Nature Medicine 2005 - Abstracts
| Nature Medicine 2005 | |||||
| Title | Subject | Authors | |||
|---|---|---|---|---|---|
| 17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration. | Health | Masahisa Katsuno, Hiroaki Adachi, Manabu Doyu, Makoto Minamiyama, Gen Sobue, Masahiro Waza, Akira Inukai, Chen Sang, Fumiaki Tanaka | |||
| 60 years of winged victories for biomedical research. | Health | Joseph L. Goldstein | |||
| Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity. | Health | George D. Yancopoulos, Stanley J. Wiegand, Mark W. Sleeman, Katherine Wortley E., Ka-man V. Lai, Lori C. Gowen, Jennifer Kintner, William O. Kline, Karen Garcia, Trevor N. Stitt, David J. Glass | |||
| Accelerated re-epithelialization in beta3-integrin-deficient mice is associated with enhanced TGF-beta1 signaling. | Health | M. Stone, M. Lucas, L.E. Reynolds, F.J. Conti, R. Grose, S. Robinson, K. Hodivala-Dilke, C. Dickson, G. Saunders, R.O. Hynes, A. Lacy-Hulbert | |||
| ACE sets up fertilization.(angiotension I converting enzyme) | Health | Pierre Corvol | |||
| A chimeric human-cat fusion protein blocks cat-induced allergy. | Health | Daocheng Zhu, Christopher L. Kepley, Ke Zhang, Tetsuya Terada, Takechiyo Yamada, Andrew Saxon | |||
| A crucial role for antigen-presenting cells and alloantigen expression in graft-versus-leukemia responses. | Health | James L.M. Ferrara, Chen Liu, Pavan Reddy, Yoshinobu Maeda, Oleg I. Krijanovski, Robert Korngold | |||
| A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension. | Health | Songling Liu, Richard T. Premont, Christopher D. Kontos, Don C. Rockley, Shoukang Zhu | |||
| A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. | Health | Josef M. Penninger, Arthur S. Slutsky, Mark Chappell, Zhong Wang, Teiji Wada, Shuan Rao, Chengyu Jiang, Keiji Kuba, Yumiko Imai, Hong Gao, Feng Guo, Bin Guan, Yi Huan, Peng Yang, Yanli Zhang, Wei Deng, Linlin Bao, Binlin Zhang, Guang Liu, Yanxin Liu, Dexian Zheng, Andreas Leibbrandt, Depei Liu, Chuan Qin | |||
| Acute rejection is associated with antibodies to non-Gal antigens in baboons using gal-knockout pig kidneys. | Health | Bertha Garcia, David J. White, Gang Chen, Hua Qian, Thomas Starzl, Hongtao Sun, Ximo Wang, Yifan Dai, Yishai Wise, Anthony Jevnikar, Wanyu Wang, Yuanqing Liu, Yuliang Xiong, William Wall, Ying Xiang, David K C. Cooper, Laura Copeman, Niroko Murase, Robert Zhong, Weihua Liu | |||
| Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2--dependent mechanisms. | Health | Kaori Sato, Kenneth Walsh, David R. Pimentel, Rei Shibata, Noriyuki Ouchi, Yukihiro Takemura, Tohru Funahashi, Shinji Kihara, Koji Ohashi | |||
| A fork in the pathway to inflammation and arthritis. | Health | Foo Y. Liew, Iain B. McInnes | |||
| A genetic Xenopus laevis tadpole model to study lymphangiogenesis. | Health | Rakesh K. Jain, Peter Carmeliet, Florea Lupu, Mieke Dewerchin, Desire Collen, Lieve Moons, Diether Lambrechts, Sunit Maity, Stephane Plaisance, Edward M. Conway, Christian Fischer, Ricky T. Tong, Annelii Ny, Christophe Heligon, Sven Terclavers, Marta Koch, Malgorzata Ciesiolka, Martin Scheider, Roland Kalin, Kris Vlemickx, Elke Neven, Wing Yan Man, Andre Brandli, Irena Senn, Sabine Wyns | |||
| AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis. | Health | Mary Carrington, David Vlahov, James J. Goedert, Susan Buchbinder, Keith Hoots, Xiaojiang Gao, Arman Bashirova, Astrid K.N. Iversen, Phair, John; Altfeld, Marcus, O'Brien Stephen J. | |||
| Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo. | Health | Nissim Hay, William S. Chen, Paul Bornstein, Juhua Chen, Payaningal R. Somanath, Olga Razorenova, Tatiana V. Byzova | |||
| A live-cell assay to detect antigen-specific CD4(super+) T cells with diverse cytokine profiles. | Health | Mario Roederer, Pratip K. Chattopadhyay, Joanne Yu | |||
| A low-carb diet for a high-octane pathogen. | Health | H.I. Boshoff, C.E. Barry III | |||
| Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors. | Health | Guo-Min Deng, Lixin Zheng, Francis Ka-Ming Chan, Michael Lenardo | |||
| Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivom. | Health | Dennis J. Selkoe, Igor Klyubin, Dominic M. Walsh, Cynthia A. Lemere, William K. Cullen, Ganesh M. Shankar, Vicki Betts, Edward T. Spooner, Liying Jiang, Roger Anwyl, Michael J. Rowan | |||
| An astrocytic basis of epilepsy. | Health | Jian Kang, Maiken Nedergaard, H. Ronald Zielke, Jane Lin, Takahiro Takano, Weiguo Peng, Guo-Feng Tian, Hooman Azmi, Xiaohai Wang, Nanhong Lou, Qiwu Xu, NancyAnn Oberheim | |||
| An essential function for NBS1 in the prevention of ataxia and cerebellar defects. | Health | Adriano Aguzzi, Zhao-Qi Wang, Pierre-Olivier Frappart, Wei-Min Tong, Ilja Demuth, Ivan Radovanovic, Zdenko Herceg, Martin Digweed | |||
| Aneurysm treatments expand. | Health | Robert W. Thompson | |||
| A new approach to an influenza live vaccine: Modification of the cleavage site of hemagglutinin. | Health | J. Stech, H. Garn, R. Wagner, M. Wegmann, H.D. Klenk | |||
| A new transgene reporter for in vivo magnetic resonance imaging. | Health | Guillem Genove, Ulrike DeMarco, Hongyan Xu, William F. Goins, Eric T. Ahrens | |||
| Angiopoietin-related growth factor antagonizes obesity and insulin resistance. | Health | Toshio Suda, Takashi Kadowaki, Takashi Urano, Yoshihiro Ogawa, Toshimasa Yamauchi, Naomi Nakagata, Haruhiko Koseki, Yuichi Oike, Masaki Akao, Kunio Yasunaga, Tohru Morisada, Yasuhiro Ito, Yoshishige Kimura, Yoshiaki Kubota, Hiromitsu Maekawa, Takeshi Miyamoto, Keishi Miyata, Shun-ichiro Matsumoto, Juro Sakai, Motohiro Takeya | |||
| Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: A new therapeutic approach. | Health | Martine Burtin, David C. Lee, Alexandre Lautrette, Li Shunqiang, Rohia Alili, Susan W. Sunnarborg, Gerard Friedlander, Fabiola Terzi | |||
| Angiotension-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization. | Health | Hiromasa Tojo, Masaru Okabe, Yusuke Maeda, Junji Takeda, Taroh Kinoshita, Gen Kondoh, Yuka Nakatani, Nobuyasa Komazawa, Chie Murata, Kazuo Yamagata, Ryo Taguchi | |||
| Annulling a dangerous liaison: Vaccination strategies against AIDS and tuberculosis. | Health | Andrew J. McMichael, Stefan H.E. Kaufmann | |||
