Genes & Development 2004 - Abstracts
| Genes & Development 2004 | |||||
| Title | Subject | Authors | |||
|---|---|---|---|---|---|
| Acf1 confers unique activities to ACF/CHRAC and promotes the formation rather than disruption of chromatin in vivo. | Biological sciences | James T. Kadonaga, Gary H. Karpen, Dmitry V. Fyodorov, Michael D. Blower | |||
| A chaperone network controls the heat shock response in E.coli. | Biological sciences | Carol A. Gross, Christophe Herman, Eric Guisbert, Chi Zen Lu | |||
| A combined computational-experimental approach predicts human microRNA targets. | Biological sciences | Marianthi Kiriakidou, Peter T. Nelson, Andrei Kouranov, Petko Fitziev, Costas Bouyioukos, Atemis Hatzigeorgiou, Zissimos Mourelatos | |||
| A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. | Biological sciences | Karen Oegema, Scott Anderson, John R. Yates III, Arshad Desai, Iain M. Cheeseman, Sherry Niessen, Francie Hyndman | |||
| Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation. | Biological sciences | Richard A. Woo, Randy Y.C. Poon | |||
| A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size. | Biological sciences | Mike Tyers, James R. Broach, Ivan Rupes, Paul Jorgensen, Jeffrey R. Sharom, Lisa Schneper | |||
| A G alpha-dependent pathway that antagonizes multiple chemoattractant responses that regulate directional cell movement. | Biological sciences | Joseph A. Brzostowski, Carole A. Parent, Alan R. Kimmel | |||
| A glutamate receptor-interacting protein homolog organizes muscle guidance in Drosophila. | Biological sciences | Stephan J. Sigrist, Andreas Schmid, Laura E. Swan, Carolin Wichman, Ulrike Prange, Manuela Schmidt, Gerd Vordbruggen, Frank Madeo, Ponimaskin Evgeni, Tobias Schwartz | |||
| Alkylating DNA damage stimulates a regulated form of necrotic cell death. | Biological sciences | Craig B. Thompson, Wei-Xing Zong, Dara Ditsworth, Daniel E. Bauer, Zhao-Qi Wang | |||
| Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: Cooperativity of Ink4a/ARF and Trp53 loss of function. | Biological sciences | Mario R. Capecchi, Ronald A. DePinho, Cheryl M. Coffin, Benjamin R. Arenkiel, Charles Keller, Nabeel El-Bardeesy | |||
| A methylation-mediator complex in hormone signaling. | Biological sciences | Ronald M. Evans, Wei Xu, Helen Cho, Shilpa Kadam, Ester M. Banayo, Anderson, Scott;, Beverly M. Emerson, John R. Yates | |||
| Aminoacyl-tRNAs: setting the limits of the genetic code. | Biological sciences | Michael Ibba, Dieter Soll | |||
| A MyoD-generated feed-forward circuit temporally patterns gene expression during skeletal muscle differentiation. | Biological sciences | Stephen J. Tapscott, Bennett H. Penn, Donald A. Bergstrom, F. Jeffrey Dilworth, Eyal Bengal | |||
| An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue. | Biological sciences | Roger J. Davis, Michael P. Czech, Anja Jaeschke | |||
| A new yeast PUF family protein, Puf6p, represses ASH1 mRNA translation and is required for its localization. | Biological sciences | Wei Gu, Robert H. Singer, Yingfeng Deng, Daniel Zenklusen | |||
| Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1). | Biological sciences | Christopher Daly, Stephanie Zabski, Vivian Wong, Elena Burova, Yi Wei | |||
| A novel nuclear receptor/coregulator complex controls C. elegans lipid metabolism, larval development, and aging. | Biological sciences | Adam Antebi, Andreas H. Ludewig, Cindy Weitzel, Kerstin Neubert, Axel Bethke, Brigit Gerisch, Harald Hutter, Corinna Kober-Eisermann | |||
| A novel role for shuttling SR proteins in mRNA translation. | Biological sciences | Javier F. Caceres, Jeremy R. Sanford, Nicola K. Gray, Karsten Beckmann | |||
| A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1- and NF-(kappa)B-regulated promoters. | Biological sciences | Peter Herrlich, Martin Gottlicher, Oliver Kassel, Sandra Schneider, Christine Heilbock, Margarethe Litfin | |||
| A pre-ribosome-associated HEAT-repeat protein is required for export of both ribosomal subunits. | Biological sciences | David Tollervey, Marlene Oeffinger, Mensur Dlakic | |||
