Cell 2004 - Abstracts

Cell 2004
TitleSubjectAuthors
A behavioral role for dendritic integration: HCN1 channels constrain spatial memory and plasticity at inputs to distal dendrites of CA1 pyramidal neurons.Biological sciencesBina Santoro, Steven A. Siegelbaum, Gael Malleret, Gyorgy Buzsaki, Matthew F. Nolan, Emma Gibbs, Josh T. Dudman, Derek L. Buhl, Svetlana Vronskaya, Alexei Morozov, Kandel Eric R.
Accelerated evolution of nervous system genes in the origin of Homo Sapiens.Biological sciencesBruce T. Lahn, Eric J. Vallender, Steve Dorus, Patrick D. Evans, Jeffrey R. Anderson, Sandra L. Gilbert, Christine M. Malcolm, Gerald J. Wyckoff, Michael Mahowald
A common mechanism for microtubule destabilizers-M type kinesins stabilizes curling of the protofilament using the class-specific neck and loops.Biological sciencesTadayuki Ogawa, Ryo Nitta, Yasushi Okada, Nobutaka Hirokawa
A common switch used by plants and animals.Biological sciencesPhilip N. Benfey
A contextual model for axonal sorting into glomeruli in the mouse olfactory system.Biological sciencesPeter Mombaerts, Paul Feinstein
A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors.Biological sciencesChristopher K. Glass, Michael G. Rosenfeld, David W. Rose, Valentina Perissi, Aneel Aggarwal
A crack in histone lysine methylation.Biological sciencesThomas Jenuwein, Stefan Kubicek
Activating the PARP-1 sensor component of the groucho/TLE1 corepressor complex mediates a CaMKinase II delta-dependent neurogenic gene activation pathway.Biological sciencesChristopher K. Glass, Michael G. Rosenfeld, David W. Rose, Bong-Gun Ju, Derek Solum, Eun Joo Song, Kong-Joo Lee
Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase.Biological sciencesAkiko Kumagai, William G. Dunphy, Anna Shevchenko, Andrej Shevchenko, Hae Yong Yoo
A Dicer-2-dependent 80S complex cleaves targeted mRNAs during RNAi in Drosophila.Biological sciencesJanice L. Pellino, Richard W. Carthew, John W. Pham, Young Silk Lee, Eric J. Sontheimer
A distinct role for Norepinephrine in memory retrieval.Biological sciencesCharles F. Murchison, Xiao-Yan Zhang, Wei-ping Zhang, Ming Ouyang, Anee. Lee, Steven A. Thomas
A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis.Biological sciencesAnn Kuo, Gerald R. Crabtree, Chang Ching-Pin, Joel R. Neilson, J. Henri Bayle, Isabella Graef A., Jason E. Gestwicki, Kryn Stankunas
After the Holy Grail: establishing a molecular basis for mammalian olfaction.Biological sciencesRandall R. Reed
AID is required for c-myc/IgH chromosome translocations in vivo.Biological sciencesAndre Nussenzweig, Tasuku Honjo, Masamichi Muramatsu, Almudena R. Ramiro, Mila Jankovic, Thomas Eisenreich, Simone Difilippantonio, Selina Chen-Kiang, Michel C. Nussenzweig
Alternative splicing of Drosophila Dscam generates axon guidance receptors that exhibit isoform-specific homophilic binding.Biological sciencesS. Lawrence Zipursky, Woj M. Wojtowicz, John Flanagan J., S. Sean Millard, James C. Clemens
A MAPKK kinase gene regulates extra-embryonic cell fate in Arabidopsis.Biological sciencesWolfgang Lukowitz, Adrienne Roeder, Dana Parmenter, Chris Somerville
A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors.Biological sciencesMinoru Fukuda, Erkki Ruoslahti, Yen-Liang Chen, Yiwen Jan, Michelle Matter, Jan Pilch, Edgar Ong, masanobu Komatsu
A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling.Biological sciencesDavid D. Ginty, Kuruvilla, Rejji; Zweifel, Larry S., Glebova, Natalia O.; Lonze, Bonnie E., Gregorio Valdez, Haihong Ye
Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at purkinje axon initial segment.Biological sciencesF. Ango, G. Di Cristo, H. Higashiyama, V. Bennett, P. Wu, Z.J. Huang
A Nobel for smell.Biological sciencesDavid Julius, Lawrence C. Katz
A nuclear strike against Listeria-the evolving life of LXR.Biological sciencesG.D. Barish, R.M. Evans
A palmitoylation switch mechanism in the regulation of the visual cycle.Biological sciencesRobert R. Rando, Linlong Xue, Deviprasad R. Gollapalli, Pranab Maiti, Wan Jin Jahng
APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment..Biological sciencesSavvas Christoforidis, Marino Zerial, Anna Shevchenko, Angelika Giner, Marta Miaczynska, Sandrine Uttenweiler-Joseph, Matthia Wilm, Bianca Habermann, Robert G. Parton
A protein complex containing Mei5 and Sae3 promotes the assembly of the meiosis-specific RecA homolog Dmc1.Biological sciencesHayase, Atsuko; Shinohara, Akira, Misato Takagi, Toshiko Miyazaki, Hiroyuki Oshiumi, Miki Shinohara
Architecture of the Hin synaptic complex during recombination: The recombinase subunits translocate with the DNA strands.Biological sciencesGautam Dhar, Erin R. Sanders, Reid C. Johnson
Arginine methylation of STAT1: A reassessment.Biological sciencesUwe Vinkemeier, Torsten Meissner, Eberhard Krause, Inga Lodige
A ribonucleolytic rat torpedoes RNA polymerase II.Biological sciencesDavid Bentley, Weifei Luo
A role for Drosophila IAP1-mediated caspase inhibition in Rac-dependent cell migration.Biological sciencesDenise J. Montell, Erika R. Geisbrecht
A role for insect galectins in parasite survival.Biological sciencesCarolina Barillas-Mury, Sanjeev Kumar, David L. Sacks, Shaden Kamhawi, Marcelo Ramalho-Ortigao, Van M. Pham, Philip G. Lawyer, Salvatore J. Turco, Jesus G. Valenzuela
Around the world of DNA damage INO80 days.Biological sciencesBradley R. Cairns
A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans.Biological sciencesArnold J. Levine, Louise C. Strong, Helge Taubert, Elisabeth E. Bond, Gareth L. Bond, Wenwei Hu, Guillermina Lozano Lozano, Harlan Robins, Stuart G. Lutzker, Nicoleta C. Arva, Jill Bargonetti, Frank Bartel, Peter Wuerl, Shih-Jen Hwang, Kenan Onel
A small modulatory dsRNA specifies the fate of adult neural stem cells.Biological sciencesFred H. Gage, Kazunari Taira, Tomoko Kuwabara, Kinichi Nakashima, Jenny Hsieh
ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology: implication for Coffin-Lowry syndrome.Biological sciencesGerard Karsenty, Paolo Sassone-Corsi, Xiangli Yang, Koichi Matsuda, Peter Bialek, Sylvie Jacquot, Howard C. Masuoka, Thorsten Schinke, Lingzhen Li, Stefano Brancorsini, Tim M. Townes, Andre Hanauer
Atomic snapshots of an RNA packaging motor reveal conformational changes linking ATP hydrolysis to RNA translocation.Biological sciencesDavid I. Stuart, Denis E. Kainov, Erika J. Mancini, Roman Tuma, Jonathan M Grimes, Dennis H Bamford
At the crossroads of inflammation and cancer.Biological sciencesHans Clevers
Autophagy is a defense mechanism inhibiting BCG and mycobacterium tuberculosis survival in infected macrophages.(Bacille Calmette-Guerin)Biological sciencesMaximiliano G. Gutierrez, Vojo Deretic, Sharon S. Master, Sudha B. Singh, Gregory A. Taylor, Maria I. Colombo
Axon guidance of mouse olfactory sensory neurons by odorant receptors and the beta2 adrenergic receptor.Biological sciencesPeter Mombaerts, Paul Feinstein, Thomas Bozza, Ivan Rodriguez, Anne Vassalli
Back to the future with ubiquitin.Biological sciencesCecile M. Pickart
Bacterial mitotic machineries.Biological sciencesKenn Gerdes, Jakob Moller-Jensen, Gitte Ebersbach, Thomas Kruse, Kurt Nordstrom