| Antiaging drug trials compel creative testing methods. | Health | Emma Marris | |||
| A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease. | Health | James Fallon, Leon Thal, Armin Blesch, Mark H. Tuszynski, Mary Pay, David P. Salmon, Hoi Sang U., Roy Bakay, Piyush Patel, H. Lee Vahlsing, Gilbert Ho, Gang Tong, Steven G. Potkin, Lawrence Hansen, Elliott J. Mufson, Jeffrey H. Kordower, Christine Gall, James Conner | |||
| A plague upon the phagocytes. | Health | Frank R. DeLeo, Joseph Hinnebusch | |||
| Apoliprotein M is required for prebeta-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis. | Health | Markus Stoffel, Christian Wolfrum, Matthew N. Poy | |||
| A radically twisted lipid regulates vascular death. | Health | Lois E.H. Smith, Kip M. Connor | |||
| A rapid and potent DNA vaccination strategy defined by in vivo monitoring of antigen expression. | Health | John B.A.G. Haanen, Ton N.M. Schumacher, Adriaan D. Bins, Annelies Jorritsma, Monika C. Wolkers, Chien-Fu Hung, T.-C. Wu | |||
| A role for LEDGF/p75 in targeting HIV DNA integration. | Health | Joseph R. Ecker, Frederic Bushman, Angela Ciuffi, Manuel Llano, Eric Poeschla, Christian Hoffman, Jeremy Leipzig, Paul Shinn | |||
| Astrocytes get in the act in epilepsy. | Health | Michael A. Rogawski | |||
| ATM regulates target switching to escalating doses of radiation in the intestines. | Health | Francois Paris, Zvi Fuks, Richard Kolesnick, Hui-Ju Ch'ang, Jerzy G. Maj, H. Rosie Xing, Jianjun Zhang, Jean-Philip Truman, Carlos Cardon-Cardo, Adriana Haimovitz-Friedman | |||
| A Toll-like trigger for autoimmune disease. | Health | Jean-Francois Bach | |||
| Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf animals. | Health | Masahiko Izumikawa, Ryosei Minoda, Karen A. Abrashkin, David F. Dolan, Douglas E. Brough, Kohei Kawamoto, Donald L. Swiderski, Yehoash Raphael | |||
| Autoimmunity and apoptosis: Refusing to go quietly. | Health | Peter M. Henson, Donna L. Bratton | |||
| Bacteria spurned by self-absorbed cells. | Health | Jean-Pierre Gorvel, Chantal De Chastellier | |||
| Bad medicine. | Health | ||||
| B-cell lymphoma: Suppressing a tumor suppressor. | Health | Alexander Dent | |||
| Ben Barres. | Health | Kris Novak | |||
| Beyond beta blockers. | Health | Donald M. Bers | |||
| Blockade of P13Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. | Health | Thierry Martin, Montserrat Camps, Emilio Hirsch, Dominique Perrin, Matthias P. Wymann, Matthias K. Schwarz, Thomas Ruckle, Christian Rommel, Bernard Francon, Corine Gillieron, Denise Gretener, Hong Ji, Christian Chabert, Rocco Cirillo, Vittoria Ardissone, Chiara Ferrandi, Didier Leroy, Felix Rintelen, Jeffrey Shaw, Pierre-Alain Vitte | |||
| Bugs gain vital ground in their battle against drugs. | Health | Emma Marris | |||
| Calculated resistance in cancer. | Health | Charles L. Sawyers | |||
| Calmodulin kinase II inhibition protects against structural heart disease. | Health | Long-Sheng Song, Silvia Guatimosim, Rong Zhang, Michelle S.C. Khoo, Yuejin Wu, Yingbo Yang, Chad E. Grueter, Gemin Ni, Edward E. Price Jr., William Thiel, Ernest C. Madu, Anisha N. Shah, Tatiana A. Vishnivetskaya, James B. Atkinson, Vsevolod V. Gurevich, Guy Salama, W.J. Lederer, Roger J. Colbran, Mark E. Anderson | |||
| Cancer researchers usher in dog days of medicine. | Health | George S. Mack | |||
| Cancer: The matrix is now in control. | Health | Livio Trusolino, Paolo M. Comoglio | |||
| Can successful vaccines teach us how to induce efficient protective immune responses? | Health | Paul-Henri Lambert, Margaret Liu, Claire-Anne Siegrist | |||
| Cathepsin L is required for endothelial progenitor cell-induced neovascularization. | Health | Christopher Heeschen, Stefanie Dimmeler, Andreas M. Zeiher, Alexandra Aicher, Carmen Urbich, Ken-ichiro Sasaki, Thomas Bruhl, Mohammad R. Farhadi, Peter Vajkoczy, Wolf K. Hofmann, Christoph Peters, Len A. Pennacchio, Nasreddin D. Abolmaali, Emmanouil Chavakis, Thomas Reinheckel | |||
| Caution on circumcision cuts South Africa's AIDS researchers. | Health | Lauren Beukes | |||
| CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection. | Health | Michael J. Walter, Jeffrey W. Tyner, Osamu Uchida, Naohiro Kajiwara, Edy Y. Kim, Anand C. Patel, Mary P. O'Sullivan, Reto A. Schwendener, Donald N. Cook, Theodore M. Danoff, Michael J. Holtzman | |||
| Cdk5-dependent regulation of glucose-stimulated insulin secretion. | Health | Kazuaki Nagashima, Katsuhiko Mikoshiba, Masayuki Matsushita, Kazuhito Tomizawa, Fan-Yan Wei, Hideki Matsui, Yutaka Seino, Toshio Ohshima, Yasunori Saheki, Yuichiro Yamada, Yun-Fei Lu | |||
| Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice. | Health | Viswanathan Natarajan, Rubin M. Tuder, Irina Petrache, Lijie Zhen, Terry R. Medler, Chung Cho, Amy Richter, Walter C. T. Hubbard, Evgeny V. Berdyshev | |||
| Changing ethics rules land Spanish stem cell scientist in hot water. | Health | Xavier Bosch | |||
| Cholesterol, racial variation and targeted medicines. | Health | Eric J. Topol | |||
| Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy. | Health | E. Rene Rodriguez, David A. Kass, Hunter C. Champion, Eiki Takimoto, Manxiang Li, Diego Belardi, Shuxun Ren, Djahida Bedja, Kathleen L. Gabrielson, Yibin Wang | |||
| Clock reset for alcoholism. | Health | Mary Jeanne Kreek, Vadim Yuferov, Gavin Bart | |||
| Contribution of bone marrow-derived endothelial cells to human tumor vasculature. | Health | Christoph Lengauer, Kenneth W. Kinzler, Bert Vogelstein, Joseph H. Antin, Stanley R. Hamilton, David Myerson, Kornelia Polyak, Brock A. Peters, Eva C. Guinan, Luis A. Diaz Jr., Leslie Meszler, Kathy Romans | |||
| Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies. | Health | Rainer Weber, Hermann Katinger, Gabriela Stiegler, Marek Fischer, Beda Joos, Huldrych F. Gunthard, Annette Oxenius, Michael Huber, Alexandra Trkola, Herbert Kuster, Peter Rusert, Christine Leeman, Amapola Manrique, Manuela Rehr, Brigitta Vcelar, Leonardo Aceto | |||
| Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. | Health | Morris F. White, Masato Kasuga, Naoko Hashimoto, Hiroshi Sakaue, Tohru Uchida, Takehiro Nakamura, Tomokazu Matsuda, Ko Kotani, Yoshiaki Kido, Yoshitake Hayashi | |||
| Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action. | Health | Jerrold M. Olefsky, Andrea L. Hevener, Emilie A. Brad-Chapeau, Shinong Long, Eric E. Zhang, Gen-Sheng Feng | |||
| Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis. | Health | Randolph J. Noelle, Frank L. Heppner, Melanie Greter, Burkhard Becher, Maria P. Lemos, Norbert Goebels, Bernhard M. Odermatt, Terri Laufer | |||
| Detection of prions in blood. | Health | Claudio Soto, Joaquin Castilla, Paula Saa | |||
| Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus. | Health | Michael S. Diamond, Theodore Oliphant, Michael Engle, Grant E. Nybakken, Chris Doane, Syd Johnson, Ling Huang, Sergey Gorlatov, Erin Mehlhop, Anantha Marri, Kyung Min Chung, Gregory D. Ebel, Laura D. Kramer, Daved H. Fremont | |||
| Direct access to CD4(super +) T cells for defined antigens according to CD154 expression. | Health | Alexander Scheffold, Marco Frentsch, Olga Arbach, Dennis Kirchhoff, Andreas Thiel, Beate Moewes, Margitta Worm, Martin Rothe | |||
| Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia. | Health | Lars Nilsson, Gunnar Juliusson, Kjeld Schmiegelow, Sten Eirik Jacobsen, Kristina Anderson, Anders Castor, Ingbritt Astrand-Grundstrom, Miranda Buitenhius, Carole Ramirez, Bodil Strombeck, Stanislaw Garwicz, Albert N. Bekassy, Birgitte Lausen, Peter Hokland, Soren Lehmann, Bertil Johansson | |||
| Diverse compounds mimic Alzheimer disease - causing mutations by augmenting Abeta42 production. | Health | Edward H. Koo, Sascha Weggen, Jason L. Eriksen, Sarah A. Sagi, Tawnya E. Smith, Todd E. Golde, Thomas Kukar, Michael Paul Murphy, Thomas Ladd, Murad A. Khan, Rajashaker Kache, Jenny Beard, Mark Dodson, Sami Merit, Victor V. Ozols, Panos Z. Anastasiadis, Pritam Das, Abdul Fauq | |||
| DNA instability in the brain: Survival of the 'fittest'. | Health | Carrolee Barlow, Kai Treuner | |||
| Do-all receptor takes on coagulation, inflammation. | Health | Charles Esmon | |||
| Dopamine covalently modifies and functionally inactivates parkin. | Health | Dennis J. Selkoe, Michael G. Schlossmacher, Beth L. Ostaszewski, Matthew J. LaVoie, Andreas Weihofen | |||
| Double jeopardy. | Health | Paroma Basu | |||
| Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation on transgenic mice. | Health | Lin Wang, Janet E. Davies, Lourdes Garcia-Oroz, Lynnette J. Cook, Coralie Vacher, Dominic G. O'Donovan, David C. Rubinsztein | |||
| Dysregulation of bacterial proteolytic machinery by a new class of antibiotics. | Health | Werner Schroeder, Dieter Beyer, Hans-Georg Sahl, Heike Brotz-Oesterhelt, Kerstin Henninger, Julia E. Bandow, Holger Paulsen, Hein-Peter Kroll, Siegfried Raddatz, Harald Labischinksi, Rainer Endermann, Berthold Hinzen, Christoph Ladel | |||
| Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry. | Health | Micah T. McClain, Gregory J. Dennis, Judith A. James, John B. Harley, Latisha D. Heinlen, Jon Roebuck | |||
| Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1. | Health | Michael S. Saag, Jurgen K. Rockstroh, Anton Pozniak, Schlomo Staszewski, Andy I.M. Hoepelman, Gerd Fatkenheuer, Margaret A. Johnson, AndreasM Plettenberg, Frank D. Geobel, Bruce J.M. Dezube, Tim M. Jenkins, Christine Medhurst, John F. Sullivan, Caroline Ridgway, Samantha Abel, Ian T. James, Mike Youle, Elna van der Ryst | |||
| EIF2B5 mutations comprise GFAP+ astrocyte generation in vanishing white matter leukodystrophy. | Health | Mark Noble, Jorg Dietrich, Michell Lacagnina, Eric Richfield, Carlo Torres, David Gass, Margot Mayer-Proschel, Christoph Proschel | |||
| Electrical impulses recharge spinal cord injury research. | Health | Gunjan Sinha | |||
| Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis. | Health | Eileen J. McMahon, Samantha L. Bailey, Carol Vanderlugt Castenada, Hanspeter Waldner, Stephen D. Miller | |||
| Ethics guidelines for research with the recently dead. | Health | John J. Kavanagh, Wadih Arap, Stuart J. Youngner, Cynthia B. Cohen, Mary S. McCabe, Rebecca D. Pentz, Mark Wicclair, Michael A. DeVita, Anne Lederman Flamm, Ann B. Hamric, Jacqueline J. Glover, Winona J. Kittiko, Kathy Kinlaw, JamesM Keller, Andrienne Asch | |||
| Experimental autoimmune encephalomyelitis repressed by microglial paralysis. | Health | Josef Priller, Marco Prinz, Thomas Rulicke, Frank L. Heppner, Melanie Greter, Denis Marino, Jeppe Falsig, Gennadij Raivich, Nadine Hovelmeyer, Burkhard Becher, Ari Waisman, Adrino Aguzzi | |||
| Extinct 1918 virus comes alive. | Health | David Jackson, Robert A. Lamb | |||
| Fast track to the porphyrins. | Health | James P. Kushner, John D. Phillips | |||
| Fat, keeping the heart healthy? | Health | Fumitaka Ushikubi, Koh-ichi Yuhki, Jun-ichi Kawabe | |||
| Fish oil fix. | Health | William F. Stenson, Stephen M. Prescott | |||
| Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. | Health | Yukihiko Sugimoto, Akira Hirasawa, Keiko Tsumaya, Takeo Awaji, Susumu Katsuma, Tetsuya Adachi, Masateru Yamada, Shunichi Miyazaki, Gozoh Tsujimoto | |||
| Gateway to the metabolic syndrome. | Health | Antonio Vidal-Puig, Gema Medina-Gomez | |||
| G-CSF prevents cardiac remodeling after myocardial infraction by activating the Jak-Stat pathway in cardiomyocytes. | Health | Hiroshi Hasegawa, Issei Komuro, Haruaki Nakaya, Mutsuo Harada, Masashi Ohtusuka, Tohru Minamino, Hiroshi Akazawa, Toshio Nagai, Yingjie Qin, Hiroyuki Takano, Katsuhisa Matsuura, Masanori Sano, Jun-ichiro Nishi, Koji Iwanaga, Yunzeng Zou, Takeshige Kunieda, Yamauchi-Takihara eiko, Haruhiro Toko, Weidong Zhu, Keita Kunisada | |||
| Genetic fingerprinting. | Health | Alec J. Jeffreys | |||
| Getting to the guts of NOD2. | Health | Brian Kelsall | |||
| Good ACE, bad ACE do battle in lung injury, SARS.(Angiotensin-converting enzyme 2 ) | Health | John Nicholls, Malik Peiris | |||
| Gut-level decisions in peace and war. | Health | Maria Rescigno, Marcello Chieppa | |||
| Gynecologic diseases get their genes. | Health | Martin M. Matzuk | |||