| Arabidopsis COP10 forms a complex with DDB1 and DET1 in vivo and enhances the activity of ubiquitin conjugating enzymes. | Biological sciences | Vicente Rubio, Yusuke Saijo, James A. Sullivan, Jian Wang, Seisuke Kimura, Xing Wang Deng, Giuliana Gusmaroli, Setsuko Komatsu, Yuki Yanagawa, Genki Suzuki, Jianning Yin, Toyotaka Ishibashi | |||
| Arginine methyltransferase affects interactions and recruitment of mRNA processing and export factors. | Biological sciences | Anne E. McBride, Suzanne Komili, Michael C. Yu, Francois Bachand, Jason M.: Silver Casolari Pamela A. | |||
| A role for beta-actin in RNA polymerase III transcription. | Biological sciences | Nouria Hernandez, Ping Hu, Si Wu | |||
| A role for E2F6 in distinguishing G1/S- and G2/M-specific transcription. | Biological sciences | Paloma H. Giangrande, Stefan Gaubatz, Wencheng Zhu, Sussane Schlisio, Xin Sun, Seiichi Mori | |||
| A role of centromere pairing in meiotic chromosome segregation. | Biological sciences | Benedict Kemp, Rebecca Maxfield Boumil, Mara N. Stewart, Dean S. Dawson | |||
| A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast. | Biological sciences | Lee Bardwell, Jeffrey Delrow, Paul J. Cullen, Ellie Graham, Erin K. van Olden, George F. Sprague, Walid Sabbagh, Molly M. Irick, Cassandra Neal | |||
| A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. | Biological sciences | Thomas Jenuwein, Danny Reinberg, Monika Lachner, Gunter Reuter, Gunnar Schotta, Kavitha Sarma, Anja Ebert, Roopsha Sengupta | |||
| A single Argonaute protein mediates both transcriptional and posttranscriptional silencing in Schizosaccharomces pombe. | Biological sciences | Phillip D. Zamore, Sigovam Alla, Nicholas Rhind | |||
| Association of the transcriptional corepressor TIF1 beta with heterochromatin protein 1 (HP1): an essential role for progression through differentiation. | Biological sciences | Pierre Chambon, Fluorence Cammas, Marielle Herzog, Thierry Lerouge, Regine Losson | |||
| A systems view of mRNP biology. | Biological sciences | Pamela A. Silver, Haley Hieronymus | |||
| ATR couples FANCD2 monoubiquitination to the DNA-damage response. | Biological sciences | Alan D. D'Andrea, Toshiyasu Taniguchi, Paul R. Andreassen | |||
| Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor. | Biological sciences | Yuki Yamaguchi, Hiroshi Handa, Rong Li, Sarah E. Aiyar, Christopher A. Moskaluk, Yun-zhe Lu, Qi-nong Ye, Amitava Mukherjee, Da-ming Ren, Jian-long Sun, Ashley L. Blair | |||
| At the interface between signaling and executing anaphase- Cdc14 and the FEAR network. | Biological sciences | Damien D'Amours, Angelika Amon | |||
| BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo. | Biological sciences | Susana M. Chuva de Sousa Lopes, Bernard A. J. Roelen, Rui M. Monteiro, Roul Emmens, Herbert Y. Lin, En Li, Kirstie A. Lawson, Christine L. Mummery | |||
| BRU1, a novel link between responses to DNA damage and epigenetic gene silencing in Arabidopsis. | Biological sciences | Ortrun Mittelsten Scheid, Jerzy Paszkowski, Hidetaka Kaya, Takashi Araki, Shin Takeda, Zerihun Tadele, Ingo Hofmann, Aline V. Probst, Karel J. Angelis, Tesfaye Mengiste, Kei-chi Shibahara, Dierk Scheel | |||
| Calorie restriction extends yeast life span by lowering the level of NADH. | Biological sciences | Leonard Guarente, Su-Ju Lin, Ethan Ford, Marcia Haigis, Greg Liszt | |||
| Cdk1-Clb4 controls the interaction of astral microtubule plus ends with sub domains of the daughter cell cortex. | Biological sciences | Hiromi Maekawa, Elmar Schiebel | |||
| Cell cycle-dependent dynamic localization of a bacterial response regulator with a novel di-guanylate cyclase output domain. | Biological sciences | Tilman Schirmer, Ralf Paul, Stefan Weiser, Nicholas C Amiot, Urs Jenal, Brnd Giese, Chan, Carmen; | |||
| Cell type-specific effects of Rb deletion in the murine retina. | Biological sciences | Tyler Jacks, Teresa Kim, Julien Sage, David MacPherson, Dennis Ho, Margaret E. McLaughlin | |||
| Cellular machineries for chromosomal DNA repair. | Biological sciences | Jacques Cote, Craig Peterson | |||