Balancing acts: molecular control of mammalian iron metabolism.Biological sciencesNancy C. Andrews, Matthias W. Hentze, Martina U. Muckenthaler
Beginning to understand the end of the chromosome.Biological sciencesThomas Cech
Biological control through regulated transcriptional coactivators.Biological sciencesB.M. Spiegelman, R. Heinrich
Calcium and a calcium-dependent protein kinase regulate gamete formation and mosquito transmission in a malaria parasite.Biological sciencesVolker Brinkmann, Oliver Billker, Sandrine Dechamps, Rita Tewari, Gerald Wenig, Blandine Franke-Fayard
Calmodulin and munc13 form a Ca(super 2+) sensor/effector complex that controls short-term synaptic plasticity.Biological sciencesChristian Rosenmund, Nils Brose, Frederique Varoqueaux, Harald J. Junge, Jeong-Seop Rhee, Olaf Jahn, Joachim Spiess, Neal M Waxham
Caspase activation: revisiting the induced proximity model.Biological sciencesYigong Shi
Cav1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and Autism.Biological sciencesPeter J. Schwartz, Silvia G. Priori, Carlo Napolitano, Raffaella Bloise, Mark T. Keating, Igor. Splwski, Niels Decher, Robert M. Joseph, Helen Tager-Flusberg, Leah M. Sharpe, Pradeep Kumar, Karen Condouris, Michael C. Sanguinetti
Caveolin-stabilized membrane domains as multifunction transport and sorting devices in endocytic membrane traffic.Biological sciencesMarino Zerial, Lucas Pelkmans, Thomas Burli, Ari Helenius
Cdc14 and condensin control the dissolution of cohesin-independent chromosome linkages at repeated DNA.Biological sciencesDamien D'Amours, Frank Stegmeier, Angelika Amon
Cdc14 phosphatase induces rDNA condensation and resolves cohesin-independent cohesion during budding yeast anaphase.Biological sciencesFrank Uhlmann, Toru Higuchi, Matt Sullivan, Vittorio L. Katis
CDK activity antagonizes Whi5, an inhibitor of G1/S transcription in yeast.Biological sciencesMike Tyers, Xiaojing Tang, Brenda Andrews, Michael Costanzo, Ivan Rupes, Joy L. Nishikawa, Jonathan S. Millman, Oliver Schub, Danielle Dewar, Kevin Breitkreuz
C.elegans HIM-17 links chromatin modification and competence for initiation of meiotic recombination.Biological sciencesAnne M. Villeneuve, Kirthi C. Reddy
C. elegans LIN-18 is a Ryk ortholog and functions in parallel to LIN-17/frizzled in Wnt signaling.Biological sciencesPaul W. Sternberg, Helieh S. Oz, Takao Inoue, Shahla Gharib, Rashmi Deshpande, Debra Wiland, Wendy S. Katz
Cell death: critical control points.Biological sciencesStanley J. Korsmeyer, Nika N. Danial
Choreography of the DNA damage response: Spatiotemporal relationships among checkpoint and repair proteins.Biological sciencesRodney Rothstein, Michael Lisby, Jacqueline H. Barlow, Rebecca C. Burgess
Chromatin architecture of the human genome: gene-rich domains are enriched in open chromatin fibers.Biological sciencesHeike Fiegler, Wendy A. Bickmore, Nick Gilbert, Shelagh Boyle, Kathryn Woodfine, Nigel P. Carter
Cilia and flagella revealed: from flagellar assembly in Chlamydomonas to human obesity disorders.Biological sciencesWilliam J. Snell, Qian Wang
Circadian gene expression in individual fibroblasts: Cell-autonomous and self-sustained oscillators pass time to daughter cells.Biological sciencesChristoph Bauer, Ueli Schibler, Emi Nagoshi, Camille Saini, Thierry Laroche, Felix Naef
Cln3 activates G1-specific transcription via phosphorylation of the SBF bound repressor Whi5.Biological sciencesCurt Wittenberg, W. Hayes McDonald, Robertus A.M. de Bruin, Tatyana I. Kalashnikova, John Yates III
Combinatorial marking of cells and organelles with reconstituted fluorescent proteins.Biological sciencesMartin Chalfie, Shifang Zhang, Charles Ma
Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene.Biological sciencesMichel R. Leroux, Patrick S. Parfrey, Jane S. Green, Susan K. Dutcher, Lisa M. Guay-Woodford, Nicholas Katsanis, Jin Billy Li, Jantje M. Gerdes, Courtney J. Haycraft, Yanli Fan, Tanya M. Teslovich, Helen May-Simera, Haitao Li, Oliver E. Blacque, Linya Li, carmen C. Leitch, Richard Allan Lewis, William S. Davidson, Gary D. Stormo, Bradley K. Yoder, Philip L. Beales
Complement-like protein TEP1 is a determinant of vectorial capacity in the malaria vector anopheles gambiae.Biological sciencesFotis C. Kafatos, Elena A. Levashina, Luis F. Moita, Stephanie Blandin, Chris J. Janse, Andrew P. Waters, Shin-Hong Shiao
Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.Biological sciencesAnnette F. Baas, Jereon Kuipers, Nicole N. van der Wel, Eduard Batle, Henk K. Koerten, Hans C Clevers, Peter J. Peters
Conformational antagonism between opposing active sites in a bifunctional Re1A/SpoT homolog modulates (p)ppGpp metabolism during the stringent response.Biological sciencesTanis Hogg, Undine Mechold, Horst Malke, Rolf Hilgenfeld
Control of dendritic branching and tiling by the tricornered-kinase/furry signaling pathway in drosophila sensory neurons.Biological sciencesK. Emoto, Y. He, B. Ye, W.B. Grueber, P.N. Adler, Y.-N. Jan
Control of fruit patterning in Arabidopsis by INDEHISCENT.Biological sciencesSarah J. Liljegren, Martin F. Yanofsky, Adrienne H.K. Roeder, Sherry A Kempin, Kristina Gremski, Lars Ostergaard, Daengnoy Reyes, Soni Guimil
Conversion of BcI - 2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3.Biological sciencesJohn C. Reed, Marcia I. Dawson, Bingzhen Lin, Siva Kumar Kolluri, Feng Lin, Wen Liu, Young - Hoon Han, Xihua Cao, Xiao-kun Zhang
Converting a motor to an anchor.Biological sciencesKathryn G. Miller
Coordination of cell division and chromosome segregation by a nucleoid occlusion protein in Bacillus subtilis.Biological sciencesJeff Errington, Ling Juan Wu
Crossover/noncrossover differentiation, synaptonemal complex formation, and regulatory surveillance at the Leptotene/Zygotene transition of meiosis.Biological sciencesNeil Hunter, Nancy Kleckner, G valentin Borner
Cryo-EM visualization of a viral internal ribosome entry site bound to human ribosomes: the IRES functions as an RNA-based translation factor.Biological sciencesChristian M.T. Spahn, Joachim Frank, Peter Sarnow, Robert A. Grassucci, Eric Jan, Anke Mulder
Crystal structure of the DegS stress sensor: how a PDZ domain recognizes misfolded protein and activates a protease.Biological sciencesMichael Ehrmann, Corinna Wilken, Karina Kitzing, Robert Kurzbauer, Tim Clausen
Crystal structures of a Formin Homology-2 domain reveal tethered dimer architecture.Biological sciencesMichael J. Eck, Yingwu Xu, David Pellman, James B. Moseley, Isabelle Sagot, Florence Poy, Bruce L. Goode
Cyclin C/Cdk3 promotes Rb-dependent G0 exit.Biological sciencesBarrett J. Rollins, Shengjun Ren
Cytokinesis monitoring during development: Rapid pole-to-pole shuttling of a signaling protein by localized kinase and phosphatase in caulobacter.Biological sciencesChristine Jacobs-Wagner, Jean-Yves Matroule, Hubert Lam, Dylan T. Burnette
Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesis.Biological sciencesCharles S. Zuker, Thomas Keil, Tomer Avidor-Reiss, Andreia M. Maer, Edmund Koundakjian, Andrey Polyanovsky, Shankar Subramaniam