| HDL as a target in the treatment of atherosclerotic cardiovascular disease.(high-density lipoprotein) | Health | Alan R. Tall, Patrick Linsel-Nitschke | |||
| Heart transplantation in baboons using alpha-1,3-galactosyltransferase gene-knockout pigs as donors: Initial experience. | Health | David H. Sachs, Akira Shimizu, Stuart L. Houser, Jay A. Fishman, Kenji Kuwaki, Yau-Lin Tseng, Frank J. M. F. Dor, Todd M. Sanderson, Yosuke Hisashi, Clive Patience, Nicolas Mueller, Michel Awwad, David K. C. Cooper, Courtney J. Lancos, Derek D. Prabharasuth, Kazuhiko Yamada, Jane Cheng, Julia L. Greenstein, Simon C. Robson, Kathleen Moran, Robert J. Hawley, Henk-Jan Schuurman | |||
| HIF, a missing link between metabolism and cancer.(hypoxia-inducible factor) | Health | Patrick H. Maxwell, Miguel A. Esteban | |||
| Hitchhiker's guide to the T cell. | Health | Cliona M. Rooney | |||
| HIV swiftly guts the immune system. | Health | Ronald S. Veazey, Andrew A. Lackner | |||
| Host-reactive CD8(super +) memory stem cells in graft-versus-host disease. | Health | Stephen G. Emerson, Yi Zhang, Jiang Zhu, Gerard Joe, Elizabeth Hexner | |||
| Human embryonic stem cells express an immunogenic nonhuman sialic acid. | Health | Maria J. Martin, Alysson Muotri, Fred Gage, Ajit Varki | |||
| Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation. | Health | Ying Liu, Larry S. Sherman, Fatima Banine, Mahendra S. Rao, Andrew Craig, Stephen A. Back, Ansi Chang, Bruce D. Trapp, Therese M.F. Tuohy, Bruce F. Bebo Jr., Hanqin Chen, Nicholas Wallingford, Ning Ling Luo, Jaime Struve | |||
| Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling. | Health | Bo Wang, Matthias Ernst, Brendan J. Jenkins, Dianne Grail, Thao Nheu, Meri Najdovska, Paul Waring, Melissa Inglese, Rachel M. McLoughlin, Simon A. Jones, Nicholas Topley, Heinz Baumann, Louise M. Judd, Andrew S. Giraud, Alex Boussioutas, Hong-Jian Zhu | |||
| Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis. | Health | Lydia Aguilar-Bryan, Silvana Obici, Luciano Rossetti, Tony K.T. Lam, Roger Gutierrez-Juarez, Joseph Bryan, Gary J. Schwartz, Alessandro Pocai | |||
| Identification of MMP-1 as a putative breast cancer predictive marker by global gene expression analysis. | Health | LaSalle D. Leffall, Indira Poola, Robert L. DeWitty, Josphine J. Marshalleck, Rakesh Bhatnagar, Jessy Abraham | |||
| IKK-beta links inflammation to obesity-induced insulin resistance. | Health | Michael Karin, Jeffrey M. Long, Florian R. Greten, Anthony Wynshaw-Boris, Andrea L. Hevener, Jerrold Olefsky, Shin Maeda, Melek C. Arkan, Zhi-Wei Li, Giuseppe Poli | |||
| IKK mediates ischemia-induced neuronal death.(I(kappa)B kinase) | Health | Hermann Bujard, Oliver Herrmann, Bernd Baumann, Rossana de Lorenzi, Sajjad Muhammad, Wen Zhang, Jens Kleesiek, Cordina Beyer, Manolis Pasparakis, Max Malferthein, James R. Burke, Markus Schwaninger, Martin Kohrmann, Mazahir T. Hasan, Ioana Potrovita, Ira Maegele, Thomas Wurth | |||
| In Bangladesh, arsenic-free water set to flow from cheap new filter. | Health | Gretchen Cuda | |||
| Induction of interleukin-8 preserves the angiogenic response in HIF-1 alpha-deficient colon cancer cells. | Health | Lawrence R. Zukerberg, Daniel C. Chung, Yusuke Mizukami, Yutaka Kohgo, Maureen P. Lynch, Won-Seok Jo, Bo R. Rueda, Eva-Maria Duerr, Othon Iliopoulos, Manish Gala, Michael A. Zimmer, Jingnan Li, Xiaobo Zhang | |||
| Inflammation and cancer: The long reach of Ras. | Health | Michael Karin | |||
| Inflammatory arthritis requires Foxo3a to prevent Fas ligand-induced neutrophil apoptosis. | Health | Paul Allen, Helena Jonsson, Stanford L. Peng | |||
| Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. | Health | Drew Pardoll, Richard Jove, Hua Yu, Marcin Kortylewski, Maciej Kujawski, Tianhong Wang, Sheng Wei, Shumin Zhang, Shari Pilon-Thomas, Guilian Niu, Heidi Kay, James Mule, William G. Kerr | |||
| Inhibition of hepatitis B virus in mice by RNA interference. | Health | Hiroyuki Nakai, Patricia L. Marion, Anton P. McCaffrey, Mark A Kay, Kusum Pandey, Zan Huang, Stefan F. Wieland, Felix H. Salazar, Hui Xu | |||
| Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy. | Health | George C. Prendergast, Alexander J. Muller, James B. DuHadaway, P. Scott Donover, Erika Sutanto-Ward | |||
| Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene. | Health | Richard F. Lockey, Hong Yang, Weidong Zhang, Xiaoyuan Kong, Subhra Mohapatra, Homera San Juan-Vergara, Gary Hellermann, Sumita Behera, Rajeswari Singam, Shyam S. Mohapatra | |||
| Inhibition of respiratory viruses by nasally administered siRNA. | Health | Vira Bitko, Alla Musiyenko, Olena Shulyayeva, Sailen Barik | |||
| Inhibition of respiratory viruses by nasally administered siRNA. | Health | Vira Bitko, Alla Musiyenko, Olena Shulyayeva, Sailen Barik | |||
| Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor way. | Health | Saverio Minucci, Lucia Altucci, Alessandra Insinga, Silvia Monestiroli, Simona Ronzoni, Vania Gelmetti, Francesco Marchesi, Andrea Viale, Clara Nervi, Pier Giuseppez Pelicci | |||
| Integrin alphavbeta3 is a coreceptor for human cytomegalovirus. | Health | Xing Wang, David Y. Huang, Shu-Mei Huong, Eng-Shang Huang | |||
| Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis. | Health | Daewoong Jo, Danya Liu, Shan Yao, Robert D. Collins, Jacek Hawiger | |||
| Introducing new vaccines into developing countries: Obstacles, opportunities and complexities. | Health | John Clemens, Luis Jodar | |||
| In vivo imaging of axonal degeneration and regeneration in the injured spinal cord. | Health | Martin E. Schwab, Jeff W. Lichtman, Martin Kerschensteiner, Thomas Misgeld | |||
| Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease. | Health | Xu Cheng, Gregory R. Dressler, Jingmei Lin, Sanjeevkumar R. Patel, Eun Ah Cho, Inna Levitan, Matthew Ullenbruch, Sem H. Phan, John M. Park | |||
| Killed but metabolically active microbes: A new vaccine paradigm for eliciting effector T-cell responses and protective immunity. | Health | W. Liu, D.G. Brockstedt, K.S. Bahjat, M.A. Giedlin, M. Leong, W. Luckett, Y. Gao, P. Schnupf, D. Kapadia, G. Castro, J.Y.H. Lim, A. Sampson-Johannes, A.A. Herskovits, A. Stassinopoulos, H.G. Archie Bouwer, J.E. Hearst, D.A. Portnoy, D.N. Cook, T.W. Dubensky Jr. | |||
