Nature Biotechnology 2004 - Abstracts

Nature Biotechnology 2004
TitleSubjectAuthors
5'-end SAGE for the analysis of transcriptional start sites.BusinessShin-ichi Hashimoto, Yutaka Suzuki, Yasuhiro Kasai, Kei Morohoshi, Tomoyuki Yamada, Jun Sese, Shinichi Morishita, Sumio Sugano, Kouji Matsushima
A bean counter's take on human resources.BusinessPaul Watson
A common open representation of mass spectrometry data and its application to proteomics research.BusinessRuedi Aebersold, Stephen G. Oliver, Brian Raught, Jimmy K. Eng, Rolf Apweiler, Norman W. Paton, Patrick G.A. Pedrioli, Eric W. Deutsch, Sequin Huang, Keix Cheung, Eugene Kapp, Randall K. Julian Jr., Chris F. Taylor, Erik Nilsson, Richard Simpson, Robert Hubley, Brian Pratt, Mark E.X McComb, Mark E. McComb, Weimin Zhu, Gilbert Omenn, Ruth H. Angeletti, Richard Smith, Mathijs Vogelzang
A conditional marker gene allowing both positive and negative selection in plants.BusinessTorgny Nasholm, Oskar Erikson, Magnus Hertzberg
A cool way to make proteins.BusinessCatherine H. Schein
Adipose-derived adult stromal cells heal critical-size mouse calvarial defects.BusinessMichael T. Longaker, Catherine M. Cowan, Yun-Ying Shi, Oliver O Aalami, Yu-Fen Chou, Carina Mari, Benjamin Wu, Christopher H Contag, Natalina Quarto, Romy Thomas
Advances in the production of human therapeutic proteins in yeasts and filamentous fungi.BusinessTillman U. Gerngross
Agbiotech firms realign product focus.BusinessJeffrey L Fox
Aggregation-resistant domain antibodies selected on phage by heat denaturation.BusinessGreg Winter, Laurent Jespers, . Oliver Schon, Kristoffer Famm
All systems go.BusinessHannah Hoag
Alternative splicing in disease and therapy.BusinessMariano A. Garcia-Blanco, Andrew P. Baraniak, Erika L. Lasda
A mightier mouse with human adaptive immunity.BusinessMarie H. Kosco-Vilbois
Analysis of genomic context: prediction of functional associations from conserved bidirectionally transcribed gene pairs.BusinessPeer Bork, Jan O. Korbel, Lars J. Jensen, Christian Von Mering
Analysis of the transcriptional complexity of Arabidopsis thaliana by massively parallel signature sequencing.BusinessMeyers, Blake C.; Vu, Tam H.; Tej, Shivakundan Singh, Ghazal, Hassan; Matvienko, Marta, Agrawal, Vikas; Ning, Jianchang, Christian D. Haudenschild
Analyzing antibody specificity with whole proteome microarrays.BusinessHong Guo, Michael Snyder, Gregory A. Michaud, Michael Salcius, Barry I. Schweitzer, Rhonda Bangham, Fang Zhou, Paul Predki
A nanoliter-scale nucleic acid processor with parallel architecture.BusinessW. French Anderson, Jong Wook Hong, Vincent Studer, Gioa Hang, Stephen R Quake
An engineered epigenetic transgene switch in mammalian cells.BusinessBeat P. Kramer, Alessandro Usseglio Viretta, Marie Daoud-El Baba, Dominique Aubel, Wilfried Weber, Martin Fussenegger
A new harvest of fluorescent proteins.BusinessGeorge H. Patterson
An image worth a thousand lives?BusinessLisa A. Hammond, Sean X. Cavanaugh, Jr. Thomas Charles R.
An improved cyan fluorescent protein variant useful for FRET.(Forster resonance energy transfer )BusinessMark A Rizzo, Gerald H Springer, Butch Granada, David W Piston
Antibody-targeted cell fusion.BusinessTakafumi Nakamura, Kah-Whye Peng, Sompong Vongpunsawad, Mary Harvey, Hayakawa Takao, Hiroyuki Mizuguchi, Russell J. Stephen, Roberto Cattaneo
Antidote-mediated control of an anticoagulant aptamer in vivo.BusinessWilliam P. Fay, Bruce A. Sullenger, Christopher P. Rusconi, Joseph D. Roberts, Shahid M. Nimjee, George Quick Jr., Geroge A. Pitoc, Rebekah R. White, Elizabeth Scardino
Antimicrobial drug discovery through bacteriophage genomics.BusinessJing Liu, Jerry Pelletier, Philippe Gros, Dominique Bergeron, Nhuan Ha, Ramakrishnan Srikumar, Jinzi J Wu, Mohammed Dehbi, Greg Moeck, Francis Arhin, Pascale Buda, Mario Callejo, Vincent Ferretti, Tony Kwan, John McCarty, Dan Wiliams, Michael Dubow
Antisense and siRNA as agonists of Toll-like receptors.BusinessSudhir Agarwal, Ekambar R. Kandimalla
A partnership between biology and engineering.BusinessRoger Brent
Apomixis technology development -- virgin births in farmers' fields?BusinessUeli Grossniklaus, Charles Spillane, Mark D. Curtis
A proposed framework for the description of plant metabolomics experiments and their result.BusinessStephen G. Oliver, Oliver Fiehn, Joachim Kopka, Douglas B. Kell, Jorn Smedsgaard, Geoffrey A. Lane, Pedro Mendes, Royston Goodacre, Robert Hall, Janet Taylor, Helen Jenkins, Nigel Hardy, Manfred Beckmann, John Draper, Aileen R. Smith, Raoul J. Bino, B. Markus Lange, Jang R. Liu, Basil J. Nikolau, Lloyd W. Sumner, Trevor Wang, Sean Walsh, Eve Syrkin Wurtele, Norman W. Paton, Sue Rhee, Ute Roessner-Tunali, Kazuki Saito
A regulatory patchwork-human ES cell research oversight.BusinessLori P. Knowles
A role for chemistry in stem cell biology.BusinessSheng Ding, Peter G Schultz
A simple method to cure established tumors by inflammatory killing of normal cells.BusinessMichael Gough, Alan Melcher, Gregory A. Daniels, Maoyi Lai, Luis Sanchez Perez, Kevin Harrington, Rosa Maria Diaz, Richard G. ile, Mahruz Karim, Timothy Kottke, Jill Thompsun, Andrew Bushell, Heung Chong
Ask the experts: how to get hired.BusinessGrace H.W. Wong
As products enter clinic... scientists shown the door.BusinessMark Ratner
Assessing the survival of transgenic plant DNA in the human gastrointestinal tract.BusinessTrudy Netherwood, Anthony G O' Donnell, Julia Graham, Sally Gockling, John C. Mathers, Susana M. Martin-Orue, Gilbert Harry J.