| Chk1 activation requires Rad9 S/TQ-site phosphorylatio to promote association with C-terminal BRCT domains of Rad4(super TOPBP1). | Biological sciences | Kanji Furuya, Thomas Caspari, Marius Poitelea, Liandi Guo, Anthony M. Carr | |||
| CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. | Biological sciences | David Ron, Stefan J. Marciniak, Chi Y. Yun, Seiichi Oyadomari, Isabel Novoa, Rivka Jungreis, Heather P. Harding, Kazuhiro Nagata, Yuhong Zhang | |||
| Chromatin decondensation and nuclear reorganization of the HoxB locus upon induction of transcription. | Biological sciences | Severine Chambeyron, Wendy A. Bickmore | |||
| Chromatin remodeling and histone modification in the conversion of oligodendrocyte precursors to neural stem cells. | Biological sciences | Toru Kondo, Martin Raff | |||
| Cip/Kip proteins: more than just CDKs inhibitors. | Biological sciences | Steven F. Dowdy, Catherine Denicourt | |||
| C-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. | Biological sciences | Christian Knabenhans, Thordur Oskarsson, Anne Wilson, Gabriela M. Oser, Anne-Catherine Pasche, Robson H. MacDonald, Andreas Turmpp, Mark J. Murphy, Konstantinos Kaloulis, Michael D. Bettess | |||
| Cold shock and regulation of surface protein trafficiking convey sensitivization to inducers of stage differentiation in Trypanosoma brucei. | Biological sciences | Markus Engstler, Michael Bsohart | |||
| Collaboration of Brca1 and Chk2 in tumor genesis. | Biological sciences | M. Prakash Hande, Benedicte Lemmers, Anne Hakem, Elzbieta Matysiak-Zablocki, Laura Tamblyn, Eva Migon, John Peter McPherson, Atsushi Hirao, Jacinth Abraham, Jeremy Squire, Rama Khohka, Tak W. Hakem Mak Razqallah, Otto Sanchez-Sweatman | |||
| Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells. | Biological sciences | Andre Nussenzweig, Frederick W. Alt, Maria Jasin, Gloria C. Li, Kevin D. Mills, Jeroen Essers, Roland Kanaar, Chrystelle Couedel, Marco Barchi, Shen Lingbo, Adam Olshen, Roger D Johnson | |||
| Computational definition of sequence motifs governing constitutive exon splicing. | Biological sciences | Xiang H-F. Zhang, Lawrence A. Chasin | |||
| Conjunction-specific small RNAs in tetrahymena have predicted properties of scan (scn) RNAs involved in genome rearrangement. | Biological sciences | Yusuke Saijo, Jian Wang, Xiaojiang S. Cheng, Seisuke Kimura, Xing Wang Deng, Giuliana Gusmaroli, Setsuko Komatsu, Kazufumi Mochizuki, Martin A. Gorovsky | |||
| Connecting two-component regulatory systems by a protein that protects a response regulator from dephosphorylation by its cognate sensor. | Biological sciences | Eduardo A. Groisman, Akinori Kato | |||
| Conservation of the global sex determination gene tra-1 in distantly related nematodes. | Biological sciences | Ralf J. Sommer, Andre Pires-daSilva | |||
| Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers. | Biological sciences | Alvin T. Kho, Qing Zhao, Cai, Zhaohui, Butte, Atul J., John Y.H. Kim | |||
| Conserved MYC transcription factors play a key role in jasmonate signaling both in tomato and Arabidopsis. | Biological sciences | Salome Prat, Marta Boter, Omar Ruiz-Rivero, Ashraf Abdeen | |||
| Constitutive activation of MEK1 in chondrocytes causes Stat 1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype . | Biological sciences | Shunichi Murakami, Gener Balmes, Sandra McKinney, Zhaoping Zhang, Givol, David; Crombrugghe, Benoit de | |||
| Conversion of myoblasts to physiologically active neuronal phenotype. | Biological sciences | Yumi Watanabe, Sei Kameoka, Vidya Gopalakrishnan, Kenneth D. Aldape, Pan, Zhizhong, Z.; Lang, Frederick F.; Majumdar, Sadhan | |||
| Conversion of neurons and glia to external-cell fates in the external sensory organs of Drosophila hamlet mutants by a cousin-cousin cell-type respecification. | Biological sciences | Yuh-Nung Jan, Lily Y. Jan, Adrian W. Moore, Roegiers, Fabrice; | |||
| Cooperativity in long-range gene regulation by the lambda CI repressor . | Biological sciences | Ian B. Dodd, Alison J. Perkins, Keith E. Shearwin, Tom Burr, Hochschild, Ann; Egan J. Barry | |||
