Genes & Development 2003 - Abstracts
| Genes & Development 2003 | |||||
| Title | Subject | Authors | |||
|---|---|---|---|---|---|
| Abberrant histone acetylation, altered transcription, and retinal degeneration in a Drosophila model of polygmutamine disease are rescued by CREB-binding protein. | Biological sciences | Kenneth H. Fischbeck, J. Paul Taylor, Addis A. Taye, Catherine Campbell, Parsa Kazemi-Esfarjani, Kyung-Tai Min | |||
| Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1.(Research Communication) | Biological sciences | Yang Shi, Rueyling Lin, Frederique Gay, Dominica Calvo, Miao-Chia Lo, Julian Ceron, Morris Maduro | |||
| A complex of LIN-5 and GPR proteins regulates G protein signaling and spindle function in C. elegans.(G protein regulator)(Caenorhabditis elegans) | Biological sciences | Daylan G. Srinivasan, Rigely M. Fisk, Huihong Xu, Sander Van Den Heuvel | |||
| A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling. | Biological sciences | Mariko Ariyoshi, John W. R. Schwabe | |||
| Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. | Biological sciences | James Horner, David A. Tuveson, Nabeel Bardeesy, Andrew J. Aguirre, Manisha Sinha, Lyle Lopez, Ronald A. DePinho, Mark S. Redstone | |||
| A divergent INS protein in Caenorhabditis elegans structurally resembles human insulin and activates the human insulin receptor. | Biological sciences | Michael A. Weiss, Qing-xin Hua, Satoe H. Nakagawa, Jill Wilken, Rowena R. Ramos, Wenhua Jia, Joseph Bass | |||
| AFP is a novel negative regulator of ABA signaling that promotes ABI5 protein degradation.(ABI five binding protein)(abscisic acid) | Biological sciences | Nam-Hai Chua, Luis Lopez-Molina, Sebastien Mongrand, Natsuko Kinoshita | |||
| A-kinase anchoring proteins and neuronal signaling mechanisms. | Biological sciences | John D. Scott, Graeme K. Carnegie | |||
| Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction. | Biological sciences | Matthew P. Scott, Kaye Suyama, Alan Jian Zhu, Limin Zheng | |||
| Alternative trans-splicing of constant and variable exons of a Drosophila axon guidance gene, lola.(lola: longitudinals lacking) | Biological sciences | Edward Giniger, Takayuki Horiuchi, Toshiro Aigaki | |||
| A mechanism for the exclusion of low-fidelity human Y-family DNA polymerase from base excision repair. | Biological sciences | Lajos Haracska, Satya Prakash, Louise Prakash | |||
| A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb.(C-terminal domain)(positive transcription elongation factor b) | Biological sciences | Fan Zhang, Matjaz Barboric, T. Keith Blackwell, B. Matija Peterlin | |||
| An essential role of Bmp4 in the atrioventricular septation of the mouse heart. | Biological sciences | Holger Kulessa, Brigid L.M. Hogan, Kai Jiao, Kevin Tompkins, Yingna Zhou, Lorene Batts, H. Scott Baldwin | |||
| An intersubunit contact stimulating transcription initiation by E. coli RNA polymerase: interaction of the alpha C-terminal domain and sigma region 4. | Biological sciences | Wilma Ross, Richard L. Gourse, David A. Schneider, Brian J. Paul, Aaron Mertens | |||
| An mRNA structure in bacteria that controls gene expression by binding lysine. | Biological sciences | Ronald R. Breaker, Narasimhan Sudarsan, J. Kenneth Wickiser, Shingo Nakamura, Margaret S. Ebert | |||
| A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo. | Biological sciences | Thomas Fellner, Daniel H. Lackner, Hans Hombauer, Patrick Piribauer, Ingrid Murdak, Katrin Zaragoza, Claudia Juno, Egon Ogris | |||
| A novel class of secreted hydrophobic proteins is involved in aerial hyphae formation in Streptomyces coelicolor by forming amyloid-like fibrils. | Biological sciences | Dennis Claessen, Rick Rink, Wouter de Jong, Jeroen Siebring, Peter de Vreugd, F. G. Hidde Boersma, Lubbert Dijkhuizen, Han A. B. Wosten | |||
| A novel pseudoknot element is essential for the action of a yeast telomerase. | Biological sciences | Elizabeth H. Blackburn, Yehuda Tzfati, Zachary Knight, Jagoree Roy | |||
| A novel regulation mechanism of DNA repair damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein. | Biological sciences | Wim Vermeulen, Kaoru Sugasawa, Gijsbertus T. J. van der Horst, Jessica M. Y. Ng, Steven Bergink, Harry Vrieling, Jan H. J. Hoeijmakers | |||
| A novel ring-like complex Xenopus proteins essential for the initiation of DNA replication. | Biological sciences | Yumiko Kubota, Youhei Takase, Yasunori Komori, Yoshitami Hashimoto, Toshiaki Arata, Yoichiro Kamimura, Hiroyuki Araki, Haruhiko Takisawa | |||
| Antagonists of Wnt and BMP signaling promote the formation of vertebrate head muscle. | Biological sciences | Eldad Tzahor, Clifford J. Tabin, Herve Kempf, Roy C. Mootoosamy, Andy C. Poon, Arhat Abzhanov, Andrew B. Lassar, Susanne Dietrich | |||
| A role for a novel 'trans-pseudoknot' RNA-RNA interaction in the functional dimerization of human telomerase. | Biological sciences | Lifeng Xu, Tristram G. Parslow, Elizabeth H. Blackburn, Hinh Ly, Melissa A. Rivera | |||
| A Serrate-expressing signaling center controls Drosophila hematopoiesis. | Biological sciences | Utpal Banerjee, Tim Lebetsky, Seung-Hye Jung | |||
| Association of the RENT complex with nontranscribed and coding regions of rDNA and a regional requirement for the replication fork block protein Fob1 in rDNA silencing.(regulator of nucleolar silencing and telophase exit) | Biological sciences | Julie Huang, Danesh Moazed | |||
| Asynchronous replication timing of imprinted loci is independent of DNA methylation, but consistent with differential subnuclear localization. | Biological sciences | En Li, Joost Gribnau, Rudolf Jaenisch, Konrad Hochedlinger, Ken Hata | |||
| ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanism. | Biological sciences | Kunihiro Matsumoto, Daisuke Nakada, Katsunori Sugimoto | |||
| A transcriptional regulatory cascade that controls left/right asymmetry in chemosensory neurons of C. elegans.(Caenorhabditis) | Biological sciences | Sarah Chang, Robert J. Johnson Jr., Oliver Hobert | |||
| Bcl-2 constitutively suppresses p53-dependent apoptosis in colorectal cancer cells. | Biological sciences | Ming Jiang, Jo Milner | |||
| Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis . | Biological sciences | Reinhard Fassler, Attila Aszodi, Ernst B. Hunziker, Cord Brakebusch | |||
| BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of trancriptional activators of the mammalian clock system. | Biological sciences | Roman V. Kondratov, Mikhail V. Chernov, Anna A. Kondratova, Victoria Y. Gorbacheva, Andrei V. Gudkov, Marina P. Antoch | |||
| cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. | Biological sciences | Ulupi S. Jhala, Marc Montminy, John Walker, Gianluca Canettieri, Robert A. Screaton, Rohit N. Kulkarni, Stan Krajewski, John (American senator) Reed, Xueying Lin, Morris White | |||
| Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. | Biological sciences | Hans Clevers, Daniel Pinto, Alex Gregorieff, Harry Begthel | |||
| Caspases signal not only apoptosis but also antigen-induced activation in cells of the immune system.(Review) | Biological sciences | Andreas Strasser, Kim Newton | |||
| Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway. | Biological sciences | Maxim V. Frolov, Olivier Stevaux, Nicholas J. Dyson, Dessislava K. Dimova | |||
| Cell fate decisions within the mouse organizer are governed by graded Nodal signals. | Biological sciences | Elizabeth J. Robertson, Dominic P. Norris, N. Ray Dunn, Stephane D. Vincent, Shigemi Hayashi | |||
| Ceramides modulate programmed cell death in plants. | Biological sciences | Hua Lu, Hua Liang, Nan Yao, Jong Tae Song, Song Luo, Jean T. Greenberg | |||
| Changes in developmental state: demolish the old to construct the new. | Biological sciences | David J. Stillman, Warren P. Voth | |||
| Chromosome integrity in Sacchromyces cerevisiae: the interplay of DNA replication initiation factors, elongation factors, and origins. | Biological sciences | Dongli Huang, Douglas Koshland | |||
| CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals. | Biological sciences | Arnold J. Levine, Brian T. Chait, Shengkan Jin, Markus Kalkum, Michael Overholtzer, Archontoula Stoffel | |||
| Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse. | Biological sciences | Stuart Orkin, Janet Rossant, William L. Stanford, Masatsugu Ema, Patrick Faloon, Wen Jie Zhang, Masanori Hirashima, Tammy Reid, Kyunghee Choi | |||
| Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. | Biological sciences | Robert Tjian, Oscar Puig, Michael T. Marr, M. Laure Ruhf | |||
| Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2553.(cyclin-dependent kinase) | Biological sciences | Kevan M. Shokat, Ira Herskowitz, Kirsten R. Benjamin, Chao Zhang | |||
| Coordinated temporal and spatial control of motor neuron and serotonergic neuron generation from a common pool of CNS progenitors. .(central nervous system) | Biological sciences | Robb Krumlauf, Johan Ericson, Alexandre Pattyn, Anna Vallstedt, Jose M. Dias, Omar Abdel Samad, Filippo M. Rijli, Jean-Francois Brunet | |||
| Cop9/signalosome subunits and Pcu4 regulate ribonucleotide reductase by both checkpoint-dependent and -independent mechanism. | Biological sciences | Antony M. Carr, Cong Liu, Kelly A. Powell, Kirsten Mundt, LeJung Wu, Thomas Caspari | |||
| Coupled degradation of a small regulatory RNA and its mRNA targets in Escherichia coli. | Biological sciences | Susan Gottesman, Eric Masse, Freddy E. Escorcia | |||
| Crystal structure of a beta-catenin/Axin complex suggests a mechanism for the beta-catenin destruction complex. | Biological sciences | David Kimelman, Wenqing Xu, Yi Xing, Wilson K. Clements | |||
| Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enchancers. | Biological sciences | Attila Remenyi, Katharina Lins, Matthias Wilmanns, Hans R. Scholer, L. Johan Nissen, Rolland Reinbold | |||
| Crystal structure of the Drosophila Mago nashi-Y14 complex. | Biological sciences | Hang Shi, Rui-Ming Xu | |||
| daf-28 encodes a C. elegans insulin superfamily member that is regulated by theenvironmental cues and acts in the DAF-2 signaling pathway. | Biological sciences | Gary Ruvkun, Weiqing Li, Scott G. Kennedy | |||
| Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. | Biological sciences | Traci A. Mansfield, Steven A. Kliewer, Jason A. Holt, Guizhen Luo, Andrew N. Billin, John Bisi, Y. Yvette McNeill, Karen F. Kozarsky, Mary Donahee, Da Yuan Wang, Bryan Goodwin, Stacey A. Jones | |||
| Degradation of targeted mRNAs in Escherichia coli: regulation by a small antisense RNA . | Biological sciences | Agamemnon J. Carpousis | |||
| Differential DNA affinity specifies roles for the origin recognition complex in budding yeast heterochromatin. | Biological sciences | Catherine A. Fox, Madeleine A. Palacios DeBeer, Ulrika Muller | |||
| Distinct HP1 and Su(var)3-9 complexes bind to sets of developmentally coexpressed genes depending on chromosomal location. | Biological sciences | Steven Henikoff, Bas van Steensel, Harmen J. Bussemaker, Frauke Greil, Ineke van der Kraan, Jeffrey Delrow, James F. Smothers, Elzo de Wit, Roel van Driel | |||
| Diversified transcription initiation complexes expand promoter selectivity and tissue-specific gene expression. | Biological sciences | Robert Tjian, Andreas Hochheimer | |||
| Dkk1 and noggin cooperate in mammalian head induction. | Biological sciences | Heiner Westphal, Christof Niehrs, Ivan del Barco Barrantes, Gary Davidson, Hermann-Josef Grone | |||
| DNA binding controls inactivation and nuclear accumulation of the transcription factor Stat1. | Biological sciences | Thomas Meyer, Andreas Marg, Petra Lemke, Burkhard Weisner, Uwe Vinkemeier | |||
| DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells. | Biological sciences | Eileen White, Andrea Cuconati, Chandreyee Mukherjee, Denise Perez | |||
| Drosophila awd, the homolog of human nm23, regulates FGF receptor levels and functions synergistically with shi/ dynamin during tracheal development. | Biological sciences | Vincent Dammai, Boris Adryan, Kim R. Lavenburg, Tien Hsu | |||
| Drosophila FACT contributes to Hox gene expression through physical and functional interactions with GAGA factor.(facilitates chromatin transcription) | Biological sciences | Hiroshi Handa, Akihiro Iwamatsu, Takahiro Nakayama, Tsakasa Shimojima, Masahiro Okada, Hitoshi Ueda, Katsuya Okawa, Susumu Hirose | |||
| Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. | Biological sciences | Susan E. Crawford, Nissim Hay, William S. Chen, Pei-Zhang Xu, Mei-Ling Chen, Xiao-ding Peng, Annett Hahn-Windgassen, Jennifer Skeen, Joel Jacobs, Deepa Sundararajan, Kevin G. Coleman | |||
| Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor. | Biological sciences | Tyler Jacks, Karen Cichowski, Sabrina Santiago, Melanie Jardim, Bryan W. Johnson | |||
| Early-replicating heterochromatin. | Biological sciences | Soo-Mi Kim, Dharani D. Dubey, Joel A. Huberman | |||
| Ecsit-ement on the crossroads of Toll and BMP signal transduction. | Biological sciences | Carl-Henrik Heldin, Aristidis Moustakas | |||
| Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. | Biological sciences | Jeffrey L. Wrana, Chen Dong, Richard A. Flavell, Brigid L.M. Hogan, Sankar Ghosh, Changchun Xiao, Jae-hyuck Shim, Michael Kluppel, Samuel Shao-Min Zhang, Xin-Yuan Fu | |||