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1 alpha null mice.Biological sciencesBradford B. Lowell, Bruce M. Spiegelman, Marcus P. Cooper, Vamsi K. Mootha, Gerald I. Shulman, Zhidan Wu, Julie St-Pierre, Jiandie Lin, Katrin S. Lindenberg, Melina C. Fan, Ann Marie Zavacki, Lindsay M. Rohas, Sibylle Jager, Chen-yu Zhang, Dimitri Krainc, Saverio Cinti, Paul T. Tarr, Pei-Hsuan Wu
Defining the CREB regulon: A genome-wide analysis of transcription factor regulatory regions.Biological sciencesRichard H. Goodman, Gregory S. Yochum, Jeremy M. Boss, Soren Impey, Sean R. McCorkle, Hyunjoo Cha-Molstad, Jami M. Dwyer, Gail Mandel, John J. Dunn, Shannon McWeeney
Derepression by depolymerization: structural insights into the regulation of Yan by Mae.Biological sciencesMichael R. Sawaya, Albert J. Courey, Feng Qiao, Haiyun Song, Chongwoo A. Kim, Jacob B. Hunter, Ilaria Rebay, James U. Bowie, Mari Gingery
Dicers at RISC: the mechanism of RNAi.Biological sciencesRonald H.A. Plasterk, Marcel Tijsterman
Discoveries of nicotinamide riboside as a nutrient and conserved Nrk genes establish a preiss-handler independent route o NAD (super +) in fungi and humans.Biological sciencesPawel Bieganowski, Charles Brenner
Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes.Biological sciencesGuy Cavet, Christopher J. Roberts, Pek Yee Lum, Daniel D. Shoemaker, Christopher D. Armour, Sergey B Stepaniants, Maria K. Wolf, Jerald C. Hinshaw, J. Scott Butler, Garnier, Phillippe ; Prestwich, Glenn D., Philip Garrett-Engele, Amy Leonardson, Christopher M. Rush, John W. Phillips, Greg Schimmack, Martin Bard
Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain.Biological sciencesNagendra Yadava, Douglas R. Green, Jean-Ehrland Ricci, Cristina Munoz-Pinedo, Mark H. Ellisman, Patrick Fitzgerald, Immo E. Scheffler, Bailly-Maitre, Guy A. Perkins
Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways.Biological sciencesErik J. Sontheimer, Young Sik Lee, Kenji Nakahara, John W. Pham, Kevin Kim, Zhengying. He, Richard W Carthew
DkA: a critical component of the transcription initiation machinery that potentiates the regulation of rRNA promoters by ppGpp and the initiating NTP.Biological sciencesJohn W. Foster, Wilma Ross, Richard L. Gourse, Brian J. Paul, Melanie M. Barker, David A Schneider, Cathy Webb
dMyc transforms cells into super competitors.Biological sciencesKonrad Basler, Eduardo Moreno
Drosophila Dpp morphogen movement is independent of dynamin-mediated endocytosis but regulated by the clypican members of heparan sulfate proteoglycans.Biological sciencesH. Liu, T.Y. Belenkaya, C. Han, D. Yan, R.J. Opoka, M. Khodoun, X. Lin
Drosophila Myc regulates organ size by inducing cell competition.Biological sciencesClaire de la Cova, Mauricio Abril, Paola Bellosta, Peter Gallant, Laura A Johnston
Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning.Biological sciencesAlexandra L. Joyner, Ahn Sohyun
Early Decision: meiotic crossover interference prior to stable strand exchange and synapsis.Biological sciencesDouglas K. Bishop, Denise Zickler
Endocytosis by random initiation and stabilization of clathrin-coated pits.Biological sciencesTomas Kirchhausen, Max L. Nibert, Marcelo Ehrlich, Werner Boll, Antoine van Oijen, Ramesh Hariharan, Kartik Chandran
Epithelial-Mesenchymal transitions: twist in development and metastasis.Biological sciencesYibin Kang, Joan Massagne
Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock.Biological sciencesJonathan S. Stamler, Limin Liu, Jian Zhang, Yun Yan, Martha A. Hanes, Gregory Ahearn, Timothy J. McMahon, Timm Dickfeld, Harvey E. Marshall, Loretta G. Que
Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities.Biological sciencesAndrew P. McMahon, Clifford J. Tabin, Brian D. Harfe, Paul J. Scherz, Sahar Nissim, Hua Tian
Exploration of essential gene functions via titratable promoter alleles.Biological sciencesWen-Tao Peng, Sanie Mnaimneh, Nevan J. Krogan, Quaid Morris, Armaity P. Davierwala, Jorg Grigull, Xueqi Yang, Wen Zhang, Jennifer Haynes, Jason Moffat, Jeff Pootoolal, Gordon Chua, Andres Lopez, Miles Trochesset, Darcy Morse, Zhijian Li, Shawna L. Hiley, Mitsakakis, Nicholas; Roberts, Christopher J.; Greenblatt, Jack F., Boone, Charles; Kaiser, Chris A.; Andrews, Brenda J.; Hughes, Timothy R.
Factor XIIIA transglutaminase crosslinks AT(sub 1) receptor dimers of monocytes at the onset of atherosclerosis.Biological sciencesSaid AbdAlla, Heinz Lother, Ursula Quitterer, Andreas Langer, Yaseer el Faramawy
Ferritin heavy chain upregulation by NF-KappaB inhibits TNF alpha-induced apoptosis by suppressing reactive oxygen species.Biological sciencesEnrico De Smaele, Francesca Zazzeroni, Salvatore Papa, Joy Jones, Guido Franzoso, Can G. Pham, Concetta Bubici, Kellean Alvarez, Shanthi Jayawardena, Carole Beaumont, Rong Cong, Frank M. Torti, Suzy V. Torti
FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain.Biological sciencesHisashi Umemori, David M. Ornitz, Joshua R. Sanes, Michael W. Linhoff
Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysis.Biological sciencesCoumaran Egile, Dominique Didry, Marie-France Carlier, Stephane Romero, Christophe Le Clainche, Dominique Pantoloni
FoxOs at the crossroads of cellular Metabolism, differentiation, and transformation.Biological sciencesDomenico Accili, Karen C. Arden
Foxo transcription factors induce the atrophy-related ubiquitin ligase Atrogin-1 and cause skeletal muscle atrophy.Biological sciencesAlfred L. Goldberg, Kenneth Walsh, Marco Sandri, Claudia Sandri, Alex Gilbert, Carsten Skurk, Elisa Calabria, Anne Picard, Stefano Schiaffino, Stewart H. Lecker
Francis Crick (1916-2004).(Obituary)(Obituary)Biological sciencesRobin Holliday
From silencing to gene expression: real-time analysis in single cells.Biological sciencesThomas Ried, William P. Tansey, David L. Spector, Ravi Sachidanandam, Susan M. Janicki, Toshiro Tsukamoto, Simone E. Salgjetti, Kannanganattu V. Prasanth, Yaron Shav-Tal, Edouard Bertrand, Robert H. Singer
Fueling synapses.Biological sciencesDavid Chan, Erin Schuman
Function of trigger factor and DnaK in multidomain protein folding: Increase in yield at the expense of folding speed.Biological sciencesManajit Hayer-Hartl, Vishwas R Agashe, Suranjana Guha, Hung-Chun Chang, Pierre Genevaux, Hartl F Ulrich, Jose M Barral, Costa Georgopoulus, Markus Stemp
Fus3-regulated Tec1 degradation through SCFCdc4 determines MAPK signaling specificity during mating in yeast.Biological sciencesSong Chou, Lan Huang, Haoping Liu
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.Biological sciencesGuillermina Lozano, Adel K. El-Naggar, John M. Parant, Gene A. Lang, Tomoo Iwakuma, Yasmine A. Valentin-Vega, Young-Ah Suh, Tamara Terzian, Geng Liu, Ashutosh Rao
Generation of pluripotent stem cells from neonatal mouse testis.Biological sciencesAtsuo Ogura, Kimiko Inoue, Mitsuo Oshimura, Mito Kanatsu-Shinohara, Jiyoung Lee, Momoko Yoshimoto, Narumi Ogonuki, Fumitoshi Ishino, Megumi Toyoshima, Hiromi Miki, Ohtsura Niwa, Shiro Baba, Takashi Shinohara, Takeo Kata, Toshio Heike, Yasuhiro Kazuki, Tatsutoshi Nakahata, Shinya Toyokuni