| Coordination of replication and transcription along a Drosophila chromosome. | Biological sciences | David M. MacAlpine, Stephen P. Bell, Heather K. Rodriguez | |||
| Cyclic GMP-dependent protein kinase II is a molecular switch from proliferation to hypertrophic differentiation of chondrocytes. | Biological sciences | Hirotaka Chikuda, Takashi Shimoaka, Kozo Nakamura, Fumitaka Kugimiya, Hirotaka Kawano, Kajuro Komeda, Kazuto Hoshi, Satoru Kamekura, Ung-il Chung, Toshiyuki Ikeda, Atsuko Tsuchida, Hiroshim Kawaguchi, Toru Ogasawara, Norihide Yokoi | |||
| Differential gene regulation by the SRC family of coactivators. | Biological sciences | Hua Zhang, Xiaojing Sun, Bin Shi, Dan Wang, Yongfeng Shang, Xia Yi, Na Yin, Huijian Wu, Ge Wu | |||
| Distinct aerobic and hypoxic mechanisms of HIF-alpha regulation by CSN5. | Biological sciences | Wayne Zundel, Amato J. Giaccia, Lynne Bemis, Denise A. Chan, Carla V. Finkielstein, Patrick D. Sutphin, Kurt Stenmark, Xiaojiang Chen | |||
| Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways. | Biological sciences | Katsutomo Okamura, Akira Ishizuka, Haruhiko Siomi, Mikiko C. Siomi | |||
| Distinct roles for PP1 and PP2A in the Neurospora circadian clock. | Biological sciences | Yuhong Yang, Qun He, Ping Cheng, Philip Wrage, Yarden, Oded; Liu, Yi | |||
| Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C delta. | Biological sciences | Keiko Nakayama, Stephen P. Goff, Baojie Li, Xueying Wang, Naslin Rasheed, Yuanyu Hu, Sharon Boast, Tetsuro Ishii, Keiichi I. Nakayama | |||
| Divergent functions of murine Pax3 and Pax7 in limb muscle development. | Biological sciences | Margaret Buckingham, Ahmed Mansouri, Frederic Relaix, Didier Rocancourt | |||
| Dm-myb mutant lethality in Drosophila is dependent upon mip130: positive and negative regulation of DNA replication. | Biological sciences | Michael R. Botchan, Eileen L. Beall, Maren Bell, Daphne Georlette | |||
| DNA trajectory in the Gal repressosome. | Biological sciences | Sankar Adhya, Szabolcs Semsey, Michail Y. Tolstorukov, Konstantin Virnik, Victor B. Zhurkin | |||
| Dosage-sensitive requirement for mouse D114 in artery development. | Biological sciences | John R. Shutter, Janet Rossant, Masanori Hirashima, Antonio Duarte, Evguenia Bekman, Luis Costa, Rui Benedito, Domingos Henrique, Alexandre Trindade, Patricia Diniz | |||
| Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect. | Biological sciences | Michael H. Brodsky, Claudio E. Sunkel, Saeko Takada, Sarah R. Oikemus, Nadine McGinnis, Joana Queiroz- Machado, Hanna Tukachinsky | |||
| Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2. | Biological sciences | Hong Zhang, Toyofuku, Toshihiko;, Atsushi Kumanogoh, Noriko Takegahara, Fumikazu Suto, Junko Kamei, Kazuhiro Aoki, Masanori Yabuki, Masatsugu Hori, Hitoshi Kikutani, Hajime Fujisawa | |||
| Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells. | Biological sciences | Chih-Hsien Chiu, Wen-Der Lin, Shao-Yong Huang, Ying-Hue Lee | |||
| Ehd1, a b-type response regulator in rice, confers short-day promotion of flowering and controls FT-like gene expression independently of Hd1. | Biological sciences | Kazuyuki Doi, Takeshi Izawa, Takuichi Fuse, Utako Yamanouchi, Takahiko Kubo, Atsushi Yoshimura, Yano Masahiro, Zenpei Shimatani | |||
| Elongation by RNA polymerase II: The short and long of it. | Biological sciences | Danny Reinberg, Robert J. Sims III, Rimma Belotserkovskaya | |||
| Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3 beta . | Biological sciences | LiKe Qu, Shirley Huang, Dionissios Baltzis, Ana-Maria Rivas-Estilla, Pluquet, Olivier; Hatzoglou, Maria; Koume | |||
| Ephrin-B1 forward and reverse signaling is required during mouse development. | Biological sciences | Philippe Soriano, Alice Davy, Josee Aubin | |||
| Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5(super -/-) mice. | Biological sciences | Tao Yang, Farrah Kheradmand, Dongcai Liang, Peter J. Koch, Daniel Hohl, Pual A. Overbeek | |||
| Epigenetics and cancer. | Biological sciences | Maarten van Lohuizen, Anders H. Lund | |||
| Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors. | Biological sciences | David Bilder | |||
| Essential and separable roles for syndecan-3 and syndecan-4 in skeletal muscle development and regeneration. | Biological sciences | Heikki Rauvala, D.D.W. Cornelison, Sarah A. Wilcox-Adelman, Paul F. Goetinck, Alan C. Rapraeger, Bradley B. Olwin | |||
| Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions. | Biological sciences | Walter Birchmeier, Felix H. Brembeck, Thomas Schwarz-Romond, Joroen Bakkers, Sabine Wilhelm, Matthias Hammerschmidt | |||
| Establishing neuronal circuitry: Hox genes make the connection. | Biological sciences | James Briscoe, David G. Wilkinson | |||
| Exploiting different ways to die. | Biological sciences | Eileen White, Deirdre A. Nelson | |||
| Exploiting quantitative trait loci in gene discovery. | Biological sciences | Sarah Hake, Tobert Rocheford | |||
| Extending the repertoire of the mixed-lineage leukemia gene MLL in the leukemogenesis. | Biological sciences | Terence H. Rabbitts, Angelika Daser | |||
| Fine-tuning of the Escherichia coli sigma(super E) envelope stress response relies on multiple mechanisms to inhibit signal-independent proteolysis of the transmembrane anti-sigma factor, RseA. | Biological sciences | Carol A. Gross, Benjamin M. Alba, Irina L. Grigorova, Rachna Chaba, Hong Ji Zhong, Virgil Rhodius, Christophe Herman | |||
| Form follows function: the genomic organization of cellular differentiation. | Biological sciences | Mark Groudine, Steven T. Kosak | |||
| Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19(super ARF) tumor suppressor. | Biological sciences | Vladimir V. Kalinichenko, Micahel L. Major, Xinhe Wang, Vladimir Petrovic, Joseph Kuechle, Robert H. Costa, Pradip Raychaudhuri, Abhishek Datta, Brian Shin, Margaret B. Dennewitz, Helena M. Yoder | |||
| Functional links between telomeres and proteins of the DNA-damage response. | Biological sciences | Stephen P. Jackson, Fabrizio d'Adda di Fagagna, Soo-Hwang Teo | |||
| Genome-wide mRNA surveillance is coupled to mRNA export. | Biological sciences | Pamela A. Silver, Haley Hieronymus, Michael C. Yu | |||
| Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1. | Biological sciences | Mark T. Keating, Charles Lee, Kenneth D. Poss, Alex Nechiporuk, Keith F. Stringer | |||
| Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth. | Biological sciences | Gunther Schutz, Francois Tronche, Christian Opherk, Richard Moriggl, Christoph Kellendonk, Andreas Reimann, Lukas Schwake, Holger M. Reichardt, Katharina Stangl, Daniel Gau, Andreas Hoeflich, Hartmutt Beug, Wolfgang Schmid | |||
| Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG. | Biological sciences | Lin-Quan Sun, David W. Lee, Quangeng Zhang, Weihong Xiao, Eric H. Raabe | |||
| GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs. | Biological sciences | Tami J. Kingsbury, Kyle W. Cunningham, Zoe Hilioti, Deirdre A. Gallagher, Shalini T. Lo-Nam, Priya Ramaswamy, Pawel Gajer, Christine J. Birchwood, Andre Levchenko | |||
| Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. | Biological sciences | John R. Shutter, Kevin L. Stark, Luke T. Krebs, Thomas Gridley, Tasuku Honjo, Kenji Tanigaki | |||
| Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. | Biological sciences | Andrew P. McMahon, Juhee Jeong, Toyoaki Tenzen, Junhao Mao, Andreas H. Kottmann | |||
| Holoenzyme proteins required for the physiological assembly and activity of telomerase. | Biological sciences | Keren L. Witkin, Kathleen Collins | |||
| Hoxb1 functions in both motoneurons and in tissues of the periphery to establish and maintain the proper neuronal circuitry. | Biological sciences | Mario R. Capecchi, Benjamin R. Arenkiel, Petr Tvrdik, Gary O. Gaufo | |||
| hRIP, a cellular cofactor for Rev function, promotes release of HIV RNAs from the perinuclear region. | Biological sciences | Sanchez-Velar Nuria, Enyeneama B. Udofia, Zhong Yu, Maria L. Zapp | |||