| Ectodermal WNT3/betap-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge. | Biological sciences | Andrew P. McMahon, Kirk R. Thomas, Mario R. Capecchi, Robert Moore, Jeffery R. Barrow, Oreda Boussadia-Zahui, Rolf Kemler | |||
| ELAV inhibits 3'-end processing to promote neural splicing of ewg pre-mRNA.(embryonic lethal abnormal visual system) | Biological sciences | Kalpana White, Matthias Soller | |||
| Elimination of Mcl-1 is reguired for the initiation of apoptosis following ultraviolet irradiation. | Biological sciences | Xiaodong Wang, Deepak Nijhawan, Min Fang, Elie Traer, Qing Zhong, Wenhua Gao, Fenghe Du | |||
| Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall.(platelet-derived growth factor) | Biological sciences | Per Lindblom, Holger Gerhardt, Stefan Liebner, Alexandra Abramsson, Maria Enge, Mats Hellstrom, Gudrun Backstrom, Simon Fredriksson, Ulf Landegren, Henrik C. Nystrom, Goran Bergstrom, Elisabetta Dejana, Arne Ostman, Per Lindahl, Christer Betsholtz | |||
| Enhancer-promoter communication mediated by Chip during Pannier-driven proneural patterning is regulated by Osa. | Biological sciences | Pascal Heitzler, Luc Vanolst, Inna Biryukova, Philippe Ramain | |||
| Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice. | Biological sciences | Markus Grompe, Stephen N. Jones, Milton J. Finegold, Scott Houghtailing, Cynthia Timmers, Meenakshi Noll, M. Stephen Meyn | |||
| Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. | Biological sciences | David Baltimore, Eric J. Brown | |||
| Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity. | Biological sciences | Pamela S. Ohashi, Andrew Wakeham, Razqallah Hakem, Denis Bouchard, Benedicte Lemmers, Leonardo Salmena, Anne Hakem, Elzbieta Matysiak-Zablocki, Kiichi Murakami, P.Y. Billie Au, Donna M. Berry, Laura Tamblyn, Amro Shehabeldin, Eva Migon, Wen Chen Yeh, Jane C. McGlade | |||
| Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. | Biological sciences | Bryan R. Cullen, Ian G. Macara, Rui Yi, Yi Qin | |||
| Facilitation of dendritic mRNA transport by CPEB.(cytoplasmic polyadenylation element) | Biological sciences | Joel D. Richter, Elisa Barbarese, John H. Carson, Yi-Shuian Huang | |||
| Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung. | Biological sciences | Andrew P. McMahon, Pao-Tien Chuang, T'Nay Kawcak | |||
| Formation of higher-order secondary and tertiary chromatin structures by genomic mouse mammary tumor virus promotes. | Biological sciences | Jeffrey C. Hansen, Philippe T. Georgel, Terace M. Fletcher, Gordon L. Hager | |||
| Functional interactions between the transcription and mRNA 3' end processing machineries mediated by Ssu72 and Sub1. | Biological sciences | Michael Hampsey, Xiaoyuan He, Asad U. Khan, Hailing Cheng, Donald L. Pappas Jr., Claire L. Moore | |||
| GATA-3: an unexpected regulator of cell lineage determination in skin. | Biological sciences | Elaine Fuchs, Charles K. Kaufman, Ping Zhou, H. Amalia Pasolli, Michael Rendl, Diana Bolotin, Kim-Chew Lim, Xing Dai, Maria-Luisa Alegre | |||
| Generation of Ski-knockdown mice by expressing a long double-strand RNA from an RNA polymerase II promoter. | Biological sciences | Shunsuke Ishii, Toshie Shinagawa | |||
| Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb.(apical ectodermal ridge) | Biological sciences | Makoto M. Taketo, Joerg Huelsken, Walter Birchmeier, Natalia Soshnikova, Dietmar Zechner, Yuji Mishina, Richard R. Behringer, E. Bryan Crenshaw III | |||
| Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network. | Biological sciences | Ling Li, Bruce A. Edgar, Shaun M. Cowley, Robert N. Eisenman, Tomoyuki Sawado, Amir Orian, Bas van Steensel, Jeffrey Derlow, Harmen J. Bussemaker, Eleanor Williams, Lenora W. M. Loo, Cynthia Yost, Sarah Pierce, Susan M. Parkhurst | |||
| Genomic instability and endoreduplication triggered by RAD17 deletion. | Biological sciences | Stephen J. Elledge, Xin Wang, Lee Zou, Huyong Zheng, Qingyi Wei, Lei Li | |||
| Genomic targets of the human c-Myc protein. | Biological sciences | Scott R. Frank, Marianne Schroeder, Bruno Amati, Paula C. Fernandez, Luquan Wang, Suxing Liu, Jonathan Greene, Andrea Cocito | |||
| GI cyclin-dependent kinases are insufficient to reverse dE2F2-mediated repression.(Research Communication) | Biological sciences | Maxim V. Frolov, Olivier Stevaux, Dessislava Dimova, Nicholas J. Dyson, Nam-Sung Moon, Eun-Jeong Kwon, Erick J. Morris | |||
| GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast.(Go, Ichi, Nii, San-five, one, two, three in Japanese) | Biological sciences | Akio Sugino, Hiroyuki Araki, Yuko Takayama, Kamimura, Yoichiro, Mariko Okawa, Sachiko Muramatsu | |||
| Heritable activity: a prion that propagates by covalent autoactivation. | Biological sciences | Reed B. Wickner, B. Tibor Roberts | |||
| Heterochromatin: stable and unstable invasion at home and abroad. | Biological sciences | Stephen B. Baylin, Jill A. Fahrner | |||
| Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. | Biological sciences | Peter K. Sorger, Peter De Wulf, Andrew D. McAinsh | |||
| How does an axon grow? | Biological sciences | Jeffrey L. Goldberg | |||
| How does calorie restriction work? | Biological sciences | Leonard Guarente, Jana Koubova | |||
| Human and mouse TPIT gene mutations cause early onset pituitary ACTH deficiency.(Research Communication) | Biological sciences | Anne-Marie Pulichino, Yves Gauthier, Thierry Brue, Jacques Drouin, Michel David, Catherine Couture, Georges Malpuech, Cheri Deal, Guy Van Vliet, Monique De Vroede, Felix G. Riepe, Carl-Joachim Partsch, Wolfgang G. Sippell, Merih Berberoglu, Begum Atasay, Sophie Vellette-Kasic | |||
| Human and mouse TPIT gene mutations cause early onset pituitary ACTH deficiency.(Research Communication)(adrenocorticotropin) | Biological sciences | Anne-Marie Pulichino, Yves Gauthier, Thierry Brue, Jacques Drouin, Michel David, Sophie Vallette-Kasic, Catherine Couture, Georges Malpuech, Cheri Deal, Guy Van Vliet, Monique De Vroede, Felix G. Riepe, Carl-Joachim Partsch, Wolfgang G. Sippell, Merih Berberoglu, Begum Atasay | |||
| Human DNA polymerase kappa uses template-primer misalignment as a novel means for extending mispaired termini and for generating single-base deletions. | Biological sciences | Satya Prakash, Louise Prakash, M. Todd Washington, William T. Wolfle | |||
| Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. | Biological sciences | Robert N. Eisenman, Winship Herr, Joanna Wysocka, Michael P Myers, Carol D. Laherty | |||
| ICE1: a regulator of cold-induced transcriptome and freezing tolerance in Arabidopsis.(inducer of CBF expression 1) | Biological sciences | Jian-Kang Zhu, Byeong-ha Lee, Viswanathan Chinnusamy, Masaru Ohta, Siddhartha Kanrar, Xuhui Hong, Manu Agarwal | |||