| Killing pain, killing neurons? | Health | Tony Wyss-Coray | |||
| Lack of interferon response in animals to naked siRNAs. | Health | Mark E. Davis, Jeremy D. Heidel, Siwen Hu, Xian Fang Liu, Timothy J. Triche | |||
| Lactadherin promotes VEGF-dependent neovascularization. | Health | Bernard Levy, Clotilde Thery, Sebastian Amigorena, Jacques Boddaert, Jean-Sebastien Silvestre, Ghislaine Hamard, Barbara Aguilar, Alain Delcayre, Christophe Houbron, Radia Tamarat, Olivier Blanc-Brude, Sylvia Heeneman, Michel Clergue, Micheline Duriez, Regine Merval, Alain Tedgui, Ziad Mallat | |||
| Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS. | Health | Christopher E. Henderson, Cedric Raoul, Toufik Abbas-Terki, Jean-Charles Bensadoun, Sandrine Guillot, Georg Haase, Jolanta Szulc, Patrick Aebischer | |||
| Lentiviral-mediated silencing of SOD1 through RNA interferences retards disease onset and progression in a mouse model of ALS. | Health | Christopher E. Henderson, Cedric Raoul, Toufik Abbas-Terki, Jean-Charles Bensadoun, Sandrine Guillot, Georg Haase, Jolanta Szulc, Patrick Aebischer | |||
| Lentiviral vector retargeting to P-glycoprotein on metastatic melanoma through intravenous injection. | Health | Irvin S.Y. Chen, Yiming Xie, Kouki Morizono, Gene-Errol Ringpis, Mai Johnson, Lily Wu, Hoorig Nassanian, Benhur Lee | |||
| Less stress, longer life. | Health | M. Flint Beal | |||
| Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract. | Health | Jinsong Liu, Wenjun Cheng, Hiroyuki Yoshida, Daniel Rosen, Honami Naora | |||
| Lipid let loose in pulmonary emphysema. | Health | Jack A. Elias, Chun Geun Lee | |||
| Local and systemic insulin resistance resulting from hepatic activation of 1KK-beta and NF-kappa B. | Health | Steven E. Shoelson, Lone Hansen, Dongsheng Cai, Minsheng Yuan, Daniel F. Frantz, Peter A. Melendez, Jongsoon Lee | |||
| Locating heart failure. | Health | Jeffery D. Molkentin | |||
| Logistical hurdles slow California's lofty stem cell scheme. | Health | Jonathan Knight | |||
| Loss of function of a lupus-associated Fc(gamma)RIIb polymorphism through exclusion from lipid rafts. | Health | R. Andres Floto, Nicholas A. Watkins, Kenneth G.C. Smith, Menna R. Claworthy, Janet M. Allen, Karen R. Heilbronn, Willem H. Ouwehand, Dalya R. Rosner, Paul J. Lehner, Paul A. MacAry, Angela Rankin | |||
| Lovastatin and beyond: The history of the HMG-COA reductase inhibitors.(hydroxy-3-methyl-glutaryl-CoA ) | Health | Jonathan A. Tobert | |||
| Lyme disease agent borrows a practical coat. | Health | Patricia Rosa | |||
| Lymphopenia and interleukin-2 therapy alter homeostasis of CD4(super +)CD25(super +) regulatory T cells. | Health | Charles S. Carter, Hua Zhang, Jay A. Berzofsky, Thomas A. Fleisher, Daniel C. Douek, Brenna Hill, Kevin S. Chua, Martin Guimond, Veena Kapoor, Margaret V. Brown, Lauren M. Long, Donna Bernstein, E.J. Read, Lee J. Helman, Crystal L. Mackall | |||
| Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha-1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. | Health | David H. Sachs, Megan Sykes, Akira Shimizu, Yosuke Hisashi, Clive Patience, Michel Awwad, David K. C. Cooper, Kazuhiko Yamada, Robert J. Hawley, Henk-Jan Schuurman, Koji Yazawa, Takehiro Iwanaga, Matthew Nuhn, Jay Fishman, Patricia O'Malley, Shuji Nobori, Parsia A Vagefi, Julia Greenstein | |||
| Masters of angiogenesis. | Health | Robert M. Strieter | |||
| Memory stem cells sustain disease. | Health | Claudio Anasetti, Xue-Zhong Yu | |||
| MET orchestrates cancer and blood coagulation. | Health | Edward F. Plow, Olga I. Stenina | |||
| Mina Bissell.(cell biologist) | Health | Kristine Novak | |||
| Modulating autoimmunity: Pick your P13 kinase. | Health | Pamela S. Ohashi, James R. Woodgett | |||
| Molecular, cellular and functional imaging of atherothrombosis. | Health | Valentin Fuster, Zahi A. Fayad, Robin P. Choudhary | |||
| More neurons, less weight. | Health | Randy J. Seeley | |||
| Mucolipidosis II is caused by mutations in GNPTA encoding the alpha/beta GlcNAc-1-phosphotransferase. | Health | Bernard Henrissat, Stephan Tiede, Stephan Storch, Torben Lubke, Thomas Braulke, Ruth Bargal, Annick Raas-Rothschild | |||
| Mucosal immunity and vaccines. | Health | Jan Holmgren, Cecil Czerkinsky | |||
| Multiple diagnostic techniques identify previously vaccinated individuals with protective immunity against monkeypox . | Health | Erika Hammarlund, Scott G. Hansen, Lisa I. Strelow, Mark K. Slifka, Jon M. Hanifin, Matthew W. Lewis, Shirley V. Carter, Paul Yoshihara, Ian Amanna, Scott W. Wong | |||
| Multiple sclerosis: Trapped in deadly glue. | Health | Lawrence Steinman, Michael Platten | |||
| Muscle disease: A giant feels the strain. | Health | John Trinick, Larissa Tshovrebova | |||
| Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence. | Health | John D. McKinney, Ernesto J. Munoz-Elias | |||
| Neuroscience meeting draws fire over Dalai Lama lecture. | Health | David Cyranoski | |||
| Neutralizing antibodies take a swipe at HIV in vivo. | Health | David C. Montefiori | |||
| Newborn screening grows up. | Health | ||||
| New patent rules drive Indian drug firms to research. | Health | K.S. Jayaraman | |||
| New York City foster home accused of unethical AIDS drug trials. | Health | Jascha Hoffman | |||
| NFAT and Osterix cooperatively regulate bone formation.(nuclear factor of activated T cells) | Health | Tatsuhiko Kodama, Takako Koga, Hiroshi Takayanagi, Masataka Asagiri, Yuichi Matsui, Benoit de Crombrugghe, Nakashima Kazuhisa | |||
| Nipping cat allergy with fusion proteins. | Health | Stephen J. Galli, Janet Kalesnikoff | |||
| NKCC1 transporter facilitates seizures in the developing brain. | Health | Volodymyr I. Dzhala, Delia M. Talos, Dan A. Sdrulla, Audrey C. Brumback, Gregory C. Mathews, Timothy A. Benke, Eric Delpire, Frances E. Jensen, Kevin J. Staley | |||
| NK cells promote islet allograft tolerance via a perforin-dependent mechanism. | Health | Joshua N. Beilke, Nathan R. Kuhl, Luc Van Kaer, Ronald G. Gill | |||
| Old approach yields new antibiotic. | Health | John S. Blanchard | |||