| Hsp70 promotes TNF-mediated apoptosis by binding IKKgamma and impairing NF-kappaB survival signaling. | Biological sciences | Lu Zhang, Ruiqiong Ran, Huichun Xu, Aigang Lu, Yuxin Feng, Chun Han, Yang Tang, Guoping Zhou, Hongyan Zhu, Frank R. Sharp, Alan C. Rigby | |||
| Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. | Biological sciences | Titia de Lange, Hiroyuki Takai, Frank Eisenhaber, Joshua Silverman, Sara B. C. Buonomo | |||
| Hypoxia and defective apoptosis drive genomic instability and tumorigenesis. | Biological sciences | Eileen White, Deirdre A. Nelson, Diana Anderson, Kurt Degenhardt, Arnold B. Rabson, Ting-Ting Tan | |||
| Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex. | Biological sciences | Eileen L. Beall, Daphne Georlette, Peter W. Lewis, Micheal R. Botchan, Tracey C. Fleischer, Andrew J. Link | |||
| Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex. | Biological sciences | Lindy Gewin, Hadley Myers, Tohru Kiyono, Denise A. Gallowway | |||
| Identification of C. elegans DAF-12-binding sites, response elements, and target genes. | Biological sciences | Keith R. Yamamoto, Adam Antebi, Yuriy Shostak, Marc R. Van Gilst | |||
| Idling by DNA ploymerase delta maintains a ligatable nick during lagging-strand DNA replication. | Biological sciences | Erik Johansson, Parie Garg, Carrie M. Stith, Nasim Sabouri, Peter M. Burgers | |||
| Iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo. | Biological sciences | Robert Geisler, Christian (German philosopher) Wolff, Philip W. Ingham, Pascal Haffter, Sudipto Roy, Katharine E. Lewis, Heike Schauerte, Gerd Joerg-Rauch, Annette Kirn, Christian Weiler | |||
| Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging. | Biological sciences | Juan Martin-Caballero, Juana M. Flores, Manuel Serrano, Ander Matheu, Peter Klatt, Cristina Pantoja, Alejo Efeyan, Luis M. Criado | |||
| Incredible journey: How do developmental signals travel through tissue? | Biological sciences | Matthew P. Scott, Alan Jian Zhu | |||
| Interaction between Sox 9 and beta-catenin control chondrocyte differentiation. | Biological sciences | Haruhiko Akiyama, Jon P. Lyons, Yuko Mori Akiyama, Xiaohong Yang, Ren Zhang | |||
| Interaction of the S-phase cylin Clb5 with an 'RXL' docking sequence in the initiator protein Orc6 provides an origin-localized replication control switch. | Biological sciences | Gwendolyn M. Wilmes, Vincent Archambault, Richard J. Austin, Stephen P Bell, Matthew Jacobson | |||
| Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA. | Biological sciences | Nancy Maizels, Michelle L. Duquette, Priya Handa, Andrew F. Taylor, Jack A. Vincent | |||
| In vivo convergence of BMP and MAPK signaling pathways: impact of differentia Smad1 phosphorylation on development and homeostasis. | Biological sciences | Philippe Soriano, Alice Davy, Josee Aubin | |||
| In vivo investigation of the transcription, processing, endonucleolytic activity, and functional relevance of the spatial distribution of a plant miRNA. | Biological sciences | Eneida Abreu Parizotto, Patrice Dunoyer, Nadia Rahm, Christophe Himber, Olivier Voinnet | |||
| In vivo requirements for rDNA chromosome condensation reveal two cell-cycle-regulated pathways for mitotic chromosome folding. | Biological sciences | Brigitte D. Lavoie, Eileen Hogan, Doug Koshland | |||
| In vivo target of a transcriptional activator revealed by fluorescence resonance energy transfer . | Biological sciences | Michael R. Green, Sukesh R. Bhaumik, Tamal Raha, David P. Aiello | |||
| JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. | Biological sciences | Roger J. Davis, Richard A. Flavell, Juan-Jose Ventura, Patricia Cogswell, Albert S. Baldwin Jr. | |||
| LEF1-mediated regulation of Delta-like 1 links Wnt and Notch signaling lin somitogenesis. | Biological sciences | Rudolf Grosschedl, Juan Galceran, Claudio Sustmann, Shu-Chi Hsu, Stephanie Folberth | |||
| Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity. | Biological sciences | Polina Iakova, Nikolai A. Timchenko, Guo-Li Wang, Margie Wilde, Samir Awad | |||
| Living with or without cyclins and cyclin-dependent kinases. | Biological sciences | James M. Roberts, Charles J. Sherr | |||