| Identification of a DNA-binding site and transcriptional target for the EWS-WT1(+KTS) oncoprotein. | Biological sciences | Daniel A. Haber, Vijay Yajnik, Paul A. Reynolds, Gromoslaw A. Smolen, Rachel E. Palmer, Dennis Sgroi, William L. Gerald | |||
| Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi.(Caenorhabditis)(RNA interference) | Biological sciences | Andrew G. Fraser, Ravi S. Kamath, Julie Ahringer, Ronald H. A. Plasterk, Joris Pothof, Gijs van Haaften, Karen Thijssen, Marcel Tijsterman | |||
| Identification of the C-signal, a contact-dependent morphogen coordinating multiple developmental responses in Myxococcus xanthus. | Biological sciences | Sune Lobedanz, Lotte Sogaard-Andersen | |||
| Impact of p53 loss on reversal and recurrence of conditional Wnt-induced turmorigenesis. | Biological sciences | Edward J. Gunther, Susan E. Moody, George K. Belka, Robert D. Cardiff, Lewis A. Chodosh, Kristina T. Hahn, Nathalie Innocent, Katherine D. Dugan | |||
| Inactivation of exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility. | Biological sciences | Harry Hou Jr., Burkhard Kneitz, Paula E. Cohen, Michael F. Kane, Winfried Edelmann, Richard D. Kolodner, Thomas A. Kunkel, Kaichun Wei, Alan B. Clark, Edmund Wong, Dan J. Mazur, Tchaiko Parris, Nadine K. Kolas, Robert Russell, Guohze Yang | |||
| Inheritance of polycomb-dependent chromosomal interactions in Drosophila. | Biological sciences | Frederic Bantignies, Charlotte Grimaud, Sergey Lavrov, Mathieu Gabut, Giacomo Cavalli | |||
| Insulin worms its way into the spotlight.(Perspective) | Biological sciences | Donald W. Nelson, Richard W. Padgettt | |||
| Integral role of Noxa in p53-mediated apoptotic response. | Biological sciences | Hiroshi Tanaka, Kiyoshi Takeda, Shizuo Akira, Tadatsugu Taniguchi, Nobuyuki Tanaka, Akinori Takaoka, Tsukasa Shibue, Eri Oda, Hideki Murasawa, Yasuyuki Morishita | |||
| Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction. | Biological sciences | Atsushi Ikeda, Edgar M. Pera, Edward Eivers, Eddy M.De Robertis | |||
| Integration of Smad and MAPK pathways: A link and a linker revisited. | Biological sciences | Joan Massague | |||
| Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adnesion, and controlling actin accumulation. | Biological sciences | Reinhard Fassler, Takao Sakai, Keiko Sakai, Shaohua Li, Denitsa Docheva, Carsten Grashoff, Gunter Kostka, Atilla Braun, Alexander Pfeifer, Peter D. Yurchenco | |||
| In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. | Biological sciences | Gabriela Dontu, Wissam M. Abdallah, Jessica M. Foley, Kyle W. Jackson, Michael F. Clarke, Mari J. Kawamura, Max S. Wicha | |||
| In vivo analysis of a developmental circuit for direct transcriptional activation and repression in the same cell by a Runx protein. | Biological sciences | Utpal Banerjee, Jude Canon | |||
| IRF-4,8 orchestrate the pre-B-to-B transition in lymphocyte development.(interferon regulatory factors) | Biological sciences | Kay L. Medina, Runqing Lu, David W. Lancki, Harinder Singh | |||
| JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissue.(c-Jun NH (sub)2 -terminal kinase) | Biological sciences | Roger J. Davis, Richard A. Flavell, Claire R. Weston, Anthony Wong, J. Perry Hall, Mary E. P. Goad | |||
| KNL-1 directs assembly of the microtubule-binding interface of the kinetochore in C. elegans. | Biological sciences | Karen Oegema, Anna Shevchenko, Arshad Desai, Sonja Rybina, Thomas Muller-Reichert, Andrej Shevchenko, anthony Hyman | |||
| Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends. | Biological sciences | Daniel E. Gottschling, Anne E. Stellwagen, Zara W. Haimberger, Joshua R. Veatch | |||
| Latent ClpX-recognition signals ensure LexA destruction after DNA damage. | Biological sciences | Robert T. Sauer, Saskia B. Neher, Julia M. Flynn, Tania A. Baker | |||
| Life on a planet of its own: regulation of RNA polymerase I transcription in the nucleolus. | Biological sciences | Ingrid Grummt | |||
| Lipoprotein receptors and a disabled family cytoplasmic adaptor protein regulate EGL-17/FGF export in C. elegans. | Biological sciences | Jonathan A. Cooper, Darren M. Kamikura | |||
| Localized recruitment of a chromatin-remodeling activity by an activator in vivo drives transcriptional elongation. | Biological sciences | Robert E. Kingston, Laura L. Corey, Christine S. Weirich, Ivor J. Benjamin | |||
| Local regulation of fat metabolism in peripheral nerves. | Biological sciences | Patrick Burrola, Greg Lemke, Mark H.G. Verheijen, Roman Chrast | |||
| Local spreading of MSL complexes from roX genes on the Drosophila X chromosome. | Biological sciences | Mitzi I. Kuroda, Hyangyee Oh, Yongkyu Park | |||
| Loss of circadian rhythmicity in aging mPer1 (super)-/- mCry2 (super)-/- mutant mice. | Biological sciences | Urs Albrecht, Henrik Oster, Stephanie Baeriswyl, Gijsbertus T. J. van der Horst | |||
| MAX4 amd RMS1 are orthologous dioxygenase-like genes that regulate shoot branching in Arabidopsis and pea. | Biological sciences | Ottoline Leyser, Karim Sorefan, Jon Booker, Karine Haurogne, Magali Goussot, Katherine Bainbridge, Eloise Foo, Steven Chatfield, Sally Ward, Christine Beveridge, Catherine Rameau | |||
| mBtd is required to maintain signaling during murine limb development. | Biological sciences | Peter Gruss, Herbert Jackle, Frieder Schock, Ahmed Mansouri, Dieter Treichel | |||
| Mechanism of p38 MAP kinase activation in vivo.(mitogen-activated protein) | Biological sciences | Roger J. Davis, Richard A. Flavell, Nyaya Kelkar, Deborah Brancho, Nobuyuki Tanaka, Anja Jaeschke, Juan-Jose Ventura, Yoshinori Tanaka, Masanao Kyuuma, Toshikazu Takeshita | |||
| Meiotic double-strand breaks at the interface of chromosome movement, chromosome remodeling, and reductional division. | Biological sciences | Nancy Kleckner, Denise Zickler, Aurora Storlazzi, Sophie Tesse, Silvana Gargano, Francoise James | |||
| Mice lacking a transcriptional corepressor Tob are predisposed to cancer. | Biological sciences | Toru Suzuki, Tadashi Yamamoto, Tetsuo Noda, Kenzaburo Tani, Yutaka Yoshida, Hisashi Umemori, Shunsuke Ishii, Takahisa Nakamura, Masato Komoda, Hitoshi Satoh, Junko K. Tsuzuku, Takashi Miyasaka, Eri K. Yoshida, Reiko K. Kunisaki, Shigeo Mori, Masami Suganuma | |||
| Model for the Brain Tumor-Pumilio translation repressor complex. | Biological sciences | Robin P. Wharton, Thomas A. Edwards, Aneel K. Aggarwal, Brian D. Wilkinson | |||
| Molecular analysis of the LATERAL SUPPERSSOR gene in Arabidopsis reveals a conserved control mechanism for axillary meristem formation. | Biological sciences | Thomas Greb, Oliver Clarenz, Elisabeth Schafer, Dorte Muller, Ruben Herrero, Gregor Schmitz, Klaus Theres | |||
| Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains.(heterochromatin protein 1) | Biological sciences | C. David Allis, Wolfgang Fischle, Yanming Wang, Steven A. Jacobs, Youngchang Kim, Sepideh Khorasanizadeh | |||
| Molecular imaging in living subjects: seeing fundamental biological processes in a new light. | Biological sciences | Sanjiv S. Gambhir, Tarik F. Massoud | |||
| Mouse knockout solves endocrine puzzle and promotes new pituitary lineage model.(Perspective) | Biological sciences | Catherine E. Keegan, Sally A. Camper | |||
| Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53. | Biological sciences | Stephen J. Elledge, Alexander J. Osborn | |||
| mSin3-associated protein, mSds3, is essential for pericentric heterochromatin formation and chromosome segregation in mammalian cells. | Biological sciences | Ronald A. DePinho, Gregory David, Garth M. Turner, Yao Yao, Alexei Protopopov | |||
| Multiple roles of ephrins in morphogenesis, neuronal networking, and brain function. | Biological sciences | Rudiger Klein, Amparo Palmer | |||
| NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in Drosophila. | Biological sciences | Yuki Yamaguchi, Hiroshi Handa, Chwen-Huey Wu, Lawrence R. Benjamin, Maria Horvat-Gordon, Jodi Washinsky, Espen Enerly, Jan Larsson, Andrew Lambertsson, David Gilmour | |||
| NF2 deficiency promlotes turmogenesis and metastasis by destabilizing adherens junctions. | Biological sciences | Andrea I. McClatchey, Dominique Lallemand, Marcello Curto, Ichiko Saotome, Marco Giovannini | |||
| NF-kappaB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism. | Biological sciences | Raquel Sitcheran, Patricia C. Cogswell, Albert S. Jr. Baldwin | |||
| Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos. | Biological sciences | Yasuhiko Kawakami, Dirk Buscher, Tohru Itoh, Angel Raya, Concepcion Rodriguez-Esteban, Christopher M. Koth, Masanobu Morita, R. Marina Raya, Ilir Dubova, Joaquin Grego Bessa, Jose Luis de la Pompa, Juan Carlos Izpisua Belmonte | |||
| Notch signaling regulates left-right asymmetry determination by inducing Nodal expression. | Biological sciences | Luke T. Krebs, Thomas Gridley, Yukio Saijoh, Hiroshi Hamada, Naomi Iwai, Shigenori Nonaka, Ian C. Welsh, Yu Lan, Rulang Jiang, Timothy P. O'Brien | |||
| NQK1/NtMEK1 is a MAPKK that acts in the NPK1 MAPKKK-mediated MAPK cascade and is required for plant cytokinesis.(MAPK= mitogen-activated protein kinase)(MAPKK= MAPK kinase)(MAPKKK= MAPK kinase kinase) | Biological sciences | Ryuichi Nishihama, Masaki Ishikawa, Takashi Soyano, Yasunori Machida, Kayoko Morikiyo | |||
| Nurr1-RXR heterodimers mediate RXR ligand-induced signaling in neuronal cells. | Biological sciences | Wallen-Mackenzie, Asa; Urquiza, Alexander Mata de;Petresson,Susanna, Rodriguez, Francisco J.; Friling, Stina; Wagner, Joseph, Ordentlich, Peter; Lengqvist, Johan, Heyman, Richard A.;Arenas, Ernest ; Perlmann,Thomas | |||
| Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis. | Biological sciences | Chunying Du, Qi-Heng Yang, Robin Church-Hajduk, Jinyu Ren, Michelle L. Newton | |||
| Opportunities and challenges in the development of kinase inhibitor therapy for cancer. | Biological sciences | Charles L. Sawyers | |||
| Opposing actions of Arx and Pax4 in endocrine pancreas development. | Biological sciences | Peter Gruss, Patrick Collombat, Ahmed Mansouri, Jacob Hecksher-Sorensen, Palle Serup, Jens Krull, Gerard Gradwohl | |||
| Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor. | Biological sciences | Richard K. Bruick | |||
| p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13.3. | Biological sciences | Chengkai Dai, Eric C. Holland, Marilyn D. Resh, Rebecca M. Wolf, Nicole Draghi, Xiquan Liang, Lene Uhrbom, Charlotta Eklof, Bengt Westermark | |||
| P2Y-like receptor, GPR105 (P2Y (sub)14), identifies and mediates chemotaxis of bone-marrow hematopoietic stem cells. | Biological sciences | Andrew D. Luster, David T. Scadden, Tao Cheng, David Dombkowski, Daniel A. Haber, Byeong-Chel Lee, Gregor B. Adams, Eyal B. Attar, Nobuyuki Miura, Sean Bong Lee, Yoriko Saito, Ivona Olszak, Douglas P. Olson, Julie Hancock, Peter S. Choi | |||
| Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad. | Biological sciences | Blanche Capel, Jennifer Brennan, Christopher Tilmann | |||
| Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock. | Biological sciences | Yasumasa Bessho, Ryoichiro Kageyama, Hiromi Hirata, Yoshito Masamizu | |||
| Phage N4 RNA polymerase II recruitment to DNA by a single-stranded DNA-binding protein. | Biological sciences | Richard H. Carter, Alexander A. Demidenko, Susan Hattingh-Willis, Lucia B. Rothman-Denes | |||
| Phospholipase C gamma-1 is required downstream of vascular endothelial growth factor during arterial development. | Biological sciences | Nathan D. Lawson, Joshua W. Mugford, Brigid A. Diamond, Brant M. Weinstein | |||
| Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast.(C-terminal domain) | Biological sciences | Brian D. Strahl, Tiaojiang Xiao, Hana Hall, Kelby O. Kizer, Yoichiro Shibata, Mark C. Hall, Christoph H. Borchers | |||
| Physical and functional interactions between polo kinase and the spindle pole component Cut12 regulate mitotic commitment in S. pombe.(Schizosaccharomyces pombe) | Biological sciences | Fiona H. MacIver, Kayoko Tanaka, Alasdair M. Robertson, Iain M. Hagan | |||
| Pin 1 modulates the structure and function of human RNA polymerase II. | Biological sciences | Yutaka Hirose, Xiao Zhen Zhou, Kun Ping Lu, Yu-Xin Xu, Manley James L. | |||
| PKC(sigma) is essential for Dishevelled function in a noncanonical Wnt pathway that regulates Xenopus convergent extension movements.(protein kinase C) | Biological sciences | Naoto Ueno, Noriyuki Kinoshita, Hidekazu Iioka, Akira Miyakoshi | |||
| Position of eukaryotic initiation factor eIFI on the 40S ribosomal subunit determined by directed hydroxyl radical probing. | Biological sciences | Tatyana V. Pestova, Victoria G. Kolupaeva, Gerhard Wagner, Ivan B. Lomakin, Assen Marintchev | |||
| Post-transcriptional regulation of the E/Daughterless ortholog HLH-2, negative feedback, and birth order bias during the AC/VU decision in C. elegans. | Biological sciences | Xantha Karp, Iva Greenwald | |||
| Pre-mRNA splicing and human disease. | Biological sciences | Nuno Andre Faustino, Thomas A. Cooper | |||
| Proplatelet formation of megakaryocytes is triggered by autocrine-synthesized estradiol. | Biological sciences | Yuka Nagata, Jun Yoshikawa, Atsushi Hashimoto, Masayuki Yamamoto, Anita H. Payne, Kazuo Todokoro | |||