Atazanavir sulphate.Business 
A tethered catalysis, two-hybrid system to identify protein-protein interactions requiring post-translational modifications.BusinessStanley Fields, Dawei Guo, Tony R. Hazbun, Xin-Jing Xu, Sze-Ling Ng, Min-Hao Kuo
A universal Tango?BusinessVijay S. Pande
Australia experiments with 'experimental use' exemption.BusinessAmanda McBratney, Katherine Nielsen, Fiona McMillan
Baculovirus expression system for heterologous multiprotein complexes.BusinessTimothy J. Richmond, Imre Berger, Daniel J. Fitzgerald
Baculovirus solves a complex problem.BusinessPolly Roy
Beta-cell precursors-a work in progress.BusinessGordon C. Weir, Susan Bonner Weir
Beyond the Petri dish.BusinessShuguang Zhang
Biomaterials science and high-throughput screening.BusinessJeffrey A. Hubbell
Bio-ontologies -- fast and furious.BusinessJudith Blake
Biotechnology financing dilemmas and the role of special purpose entities.BusinessLeora Schiff, Gloria Bevan
Bortezomib.Business 
Breaching the skin's barrier to drugs.BusinessBrian W. Barry
Caged phosphopeptides reveal a temporal role for 14-3-3 in G1 arrest and S-phase checkpoint function.BusinessMichael B. Yaffe, Anhco Nguyen, Dborah M. Rothman, Justice Stehn, Barbara Imperiali
Cancer surgery joins the dots.BusinessRoger F. Uren
Can complexity be commercialized?BusinessGeorge S. Mack
Capturing and profiling adult hair follicle stem cells.BusinessGeorge Cotsarelis, Rebecca J. Morris, Yaping Liu, Lee Marles, Carol Trempus, Shulan Li, Jamie S. Lin, Janet A Sawicki
Changing talent needs to realize biotech products.BusinessMary Ann Rafferty
Characterizing biological products and assessing comparability following manufacturing changes.BusinessArthur J. Chirino, Anthony Mire-Sluis
Chemical screening by mass spectrometry to identify inhibitors of anthrax lethal factor.BusinessDal-Hee Min, Wei-Jen Tang, Milan Mrksich
Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation.BusinessMark C. Fishman, Randall T. Peterson, Stanley Y. Shaw, Travis A. Peterson, David J. Milan, Tao P Zhong, Calum A MacRae, Stuart L Schreiber
Chile launches policy to boost biotech.BusinessClaudia Orellana
China approves first gene therapy.(Gendicine)BusinessJeffrey F. Fox
Climbing the protein ladder.BusinessNorman J. Dovichi
Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages.BusinessGregory Korbutt, Michael B. Wheeler, Raewyn.M. Seaberg, Simon R. Smukler, Timothy J. Kieffer, Derek Kooy
Cold-shock induced high-yield protein production in Escherichia coli.BusinessMitsuhiko Ikura, Guoliang Qing, Masanori Mitta Takayama, Li-Chung Ma, Bing Xia, Ahmad Khorchid, Sangita Phadtare, G. V. T. Swapna, Haiping Ke, Tapas K. Mal, Gaetano T. Montelione, Masayori Inouye
Collaborative research presents special problems for patent seekers.BusinessLeigh W. Thorne, Edward R. Ergenzinger, W. Murray Spruill
Complete genome sequence of the metabolically versatile photosynthetic bacterium Rhodopseudomonas palustris.BusinessCaroline S. Harwood, Jane Gibson, Frank W. Larimer, Jane Lamerdin, Patrick Chain, Andrew S. Lang, Loren Hauser, Stephaine Malfatti, F Robert Tabita, Lon Do, Caroline Peres, Miriam L. Land, Janet L. Gibson, Faith H Harrison, Dale A. Pelletier, Thomas E. Hanson, J Thomas Beatty, Cedric Bobst, Torres y, Janelle L. Torres
Complete sequence and comparative genome analysis of the diary bacterium Streptococcus thermophilus.BusinessAlexander Bolotin, S. Dusko Ehrlich, Pierre Renault, Jean Delcour, Pascal Hols, Alla Lapidus, Michael Mazur, Eugene Goltsman, Michael Fonstein, Ross Overbeek, Andre Goffeau, Benoit Quinquis, Alexei Sorokin, Saulius Kulakauskas, Gordon D. Pusch, Nikos Kyprides, Benedicte Purnelle, Deborah Prozzi, Katrina Ngui, David Masuy, Frederic Hancy, Sophie Burteau, Marc Boutry
Computer security in academia -- a potential roadblock to distributed annotation of the human genome.BusinessAndrew Smith, Mark Gerstein, Michael Fischer, Dov Greenbaum, Shawn M. Douglas, Joanna Lim, Martin Schultz
Converting biotech scientists to managers.BusinessDavid G. Jensen, Eileen Dougherty
Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector.BusinessElio F. Vanin, Andrea L. Szymczak, Creg J. Workman, Yao Wang, Kate M. Vignali, Smaroula Dilioglou, Dario A. A. Vignali
Custom design of metabolism.BusinessJames C Liao
Daniel Callahan.(bioethicists)BusinessStephen Herrera
Daptomycin.Business 
Data standards for 'omic' science.BusinessJohn Quackenbush
Differential quantitative analysis of MHC ligands by mass spectrometry using stable isotope labeling.BusinessHans-Georg Rammensee, Stefan Stevanovic, Claudia Lemmel, Steffen Weik, Ute Eberle, Jorn Dengjel, Thomas Kratt, Horst-Dieter Becker
Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer.BusinessRakesh K. Jain, Lance L. Munn, David P. Ryan, Alan J. Fischman, David T. Scadden, Christopher G. Willett, Paul C. Shellito, Helen X. Chen, Dushyant V. Sahani, Gregory Y. Lauwers, Daniel C. Chung, Mari Mino, Sergey V. Kozin, Ricky T. Tong, Dan G. Duda, Sanjeeva P. Kalva, Alan C. Hartford, Kenneth S. Cohen, Lawrence S. Blaszkowsky, Boucher Yves, Emmanuelle Di Tomaso, Jeffery W. Clark, Andrew X. Zhu
Direct proteomic mapping of the lung microvascular endothelial cell surface in vivo and in cell culture.BusinessJohn R. Yates, Eberhard Durr, Karolina M. Krasinka, Phil Oh, Jan E. Schnitzer, Jingyi Yu, Lucy A. Carver, Jacqueline E. Testa
Discovery of transdermal penetration enhancers by high-throughput screening.BusinessSamir Mitragotri, Pankaj Karande, Amit Jain
DNA as a template for reaction discovery.BusinessScott J. Miller
DNA vaccines-back in the saddle again?BusinessKendall Powell
Do cloned mammals skip a reprogramming step?.BusinessAtsuo Ogura, Josef Fulka Jr., Norikazu Miyashita, Takashi Nagai
Does your chairman need to be a superma.BusinessNicolas Hollanders
Drugs in crops-the unpalatable truth.Business 
Editing the message from A to I.BusinessKazuko Nishikura
Effecting a comprehensive intellectual property strategy using the Madrid protocol.BusinessWilliam J. Simmons
Either/or selection markers for plant transformation.BusinessOrtrun Mittelsten Scheid
Electromechanical integration of cardiomyocytes derived from human embryonic stem cells.BusinessIzhak Kehat, Oren Caspi, Rona Shofti, Irit Huber, Joseph Itskovitz-Eldor, Leonid Khimovich, Amira Gepstein, Gil Arbel, Jonathan Satin, Lior Gepstein
Embryonic stem cells pace the heart.BusinessPhilippe Menasche
Encoded self-assembling chemical libraries.BusinessSamu Melkko, Jorg Scheuermann, Christoph E. Dumelin, Dario Neri
Enfuvirtide.Business 
Engineered antibodies.BusinessPeter J. Hudson, Christelle Souriau
Engineered endophytic bacteria improve phytoremediation of water-soluble, volatile, organic pollutants.BusinessDaniel van der Lelie, Jaco Vangronsveld, Tanja Barac, Safiyh Taghavi, Brigitte Borremans, Ann Provoost, Licy Oeyen, Jan V. Colpaert
Engineered riboregulators enable post-transcriptional control of gene expression.BusinessDaniel J. Dwyer, Charles R. Cantor, Farren J. Isaacs, Chunming Ding, Dmitri D. Pervouchine, James J Collins
Engineered T-cell receptor tetramers bind MHC-peptide complexes with high affinity.BusinessNorman L. Letvin, Ramu A. Subbramanian, Kristi L. Martin, Akira Naoi, Darci A. Gorgone, Jorn E. Schmitz, Chikaya Motiya, Atsuhiko Hasegawa, Fred W. Peyerl, Patrick Attisier, Heng Chhay, Michelle A. Lifton, Kristine Kuus-Reichel, Marcelo J. Kuroda
Engineering plants with increased levels of the antioxidant chlorogenic acid.BusinessRicarda Niggeweg, Anthony J. Michael, Cathie Martin
Engineering sweet targets for magic bullets.BusinessTen Feizi
Enlightened receptor dynamics.BusinessYosef Yarden, Gal Gur
Enzyme immobilization in a biomimetic silica support.BusinessJim C. Spain, Rajesh R. Naik, Morley O. Stone, Heather R. Luckarift
EU expansion: enlarged horizons or false dawn?.BusinessClare Sansom
Europe makes way into structural biology.(Partnership for Structural Biology)BusinessSally Goodman
Evolution of a T7 RNA polymerase variant that transcribes 2'-o-methyl RNA.BusinessAndrew D. Ellington, Jijumon Chelliserrykattil
Ex planta phytoremediation of trichlorophenol and phenolic allelochemicals via an engineered secretory laccase.BusinessGuo-Dong Wang, Qian-Jin Li, Bin Luo, Xiao-Ya Chen