| Organ transplantation-how much of the promise has been realized? | Health | Megan Sykes, Laurence A. Turka, Robert I. Lechler, Angus W. Thomson | |||
| Oxidative stress is the new stress. | Health | Jay A. Gingrich | |||
| P12Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus. | Health | Dimitrios Balomenos, Juana M. Flores, Carlos Martinez-A, Ana C. Carrera, Santiago Rodriguez, Montserrat Camps, Domingo F. Barber, Almira Bartolome, Matthias K. Schwarz, Carmen Hernandez, Thomas Ruckle, Christian Rommel, Clara Redondo, Cristina Fernandez-Arias | |||
| Pain killer without a high. | Health | Krisztina Monory, Beat Lutz | |||
| Part-time cop nabs deviant DNA. | Health | Robert T. Abraham | |||
| Peptide-based therapeutic vaccines for allergic and autoimmune diseases. | Health | Mark Larche, David C. Wraith | |||
| Perspectives on the properties of stem cells. | Health | Ernest A. McCulloch, James E. Till | |||
| PI 3-kinase p110beta: A new target for antithrombotic therap. | Health | Lucy Lu, Shaun P. Jackson, Simone M. Schoenwaelder, Isaac Goncalves, Warwick S. Nesbitt, Cindy L. Yap, Christine E. Wright, Vijaya Kenche, Karen E. Anderson, Sacha M. Dopheide, Yuping Yuan, Sharelle A. Sturgeon, Hishani Prabaharan, Philip E. Thompson, Gregg D. Smith, Peter R. Shepherd, Nathalie Daniele, Suhasini Kulkarni, Belinda Abbott, Dilek Saylik, Catherine Jones, Simon Giuliano, Sascha C. Hughan, James A. Angus, Alan D. Robertson, Hatem H. Salem | |||
| Platelets mediate cytotoxic T lymphocyte-induced liver damage. | Health | M. Iannacone, Giovanni Sitia, Masanori Isogawa, Patrizia Marchese, Maria G. Castro, Pedro R. Lowenstein, Francis V. Chisari, Zaverio M. Ruggeri, Luca G. Guidotti | |||
| Prevention of diabetes by manipulation of anti-IGRP autoimmunity: High efficiency of a low-affinity peptide. | Health | Abdelaziz Amrani, Pau Serra, Pere Santamaria, Bingye Han, Jun Yamanouchi, Athanasius F.M. Maree, Leah Edelstein-Keshet | |||
| Price of mice to plummet under NIH's new scheme. | Health | Emily Waltz | |||
| Protecting the host naturally. | Health | Megan Sykes, Thomas R. Spitzer | |||
| Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor. | Health | Preston A. Marx, John P. Moore, Ronald S. Veazey, Per Johan Klasse, Martin S. Springer, Jason Dufour | |||
| Psoriasis: More than skin deep. | Health | Mark R. Pittelow | |||
| Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo. | Health | Rakesh K. Jain, David T. Scadden, Edward B. Brown, Dai Fukumura, Moungi G. Bawendi, Dan G. Duda, Kenneth S. Cohen, Mark Strh, John P. Zimmer, Tatyana S. Lavchenko, Vladimir P. Torchilin | |||
| Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization. | Health | David A. Williams, Keith F. Stringer, Jose A. Cancelas, Andrew W. Lee, Rethinasamy Prabhakar, Yi Zheng | |||
| Radiation's outer limits. | Health | Ralph Weichselbaum | |||
| Re-engineered CD40 receptor enables potent pharmacological activation of dendritic-cell cancer vaccines in vivo. | Health | Michael Barry, Kevin M. Slawin, Brent A. Hanks, Jianghong Jiang, Rana A.K. Singh, Weitao Song, Mary H. Huls, David M. Spencer | |||
| Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase. | Health | Hiroki Aoki, Yasuhiro Ikeda, Romeo Ricci, Nobuyuki Tanaka, Masunori Matsuzaki, Koichi Yoshimura, Kozo Fujji, Norio Akiyama, Tokuhiro Ishihara, Yoshiobu Hoshii, Kimikazu Hamano, Akira Furutani, Kensuke Esato | |||
| Regulation of lung injury and repair by Toll-like receptors and hyaluronan. | Health | Richard Bucala, Ruslan Medzhitov, Yi Luo, Deborah A. Quinn, Glenn D. Prestwich, Paul W. Noble, Robert J. Homer, Dianhua Jiang, Jiurong Liang, Juan Fan, Shuang Yu, Suping Chen, Marcella M. Mascarenhas, Hari G. Garg, Daniel R. Goldstein, Patty J. Lee | |||
| Regulation of NKT cell development by SAP, the protein defective in XLP. | Health | Pamela L. Schwartzberg, Gary A. Koretzky, Kim E. Nichols, Shun-You Gong, Cindy S. Ma, Stuart G. Tangye, Jamie Hom, Arupa Ganguly, Jennifer L. Cannons, Paul L. Stein | |||
| Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy. | Health | Takashi Nakamura, Hiromu Ito, Kirill Gromov, Xinping Zhang, R. Jude Samulski, Regis J. O'Keefe, Mette Koefoed, J. Jeffrey Goater, Paul T. Rubrey, Brendan F.M Boyce, Edward M. Schwarz, Prarop Tiyapatanaputi, Jonathan Carmouche, Joseph Rabinowitz, Kjeld Soballe | |||
| Rescuing troubled vessels in Alzheimer disease. | Health | Costantino Iadecola | |||
| Researchers probe the real effect of placebos. | Health | Alla Katsnelson | |||
| Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer. | Health | Edward A. Stadtmauer, Cheryl Sickles, David L. Porter, Lei Zhang, Carl H. June, Robert Edelman, Alan Cross, Aaron P. Rapoport, Nicole Aqui, Ashraf Badros, Julio Cotte, Lisa Chrisley, Elizabeth Veloso, Zhaohui Zheng, Sandra Westphal, Rebecca Mair, Nina Chi, Bashi Ratterree, Mary Francis Pochran, Sabrina Natt, Joanne Hinkle, Ambika Sohal, Kathleen Ruehle, Christian Lynch, Selina Luger, Chuanfa Guo, Hong-Bin Fang, William Blackwelder, Kim Hankey, Dean Mann, Carl Frasch, Bruce L. Levine | |||
| Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome. | Health | Tom Misteli, Paola Scaffidi | |||
| Reversing systematic inflammatory response syndrome with chemokine receptor pepducins. | Health | Anika Agarwal, Athan Kuliopulos, Nicole C. Kaneider, Andrew J. Leger | |||
| Revolt in Bethesda. | Health | George S. Mack | |||
| RIGing a virus trap. | Health | Carl F. Ware, Chris A. Benedict | |||
| RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia. | Health | Harry T. Orr, Beverly L. Davidson, Steven L. Eliason, Scott Q. Harper, Ines H. Martins, Henry L. Paulson, Linda Yang, Robert M. Kotin, Haibin Xia, Qinwen Mao | |||
| Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer. | Health | Tyler Jacks, Denise Crowley, Daniela M. Dinulescu, Tan A. Ince, Bradley J. Quade, Sarah A. Shafer | |||
| Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. | Health | Berislav V. Zlokovic, Rashid Deane, Florence Hofman, Dong Liu, Huang Guo, Zhenhua Wu, Abhay Sagare, Fang Li, Anna Rubio, Don Armstrong, Nienwen Chow, Suhasini Kanagala, Thomas Gasiewicz, Jan Sallstrom, Andrew I. Brooks, Raphael Zidovetzki, Robert D. Bell, Xiamomei Song | |||
