Michael et al Keyoung |
| Holistic approaches to glycobiology.(The Genetic Selection of Mutant Cells in a Glycoconjugate Biosyntheitc Pathway may Provide Insights into Metabolic Disease) | Business | Pauline et al Rudd |
| Hotwiring biosensors.(integrated circuits with biomolecules)(Illustration) | Business | |
| Illegal Bt cotton in India haunts regulators. | Business | KS Jayaraman |
| Immobilized RNA switches for the analysis of complex chemical and biological mixtures. | Business | et al, Sukeerthi Seetharaman |
| Indian regulatory system stifles industry growth. | Business | KS Jayaraman |
| Indian seed bill forges new ground. | Business | K.S. Jayaraman |
| Informatics and multiplexing of intact protein identification in bacteria and the archaea.(Illustration)(Statistical Data Included) | Business | Fanyu Meng, Bengamin J. Cargile, Leah M. Miller, Andrew J. Forbes, Jeffrey R. Johnson, Neil L. Kelleher |
| In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data. | Business | Jeremy S. Edwards, Rafael U. Ibarra, Bernhard O. Palsson |
| In vitro differentiation of transplantable neural precursors from human embryonic stem cells. | Business | Su-Chun et al Zhang |
| In vitro selection of necleoprotein enzymes. | Business | Michael P. Robertson, andrew D. Ellington |
| In vivo near-infrared fluorescence imaging of osteoblastic activity. | Business | Atif et al Zaheer |
| Isjolation of high-affinity ligand-binding proteins by periplasmic expression with cytometric screening (PECS). | Business | Gang et al Chen |
| Italy performs GMO trial about-face. | Business | Anna Meldolesi |
| Knockout drug screens.(recognizing compounds with gene-selective properties)(Illustration) | Business | George C. Prendergast |
| Listening for viral infection. | Business | Paul W.H.I. Parren, Erica Ollmann |
| Living on the edges.(molecular component interactions) | Business | Harvey Bialy |
| Local endostatin treatment of gliomas administered by microencapsulated producer cells. | Business | Rupert Timpl, Tracy-Ann Read, Dag R. Sorensen, Rupavathana Mahesparan, Per Enger, Bjorn R. Olsen, Mari H.B. Hjelstuen, Olav Haraldseth, Rolf Bjerkvig |
| Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells. | Business | Jeff W.M. et al. Bulte |
| Market woes drag down biotech shares.(Brief Article)(Statistical Data Included) | Business | |
| Molecular biology meets microelectronics. | Business | Erwin Neher |
| Monoclonal antibodies in the clinic.(Despite initial teething problems, the number of clinically effective monoclonal antibodies is growing.) | Business | Janice M. Reichert |
| More biotechs gamble on convertibles. | Business | Pete Mitchell |
| Multiphoton-evoked color change of DsRed as an optical highlighter for cellular and subcellular labeling. | Business | Jonathan S. et al Marchant |
| Multiplex metallica. Molecular tag made of small metal rods may enable parallel and quantitative single-tube assays. | Business | David J. Lockart, Mark O. Trulson |
| Nanopores with a spark for single-molecule detection.(DNA sequencing) | Business | Hui Wang, Daniel Branton |
| Neural progenitors from human embryonic stem cells. | Business | Reubinoff et al. |
| New Zealand's comprimise calms GMO lobby.(compromise found with the genetically-modified foods lobby) | Business | Cheryl Norrie |
| Nonenzymatic autoligation in direct three-color detection of RNA and DNA point mutations. | Business | Yanzheng Xu, Nilesh B. Karalkar, Eric T. Kool |
| Nuclear security breached. DNA chemistry may provide a solution to the deceptively difficult problem of enhancing DNA nuclear transport in nonviral vectors.(introduction to article in this this issue by Rebuffat et al) | Business | Jon Wolff |
| OECD says industrial biotech not realizing potential.(Organization for Economic Cooperation and Development)(Brief Article) | Business | |
| Overexpression of a cyanobacterial fructose-1, 6-/sedoheptulose-1, 7-bisphosphatase in tobacco enhances photosynthesis and growth.(Illustration)(Statistical Data Included) | Business | Yoshiko Miyagawa, Masahiro Tamoi, Shigeru Shigeoka |
| PDL's mAb technology finds right timing. | Business | |
| Phytodetoxification of TNT by transgenic plants expressing a bacterial nitroreductase.(genetically-modified tobacco plants used to decontaminate soil of TNT) | Business | Nerissa et al Hannink |
| Pigs expressing salivary phytase produce low-phosporus manure. | Business | |
| Pink water, green plants, and pink elephants. Tobacco has been engineered with a bacterial nitroreductase that facilitates degradation of trinitrotoluene.(introduction to article in this issue by Hannink et al) | Business | Richard B. Meagher |
| Plastid engineering bears fruit.(The tomato has been engineered to express in its plastids high levels of a recombinant protein) | Business | Pal Maliga |
| Polymeric system for dual growth factor delivery.(Research article)(Illustration) | Business | Ricardson, Thomas P.; Peters, Martin C.; Ennett, Alexandra B. and Mooney, David J. |
| Production of calves from G1 fibroblasts.(methods for cloning calves) | Business | Poothappillai et al Kasinathan |
| Protein hinges for bioelectronics.(The creation of chemoresponsive bioelectronic sensors) | Business | Itamar illner |
| Protein solubility and folding monitored in vivo by structural complementation of a genetic marker protein. | Business | Philip J. Thomas, W. Christian Wigley, Rhesa D. Stidham, Nathan M. Smith, John F. Hunt |