Exploiting biological complexity for strain improvement through systems biology.BusinessGregory Stephanopoulos, Hal Alper, Joel Moxley
Expression profiling using a hexamer-based universal microarray.BusinessMatthew E Roth, Li Feng, Kevin J McConnell, Paul J Schaffer, Cesar E Guerra, Jason P Affourtit, Kevin R Piper, Lorri Guccione, Jayashree Hariharan, Maura J Ford, Stephen W Powell, Harish Krishnaswamy, Jennifer Lane, Lisa Guccione, Gino Intrieri, Jane S Merkel, Anthony Valerio, Clotilde Perbost, Carol D Graham, Brenda Zolla, Jonathan Hnath, Chris Michaelson, Rixin Wang, Conrad Halling, Baoge Ying, Craig E Parman, Debasish Raha, Ji Liao, Barbara Jedrzkiewicz, Brent Orr
FDA and EMEA pool scientific advice.(European Medicines Agency)BusinessAlla Katsnelson
Finding enzymatic gold on silver surfaces.BusinessUwe T. Bornscheueer
Finding needles in haystacks.BusinessJonathan A Javitch
Finding time for allosteric interactions.BusinessIrving W. Wainer
Fingerprinting the circulating repertoire of antibodies from cancer patients.BusinessRenata Pasqualini, Wadih Arap, Waun Ki Hong, Massimo Cristofanilli, Paul J. Mintz, Marco A. Arap, Patricia Troncoso, Jeri Kim, Christopher J. Logothetis, Kim-Anh Do
Flies in the soup - European GM labeling legislation.BusinessNeville Craddock
France to focus on few biotech clusters.BusinessEmilie Balcon
FRET between cardiac Na+ channel subunits measured with a confocal microscope and a streak camera.(Forster resonance energy transfer)BusinessKlaus Benndorf, Christoph Biskup, Thomas Zimmer
From alpha to omega -- producing essential fatty acids in plants.BusinessAllan G. Green
Functional proteomic screens reveal an essential extracellular role for hsp90alpha in cancer cells invasiveness.BusinessLen Neckers, Brenda K. Eustace, Dean Yimlamai, Blanca Lain, Gerald Beste, Leodevico Ilag, Takashi Sakurai, Jean K. Stewart, Christine Unger, Carol Zehetmeier, Claudia Torella, Stefan W. Henning, Bradley T. Scroggins, Daniel G. Jay
Funding high-throughput data sharing.BusinessGavin Sherlock, Alvis Brazma, V Catherine A. Ball
Fusion proteins comprising a Fusarium-specific antibody linked to antifungal peptides protect plants against a fungal pathogen.BusinessDieter Peschen, He-Ping Li, Fritz Kreuzaler, Rainer Fischer, Yu-Cai Liao
Gaining confidence in high-throughput protein interaction networks .BusinessJonathan M. Rothberg, Joel S. Bader, Amitabha Chaudhuri, John Chant
Gas-inducible transgene expression in mammalian cells and mice.BusinessDominique Aubel, Wilfried Weber, Martin Fussenegger, Markus Rimman, Manuela Spielmann, Bettina Keller, Marie Daoud-El baba, Cornelia C. Weber
Gefitinib.Business 
Genentech discloses safety concerns over Avastin.BusinessMark Ratner
Generation of a synthetic lymphoid tissue-like organoid in mice.BusinessTakeshi Watanabe, Sachiko Suematsu
Generation of marker-free plastid transformants using a transiently cointegrated selection gene.BusinessSebastian M.J. Klaus, Fong-Chin Huang, Timothy J. Golds, Hans-Ulrich Koop
Generic expansion of the substrate spectrum of a DNA polymerase by directed evolution.BusinessRoger Woodgate, Shigenori Iwai, Francois Boudsocq, Farid J. Ghadessy, Anthony Brown, Philipp Holliger, David Loakes, Nicola Ramsay, Alexandra Vaisman
Genetic sequences: how are they patented?BusinessGuillaume Dufresne, Manuel Duval
Genome sequence of lignocellulose degrading fungus Phanerochaete chrysosporium strain RP78.BusinessLuis F. Larrondo, Dan Cullen, Bernard Henrissat, Jarrod Chapman, Diego Martinez, Nik Putnam, Maarten D. Sollewijn Gelpke, Katherine Huang, Kevin G. Helfenbein, Preethi Ramaiya, J. Chris Detter, Daniel Rokhsar, Randy Berka, Pedro M. Coutinho, Frank Larimer
Genomics companies shop around for chemical expertise.BusinessLiz Fletcher
Genomics taken to the extreme.BusinessWolfgang Liebl
Genta sued over NDA withdrawal.BusinessGeorge S. Mack
Germany reattempts to spark innovation.BusinessMartina Habeck
Goodbye Columbus! New NRDOs forego discovery.BusinessKarl A Thiel
Health biotechnology in China-reawakening of a giant.BusinessHalla Thorsteinsdottir, Uyen Quach, Li Zhenzhen, Zhang Jiuchun, Singer, Peter A.; Daar, Abdallah S.