| R-Ras is a global regulator of vascular regeneration that suppress intimal hyperplasia and tumor angiogenesis. | Health | Erkki Ruoslahti, Masanobu Komastu | |||
| Savior and slayer: The two face of p53. | Health | Karen H. Vousden, Karim Bensaad | |||
| Scientific and therapeutic advances in antiplatelet therapy. | Health | Eric J. Topol, Deepak L. Bhatt | |||
| Senescence comes of age. | Health | Scott W. Lowe, Masashi Narita | |||
| Sensing the danger in RNA. | Health | John J. Rossi, Marjorie A. Robbins | |||
| Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. | Health | Ian MacLachlan, Adam D. Judge, Vandana Sood, Janet R. Shaw, Dianne Fang, Kevin McClintock | |||
| Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. | Health | Shizuo Akira, Stefan Endres, Satoshi Uematsu, Veit Hornung, Carole Bourquin, Margit Guenthner-Biller, Andrea Ablasser, Anne Noronha, Antonin de Fougerolles, Gunther Hartmann, Martin Schlee, Muthiah Manoharan | |||
| Sequence-specific potent induction of IFN-alpha by short interfering RNA in the plasmacytoid dendritic cells through TLR7. | Health | Shizuo Akira, Stefan Endres, Satoshi Uematsu, Veit Hornung, Carole Bourquin, Margit Guenthner-Biller, Andrea Ablasser, Anne Noronha, Antonin de Fougerolles, Gunther Hartmann, Martin Schlee, Muthiah Manoharan | |||
| Setting a trap for tissue fibrosis. | Health | Eric G. Neilson | |||
| Signal amplification in molecular imaging by pretargeting a multivalent, bispecific antibody. | Health | Robert M. Sharkey, Thomas M. Cardillc, Edmund A. Rossi, Chien-Hsing Chang, Habibe Karacay, William J. McBride, Hans J. Hansen, Ivan D. Horak, David M. Goldenberg | |||
| Silencing mutant SOD1 using RNAi protects against neurodegenration and extends survival in an ALS model. | Health | Linda Greensmith, Mimoun Azzouz, Susan M. Kingsman, G. Scott Ralph, Kyriacos A. Mitrophanous, Nicholas D. Mazarakis, Pippa A. Radcliffe, Denise M. Day, Janine M. Carthy, Marie A. Leroux, Debbie C. P. Lee, Liang-Fong Wong, Lynsey G. Bilsland | |||
| Silencing mutant SOD1 using RNAi protects against neurodegenration and extends survival in an ALS model. | Health | Linda Greensmith, Mimoun Azzouz, Susan M. Kingsman, G. Scott Ralph, Kyriacos A. Mitrophanous, Nicholas D. Mazarakis, Pippa A. Radcliffe, Denise M. Day, Janine M. Carthy, Marie A. Leroux, Liang-Fong Wong, Lynsey G. Bilsland, Debbie C.P. Lee | |||
| Somatostatin regulates brain amyloid beta peptide Abeta(sub 42) through modulation of proteolytic degradation. | Health | Nobuhisa Iwata, Satoshi Tsubuki, Yoshie Takaki, Takaomi C. Saido, Takashi Saito, Jiro Takano, Shu-Ming Huang, Takahiro Suemoto, Makoto Higuchi | |||
| Sonic hedgehog myocardial gene therapy: Tissue repair through transient reconstitution of embryonic signaling. | Health | Marcy Silver, Cynthia Curry, Marianne Kearney, Roberto Pola, Jeffery A. Porter, Kengo F. Kusano, Toshinori Murayama, Atsuhiko Kawamoto, Atsushi Iwakura, Satoshi Shintani, Masaaki Ii, Jun Asai, Tengiz Tkebuchava, Tina Thorne, Hideya Takenaka, Ryuichi Aikawa, David Goukassian, Patrick von Samson, Hiromichi Hamada, Young-sup Yoon, Elizabeth Eaton, Hong Ma, Lindsay Heyd, William Munger, Raj Kishore, Douglas W. Losordo | |||
| Sound of silence. | Health | Stefan Heller, Kazuo Oshima | |||
| Spirituality's rising role in medicine stirs debate. | Health | Paroma Basu | |||
| Spontaneous fetal loss caused by placental thrombosis in estrogen sulfotransferase-deficient mice. | Health | John A. Lawson, Ping Liu, Hong Jiang, Ming Han Tong, Lawrence F. Brass, Wen-Chao Song | |||
| Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target. | Health | David E. Levy, Roberto Chiarle, Simmons J. William, Honjying Cai, Girish Dhall, Alberto Zamo, Regina Raz, James G. Karras, Giorgio Inghirami | |||
| Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model. | Health | Brian J. Nickoloff, Shigetoshi Sano, Keith Syson Chan, Steve Carbajal, John Clifford, Mary Peavey, Kaoru Kiguchi, Satoshi Itami, John DiGiovanni | |||
| Staying in SHIP shape. | Health | Alan R. Saltiel, Stuart J. Decker | |||
| Stem cells in the follicle bulge contribute to wound repair but not to homeostasis of the epidermis. | Health | George Cotsarelis, Rebecca J. Morris, Yaping Liu, Mayumi Ito, Zaixin Yang, Jane Nguyen, Fan Kiang | |||
| Stressed and depressed. | Health | Huda Akil | |||
| 'Sumo' rats set researchers on hunt for obesity genes. | Health | K.S. Jayaraman | |||
| Suppressing a sick heart. | Health | Levon M. Khachigian | |||
| Targeting the innate immune response with improved vaccine adjuvants. | Health | Achal Pashine, Nicholas M. Valiante, Jeffrey B. Ulmer | |||
| Targeting toxic proteins for turnover. | Health | Patrick Weydt, Albert R. La Spada | |||
| T cells targeted against a single minor histocompatibility antigen can cure solid tumors. | Health | Chantal Baron, Claude Perreault, Julie Bergeron, Marie-Christine Meunier, Jean-Sebastien Delisle, Vincent Rineau | |||
| T cell vaccines for microbial infections. | Health | Harriet L. Robinson, Rama Rao Amara | |||
| The adult muscle stem cell comes of age. | Health | Thomas A. Rando | |||
| The antioxidant function of the p53 tumor suppressor. | Health | Anna A. Sablina, Andrei V. Budanov, Galina V. Ilyinskaya, Larissa S. Agapova, Julia E. Kravchenko, Peter M. Chumakov | |||
| The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk. | Health | Alfred H. Schinkel, Johan W Jonker, Gracia Merino, Sandra Musters, Antonius E. van Herwaarden, Ellen Bolscher, Els Wagenaar, Mesman Elly, Trevor Dale | |||
| The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption. | Health | Urs Albrecht, Mark Lathrop, Rainer Spanagel, Gurudutt Pendyala, Carolina Abarca, David Zghoul, Carles Sanchis-Segura, Maria Chiara Magnone, Stefan Schreiber, Jesus Lascorz, Fumihiko Matsuda, Martin Depner, David Holzberg, Gunter Schumann, Michael Soyka | |||
| The fibrin-derived peptide Bbeta(sub 15-42) protects the myocardium against ischemia-reperfusion injury. | Health | Peter Petzelbauer, Yasuhiro Miyazaki, Francis J. Castellino, Klaus Wolff, Paula A. Zacharowski, Peter Friedl, Marion Groger, Kai Zacharowski, Georg Wickenhauser | |||