| Protein ISGylation modulates the JAK-STAT signaling pathway. | Biological sciences | Dong-Er Zhang, Ke Shuai, Oxana A. Malakhova, Ming Yan, Michael P. Malakhov, Youzhong Yuan, Kenneth J. Ritchie, Keun Il Kim, Luke F. Peterson | |||
| Protein:protein interactions and the pairing of boundary elements in vivo. | Biological sciences | Paul Schedl, Jason Blanton, Miklos Gaszner | |||
| Recognition and repair of the cyclobutane thymine dimer, a major cause of skin cancers, by the human excision nuclease. | Biological sciences | Aziz Sancar, Joyce T. Reardon | |||
| Reconstructing MYC. | Biological sciences | David L. Levens | |||
| Recruitment of terminal protein to the ends of Streptomyces linear plasmids and chromosomes by a novel telomere-binding protein essential for linear DNA replication. | Biological sciences | Stanley N. Cohen, Kai Bao | |||
| Recruitment of Thr 319-phosphorylated Ndd1p to the FHA domain of Fkh2p required Clb kinase actuivity: a mechanism for CLB cluster gene activation.(FHA: forkhead-associated) | Biological sciences | David Reynolds, Stephen Dalton, Bu Jun Shi, Cameron McLean, Frosa Katsis, Bruce Kemp | |||
| Redox regulation of mammalian heat shock factor 1 is essential for Hsp gene activation and protection from stress. | Biological sciences | Dennis J. Thiele, Sang-Gun Ahn Ahn | |||
| Regulated CPEB phosphorylation during meiotic progression for temporal control of maternal mRNA translation. | Biological sciences | Joel D. Richter, Joyce Tay, Rebecca Hodgman, Madathia Sarkissian | |||
| Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation.(heterochromodomain protein 1) | Biological sciences | David C. Schultz, Kasirajan Ayyanathan, Mark S. Lechner, Peter Bell, Gerd G. Maul, Yoshihiko Yamada, Kazuhiro Tanaka, Kiyoyuki Torigoe, Frank J. Rauscher III | |||
| Regulation of Polycomb group complexes by the sequence-specific DNA binding proteins Zeste and GAGA. | Biological sciences | Robert E. Kingston, Niveen M. Mulholland, Ian F. G. King | |||
| Regulation of the transcriptional activator NtrC1: structural studies of the regulatory and AAA (super)+ ATPase domains. | Biological sciences | B. Tracy Nixon, Dalai Yan, Seok-Yong Lee, Armando De La Torre, David E. Wemmer, Sydney Kustu | |||
| Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.(Kruppel-associated box) | Biological sciences | Christopher J. Krebs, Leslie K. Larkins, Ryan Price, Kathryn M. Tullis, Raymond D. Miller, Diane M. Robins | |||
| Retraction of the Drosophila germ band requires cell-matrix interaction. | Biological sciences | Norbert Perrimon, Frieder Schock | |||
| Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.(tuberous sclerosis complex)(GTPase-activating protein)(mammalian target of rapamycin) | Biological sciences | Kun-Liang Guan, Tian Xu, Ken Inoki, Yong Li | |||
| RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development. | Biological sciences | George C. Prendergast, Irit Adini, Isaac Rabinovitz, Jing Fang Sun, Laura E. Benjamin | |||
| RNA polymerase mutations that impair conversion to a termination-resistant complex by Q antiterminator proteins. | Biological sciences | Robert Landick, Jeffrey W. Roberts, Thomas J. Santangelo, Rachel Anne Money | |||
| SCARECROW is involved in positioning the stem cell niche in the Arabidopsis root meristem. | Biological sciences | Sabrina Sabatini, Renze Heidstra, Marjolein Wildwater, Ben Scheres | |||
| SCF (super beta-TRCP) links Chk1 signaling to degradation of the Cdc25A protein phosphatase. | Biological sciences | Stephen J. Elledge, Takahiro Shirogane, Jianping Jin, Lai Xu, Grzegorz Nalepa, Jun Qin, J.Wade Harper | |||
| Senseless acts as a binary switch during sensory organ precursor selection. | Biological sciences | Riitta Nolo, Hugo J. Bellen, Susan M. Parkhurst, Hamed Jafar-Nejad, Melih Acar, Haluk Lacin, Hongling Pan | |||
| Sequence-independent DNA binding and replication initiation by the human origin recognition complex. | Biological sciences | Thomas J. Kelly, Sanjay Vashee, Christin Cvetic, Wenyan Lu, Pamela Simancek, Johannes C. Walter | |||
| Sexual dimorphism of hepatic gene expression: novel biological role of KRAB zinc finger repressors revealed.(Kruppel-associated box) | Biological sciences | David J. Waxman, John L. Celenza | |||
| Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. | Biological sciences | Irving L. Weissman, Emmanuelle Passegue, Michael L. Cleary, Paul M. Ayton, Antonio Cozzio, Holger Karsunky | |||
| siRNAs can function as miRNAs.(short interfering RNA)(microRNA) | Biological sciences | John G. Doench, Christian P. Petersen, Philip A. Sharp | |||
| Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development. | Biological sciences | Lilianna Solnica-Krezel, Jacek Topczewski, Oleg V. Lagutin, Changqi C. Zhu, Daisuke Kobayashi, Kenji Shimamura, Luis Puelles, Helen R. C. Russell, Peter J. McKinnon, Guillermo Oliver | |||
| Sizing up the heart: development redux in disease. | Biological sciences | Eric N. Olson, Michael D. Schneider | |||
| Skewing X chromosome choice by modulating sense transcription across the Xist locus. | Biological sciences | Neil Brockdorff, Tatyana B. Nesterova, Colette M. Johnston, Ruth Appanah, Alistair E. T. Newall, Jonathan Godwin, Maria Alexiou | |||
| SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response.(SKN-1: transcription factor)(Caenorhabditis elegans) | Biological sciences | T. Keith Blackwell, Jae Hyung An | |||
| Slx1-Slx4 is a second structure-specific endonuclease functionally redundant with Sgs1-Top3. | Biological sciences | Steven J. Brill, William M. Fricke | |||
| Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail. | Biological sciences | Jin Jiang, Jianhang Jia, Chao Tong | |||
| Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein. | Biological sciences | Ashok R. Venkitaraman, Mikhail Lomonosov, Shubha Anand, Mahesh Sangrithi, Rachel Davies | |||
| Stable inheritance of telomere chromatin structure and function in the absence of telomeric repeats. | Biological sciences | Mahito Sadaie, Taku Naito, Fuyuki Ishikawa | |||
| Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation. | Biological sciences | Gerard Karsenty, Tadatsugu Taniguchi, Sunhwa Kim, Takako Koga, Miho Isobe, Britt E. Kern, Taeko Yokochi, Y. Eugene Chin, Hiroshi Takayanagi | |||
| STAT3-dependent enhanceosome assembly and disassembly: synergy with GR for full transcriptional increase of the alpha2-macroglobulin gene.(signal transducers and activators of transcription)(glucocorticoid receptor) | Biological sciences | Lorena Lerner, Melissa A. Henriksen, Xiaokui Zhang, James E. Darnell Jr. | |||
| Stem cells in the skin: waste not, Wnt not. | Biological sciences | Elaine Fuchs, Laura Alonso | |||