High-affinity binders selected from designed ankyrin repeat protein libraries .BusinessMarkus G. Grutter, Andreas Pluckthun, H. Kaspar Binz, Patrick Amstutz, Andreas Kohl, Michael T. Stumpp, Briand, Christophe;, Patrik Forrer
High-resolution genome-wide mapping of histone modifications.BusinessKeji Zhao, David Landsman, Tae-Young Roh, Wong Chi Ngau, Karrong Cui
High-throughout biochemistry heats up.BusinessRaymond F. Salemme
Homogenous detection of unamplified genomic DNA sequences based on colorimetric scatter of gold nanoparticle probes.BusinessJames J. Storhoff, Adam D. Lucas, Viswanadham Garimella, Y. Paul Bao, Uwe R. Muller
Hsp90 invades the outside.BusinessDidier Picard
Humboldt University beefs up technology transfer.BusinessMartina Habeck
Imaging the pharmacodynamics of HER2 degradation in response to Hsp90 inhibitors.BusinessTimothy Akhurst, Steven M. Larson, Peter M. Smith-Jones, David B. Solit, Neal Rosen
Imaging the pharmacodynamics of HER2 degradation in response to Hsp90 inhibitors.BusinessTimothy Akhurst, Steven M. Larson, Peter M. Smith-Jones, David B. Solit, Neal Rosen, Farzana Afroze
Immunotherapy dispenses with tumor antigens.BusinessSoldano Ferrone
Immunotherapy: Past, present and future.BusinessThomas A. Waldmann
Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein.BusinessRoger Y. Tsien, Ben N.G. Giepmans, Nathan C. Shaner, Robert E. Campbell, Paul A. Steinbach, Amy E. Palmer
India aims to become the main bioinformatics hub.BusinessSabine Louet, K. S. Jayaraman
India produces homegrown GM cotton.(Swarna Bharat Biotechnics Private)BusinessK.S. Jayaraman
Inhaled insulin products puff along.BusinessKendall Powell
In silico simulation of biological network dynamics.BusinessDavid Eisenberg, Lukasz Salwinski
Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways.BusinessTimothy R. Hughes, Charles Boone, Zhijian Li, Ainslie B. Parsons, Bilal Sheikh, Renee L. Brost, Grant W. Brown, Himing Ding, Patricia M. Kane, Chaoying Zhang
Intellectual property law in Israel, and US and European objections: Market exclusivity vs. data exclusivity.BusinessTamar Morag-Sela, Ilan Cohn, Thomas J. Kowalski, Judy Jarecki-Black, Zoe Clyde-Watson
Intellectual property-the dispute between research institutions and voluntary health agencies.BusinessMarshall A Lichtman, Marjorie D Hunter, Gunta J Liders
Intensity-based protein identification by machine learning from a library of tandem mass spectra.BusinessSteven P. Gygi, Joshua E. Elias, Francis D. Gibbons, Oliver D. King, Frederick P. Roth
Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase.BusinessJohn J. Rossi, Dong-Ho Kim, Michael Longo, Young Han, Patric Lundberg, Edouard Cantin
International benchmarking of biotech research centers-lessons and perspectives.BusinessViola Peter
Introduction: Promoting global health through biotechnology.BusinessDouglas Martin, Peter A. Singer, Abdallah S. Daar, Halla Thorsteinsdottir, Uyen Quach
In vivo cancer targeting and imaging with semiconductor quantum dots.BusinessXiaohu Gao, Shuming Nie, Yuanyuan Cui, Richard M. Levenson, Leland W. K. Chung
IPO plans sour on both sides of the pond.(initial public offering)Business 
IPOs: The narrow window closes?BusinessStacy Lawrence
Italian biotech too reliant on big pharma.BusinessAnna Meldolesi
Japanese firms broaden investment focus to early biotech.BusinessSabine Louet, Doug Sipp
Japanese national universities are now 'incorporated'.BusinessKeiko Kandachi
Keeping dry and crossing membranes.BusinessAriel Fernandez
Knockdown by RNAi-proceed with caution.BusinessCharles E. Samuel
Knocking the SOCS1 off dendritic cells.(suppressor of cytokine signaling-1)BusinessEli Gilboa
Label-free detection becomes crystal clear.BusinessPaul S. Cremer
Lack of interferon response in animals to naked siRNAs.(small interfering ribonucleic acids)BusinessJeremy D. Heidel, Siwen Hu, Xian Fang Liu, Timothy J. Triche, Davis Mark E.
Ligand selectivity and competition between enzymes in silico.BusinessA. Macchiarulo, Irene Nobeli
Make or break for costimulatory blockers.BusinessKen Garber
Making prevention pay.BusinessAlan Dove
Managing innovation: university-industry partnerships and the licensing of the Harvard mouse.BusinessSasha Blaug, Colleen Chien, Michael J. Shuster
Managing your compensation expectations in today's environment: a second look.BusinessJohn Radford
Mechanisms of gene silencing by double-stranded RNA.BusinessThomas Tuschi, Gunter Meister
Memantine hydrochloride.Business 
Microarray reality checks in the context of a complex disease.BusinessGeorge L. Gabor Miklos, Ryszard Maleszka
Monitoring and modeling horizontal gene transfer.BusinessKaare M. Nielson, Jeffrey P. Townsend
Moving in and out with quantum dots.BusinessRakesh K. Jain, Mark Stroh
Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells.BusinessRobert Langer, Daniel G. Anderson, Shulamit Levenberg
Nanospheres for DNA separation chips.BusinessMari Tabuchi, Noritada Kaji, Yukio Nagasaki; Kenichi Yoshikawa, Kazunori Kataoka, Yoshinoby Baba, Masanori Ueda, Yuichi Yamasaki
Navigating US conflict-of-interest rules when commercializing research.BusinessJohn Otrompke
Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping.BusinessAkira Nakayama, Sungjee Kim, Lawrence H. Cohn, Young Taik Lim, Moungi G. Bawendi, J Anthony Parker, Edward G. Soltesz, John V Frangioni, Tomislav Mihaljevic, Alec M. De Grand, Rita G. Laurence, Lee, Jaihyoung; Dor, Delphine M.