Gene switching and the stability of odorant receptor gene choice.Biological sciencesRichard Axel, Adriana Nemes, Sean O'Donnell, Monica Mendelsohn, Benjamin M. Shykind, S. Christy Rohani, Gilad Barnea, Yonghua Sun
Gene targeting: attention to detail.Biological sciencesMichael D. Waterfield, Bart Vanhaesebroeck, Jennifer L. Rohn
Genetic and epigenetic regulation of the FLO gene family generates cell-surface variation in yeast. .Biological sciencesGerald R. Fink, Adrian Halme, Stacie Bumgarner, Cora Styles
Genome-wide localization of the nuclear transport machinery couples transcriptional status and nuclear organization.Biological sciencesJason M. Casolari, Christopher R. Brown, Suzanne Komili, Jason West, Haley Hieronymus, pamela A. Silver
GMAP-210 recruits gamma-tubulin complexes to cis- Golgi membranes and is required for Golgi ribbon formation.Biological sciencesMichel Bornens, Rosa M. Rios, Arancha Sanchis, Anne Marie Tassin, Concepcion Fedriani
Going the distance, or not, with neurotropin signals.Biological sciencesLouis F. Reichardt, William C. Mobley
Golgi membranes remain segregated from the endoplasmic reticulum during mitosis in mammalian cells.Biological sciencesVivek Malhotra, Matt Yasuo Pecot
Heritable integration of kDNA minicircle sequences from Trypanosoma cruzi into the Avian Genome: insights into human chagas disease.Biological sciencesNadjar Nitz, Clever Gomes, Ana de Cassia Rosa, Mari D'souza-Ault, Francisco Moreno, Liana Lauria-Pires, Rubens Nascimento, Antonio R.L. Teixeira
Heterochromatin regulates cell type-specific long-range chromatin interactions essential for directed recombination.Biological sciencesSongtao Jia, Takatomi Yamada, Shiv I.S. Grewal
Heterotrimeric G proteins: New tricks for an old dog.Biological sciencesJuergen A. Knoblich, Bernhard Hampoelz
Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis.Biological sciencesGerard Karsenty, John M. Shelton, James A. Richardson, Eric N. Olson, John McAnally, Rick B. Vega, Yang Xiangli, Chris Pomajzl, Eric Meadows
Histone deimination antagonizes arginine methylation.Biological sciencesGraeme L. Cuthbert, Sylvain Daujat
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1.Biological sciencesYang Shi, Johnathan R. Whetstine, Philip A. Cole, Yujiang Shi, Fei Lan, Caitlin Matson, Peter Mulligan, Robert A. Casero
Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis.Biological sciencesYoshihiro Nakatani, Genevieve Almouzni, Hideaki Tagami, Dominique Ray-Gallet
Homeostatic expansion of T cells during immune insufficiency generates autoimmunity.Biological sciencesCecile King, Alex Illic, Kersten Koelsch, Nora Servetnick
Homologous recombination generates T-loop-sized deletions at human telomeres.Biological sciencesRichard C. Wang, Agata Smogorzewska, Titia de Lange
Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules.Biological sciencesMarcy E. MacDonald, laurent R. Gauthier, Benedicte C. Charrin, Maria Borrell-Pages, Jim P. Dompierre, Helene Rangone, LeBmann, Volkmar;, Fabrice P. Cordelieres, Frederic Saudou, Sandrine Humbert, Jan De Mey
Identification and distinct regulation of yeast TATA box-containing genes.Biological sciencesAndrew D. Basehoar, Sara J. Zanton, B. Franklin Pugh
Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation.Biological sciencesStuart W. Peltz, Sergey V. Paushkin, Meenal Patel, Bansri S. Furia, Christopher R. Trotta
Identification of a human heme exporter that is essential for erythropoiesis.Biological sciencesJohn D. Phillips, Janis L. Abkowitz, Zhantao Yang, John G Quigley, Mark T. Worthington, Daniel E. Sabath, Kathleen M Sabo, Brent L. Wood, Shigeru Sassa, Carl L Berg
Identification of two origins of replication in the single chromosome of the archaeon Sulfolobus solfataricus.Biological sciencesIsabelle Dionne, Rolf Bernander, Nicholas P. Robinson, Magnus Lundgren, Victoria L. Marsh, Stephen D. Bell
IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.Biological sciencesMickey C.-T Hu, Dang-Fang Lee, Weiya Xia, Leonard S Golfman, Fu Ou-Yang, Hitomi Saso, Norihisa Hanada, Shilai Bao, Mien-Chie Hung, Yiyu Zou, Ryuji Kobayashi, Jer-Yen Yang
IKKbeta links inflammation and tunorigenesis in a mouse model of colitis-associated cancer.Biological sciencesMichael Karin, Florian R. Greten, Zhi-Wei Li, Jin Mo Park, Lars Eckmann, Tim F. Greten, Marin F. Kagnoff, Lawrence J. Egan
IKKbeta/NF-kappaB activation causes severe muscle wasting in mice.Biological sciencesJ. Lee, D. Cai, J.D. Frantz, N.E. Jr. Tawa, P.A. Melendez, B.-C Oh, H.G.W. Lidov, P.-O. Hasselgren, W.R. Frontera, D.J. Glass, S.E. Shoelson
Imposition of crossover interference through the nonrandom distribution of synapsis initiation complexes.Biological sciencesG. Shirleen Roeder, Jennifer C. Fung, Beth Rockmill, Michael Odell
Independent regulation of synaptic size and activity by the anaphase-promoting complex.Biological sciencesIain M. Robinson, Andrea H. Brand, Peter van Roessel, David A. Elliott, Andreas Prokop
Inflammatory caspases: linking an intracellular innate immune system to auto inflammatory diseases.Biological sciencesJurg Tschopp, Fabio Martinon
Initiating cellular stress responses.Biological sciencesMichael B. Kastan, Christopher J. Bakkenist
Initiation of DNA replication: a new hint from Archaea.Biological sciencesGiordano Liberi, Marco Foiani
INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair.(Adenosine triphosphate)(Deoxyribonucleic acid)Biological sciencesJames E. Haber, Nevan J. Krogan, Jack F. Greenblatt, Ashby J. Morrison, Jessica Highland, Xuetong Shen, Ayelet Arbel-Eden
Instruction of distinct CD4 T helper cell fates by different Notch ligands on antigen-presenting cells.Biological sciencesRichard A. Flavell, Tasuku Honjo, Derk Amsen, J. Magarian Blander, Gap Ryol Lee, Kenji Tanigaki
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.Biological sciencesJoan Seaone, Hong-Van Le, Lijian Shen, Stewart A. Anderson
Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes.Biological sciencesPeter M. Howley, Akiko Nishimura, Jianxin You, Jennie L. Croyle, Keiko Ozato
Isolation of adult mouse myogenic progenitors: Functional heterogeneity of cells within and engrafting skeletal muscle.Biological sciencesIrving L. Weissman, Amy J. Wagers, Julie L. Christensen, Thomas A. Rando, Richard I. Sherwood, Irina M. Conboy, Michael J. Conboy
JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells.Biological sciencesErwin F. Wagner, Irving L. Weissman, Emmanuelle Passegue
JunD reduces tumor angiogenesis by protecting cells from oxidative stress.Biological sciencesGerald, Damien; Berra, Edurne; Frapart, Yves M., Denise A. Chan; Giaccia, Amato J., Mansuy, Daniel; Pouyssegur, Jacques
Kinetochore orientation in mitosis and meiosis.Biological sciencesSilke Hauf, Yoshinori Watanabe
Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end.Biological sciencesFrank B. Gertler, Marisan R. Mejillano, Shin-ichiro Kojima, Derek Anthony Applewhite, Tatyana M. Svitkina, Gary G. Borisy
Like poles repel: molecular mechanisms of dendritic tiling.Biological sciencesT. Chihara, Luo.L.