| Strange bedfellows: polyadenylation factors at the promoter. | Biological sciences | James L. Manley, Olga Calvo | |||
| Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factor. | Biological sciences | Barry L. Stoddard, Jill M. Bolduc, P. Clint Spiegel, Piyali Chatterjee, Kristina L. Brady, Downing, Maureen E.; Caprara, Mark G., Richard B. Waring | |||
| Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27. | Biological sciences | Yi Zhang, Jinrong Min, Rui-Ming Xu | |||
| Structure and function of the PWI motif: a novel nucleic acid-binding domain that facilitates pre-mRNA processing. | Biological sciences | John Bowman, Cheryl H. Arrowsmith, Blair R. Szymczyna, Susan McCracken, Antonio Pineda-Lucena, Ying Lu, Brian Cox, Mark Lambermon, Brenton R. Graveley, Benjamin J. Blencowe | |||
| Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior. | Biological sciences | Cynthia Wolberger, Nicole A. LaRonde-LeBlanc | |||
| SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression. | Biological sciences | Rudolf Grosschedl, Gergana Dobreva, Julia Dambacher | |||
| Suppression of Ras-stimulated transformation by the JNK signal transduction pathway.(c-Jun NH (sub)2 -terminal kinase) | Biological sciences | Roger J. Davis, Richard A. Flavell, Dafna Bar-Sagi, Stephen N. Jones, Norman J. Kennedy, Hayla K. Sluss | |||
| SWI/SNF-dependent chromatin remodeling of RNR3 requires TAF (sub)II s and the general transcription machinery. | Biological sciences | Bing Li, Joseph C. Reese, Vishva Mitra Sharma | |||
| Synapse disassembly. | Biological sciences | Benjamin A. Eaton, Graeme W. Davis | |||
| Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for anthropathy. | Biological sciences | Lei Zhang, Ikuro Maruyama, Kusuki Nishioka, Tetsuya Amano, Satoshi Yamasaki, Naoko Yagishita, Kaneyuki Tsuchimochi, Hiroshi Shin, Ko-ichi Kawahara, Satoko Aratani, Hidetoshi Fujita, Rie Ikeda, Ryoji Fujii, Naoki Miura, Setsuro Komiya, Akiyoshi Fukamizu, Toshihiro Nakajima | |||
| Tap and NXT promote translation of unspliced mRNA. | Biological sciences | Li Jin, Brian W. Guzik, Yeou-cherng Bor, David Rekosh, Marie-Louise Hammarskjold | |||
| Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1. | Biological sciences | Natalie Rezai-Zadeh, Xiaohong Zhang, Fares Namour, Gyorgy Fejer, Yu-Der Wen, Ya-Li Yao, Ildiko Gyory, Kenneth Wright, Edward Seto | |||
| Template boundary definition in mammalian telomerase. | Biological sciences | Jiunn-Liang Chen, Carol W. Greider | |||
| Tethering sigma(super 70) to RNA polymerase reveals high in vivo activity of sigma(super 70)-dependent pausing at promoter-distal locations. | Biological sciences | Robert Landick, Rachel Anne Mooney | |||
| The bloody fate of endothelial stem cells. | Biological sciences | Hajime Kubo, Kari Alitalo | |||
| The budding yeast silencing protein Sir1 is a functional component of centromeric chromatin. | Biological sciences | Kelly A. Gardner, Catherine A. Fox, Sharp. Judith A., Denise C. Krawitz, Paul D. Kaufman | |||
| The chaplins: a family of hydrophobic cell-surface proteins involved in aerial mycelium formation in Streptomyces coelicolor. | Biological sciences | Stanley N. Cohen, Jianqiang Huang, Marie A. Elliot, Nitsara Karoonuthaisiri, Maureen J. Bibb, Camilla M. Kao, Mark J. Buttner | |||
| The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells. | Biological sciences | Jordan W. Raff, Fanni Gergely, Viji M. Draviam | |||
| The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer. | Biological sciences | Harold E. Varmus, Brian C. Lewis, David S. Klimstra | |||
| The COP1-SPA1 interaction defines a critical step in phytochrome A-mediated regulation of HY5 activity. | Biological sciences | Xing Wang Deng, Vicente Rubio, Yusuke Saijo, James A. Sullivan, Haiyang Wang, Jianping Yang, Yunping Shen, Ligeng Ma, Ute Hoecker | |||
| The death domain kinase RIP has an essential role in DNA damage-induced NF-(kappa)B activation. | Biological sciences | Gang Min Hur, Joseph Lewis, Qingfeng Yang, Yong Lin, Hiroyasu Nakano, Sergei Nedospasov, Zheng-gang Liu | |||
| The Drosophila cell cycle kinase PAN GU forms an active complex with PLUTONIUM and GNU to regulate embryonic divisions. | Biological sciences | Terry L. Orr-Weaver, Laura A. Lee, Douglas Van Hoewyk | |||
| The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. | Biological sciences | Jin Jiang, Bing Wang, Wensheng Zhang, Jianhang Jia, Richard Trinko | |||
| The Fanconi road to cancer. | Biological sciences | Alan D. D'Andrea | |||
| The initial somitic phase of Myf5 expression requires neither Shh signaling nor Gli regulation. | Biological sciences | Peter W.J. Rigby, Lydia Teboul, Dennis Summerbell | |||
| The knotted1-like homeobox gene BREVIPEDICELLUS regulates cell differentiation by modulating metabolic pathways. | Biological sciences | Sarah Hake, Yutaka Sato, Giovanni Mele, Naomi Ori | |||
| The master regulator for entry into sporulation in Bacillus subtilis becomes a cell-specific transcription factor after asymmetric division. | Biological sciences | Richard Losick, Masaya Fujita | |||
| The micoRNAs of Caenorhabditis elegans. | Biological sciences | David P. Bartel, Lee P. Lim, Nelson C. Lau, Earl G. Weinstein, Aliaa Abdelhakim, Soraya Yekta, Matthew W. Rhoades, Christopher B. Burge | |||
| The nucleotides responsible for the direct physical contact between the chromatin insulator protein CTCF and the H19 imprinting control region manifest parent origin-specific long-distance insulation and methylation-free domains. | Biological sciences | Rainer Heuchel, Vinod Pant, Piero Mariano, Chandrasekhar Kanduri, Anita Mattsson, Victor Lobanenkov, Rolf Ohlsson | |||
| The pims and outs of survival signaling: role for the Pim-2 protein kinase in the suppression of apoptosis by cytokines. | Biological sciences | Eileen White | |||
| The Polycomb-group protein MEDEA regulates seed development by controlling expression of the MADS-box gene PHERES1. | Biological sciences | Ueli Grossniklaus, Claudia Kohler, Lars Henning, Charles Spillane, Stephane Pien, Wilhelm Gruissem | |||
| The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development. | Biological sciences | Frank Grosveld, Martine Jaegle, Mehrnaz Ghazvini, Wim Mandemakers, Marko Riirsoo, Siska Driegen, Francoise Levavasseur, Smiriti Raghoenath, Dies Meijer | |||
| The RAG 1 N-terminal domain is an E3 ubiquitin ligase. | Biological sciences | Vyacheslav Yurchenko, Zhu Xue, Moshe Sadofsky | |||
| Ther beta-globin locus control region (LCR) functions primarily by enhancing the transition from transcription initiation to elongation. | Biological sciences | Mark Groudine, Tomoyuki Sawado, Jessica Halow, M. A. Bender | |||