| Proteomics comes to the surface.(studying protein function on a genome-wide scale) | Business | Gavin MacBeath |
| Putting a price on biotechnology.(Many bioentrepreneurs incorrectly estimate the value of their technology by failing ot account adequately for the cost, risk, and time inherent in product development.) | Business | Jeffrey J. Stewart, Peter N. Allison, Ronald S. Johnson |
| Quantitative profiling of differentiation-induced microsomal proteins using isotope-coded affinity tags and mass spectrometry.(Illustration)(Statistical Data Included) | Business | Ruedi Aebersold, David K. Han, Jimmy Eng, Huilin Zhou |
| quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules. | Business | Mingyong et al Han |
| Quicker drug approvals on the way for Europe. | Business | Sylvia Davidson |
| Quorex Pharmaceuticals.(New Antimicrobials Quiet Bacterial Talk) | Business | |
| Realism in drug discover - could Cassandra be right?(commentary)(Critical Essay) | Business | David F. Horrobin |
| Recent patents in molecular evolution.(list of U.S. patents with brief description, company, etc.) | Business | |
| Receptor-targeted optical imaging of tumors with near-infrared flurorescent ligands. | Business | et al, Andraes Becker |
| Recombinant maxi-K channels on transistor, a prototype of iono-electronic interfacing. | Business | Bernhard Straub, Elisabeth Meyer, Peter Fromherz |
| Redefining priorities in gene-based drug discovery. | Business | Mehran M. Khodadoust, Thomas P. Klein |
| Re-engineering adenovirus regulatory pathways to enhance oncolytic specificity and efficacy.(Reasearch article)(Illustration) | Business | Murali et al Ramachandra |
| Regulation and exploitation of genetically modified crops. Functional foods, nutraceuticals, and plant-derived mediciens may improvempublic relations for transgeneic crop technology, but could leave manufacturers with tricky business decisions to make. | Business | et al, Gijs A. Kleter |
| Selection of insertional mutants using subgenic-resolution arrays.(Research article)(Illustration) | Business | Vasudeo et al Badarinarayana |
| Selective enhancement of gene transfer by steroid-medicated gene delivery. | Business | Alexandre et al Rebuffat |
| Shedding light on molecular timing.(use of jellyfish's green fluorescent protein in cellular research) | Business | Fred Schaufele |
| Single-mismatch detection using gold-quenched fluorescent oligonucleotides. | Business | Benoit Dubertret, Michel Calame, Albert H. Libchaber |
| Single-molecule observation of protein-protein interactions in the chaperonin system. | Business | Masasuke Yoshida, Hideki Taguchi, Taro Ueno, Hisashi Tadakuma, Takashi Funatsu |
| Stable, genetic transformation of tomato plastids and expression of a foreign protein in fruit. | Business | Stephanie Ruf, Marita Hermann, Irving J. Berger, Helaine Carrer, Ralph Bock |
| Stem cells with brainpower. Two studies demonstrate the efficient generation of brain cells from human ES cells.(introduction to two articles in this issue discussing stem cell research) | Business | Lorenz Studer |
| Suppression of a P450 hydroxylase gene in plant trichome glands enhances natural-product-based aphid resistance. | Business | et al, Erming Wang |
| Switching nucleic acids for antibodies. Can ribozymes replace antibodies i future array formats for proteomics and metabolomics? | Business | Andrew D. Ellington, David Hoffman, Jay Hesselberth |
| The complexities of bioethics.(Commentary) | Business | Richard C. Strohman |
| The HIV Tat protein transduction domain improves the biodistribution of Beta- glucuronidase expressed from recombinant viral vectors. | Business | Haibin et al Xia |
| The path not taken.(Protein paths) | Business | Edward M. Maracotte |
| The potential of nucleic acid repair in functional genomics. | Business | Michael C. Rice, Kirk Czymmek, Eric B. Kmiec |
| The right chemistry for marker gene removal? | Business | David W. Ow |
| Toward knockout sheep.(The Targeted Disruption of two Genes in Sheep Confirms the Feasibility of Gene TArgeting in large Animals, but Falls Short of Producing Viable Offspring) | Business | Kevin Wells |
| Toward the phosphoproteome.(Two chemical protocols for the rapid analysis of protein phosphorylation by mass spectrometry promise to expand the schope of proteomics research.) | Business | Natalie G. Ahn, Katheryn A. Resing |
| Training needs in regulatory science for the biopharmaceutical industry. | Business | Larry E. Gundersen |
| Transplantation of brain cells assembled around programmable synthetic microenvironment.(Illustration)(Statistical Data Included) | Business | W. Mark Saltzman, Melissa J. Mahoney |
| Use of isogenic human cancer cells for high-throughput screening and drug discovery.(Illustration)(Statistical Data Included) | Business | Kenneth W. Kinzler, Bert Vogelstein, Christopher J. Torrance, Vijai Agrawal |
| US presidential transition prompts biotech policy frenzy. | Business | Jeffrey Fox |
| Vaccines to die for.(Induction of Apoptotic Death by Modified Caspases Enhances the Function of "Naked" DNA Vaccination) | Business | Nicholas P. Restifo |
| Vironcology -- not yet, but soon? | Business | Richard G. Vile |
| Why biodefense won't work.(The problems of defending against bioterrorism)(Brief Article) | Business | |
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