LXR-dependent gene expression is important for macrophage survival and the innate immune response.Biological sciencesS.B. Joseph, M.N. Bradley, A. Castrillo, K.W. Bruhn, P.A. Mak, L. Pei, J. Hogenesch, R.M. O'Connell, G. Cheng, E. Saez, J.F. Miller, P. Tontonoz
Magnitude of binocular vision controlled by Islet-2 repression of a genetic program that specifies laterality of retinal axon pathfinding.Biological sciencesSamuel L. Pfaff, Winnie Pak, Robert Hindges, Yoo-Shick Lim, Dennis D.M. O'Leary
Maintaining the ribosomal reading frame: the influence of the E site during translation regulation of release factor 2.Biological sciencesWarren P. Tate, Viter Marquez, Daniel N. Wilson, Francisco Triana-Alonso, Knud H. Nierhaus
Making the right choice - long-range chromosomal interactions in development.Biological sciencesJames R. Broach
Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6.Biological sciencesMarcos Malumbres, Rocio Sorillo, David Santamaria, Javier Galan, Ana Cerezo, Sagrario Ortega, Mariano Barbacid, Pierre Dubus
Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins.Biological sciencesIan G. Macara, Quansheng Du
Mammalian prion biology: one century of evolving concepts.Biological sciencesAdriano Aguzzi, Magdalini Polymenidou
Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth.Biological sciencesDavid Baltimore, Wange Lu, Vicky Yamamoto, Blanca Ortega
Mammalian SIRT1 represses forkhead transcription factors.Biological sciencesLeonard Guarente, Delin Chen, Wei Gu, Nullin Divecha, Maria Carla Motta, Madeleine Lemieux, Chrostopher Kamel, Yvette Bultsma, Michael McBurney
Mannose 6-Phosphate receptor dependence of varicella zoster virus infection in vitro and in the epidermis during varicella and zoster.Biological sciencesAnne A. Gershon, Michael D. Gershon, Jason J. Chen, Zhenglun Zhu
MAP kinase-mediated stress relief that precedes and regulates the timing of transcriptional induction.Biological sciencesKevin Struhl, Markus Proft
Mapping global histone acetylation patterns to gene expression.Biological sciencesMichael Grunstein, Saeed Tavazoie, Siavash K. Kurdistani
Mapping the location of TFIIB within the RNA polymerase II transcription preinitiation complex: a model for the structure of the PIC.Biological sciencesH.-T. Chen, S. Hahn
Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity.Biological sciencesRonald T. Hay, David P. Lane, Dimitris P. Xirodimas, Mark K. Saville, Jean-Christophe Bourdon
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF.Biological sciencesDavid Barford, S. Mark Roe, Richard Marais, Christopher J. Marshall, Michael C. Jones, Paul T.C. Wan, Mathew J. Garnett, Sharlene Lee, Dan Niculescu-Duvaz, Caroline J. Springer, Valerie M. Good
Mechanisms of conformational change for a replicative hexameric helicase of SV40 large tumor antigen.Biological sciencesDawei Li, Rui Zhao, Dahai Gai, Xiaojiang S. Chen, carla V. Finkielstein
Metal import through microbial membranes.Biological sciencesAndrew D. Ferguson, Johann Deisenhofer
Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage.Biological sciencesTony Kouzarides, Juan Mata, Robin C. Allshire, Steven L. Sanders, Manuela Portoso, Jurg Bahler
MicroRNAs: genomics, biogenesis, mechanism, and function.Biological sciencesDavid P. Bartel
Mis16 and Mis18 are required for CENP-a loading and histone deacetylation at centromeres.Biological sciencesYohta Fujita, Takeshi Hayashi, Osamu Iwasaki, Yoh Adachi, Kohta Takahashi, Yanagida Mitsuhiro
Molecular and cellular cognition: the unraveling of memory retrieval.Biological sciencesRobert Brown, Alcino J. Silva
Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin.(Alpha-hemoglobin stabilizing protein)Biological sciencesLiang Feng, Suiping Zhou, David A. Gell, Lichuan Gu, Jianqing Li, King of Korea Sonjo, Min Hu; Nieng Yan, Ann M. Rich, Christopher Lee, Robert S. Armstrong, Andrew J. Gow, Peter A. Lay, Mitchell J. Weiss, Joel P. Mackay
Molecular mechanisms of muscle atrophy.Biological sciencesMichael A. Rudnicki, Iain W. McKinnell
Molecular recognition by LARGE is essential for expression of functional dystroglycan.Biological sciencesMichael B.A. Oldstone, Kevin P. Campbell, Rita Barresi, Daniel E. Michele, Motoi Kanagawa, Jan P. Dumanski, Fumiaki Saito, Stefan Kunz, Takako Yoshida-Moriguchi, John Muschler, Yvonne M. Kobayashi
Mouse development and cell proliferation in the absence of D-cyclins.Biological sciencesKoichi Akashi, Vivienne I. Rebel, Roderick T. Bronson, Piotr Sicinski, Ewa Sicinska, Shoumo Bhattacharya, Katarzyna Kozar, Maria A. Ciemerych, Hirokazu Shigematsu, Yu Qunyan, Yan Gneg, Agnieszka Zagozdzon
M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage.Biological sciencesHeiko Herwald, Hans Flodgaard, Lennart Lindbom, Anna Norrby-Teglund, Matthias Morgelin, Ulla Sollenberg, Lars Bjorck, Henning Cramer, Wayne Russell
MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation.Biological sciencesNaoyuki Fujita, David L. Jaye, Cissy Geigerman, Paul A. Wade, Adil Akyildiz, Jeremy M. Boss
Multiubiquitin chain receptors define a layer of substrate selectivity in the ubiquitin-proteasome system.Biological sciencesRati Verma, Raymond J. Deshaies, Robert Oania, Johannes Graumann
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome.Biological sciencesTyler Jacks, Roderick T. Bronson, Denise Crowley, David A. Tuveson, Kenneth P. Olive, Zachary C. Ruhe, Bob Yin, Nicholas A. Willis
Mutual control of membrane fission and fusion proteins.Biological sciencesChristopher Peters, Susanne Buhler, Andreas Mayer, Tonie L. Baars
Myc: A weapon of mass destruction.Biological sciencesRobert N. Eisenman, Sarah B. Pierce, Julie Secombe
Myosin assembly: the power of multiubiquitylation.Biological sciencesPierre Gonczy
Myosin II-dependent cortical movement is required for centrosome separation and positioning during mitotic spindle assembly.Biological sciencesJody Rosenblatt, Louise P. Cramer, Buzz Baum, Karen M. McGee
NAD+- dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1.(Nicotinamide Adenine Dinucleotide )(Poly ADP-Ribose Polymerase)Biological sciencesJohn T. Lis, W. Lee Kraus, Mi Young Kim, Steven Mauro, Nicolas Gevry
Nanoscale organization of multiple GPI-anchored proteins in living cell membranes.Biological sciencesIra, G. Krishnamoorthy, Pranav Sharma, Rajat Varma, R. C. Sarasji, Karine Gousset, Madan Rao, Satyajit Mayor
Nascent membrane and secretory proteins differ in FRET-detected folding far inside the ribosome and in their exposure to ribosomal proteins.Biological sciencesArthur E. Johnson, Cheryl A. Woolhead, Peter J. McCormick
Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes.Biological sciencesA. Brehm, M. Korenjak, B. Taylor-Harding, U.K. Binne, J.S. Satterlee, O. Stevaus, R. Aasland, H. White-Cooper, N. Dyson
Negative regulation of dE2F1 by cyclin-dependent kinases controls cell cycle timing.Biological sciencesBruce A. Edgar, Tania Reis
Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins.Biological sciencesMichael W. Linhoff, Ethan R. Graf, XueZhao Zhang, Shan-Xue Jin, Ann Marie Craig
Neuroprotection in Ischemia: Blocking calcium-permeable acid-sensing ion channels.Biological sciencesMargaret P. Price, Michael J. Welsh, John F. MacDonald, Zhi-Gang Xiong, Xiang-Ping Chu, Xiao-Man Zhu, Manabu Minami, Jessica Hey, Wen-Li Wei, John A. Wemmie, Simon Roger P.
Nkx2-5 pathways and congenital heart disease: loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block.Biological sciencesJames R. Feramisco, Richard Kondo, Mohammad Pashmforoush, Jonathan T. Lu, Hanying Chen, Tara St. Amand, Sylvain Pradervand, Sylvia M. Evans, Bob Clark, Michael Silberbach, Weinian Shou, Wayne Giles, Siew Yen Ho, D. Woodrow Benson, Kenneth R. Chien
Noncanonical function of Glutamly-Prolyl-tRNA synthetase: gene-specific silencing of translation.Biological sciencesP. Sampath, B. Mazumdar, V. Seshadri, C.A. Gerber, L. Chavatte, M. Kinter, S.M. Ting, J.D Dignam, S. Kim, D.M. Driscoll, P.L. Fox
Nuclear retention of unspliced mRNAs in yeast is mediated by perinuclear MIp1.Biological sciencesVincent Galy, Ulf Nehrbass, Olivier Gadal, Micheline Fromont-Racine, Alper Romano, Alain Jacquier
Obesity wars: molecular progress confronts an expanding epidemic.Biological sciencesJeffrey S. Flier
Old drugs, new tricks: using genetically sensitized yeast to reveal drug targets.Biological sciencesCharles Boone, Tim Hughes, Brenda Andrews
One nucleotide in a (sub K) B site can determine cofactor specificity for NF- (sub K) B dimers.Biological sciencesDavid Baltimore, Alexander Hoffmann, Thomas H. Leung
Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53.Biological sciencesRobert G. Roeder, Woojin An, Jaehoon Kim
P13K gamma modulates the cardiac response to chronic pressure overload by distinct Kinase-dependent and independent effects.Biological sciencesGiovanni Russo, Reinhard Wetzker, Mara Brancaccio, Antonella Notte, Emilio Hirsch, Fiorella Altruda, Lorenzo Silengo, Giuseppe Lembo, Enrico Patrucco, Giulio Selvetella, Stefano Marengo, Sergei D. Rybalkin, Laura Barberis, Angelo Maffei, Ornella Azzolino, Matthias P. Wymann
PAR-1 for the course of Neurodegenaration.Biological sciencesMark E. Fortini
PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila.Biological sciencesIsao Nishimura, Yufeng Yang, Bingwei Lu
Periodic lamellipodial contractions correlate with rearward actin waves.Biological sciencesGregory Giannone, Hans-Gunther Dobereiner, Benjamin J. Dubin-Thaler, Nelly Kieffer, Bresnick, Anne R.; Sheetz, Michael P.