| Local chromatin structure at the ribosomal DNA causes replication fork pausing and genome instability in the absence of S. Cerevisiae DNA helicase . | Biological sciences | Virginia A. Zakian, Jorge Z. Torres, Jessica B. Bessler | |||
| Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. | Biological sciences | Hans Clevers, Owen J. Sansom, Ian P. Newton, Karen R. Reed, Eduard Batlle, Anthony J. Hayes, Patrica Simon-Assmann, Heather Ireland, Hannah Brinkmann, Alan Clarke R., Inke S. Nathke, Douglas J. Winton | |||
| Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport. | Biological sciences | Michel R. Leroux, Ronald H.A. Plasterk, David L. Baillie, Michael J. Reardon, Nicholas Katsanis, Oliver E. Blacque, William S. Davidson, Philip L. Beales, Jonathan McCarthy, Chunmei Li, Moe R Mahjoub, Allan K. Mah, Jose L. Badano, Stephen J. Ansley, Lynne M. Quarmby, Mark Audeh, Robert C. Johnsen, Stephen R. Wicks | |||
| Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice. | Biological sciences | Valeri Vasioukhin, Stephen J. Tapscott, Olga Klezovitch, Tania E. Fernandez | |||
| Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation. | Biological sciences | Wolfram Jochum, Kim Nasmyth, Romeo Ricci, Karin G. Wirth, Juan F. Gimenez-Abian, Shahryar Taghybeeglu, Nobauki R. Kudo, Mireille Vasseur-Cognet | |||
| MIM/BEG4, a sonic hedgehog-responsive gene that potentiates Gli- dependent transcription. | Biological sciences | Pierre A. Coulombe, Christopher A. Callahan, Anthony E. Oro, Tyler Ofstad, Lily Horng, Jordon K. Wang, Hanson H. Zhen | |||
| Mismatch repair-dependent G (super 2) checkpoint induced by low doses of S (sub N) 1 type methylating agents requires the ART kinase. | Biological sciences | Giancarlo Marra, Lovorka Stojic, Nina Mojas, Petr Cejka, Stefano Ferrari | |||
| Mitochondrial fission proteins regulate programmed cell death in yeast. | Biological sciences | Jonathan Pevsner, Yihru Fannjiang, Michael J. McCaffery, Blake R. Hill, Gorka Basanez, Marie J. Hardwick, Wen-Chih Cheng, Sarah J. Lee, Bing Qi | |||
| Modulating substrate choice: The SspB adaptor delivers a regulator of the extracytoplasmic-stress response to the AAA+ protease ClpXP for degradation. | Biological sciences | Robert T. Sauer, Julia M. Flynn, Tania A. Baker, Igor Levchenko | |||
| Modulation of mammalian life span by the short isoform of p53 . | Biological sciences | Wendy Gluba, Bernhard Maier, Brian Bernier, Terry Turner, Mohammad, Khalid; Guise, Theresa; Suth | |||
| Molecular cross-talk among chromosome fragility syndromes. | Biological sciences | Michael B. Kastan, Maria Jasin, Hans Joenje, Stephen C. West, Jordi Surralles, Stephen P. Jackjson | |||
| Mosaic analyses using marked activation and deletion clones dissect Arabidopsis SCARECROW action in asymmetric cell division. | Biological sciences | Renze Heidstra, Ben Scheres, David Welch | |||
| Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression. | Biological sciences | Francois Spitz, Anna-Pavlina G. Haramis, Aimee Zuniga, Kristina vintersten, Kuc, Sylwia; Duboule, Denis, Dono, Rosanna; Zeller, Rolf, Odysse Michos, Antonella Galli, Lia Panman, William Mansfield, Christian Klasen | |||
| mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability. | Biological sciences | Ingrid Grummt, Christine Mayer, Jian Zhao, Xuejun Yuan | |||
| Multiple interactions between regulatory regions are required to stabilize an active chromatin hub. | Biological sciences | An Langeveld, John Strouboulis, George P Patrinos, Wouter de Laat, Mariken de Krom, Ernie de Boer, Frank G. Grosveld, A.M. Ali Imam | |||
| Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression. | Biological sciences | Allan Balmain, Di Wu, Jian-Hua Mao, Minh D. To, Jesus Perez- Losada, Reyno Del Rosario | |||
| Natural genetic variation in Arabidopsis identifies BREVIS RADIX, a novel regulator of cell proliferation and elongation in the root.. | Biological sciences | Celine F. Mouchel, Georgette C.. Briggs, Christian S Hardtke | |||
| NF-Kb RelA opposes epidermal proliferation driven by TNFR1 and JNK. | Biological sciences | Paul A. Khavari, Jennifer Y. Zhang, Cheryl L. Green, Shiying Tao | |||