Negative feedback inhibition of HIV-1 by TAT-inducible expression of siRNA.BusinessJohn J. Rossi, Hoshang J. Unwalla, Ming-Jie Li, James D. Kim, Hai Tang Li, Ali Ehsani, Jessica Alluin
New Zealand launches biotech seed fund.BusinessKim Griggs
Next-generation protein drugs.BusinessIan M. Tomlinson
NIH licensing performance under par.(National Institutes of Health)BusinessKen Garber, Ann Arbor
Nuclear transfer cloning and the United Nations.BusinessAnthony CF Perry
Old dogma, new tricks-21st Century phage therapy.BusinessKarl Thiel
Oligo oligarchy -- the surprisingly small world of aptamers.BusinessKarl Thiel
Omalizumab.Business 
On the road to therapeutic cloning.BusinessTeruhiko Wakayama
Overcoming the gridlock in discovery research.BusinessJonathan Margolis, Greg D. Plowman
Para-position derivatives of fungal anthelmintic cyclodepsipeptides engineered with Streptomyces venezuelae antibiotic biosynthetic genes.BusinessKoji Yanai, Naomi Sumida, Kaoru Okakura, Tatsuki Moriya, Manabu Watanabe, Takeshi Murakami
Parent protection for protein structure analysis.BusinessShigeyuki Yokoyama, Itsuki Shimbo, Rie Nakajima, Koichi Sumikura
Patent drop reveals pressures on industry.BusinessStacy Lawrence
Patenting costs cast a shadow on European biotech.BusinessPeter Vermij
Paths to entrepreneurship in the life sciences.BusinessShreefal Mehta
Phage-inspired antibiotics?BusinessSteven Projan
Phasing in iodine for structure determination.BusinessZbigniew Dauter
Phosphoproteomics finds itEs timing.BusinessTony Hunter, Sam A. Johnson
Photoswitchable cyan fluorescent protein for protein tracking.BusinessVladislav V. Verkhusha, Dmitriy M. Chudakov, Dmitry B. Staroverov, Ekaterina A. Souslova, Sergey Lukyanov, Konstantin Lukyanov
Plant cell cultures for the production of recombinant proteins.BusinessRainer Fischer, Stephen Hellwig, Jurgen Drossard, Richard M. Twyman
Polyvalent dendrimer glocosamine conjugates prevent scar tissue formation.BusinessIan Teo, Sunil Shaunak, Sharyn Thomas, Elisabetta Gianasi, Antony Godwin, Emma Jones, Kamiar Mireskandari, Philip Luthert, Ruth Duncan, Steve Petterson, Pend Khaw, Steve Brocchini
Post-integration stabilization of a transposon vector by terminal sequence deletion in Drosophila melanogaster.BusinessAlfred .M. Handler, Grazyna .J. Zimowska, Carsten Horn
Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins.BusinessLuis Serrano, Ana-Maria Fernandez-Escamilla, Frederic Rousseau, Joost Schymkowitz
Principles of transcriptional control in the metabolic network of Saccharomyces cerevisiae.BusinessNaama Barkai, Jan Ihmels, Ronen Levy
Proactive accounting: a key factor in the success of biotechnology startups.BusinessChristian Jester
Probing the precision of the mitotic clock with a live-cell fluorescent biosensor.BusinessTobias Meyer, Joshua T. Jones, Jason W. Myers, James E. Ferrell Jr.
Problems in monitoring horizontal gene transfer in field trials of transgenic plants.BusinessJack .A. Heinemann, Terje Traavik
Production of recombinant protein therapeutics in cultivated mammalian cells.BusinessFlorian M. Wurm
Production of very long chain polyunsaturated omega-3 and omega-6 fatty acids in plants.BusinessBaoxiu Qi, Sam Mugford, Olga Sayanova, Colin M. Lazarus, Tom Fraser, Gary Dobson, A. Keith Stobart, Johnathan A. Napier, Justine Butler
Profiling epithelial stem cells.BusinessPaul A Khavari
Promoter prediction analysis on the whole human genome.BusinessYutaka Suzuki, Sumio Sugano, Vladimir B. Bajic, Sin Lam Tan
Protecting methods for treatment related to regenerative medicine and gene therapy in Japan.BusinessKiyofumi Kaneshiro, Sachika Masuda, Yayoi Tanaka, Katsuya Tamai
Protecting your investment.BusinessHarris F. Brotman
Protein interaction maps on the fly.BusinessPeter Uetz, Michael J. Pankratz
Protein sequencing by mass analysis of polypeptide ladders after controlled protein hydrolysis.BusinessYing Zhang, Liang Li, Hongying Zhong, Zhihui Wen
Public biotechnology 2003 -- the numbers.BusinessRiku Lahteenmaki, Monya Baker
Public-private collaborations and the race to sequence Agrobacterium tumefaciens.BusinessMark Harvey, Andrew McMeekin
Publish and perish: what constitutes a bar under the patent laws.BusinessMark S. Cohen, Rachel Teitelbaum
Putting the opium in poppy to sleep.BusinessJohan Memelink
Putting the rat on the map.BusinessIsmail Kola
Quantitative analysis of allosteric drug-protein binding by biointeraction chromatography.BusinessJianzhong Chen, David S. Hage
Quantum dot ligands provide new insights into erbB/HER receptor-mediated signal transduction.BusinessElizabeth A. Jares-Erijman, Thomas M. Jovin, Diane S Lidke, Rainer Heintzmann, Janine N Post, Peter Nagy, Donna J. Arndt-Jovin, Hernan E. Grecco
Rain or shine-a phototroph that delivers .BusinessJudy D. Wall
Rapid and ultra-sensitive determination of enzyme activities using surface-enhanced resonance Raman scattering.BusinessLorna Stevenson, Chris Cassidy, Barry D. Moore, AlanWatt Watt Alan, Sabine Flitsch, Nicolas J. Turner, Duncan Graham
Rational siRNA design for RNA interference.BusinessDevin Leake, Anastasia Khvorova, Angela Reynolds, Queta Boese, Stephen Scaringe, William S. Marshall
Reality and immortality-neutral stem cells for therapies.BusinessJeffrey D. Rothstein, Evan Y. Snyder
Recombinant protein folding and misfolding in Escherichia coli.BusinessFrancois Baneyx, Mirna Mujacic
Recombinant protein therapeutics - success rates, market trends and values to 2010.BusinessJanice M. Reichert, Alex K. Pavlou
Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells.BusinessJulie Johnson, Jonathan S. Draper, Kath Smith, Paul Gokhale, Harry D. Moore, Edna Maltby, Lorraine Meisner, Thomas P. Zwaka, James A. Thomson, Peter W. Andrews
Redesigner drugs.BusinessAlan Dove
Revealing the world of RNA interference.BusinessCraig C. Mello, Darryl Conte Jr.