Pheromone-dependent destruction of the Tec1 transcription factor is required for MAP kinase signaling specificity in yeast.Biological sciencesHiten D. Madhani, John R. Yates, Marie Z. Bao, Monica A. Schwartz, Greg T. Cantin
Phosphorylation by the beta-Catenin/MAPK complex promotes 14-3-3-mediated nuclear export of TCF/POP-1 in signal-responsive cells in C. elegans.Biological sciencesYang Shi, Rueyling Lin, Frederique Gay, Miao-Chia Lo, Raanan Odom
Plasticity of adult stem cells.Biological sciencesIrving Weissman, Amy J. Wagers
Polycystins: from mechanosensation to gene regulation.Biological sciencesPatrick Delmas
Polysaccharide processing and presentation by the MHCII pathway.Biological sciencesDennis L. Kasper, Brian A. Cobb, Qun Wang, Arthur O. Tzianabos
Positioning the Golgi apparatus.Biological sciencesAdam D. Linstedt
Posttranslational regulation of drosophila PERIOD protein by protein phosphatase 2A.Biological sciencesAmita Sehgal, Sriram Sathyanarayanan, Xiangzhong Zheng, Rui Xiao
Predicting gene expression from sequence.Biological sciencesMichael A. Beer, Saeed Tavazoie
Principles of tumor suppression.Biological sciencesCharles J. Sherr
Protein tyrosine phosphatases in the human genome.Biological sciencesTony Hunter, Nunzio Bottini, Adam Godzik, Tomas Mustelin, Andres Alonso, Jack Dixon, Joanna Sasin, Ilan Friedberg, Andrei Osterman, Iddo Friedberg
RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination.Biological sciencesDavid B. Roth, Gregory S. Lee, Matthew B. Neiditch, Sandra S. Salus
Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis.Biological sciencesRuslan Medzhitov, Seth Rakoff-Nahoum, Justin Paglino, Fatima Eslami-Varzaneh, Stephen Edberg
Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair.Biological sciencesSusan M. Gasser, Barbara Hohn, Haico Van Attikum, Olivier Fritsch
Recycling the cell cycle: cyclins revisited.Biological sciencesAndrew W. Murray
Regulation of murine telomere length by Rtel: an essential gene encoding a helicase-like protein.Biological sciencesMarina Gertsenstein, Andras Nagy, Hao Ding, Mike Schertzer, Peter M. Lansdorp, Xiaoli Wu, Patrick P.L. Tam
Regulation of RNA polymerase II transcription by sequence-specific DNA binding factors.Biological sciencesJames T. Kadonaga
Regulation of RNA polymerase through the secondary channel.Biological sciencesAnn Hochschild, Bryce E. Nickels
Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4 multiubiquitylation complex in C.elegans.Biological sciencesRalf Baumeister, Thorsten Hoppe, Jose M Barral, Giuseppe Cassata, Wolfdieter Springer, Alex H Hutagalung, Henry F Epstein
Regulation of WASP: PIP2 pipped by Toca-1?.Biological sciencesRobert H. Insall, Laura M. Machesky
Regulation through the secondary channel-structural framework for ppGpp-DksA synergism during transcription.Biological sciencesMarina N. Vassylyeva, Anna Perederina, Vladimir Svetlov, Tahir H Tahirov, Dmitry G Vassylyev
Removal of Ca(super 2,+) channel beta (sub 3) subunit enhances Ca(super 2,+) oscillation frequency and insulin exocytosis.Biological sciencesM. Murakami, P.-O. Berggren, M. Kohler, T. Moede, A. Fernstrom, I.B. Appelskog, C.A. Aspinwall, S.-N. Yang, S.V. Zaitsev, O. Larsson, L.M.de Vargas, C. Fecher-Trost, P. WeiBgerber, C.J. Ludwig, B. Leibiger, L. Juntti-Berggren, C.J. Barker, A.M. Efanov, J. Gromada, M. Freichel, I.B. Leibiger, S. Uhles, V. Flockerzi
Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function.Biological sciencesVenkat S.R.K. Yedavalli, Christine Neuveut, Ya-hui Chi, Lawrence Kleiman, Kuan-Teh Jeang
RGS-7 completes a receptor-independent heterotrimeric G protein cycle to asymmetrically regulate mitotic spindle positioning in C. elegans.Biological sciencesH.A. Hess, J.-C. Roper, S.W. Grill, M.R. Koelle
Rho and Rac take center stage.Biological sciencesKeith Burridge, Krister Wennerberg
Ribosome biogenesis: Giant steps for a giant problem.Biological sciences 
RIC-8 is required for GPR-1/2-dependent G alpha function during asymmetric division of C. elegans embroys.Biological sciencesK. Afshar, F.S. Willard, K. Colombo, C.A. Johnston, C.R. McCudden, D.P. Siderovski, Gonczy. P.
RISC assembly defects in the Drosophila RNAi mutant armitage.Biological sciencesBenjamin Haley, Phillip D. Zamore, Birgit S. Koppetsch, William E. Theurkauf, Heather A. Cook, Yukihide Tomari, Tingting Du, Dianne S . Schwarz, Ryan Bennett
RNA and RNA binding proteins participate in early stages of cell spreading through spreading initiation centers.(ribonucleic acid )Biological sciencesMatthias Mann, Carmen L. De Hoog, Leonard J. Foster
Robustness of cellular functions.Biological sciencesJohn Doyle, Uwe Sauer, Jorg Stelling, Zoltan Szallasi, francis J. Doyle III
RTP family members induce functional expression of mammalian odorant receptors.Biological sciencesHiroaki Matsunami, Harumi Saito, Momoka Kubota, Richard W. Roberts, Qiuyi Chi
Saccharomyces cerevisiae Mer3 helicase stimulates 3'-5' heteroduplex extension by Rad51: implications for crossover control in meiotic recombination.Biological sciencesStephen C. Kowalczykowski, Richard D. Kolodner, Olga M. Mazina, Alexander V. Mazin, Takuro Nakagawa
Science imitates art: the cloning of mice from olfactory sensory neurons.Biological sciencesJohn Ngai
Sculpting the proteome with AAA+ proteases and disassembly machines.Biological sciencesRobert T. Sauer, Julia M. Flynn, Jon A. Kenniston, Daniel N. Bolon, Randall E. Burton, Briana M. Burton, Shilpa A. Joshi
Seeing is believing: the bicoid morphogen gradient matures.Biological sciencesAnne Ephrussi, Daniel St. Johnston
Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche.Biological sciencesElaine Fuchs, William E. Lowry, Cedric Blanpain, Andrea Geoghegan, Lisa Polak
She2p is a novel RNA binding protein with a basic helical hairpin motif.Biological sciencesStephen K. Burley, Robert H. Singer, Dierk Niessing, Stefan Huttelmaier, Daniel Zenklusen
Siah2 regulates stability of prolyl-hydroxylases, controls HIF1 alpha abundance, and modulates physiological responses to hypoxia.Biological sciencesZe'ev Ronai, Hediye Erdjument-Bromage, Paul Tempst, Koh Nakayama, David D. Bowtell, Peter B. Frappell, Ian J. Frew, Mette Hagensen, Marianne Skals, Hasem Habelhah, Takayuki Kadoya, Anindita Bhoumik
Single cell profiling of potentiated phospho-protein networks in cancer cells.Biological sciencesGarry P. Nolan, Jonathan M. Irish, Randi Hovland, Peter O. Krutzik, Oystein Bruserud, Bjorn T. Gjertsen
Single processing center models for human Dicer and bacterial RNase III.Biological sciencesEric Westhof, Haidi Zhang, Fabrice A. Kolb, Lukasz Jaskiewicz, Witold Filipowicz
SIR2 regulates recombination between different rDNA repeats, but not recombination within individual rRNA genes in yeast.Biological sciencesTakashi Horiuchi, Takehiko Kobayashi, Prasad Tongaonkar, Loan Vu, Masayasu Nomura
Sir-mediated repression can occur independently of chromosomal and subnuclear contexts.Biological sciencesSusan M. Gasser, Thierry Laroche, Marc R. Gartenburg, Frank R. Meumann, Marek Blaszczyk
Socializing with the neighbors: Stem cells and their niche.Biological sciencesElaine Fuchs, Tudorita Tumbar, Geraldine Guasch
Spatial positioning: a new dimension in genome function.Biological sciencesT. Misteli
Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems.Biological sciencesTony Pawson
Specific polyunsaturated fatty acids drive TRPV-dependent sensory signaling in vivo.Biological sciencesAmanda H. Kahn-Kirby, Cornelia I. Bergmann, Jami L. M. Dantzker, Jennifer L. Watts, Alfonso Apicella J., William R. Schafer, John Browse
Stem cells and cancer: the Polycomb connection.Biological sciencesMaarten van Lohuizen, Merel Valk-Lingbeek, Sophia W.M. Bruggeman
Stepwise reprogramming of B cells into macrophages.Biological sciencesThomas Graf, Huafeng Xie, Min Ye, Ru Feng
Structural analysis of autoinhibition in the Ras activator Son of sevenless.Biological sciencesDafna Bar-Sagi, John Kuriyan, Holger Sondermann, Stephen M. Soisson, Sean Boykevisch, Shao-Song Yang
Structural basis for allosteric control of the transcription regulator CcpA by the phosphoprotein HPr-Ser46-P.Biological sciencesRichard G. Brennan, Maria A. Schumacher, Gregory S. Allen, Marco Diel
Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair.Biological sciencesBrian R. Chapados, David J. Hosfield, Seungil Han, Junzhuan Qiu, Yelent, Biana ; Shen, Binghui ; Tainer, John A.