| The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor. | Biological sciences | Craig B. Thompson, Lewis A. Chodosh, Casey J. Fox, Peter S. Hammerman, Ryan M. Cinalli, Stephen R. Master | |||
| The Sox9 transcription factor determines glial fate choice in the developing spinal cord. | Biological sciences | Michael Wegner, Andreas Schedl, C. Claus Stolt, Lommes Petra, Elisabeth Sock, Marie-Christine Chaboissier | |||
| The species-specific egg receptor for sea urchin sperm adhesion is EBR1, a novel ADAMTS protein.(egg binding receptor 1)(a disintegrin and metalloprotease with thrombospondin type-1 modules) | Biological sciences | Noriko Kamei, Charles G. Glabe | |||
| The spindle checkpoint requires cyclin-dependent kinase activity. | Biological sciences | Vincenzo D'Angiolella, Cecilia Mari, Donatella Nocera, Linda Rametti, Domencio Grieco | |||
| The transcriptional activator PAX3-FKHR rescues the defects of Pax3 mutant mice but induces a myogenic gain-of-function phenotype with ligand-independent activation of Met signaling in vivo . | Biological sciences | Margaret Buckingham, Beat W. Schafer, Frederic Relaix, Mariarosa Polimeni, Didier Rocancourt, Carola Ponzetto | |||
| The transcriptional activity of human Chromosome 22. | Biological sciences | Michael Snyder, John L. Rinn, Ghia Euskirchen, Paul Bertone, Rebecca Martone, Nicholas M. Luscombe, Stephen Hartman, Paul M. Harrison, F. Kenneth Nelson, Perry Miller, Mark Gerstein, Sherman Weissman | |||
| The transcriptional factor Net regulates the angiogenic switch. | Biological sciences | Hong Zheng, Christine Wasylyk, Adbelkader Ayadi, Joseph Abecassis, Jack A. Schalken, Hermann Rogatsch, Nicolas Wernert, Sauveur-Michel Maira, Marie-Christine Multon, Bohdan Wasylyk | |||
| Tomoregulin-1 (TMEFF1) inhibits nodal signaling through direct binding to the nodal coreceptor Cripto. | Biological sciences | Paul W. Harms, Chenbei Chang | |||
| Tousled-like kinase functions with the chromatin assembly pathway regulating nuclear divisions. | Biological sciences | Herbert Jackle, Pilar Carrera, Yuri M. Moshkin, Sebastian Gronke, Herman H. W. Sillje, Erich A. Nigg, Francois Karch | |||
| Tpit determines alternate fates during pituitary cell differentiation. | Biological sciences | Anne-Marie Pulichino, Yves Gauthier, Catherine Couture, Sophie Vellette-Kasic, Judy Peih-Ying Tsai, Jacques Crouin | |||
| Trancriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8.(Spt-Ada-Gcn5-Acetyltransferase) | Biological sciences | Shelley L. Berger, Lorraine Pillus, Karl W. Henry, Anastasia Wyce, Wan-Sheng Lo, Laura J. Duggan, N. C. Tolga Emre, Cheng-Fu Kao, Ali Shilatifard, Mary Ann Osley | |||
| Transcriptional oscillation of Lunatic fringe is essential for somitogenesis. | Biological sciences | Katrin Serth, Karin Schuster-Gossler, Ralf Cordes, Achim Gossler | |||
| Transcriptional regulation by calcium, calcineurin, and NFAT. | Biological sciences | Patrick G. Hogan, Lin Chen, Julie Nardone, Anjana Rao | |||
| Transcriptional regulation by histone ubiquitination and deubiquitination. | Biological sciences | Yi Zhang | |||
| Transcription-dependent recombination and the role of fork collision in yeast rDNA. | Biological sciences | Yasushi Takeuchi, Takashi Horiuchi, Takehiko Kobayashi | |||
| Transcription from an upstream promoter controls methylation signaling from an inverted repeat of endogenous genes in Arabidopsis. | Biological sciences | Judith Bender, Stacey Melquist | |||
| Transformation of myeloid progenitors by MLL oncoproteins is dependent in Hoxa7 and Hoxa9. | Biological sciences | Michael L. Cleary, Paul M. Ayton | |||
| Transient activation of beta-catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth of hair cycle un mice. | Biological sciences | Frank T. Kolligs, Eric R. Fearon, David Van Mater, Andrzej A. Dlugosz | |||
| Translational control by TOR and TAP42 through dephosphorylation of eIF2(alpha) kinase GCN2. | Biological sciences | Alan G. Hinnerbusch, Vera A. Cherkasova | |||
| Translational control of SCL-isoform expression in hematopoietic lineage choice. | Biological sciences | Christine Muller, Achim Leutz, Cornelis F. Calkhoven, Richard Matrin, Goradz Krosl, Trang Hoang | |||
| TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres. | Biological sciences | William Chang, Jasmin N. Dynek, Susan Smith | |||
| tRNA (super His), maturation: an essential yeast protein catalyzes addition of a guanine nucleotide to the 5' end of tRNA (super His). | Biological sciences | Michael W. Gray, Weifeng Gu, Jane E. Jackman, Amanda J. Lohan, Eric M. Phizicky | |||
| Two for the price of one: a bifunctional intron-encoded DNA endonuclease-RNA maturase. | Biological sciences | Marlene Belfort | |||
| Ubiquitin-dependent degradation of the yeast Mat(alpha)2 repressor enables a switch in developmental state. | Biological sciences | Mark Hochstrasser, Jeffrey D. Laney | |||
| Under arrest: cytostatic factor (CSF)-mediated metaphase arrest in vertebrate eggs.(Review) | Biological sciences | Brian J. Tunquist, James L. Maller | |||
| Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing. | Biological sciences | Reinhard Luhrmann, Ramesh S. Pillai, Matthias Grimmler, Gunter Meister, Cindy L. Will, Utz Fischer, Daniel Schumperli | |||
| Virulence-related surface glycoproteins in the yeast pathogen Candida glabrata are ebcoded in subtelomeric clusters and subject to RAP1- and SIR-dependent transcriptional silencing. | Biological sciences | Alejandro De Las Penas, Shih-Jung Pan, Irene Castano, Jonathan Alder, Robert Cregg, Brendan P. Cormack | |||
| Ways of dying: multiple pathways of apoptosis. | Biological sciences | Jerry M. Adams | |||
| Werner syndrome protein limits MYC-induced cellular senescence. | Biological sciences | Junko Oshima, Riccardo Dalla-Favera, Paula Fernandez, Bruno Amati, David W. Russell, Carla Grandori, Kou-Juey Wu, Celine Ngouenet, Jonathan Grim, Bruce E. Clurman, Michael J. Moser, Karen Swisshelm, Scott Frank, Raymond J. Monnat Jr. | |||
| Which end: dissecting Ku's function at telomeres and double-strand breaks. | Biological sciences | Victoria Lundblad, Alison A. Bertuch | |||
| XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators.(Caenorhabditis elegans) | Biological sciences | Adam Godzik, Ian A. Wilson, Barbara J. Meyer, John Gately Luz, Christian A. Hassig, Catherine Pickle | |||
| Yeast Enhancer of Polycomb defines global Esa1-dependent acetylation of chromatin. | Biological sciences | William S. Lane, Alexandre A. Boudreault, Dominique Cronier, William Selleck, Nicolas Lacoste, Rhea T. Utley, Stephane Allard, Julie Savard, Song Tan, Jacques Cote | |||
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