Reversible site-selective labeling of membrane proteins in live cells.BusinessEmmanuel G Guignet, Ruud Hovius, Horst Vogel
Riding the risk cycle.BusinessRoop Chandwani, Simon Portman
RNAi-mediated replacement of morphine with the nonnarcotic alkaloid reticuline in opium poppy.BusinessAnthony J. Fist, Philip J. Larkin, Robert S. Allen, Anthony G. Millgate, Julie A. Chitty, Jennifer Thisleton, James A.C. Miller, Wayne R. Gerlach
RNA silencing in plants.BusinessDavid Baulcombe
Rosuvastatin calcium.Business 
Russia becomes attractive as a source of IP for biotechs.(Intellectual property)BusinessAlla Katsnelson
Serial bull cloning by somatic cell nuclear transfer.BusinessChikara Kubota, Cindy X. Tian, Xiangzhong Yang
Should software hold data hostage?BusinessGeorge S. Michaels, H. Steven Wiley
Signal transduction inhibitors-a work in progress.BusinessJoseph Becker
Signal transduction inhibitors-a work in progress.BusinessJoseph Becker
Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity.(suppressor of cytokine signaling)BusinessLei Shen, Kevin Evel-Kabler, Randy Strube, Si-Yi Chen
Singapore trains biotech workforce abroad.BusinessJen Lin Liu
Single-chain antibodies against a plant viral RNA-dependent RNA polymerase confer virus resistance.BusinessKaJohn Boonrod, Danuta Galetzka, Peter D. Nagy, Udo Conrad, Gabi Krczal
South Africa-blazing a trail for African biotechnology.BusinessDouglas K. Martin, Halla Thorsteinsdottir, Uyen Quach, Marion Motari, Daar, Abdallah S.; Singer, Peter A.
Strategic HR for today's biotechnology companies.BusinessMary Yaroshevsky Glanville
Streptococcal genomes provide food for thought.BusinessHerve Tettelin
Structure-aided drug design's next generation.BusinessKarl A. Thiel
Swiss patent proposal prompts criticism.BusinessJane Burgermeister
Systematic identification of abundant A-to-I editing sites in the human transcriptome.BusinessLevanon, Erez Y.; Eisenberg, Esi; Yelin, Rodringo, Nemzer, Sergey; Hallegger, Martina; Shemesh, Ronen; Fligelman, Zipora; Shoshan, Avi, Pollocl, Sarah R.; Sztybel, Dan, Olshansky, Moshe; Rechavi, Gideon, Michael F. Jantsch
Systematic identification of sense-antisense transcripts in mammalian cells.BusinessOystein Rosok, Mouldy Sioud
Systemic tumor targeting and killing by Sindbis viral vectors.BusinessJen-Chieh Tseng, Daniel Meruelo, Maria Jimenez, Brandi Levin, Peter Shamamian, Alicia Hurtado, Ruzhong Jin, Yee, Herman,Novick, Richard P., Ignacio Perez de Castro, Angel Pellicer
Systems biology 101 - what you need to know.BusinessTrey Ideker
Systems biology in drug discovery.BusinessEugene C. Butcher, Ellen L. Berg, Eric J. Kunkel
Tagging all genes.BusinessJeffrey F. D. Dean
Teamwork in phytoremediation.BusinessBernard R. Glick
Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cord.BusinessMaiken Nedergaard, Steven A. Goldman, Melissa K. Carpenter, H. Michael Keyoung, Neeta S. Roy, Jane Lin, Martha Windrem, Jian Kang, Takahiro Nakano, M. Lita Alonso, william K. Rashbaum, Weiguo Peng
Telomerase modulates expression growth-controlling genes and enhances cell proliferation.BusinessJames M. Roberts, Laura L. Smith, Hilary A. Coller
Temperature-sensitive control of protein activity by conditionally splicing inteins.BusinessNorbert Perrimon, Yohanns Bellaiche, Martin P. Zeidler, Change Tan, Sara Cherry, Sabine Hader, Urte Gayko
Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics.BusinessMatthias Mann, Shao-En Ong, Blagoy Blagoev, Irina Kratchmarova
Ten thousand interactions for the molecular biologist.BusinessRobert B. Russell, Patrick Aloy
Term sheet trends in the venture capital market.BusinessLuci Staller Altman
Testing new ground.BusinessHannah Hoag
The ABCs of artificial antigen presentation.BusinessJean-Baptiste Latouche, Michel Sadelain, Isabelle Riviere, Jiyun V Kim
The best of both worlds in plant protection.BusinessHolger Bohlmann
The biological magic behind the bullets.BusinessBrent R. Stockwell
The Cartagena Protocol and the future of agbiotech.BusinessWilly De Greef
The challenges of modeling mammalian biocomplexity.BusinessElaine Holmes, Ian D. Wilson, Jeremy K. Nicholson, John C. Lindon
The emergence of Egyptian biotechnology from generics.BusinessPeter A. Singer, Abdallah S. Daar, Halla Thorsteinsdottir, Uyen Quach, Basma Abdelgafar
The emerging role of academia in commercializing innovation.BusinessShreefal Mehta
The evolution of molecular biology into systems biology.BusinessHans V. Westerhoff, Bernhard O. Palsson
The exclusion of diagnostic methods from patentability by the EPC: a case for review?.BusinessMathias Ricker
The fate of transgenes in the human gut.BusinessJohn Heritage
The functions of animal microRNAs.BusinessVictor Ambros
The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough.BusinessIan T. Paulsen, Jonathan A. Eisen, John F. Heidelberg, William C. Nelson, Robert J. Dodson, Barbara Methe, Lauren M. Brinkac, Sean C. Daugherty, Rekha Seshadri, Shelley A. Haveman, Christopher L. Hemme, James F. Kolonay, Naomi Ward, Ramana Madupu, A. Scott Durkin, Robert T Deboy, Sullivan, Steven A.; Fouts, Derrick; Haft, Daniel H.; Selengut, Jeremy; Peterson, Jeremy D.; Davidsen, Tanja M.; Zafar, Nikhat; Zhou, Liwei;, Khouri, Hoda; Gill, John; Utterback, Terry R., Feldblyum, Tamara V.; Wall, Judy D.; Voordouw, Gerrit; Fraser, Claire M., Hance, Mark; Tran, Kevin, Radune, Diana; Dimitrov, George