| The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis. | Health | Josef M. Penninger, Georg Schett, Teiji Wada, Tomoki Nakashima, Antonio J. Oliveira-dos-Santos, Hiromitsu Hara | |||
| The need for natural killer T cells. | Health | H. Robson MacDonald, Jens Schumann | |||
| The process development challenge for a new vaccine. | Health | Barry C. Buckland | |||
| Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. | Health | Jens Harborth, Victor Koteliansky, Jurgen Soutschek, Klaus Charisse, Sayda Elbashir, Gary Lavine, Ivanka Toudjarska, Muthiah Manoharan, David Bumcrot, Silvio Wuschko, Matthias John, Akin Akinc, Philipp Hadwiger, Venkitasamy Kesavan, Gang Wang, Birgit Bramlage, Anke Gelck, Stefan Limmer, Rajendra K. Pandey, Ingo Rohl, Rainer Constien, Mary Donoghue, Timothy Racie, Kallanthottathil G. Rajeev, Hans-Peter Vornlocher | |||
| The shear stress of keeping arteries clear. | Health | David G. Harrison | |||
| The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy. | Health | Ursula Keller, Kristina Lorenz, Martin J. Lohse, Monika Buitrago, Alexander H. Maass, Silke Oberdorf-Maass, Eva M. Schmitteckert, Yuri Ivashchenko, Stefan Engelhardt | |||
| Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption. | Health | Mark A. Magnuson, YouFei Guan, Chuanming Hao, Dae Ryong Cha, Reena Rao, Wendell Lu, Donald E. Kohan, Reyadh Redha, Yahua Zhang, Matthew D. Breyer | |||
| Threat of pandemic brings flu drug back to life. | Health | David Cyranoski | |||
| Thromboxane A(sub 2) and prostaglandin F(sub 2alpha) mediate inflammatory tachycardia. | Health | Fumitaka Ushikubi, Shuh Narumiya, Hiroshi Iwasaki, Koji Takayama, Yuhki Koh-ichi, Kyoichi Ono, Takayuki Fujino, Akiyoshi Hara, Takehiro Yamada, Shuhko Kuriyama, Hideji Karibe, Yuji Okada, Osamu Takahata, Takanobu Taniguchi, Toshihiko Iijima | |||
| Tissue-print and print-phoresis as platform technologies for the molecular analysis of human surgical specimens: Mapping tumor invasion of the prostrate capsule. | Health | Mark A. Rubin, Philip T. Lavin, Robert E. Lenkinski, Sandra M. Gaston, Marc A. Soares, M. Minhaj Sidiqui, Dang Vu; Upton, Melissa P., Jung M. Lee, Dana L. Goldner, Jovanna Baptista, Mark J. Brice, Jennifer C. Shih, B. Nicolas Bloch, Elizabeth M. Genega, George Perides | |||
| TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells. | Health | Barry R. Bloom, Robert L. Modlin, Peter A. Sieling, Thomas H. Rea, Stephan R. Krutzik, Maria Teresa Ochoa, Yong-Jun Liu, Belinda Tan, Huiying Li, Philip T. Lui, Sarah E. Sharfstein, Thomas G. Graeber | |||
| Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. | Health | Sanjiv A. Luther, Shizuo Akira, Rolf M. Zinkernagel, Hans Hengartner, Bernhard Odermatt, Satoshi Uematsu, Tobias Junt, Karl S. Lang, Mike Recher, Alexander A. Navarini, Nicola L. Harris, Stefan Freigang, Curdin Conrad, Lars M. Ittner, Stefanm Bauer | |||
| Tools for genomics. | Health | Edwin Southern | |||
| Traditional healers fight for recognition in South Africa's AIDS crisis. | Health | James Watson | |||
| Trans-arachidonic acids generated during nitrative stress induce a thrombospondin-1-dependent microvascular degeneration. | Health | Stephane Germain, Sylvain Chemtob, Elsa Kermorvant-Duchemin, Florina Sennlaub, Mirna Sirinyan, Sonia Brault, Gregor Andelfinger, Amna Kooli, Michael Balazy, Tang Zhu, Chantal Boisvert, Huy Ong, Pierre Hardy, D'Orelans-Juste, Pedro; Jain, Kavita | |||
| Transgenic labeling of the corticospinal tract for monitoring axonal responses to spinal cord injury. | Health | Joshua R. Sanes, Martin Kerschensteiner, Thomas Misgeld, Florence M. Bareyre | |||
| Tsunami aid spending draws fire over public health. | Health | ||||
| Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells.(histone deacetylases) | Health | Lucia Altucci, Hinrich Gronemeyer, Angela Nebbioso, Nicole Clarke, Emilie Voltz, Emmanuelle Germain, Concetta Ambrosino, Paola Bontempo, Alessandro Weisz, Rosana Alvarez, Angel R. De Lera, Ettore M. Schiavone, Felicetto Ferara, Francesco Bresciani | |||
| Tumor-targeted, systemic delivery of therapeutic viral vectors using hitchhiking on antigen-specific T cells. | Health | Richard G. Vile, Rosa Maria Diaz, Timothy Kottke, Caroline Cole, Jian Qiao, John Chester, Jill Thompson, Gregory Brunn, Atique Ahmed, Luis Sanchez-Perez | |||
| Tweaking liver progenitor cells. | Health | Nelson Fausto | |||
| TZDs and diabetes: Testing the waters. | Health | Clay F. Semenkovich | |||
| Untangling memory deficits. | Health | Karen Duff, Emmanuel Planel | |||
| Uridine adenosine tetraphosphate: A novel endothelium-derived vasoconstrictive factor. | Health | Walter Zidek, Lars Henning, Vera Jankowski, Markus Tolle, Raymond Vanholder, Gilbert Schonfelder, Markus van der Giet, Hartmut Schluter, Martin Paul, Joachim Jankowski | |||
| Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in rhesus macaque. | Health | Jun Xu, Chuan Qin, Bao-jian Li, Martin C. Woodle, Nanshan Zhong, Qingquan Tang, Bo-jian Zheng, Patrick Y. Lu, Du Cheng, Yijia Liu, Frank Y. Xie, Qiang Wei | |||
| Vaccine-induced tumor-specific immunity despite severe B-cell depletion in mantle cell lymphoma. | Health | Elaine S. Jaffe, Wyndham H. Wilson, Maryalice Stetler-Stevenson, Seth M. Steinberg, Larry W. Kwak, John E. Janik, Linda Harvey, Sattva S. Neelapu, Robin Pennington, Carol B. Kobrin, Craig W. Reynolds, Therese White, Ronald Gress, Kieron Dunleavy, Fran Hakim | |||
| Vaccines in the public eye. | Health | Paul Ritvo, Kumanan Wilson | |||
| Vaccines: Past, present and future. | Health | Stanley A. Plotkin | |||
| Vaccine wakes from the dead. | Health | Fred R. Frankel | |||
| Validating STAT3 in cancer therapy. | Health | James E. Darnell Jr. | |||
| Vav3 regulates osteoclast function and bone mass. | Health | Roberta Faccio, Steven Teitelbaum L., Jean Chappel, Victor L. Tybulewicz, F. Patrick. Ross, Keiko Fujikawa, Alberta Zallone, Wojciech Swat | |||
| Viagra: Now mending hearts. | Health | Michael E. Mendelsohn | |||
| When society meets science. | Health | Nancy G. Brinker | |||
This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.