Structural basis for substrate selection by T7 RNA polymerase..Biological sciencesShigeyuki Yokoyama, Dmitry Temiakov, Vsevolod Patlan, Michael Anikin, William T. McAllister, Dmitry G. Vassylyev
Structural basis for transcription regulation by Alarmone ppGpp.Biological sciencesShun-ichi Sekine, Shigeyuki Yokoyama, Kozo Ochi, Takeshi Hosaka, Vsevolod Patlan, Dmitry G. Vassylyev, Irina Artsimovitch, Marina N. Vassylyeva
Structural basis of ligand activation in a cyclic nucleotide regulated potassium channel.Biological sciencesJoao H. Morais-Cabral, Gina M. Clayton, William R. Silverman, Lise Heginbotham
Structural basis of transcription: Nucleotide selection by rotation in the RNA polymerase II active center.Biological sciencesRoger D. Kornberg, Kenneth D. Westover, David A. Bushnell
Structural determinants of allosteric ligand activation in RXR heterodimers.Biological sciencesDavid J. Mangelsdorf, Andrew I. Shulman, Christopher Larson, Rama Ranganthan
Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerinGTPase-activating protein .Biological sciencesJames H. Hurley, Harald Mischak, Bertram Canagarajah, Marcelo G. Kazanietz, Federico Coluccio Leskow, Jonathan Yew Seng Ho, Layla F. Saidi
Structure and protein design of a human platelet function inhibitor.Biological sciencesJie Liu, Min Lu, Jiayin Dai, Yigun Deng, Smith Thomas M.
Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of rabex-5.Biological sciencesAnna Delprato, Eric Merithew, David G. Lambright
Structure of Ero1p, source of disulfide bonds for oxidative protein folding in the cell.Biological sciencesEinav Gross, David B. Kastner, Chris A. Kaiser, Deborah Fass
Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases.Biological sciencesSeth J. Goldenberg, Thomas C. Cascio, Stuart D. Shumway, Kenneth C. Garbutt, Jidong Liu, Ning Zheng, Yue Xiong
Structure of the human transferrin receptor-transferrin complex.Biological sciencesStephen C. Harrison, Thomas Walz, Yifan Cheng, Olga Zak
Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease.Biological sciencesAlexey Rak, Olena Pylypenko, Anca Niculae, Konstantin Pyatkov, Roger S Goody, Kirill Alexandrov
Structures of mismatch replication errors observed in a DNA Polymerase.Biological sciencesSean J. Johnson, Lorena S. Beese
Survival of resting mature B-lymphocytes depends on BCR signaling via the lg alpha/beta heterodimer.Biological sciencesKlaus Rajewsky, Manfred Kraus, Marat B. Alimzhanov, Nikolaus Rajewsky
Sus1, a functional component of the SAGA histone acetylase complex and the nuclear pore-associated mRNA export machinery.Biological sciencesEd Hurt, Jose E. Perez-Ortin, Robin Reed, Susana Rodriguez-Navarro, Tamas Fischer, Ming-Juan Luo, Oreto Antunez, Susanne Brettschneider, Johannes Lechner
SWRred not shaken: mixing the histones.Biological sciencesPhilipp Korber, Wolfram Horz
Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylation.Biological sciencesKevin Ryan, James L. Manley, Joel D. Richter, Daron C. Barnard
Systematic identification and analysis of exonic splicing silencers.Biological sciencesChristopher B. Burge, Zefong Wang, Michael E. Rolish, Gene Yeo, Vivian Tung, Matthew Mawson
Taste representations in the Drosophila brain.Biological sciencesKristin Scott, Zuoren Wang, Aakanksha Singhvi, Priscilla Kong
Telomere length homeostatis is achieved via a switch between telomerase-extendible and -nonextendible states.Biological sciencesM. Teresa Teixeira, Milica Arneric, Peter Sperisen, Joachim Lingner
Telomere maintenance requires the RAD51D recombination/repair protein.Biological sciencesMaria A. Blasco, Stephen C. West, Madalena Tarsounas, Purificacion Munoz, Andreas Claas, Phillip G. Smiraldo, Douglas L. Pittman
Temporal control of differentiation by the insulin receptor/Tor pathway in Drosophila.Biological sciencesJoseph M. Bateman, Helen McNeill
TFIIH transcription factor, a target for the Rift Valley hemorrhagic fever virus.Biological sciencesJean-Marc Egly, Nicolas Le May, Sandy Dubaele, Luca Proietti De Santis, Agnes Billecocq, Michele Bouloy
The active site of the ribosome is composed of two layers of conserved nucleotides with distinct roles in peptide bond formation and peptide release.Biological sciencesElaine M. Youngman, Julie L. Brunelle, Anna B. Kochaniak, Rachel Green
The beta-thymosin/WH2 domain: structural basis for the switch from inhibition to promotion of actin assembly.Biological sciencesThomas Preat, Benoit Gigant, Marcel Knossow, Maud Hertzog, Carine Van Heijenoort, Dominique Didry, Martin Gaudier, Jerome Coutant, Gerard Didelot, Eric Guittet, Marie-France Carlier
The bicoid morphogen papers (I) : Account from CNV.Biological sciencesChristaine N. Nusslen-Volhard
The bicoid morphogen papers (II): Account from Wolfgang Driever.Biological sciencesWolfgang Driever
The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly.Biological sciencesOliver Leismann, Srinath C. Sampath, Ryoma Ohi, Andrei Pozniakovski, Hironori Funabiki
The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.Biological sciencesErnesto Guzman, Marc Montminy, Hiroshi Takemori, Robert A. Screaton, Michael D. Conkright, Yoshiko Katoh, Shawn Jeffries, Sherry Niessen, John R Yates, Mitsuhiro Okamoto
The divergent robo family protein Rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.Biological sciencesMarc Tessier-Lavigne, Eva Y.-H. P. Lee, Christelle Sabatier, Andrew S. Plump, Le Ma, Katja Brose, Atushi Tamada, Fujio Murakami
The Drosophila SDE3 homolog armitage is required for oskar mRNA silencing and embryonic axis specification.Biological sciencesBirgit S. Koppetsch, William E. Theurkauf, Heather A. Cook, Jing Wu
The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses.Biological sciencesMorgan Sheng, Yasunori Hayashi, Zheng Li, Ken-Ichi Okamoto
The lingering enigma of the allelic exclusion mechanism.Biological sciencesFrederick W. Alt, Klaus Rajewsky, Raul Mostoslavsky
The mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50.Biological sciencesS. Mark Roe, Laurence H. Pearl, Maruf M.U. Ali, Philippe Meyer, Cara K. Vaughan, Barry Panaretou, Chrisostomos Prodromou, Peter W. Piper
The mechanism of myosin VI translocation and its load-induced anchoring.Biological sciencesJames A. Spudich, David Altman, H.Lee Sweeney
The mechanisms of vesicle budding and fusion.Biological sciencesJuan S. Bonifacino, Benjamin S. Glick