The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens.BusinessSang Yup Lee, Soon Ho Hong, Sun Shim Choi, Chang Hoon Kim, Cheol Goo Hur, Jin Sik Kim, Yong Ho In, Jeong-Keun Rih, Haeyoung Jeong, Jae Jong Kim
The genome sequence of the extreme thermophile Thermus thermophilus.BusinessRobert Huber, Anke Henne, Gerhard Gottschalk, Thomas Hartsch, Andre Johann, Arnim Wiezer, Carsten Raasch, Holger Bruggemann, Heiko Liesegang, Olivia Gohl, Tanja Lienard, Rosa Martinez-Arias, Vytaute Starkuviene, Carsten Jacobi, Silke Schlenczeck, Hans-Peter Klenk, Silke Dencker, Wilfried Kramer, Hans-Joachim Fritz, Rainer Merkl
The HUPO PSI's molecular interaction format-a community standard for the representation of protein interaction data.(Proteomics Standards Initiative )(Human Proteome Organization )BusinessAlvis Brazma, Boris Steipe, David Eisenberg, Ioannis Xenarios, Akhilesh Pandey, Susan Moore, Peer Bork, Sylvain Poux, Marc Vidal, David Sherman, Chris Sander, Michael Lappe, Henning Hermjakob, Ugis Sarkans, Rong Zeng, Bernard Jacq, Luisa Montecchi-Palazzi, Gary Bader, Jerome Wojcik, Lukasz Salwinski, Arnaud Ceol, Sandra Orchard, Christian von Mering, Bernd Roechert, Eva Jung, Henning Mersch, Paul Kersey, Yixue Li, Debashis Rana, Macha Nikolski, Holger Husi, Christine Brun, K Shanker, Seth G N Grant, Weimin Zhu, Pierre Legrain, Gianni Cesarein, Chris Hogue, Rolf Apweiler
The impact of systems approaches on biological problems in drug discovery.BusinessLeroy Hood, Roger M. Perlmutter
The ins and outs of gene expression control.BusinessFrancine B. Perler
The level of disclosure necessary for patent protection of genetic innovations.BusinessRichard J. Berman, Amy EL Schoenhard
The molecular properties and applications of Anthozoa fluorescent proteins and chromoproteins.BusinessVladislav V. Verkhusha, Konstantin A. Lukyanov
The need for a public proteomics repository.BusinessRong Wang, John T. Prince, Mark W. Carlson, Peng Lu, Edward M. Marcottem
The need for speed in stochastic simulation.BusinessLarry Lok
The plasma membrane-bound phospholipase D(delta) enhances freezing tolerance in Arabidopsis thaliana.BusinessWenhua Zhang, Weiqi Li, Maoyin Li, Ruth Welti, Xuemin Wang
The prevalence of patent interferences in gene technology.BusinessJon F. Merz, Michelle R. Henry
The pulse of mitosis.BusinessConly L. Rieder, Alexei Mikhailov
The role of RNA interference in heterochromatic silencing.BusinessRob Martienssen, Zachary Lippman
The site-specific incorporation of p-iodo-L-phenylalanine into proteins for structure determination.BusinessPeter G. Schultz, Lei Wang, Jianming Xie, Ning Wu, Ansgar Brock, Glen Spraggon
The use of nanocrystals in biological detection.BusinessPaul Alivisatos
Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues .BusinessJian Yang, Stanley B. Prusiner, Stephen J. DeArmond, Fred E. Cohen, Gerold Schmitt-Ulms, Michael A. Baldwin, Cynthia Cowdrey, Jialing Liu, Kirk Hansen
Too little, too late: when is the right time for new leadership in biotech?BusinessPaul Branthwaite, Steven J. Williams
Towards quality assurance and harmonization of genetic testing services in the European Union.BusinessDolores Ibarreta, Robert Elles, Emilio Rodriguez-Cerezo, Elisabeth Dequeker
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.BusinessChunhui Xu, Yan Li, Ralph Brandenberger, Sally Zhang, Rixun Fang, Henry Wei, Gregory J. Fisk, Lawrence W. Stanton, Jane Lekowski, Ramumkar Mandalam, Mahendra S. Rao, Karl Guegler, Jaji Murage, Shirley Lei
Two-dimensional annotation of genomes.BusinessBernhard Palsson
Uninhibited antibiotic target discovery via chemical genetics.BusinessKeith Poole
Unlocking the potential of the human genome with RNA interference.BusinessGregory J. Hannon, John J. Rossi
Unnatural selection of cultured human ES cell?.BusinessMartin F. Pera
Unraveling protein interaction networks with near-optimal efficiency.BusinessLiisa Holm, Michael Lappe
Unshackling expression profiling arrays.BusinessDarrell P Chandler
US courts struggle with new patent infringement standards.BusinessPhill Jones
US food safety under siege?BusinessRichard Gilmore
US to safeguard 'dual-use' biology research.BusinessJeffrey Fox L.
Valuation - what you need to know.BusinessBenoit Leleux, Patrik Frei
Valuing the product development cycle in agricultural biotechnology-what's in a name?BusinessDavid McElroy
Vardenafil hydrochloride and tadalafil.Business 
Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emitting proteins.BusinessWerner Goebel, Yong A Yu, Tatyana M. Timiryasova, Chang Ch'ien, Ivaylo Gentschev, Aladar A. Szalay, Shahrokh Shabahang, Richard Beltz
What every CFO should know about equipment financing.BusinessJ. Alden Philbrick
What is Bayesian statistics?.BusinessSean R Eddy
What is dynamic programming?BusinessSean R Eddy
What to expect at your biotech job interview.BusinessMary Ann Rafferty
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