The molecular basis of odor coding in the Drosophila antenna.Biological sciencesElissa A. Hallem, John R. Carlson, Michael G. Ho
The nucleosome: from genomic organization to genomic regulation.Biological sciencesSepideh Khorasanizadeh
The pathway of HCV IRES-mediated translation initiation.Biological sciencesGeoff A. Otto, Joseph D. Puglisi
The PLETHORA genes mediate patterning of the Arabidopsis root stem cell niche.Biological sciencesMitsuhiro Aida, Renze Heidstra, Ben Scheres, Dimitris Beis, Viola Willemsen, Ikram Blilou, Laurent Nussaume, Carla Galinha, Yoo-Sun Noh, Richard Amasino
The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks.Biological sciencesJun Qin, David J. Moore, Joanna I Loizou, Sherif F. El-khamisy, Anastasia Ziatanou, Douglas W. Chan, Lorenzo A Pinna, Keith W Caldecott, Flavio. Meggio, Stefania. Sarno
Thermotolerance requires refolding of aggregated proteins by substrate translocation through the central pore of ClpB.Biological sciencesBernd Bukau, Francis T. F. Tsai, Eilika U. Weber-Ban, Jimena Weibezahn, Christian Schlieker, Zeljka Maglica, Hanswalter Zentgraf, Axel Mogk, David A. Dougan, Sukyeong Lee, Regina Zahn, Peter Tessarz
The small RNA chaperone Hfq and multiple small RNAs control quorum sensing in Vibrio harveyi and Vibrio cholerae.Biological sciencesBonnie L. Bassler, Brendan N. Lilley, Derrick H. Lenz, Kenny C. Mok, Rahul V. Kulkarni, Ned S. Wingreen
The structural mechanism of translocation and helicase activity in T7 RNA polymerase.Biological sciencesThomas A. Steitz, Whitney Y. Yin
The synaptic guidepost protein SYG-2 and its receptor, SYG-1, generate synaptic specificity.Biological sciencesRichard D. Fetter, Cornelia I. Bargmann, Kang Shen
The ways of PARP.(Poly Adenosine diphosphate-Ribose Polymerase)Biological sciencesVincenzo Pirrotta
Three-dimensional rearrangement of proteins in the tail of bacteriophage T4 on infection of its host.Biological sciencesPetr G. Leiman, Michael G. Rossmann, Paul R. Chipman, Victor A. Kostyuchenko, Vadim V. Mesyanzhinoc
Tie2/Angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche.Biological sciencesToshio Suda, Arai, Fumio; Hirao, Atsushi, Ohmura, Masako; Sato, Hidetaka, Matsuoka, Sahoko; Takubo, Keiyo, Ito, Keisuke; Gou Young Koh
"Tie-ing" down the hematopoietic niche.Biological sciencesIhor R. Lemischka, Kateri A. Moore
Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex.Biological sciencesMarc W. Kirschner, Steven P. Gygi, Hsin-Yi Henry H, Rajat Rohatgi, Hsin-Yi Henry Ho, Jiaxu Li
TOR regulates ribosomal protein gene expression via PKA and the forkhead transcription factor FHL1.(conserved target of rapamycin; protein kinase A)Biological sciencesMichael N. Hall, Dietmar Martin, Alexandre Soulard
Towards a splicing code.Biological sciencesXiang-Dong Fu
Translational control by MAPK signaling in long-term synaptic plasticity and memory.Biological sciencesSusumu Tonegawa, Hyejin Kang, Raymond J. Kelleher III, Arvind Govindarajan, Hae-Yoon Jung
Translation silenced by fused pair of tRNA synthetases.Biological sciencesP. Schimmel, E. Ewalt
TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferi.Biological sciencesErol Fikrig, Fred S. Kantor, Utpal Pal, Tian Wang, Xin Li, Nandhini Ramamoorthi, Ruth R. Montgomery, Aravinda M. deSilva, Yang Xiaofeng, Fukai Bao, Marc Pypaert, Sam Telford, John F. Anderson, Deepti Pradhan
Tumor necrosis factor: an apoptosis JuNKie?.Biological sciencesAvi Ashkenazi, Eugene E. Varfolomeev
Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis.Biological sciencesRobert A. Weinberg, Joana Liu Donaher, Jing Yang, Sendurai A. Mani, Sridhar Ramaswamy, Raphael Itzykson, Andrea Richardson, Inna Gitelman, Pierre Savagner, Christophe Come
Two enzymes in one: two yeast peroxiredoxins display oxidative stress-dependent switching from a peroxidase to a molecular chaperone function.Biological sciencesHo Hee Jang, Kyun Oh Lee, Yong Hun Chi, Bae Gyo Jung, Soo Kwon Park, Jin Ho Park, Jung Lee
Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs.(RNA Induced Transcriptional Silencing)Biological sciencesSteven P. Gygi, Scott A. Gerber, Danesh Moazed, Mohammad Motamedi, Andre Verdel, Serafin U. Colmenares
Ubiquitin: A Nobel protein.Biological sciencesKeith D. Wilkinson
Unbiased mapping of transcription factor binding site along human chromosomes 21 and 22 points to widespread regulation of noncoding RNA's.Biological sciencesThomas R. Gingeras, Edward A. Sekinger, Simon Clawley, Stefan Bekiranov, Gregg Helt, Kevin Struhl, Huck H., Philipp Kapranov, Sandeep Patel, Shane Brubaker, Hari Tammana, Dione Kampa, Antonio Piccolboni, Victor Sementchenko, Jill Cheng, Alan J. Williams, Raymond Wheeler, Brant Wong, Jorg Drenkow, Mark Yamanaka
Unraveling V(D)J recombination: insights into gene regulation.Biological sciencesFrederick W. Alt, David Jung
Using a quantitative blueprint to reprogram the dynamics of the flagella gene network.Biological sciencesShiraz Kalir, Uri Alon
Variegated transcriptional activation of the immunoglobulin kappa locus in pre-B cells contributes to the allelic exclusion of light-chain expression.Biological sciencesDragana Cado, Hong-Erh Liang, Lih-Yun Hsu, Mark S. Schlissel
Vascular development in the retina and inner ear: Control by Noorin and Frizzled-4, a high affinity ligand-receptor pair.Biological sciencesQiang Xu, Jeremy Nathans, Li Jiang, Yanshu Wang, AlKelley Dabdoub , Philip M Smallwood, Joh Williams, Kang Zhang, William Tasman, Matthew W.ain, Chad Woods
Vertebrate shugoshin links sister centromere choesion and kinetochore microtubule stability in mitosis.Biological sciencesAdrian Salic, Timothy J. Mitchison, Jennifer C. Waters
Visualizing gene expression: an unfolding story.Biological sciencesSteven Henikoff
Wagging the dogma: Tissue-specific cell cycle control in the mouse embryo.Biological sciencesMichele Pagano, Peter K. Jackson
Yeast Ras regulates the complex that catalyzes the first step in GPI-anchor biosynthesis at the ER.(Glucose-6-Phosphate Isomerase)(Endoplasmic Reticulum)Biological sciencesHoward Riezman, Andrew K. Sobering, Reika Watanabe, Maritn J. Romeo, Benjamin C. Yan, Charles Specht A., Peter Orlean, David E. Levin
Yin Yang 1 is a negative regulator of p53.Biological sciencesYang Shi, Steven R. Grossman, Dominica Calvo, Guangchao Sui, El Bachir Affar, Peng Yin, Mary Donohoe, Yujiang Shi, Chrystelle Brignone, Margaret P. Luke
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