| Notch3 is required for arterial identity and maturation of vascular smooth muscle cells. | Biological sciences | Luke T. Krebs, Thomas Gridley, Anne Joutel, Elisabeth Tournier-Lasserve, Valerie Domenga, Bernard Klonjkowski, Eliane Berrou, Matthias Mericskay, Zhen Li, Peggy Fardoux, Pierre Lacombe, Marie Monet, Jacqueline Maciazek | |||
| Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. | Biological sciences | Angel Raya, Jose Luis de la Pompa, Juan Carlos Izpisua Belmonte, Luika A. Timmerman, Jaoquin Grego-Bessa, Jose Maria Perez Pomares, Esther Bertran, Juan Diez, Sergio Palomo, Sergi Aranda, McCormick, Frank; | |||
| N-terminal polyubiquitination and degradation of the Arf tumor suppressor. | Biological sciences | Martine F. Roussel, Charles J. Sherr, Mei-Ling Kuo, Willem den Besten, David Bertwistle | |||
| Nuclear protein phosphatases with Kelch-repeat domains modulate the response to brassinosteroids in Arabidopsis. | Biological sciences | Joanne Chory, Santiago Mora-Garcia, Gregory Vert, Yanhai Yin, Ana Cano-Delgado, Hyeonsook Cheong | |||
| Nuclear surveillance and degradation of hypomodified initiator tRNA (super Met) in S. cerevisiae. | Biological sciences | James Anderson, Alan G. Hinnebusch, Sujatha Kadaba, Anna Krueger, Tamyra Trice, Annette M. Krecic | |||
| Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA. | Biological sciences | Elizabeth H. Blackburn, Jue Lin | |||
| Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early drosophila embryo. | Biological sciences | Takashi Ito, Takeya Nakagawa, Koji Takio, Mayumi Kaneko, Hitoshi Aihara, Kiyoshi Yasui, Ohta Tsutomu, Hirose, Susumu; Dhomae, Naoshi;, Takeshima, Yukio; Muramatsu, Masami | |||
| Ovca1 regulates cell proliferation, embryonic development, and tumorigenesis . | Biological sciences | Richard R. Behringer, Chun-Ming Chen | |||
| OVCAI: emerging as a bona fide tumor suppressor. | Biological sciences | Kristian Helin, Michael Ruggard Jensen | |||
| p27Kip1 modulates cell migration through the regulation of RhoA activation. | Biological sciences | James M. Roberts, Alan Hall, Arnaud Besson, Mark Gurian-West, Anja Schmidt | |||
| p53 and stress in the ER. . | Biological sciences | Thanos D. Halazonetis, Elena S. Stravridi | |||
| p63 and the epithelial stem cell: more than status quo?. | Biological sciences | Frank McKeon | |||
| p63 is the molecular switch for initiation of an epithelial stratification program. | Biological sciences | Alea A. Mills, Dennis R. Roop, Maranke I Koster, Soeun Kim, Francesco J. DeMayo | |||
| p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2. | Biological sciences | Carol Prives, Tomoaki Tanaka, Marshall Urist, Masha V. Poyurovsky | |||
| PAF1-complex-mediated histone methylation of FLOWERING LOCUS C chromatin is required for the vernalization-responsive, winter-annual habit in Arabidopsis. | Biological sciences | Richard M. Amasino, Yuehui He, Mark R. Doyle | |||
| Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. | Biological sciences | Pao-Tien Chuang, Miao-Hsueh Chen, Li, Ya-Jun;, Takotoshi Kawakami, Shan-Mei Xu | |||
| Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: Implications for alveolar rhabdomysarcoma cell of origin. | Biological sciences | Charles Keller, S. Mark Hansen, M. Cheryl Coffin, R. Mario Capecchi | |||
| Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene. | Biological sciences | Martin Fuxa, Jane Skok, Abdallah Souabni, Giorgia Salvagiotto, Roldan, Esther; Busslinger, Meinrad | |||
| Peroxisome proliferator-activated receptor-lambda coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR. | Biological sciences | Frank J. Gonzalez, Yanqiao Zhang, Lawrence W. Castellani, Christopher J. Sinal, Peter A. Edwards | |||
| Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation. | Biological sciences | Andrew Mehle, Joao Goncalves, Mariana Santa-Marta, Mark McPike, Dana Gabuzda | |||
| Phosphorylation of eIF4E by Mnk-1 enhances HSV-1 translation and replication in quiscent cells.. | Biological sciences | Derek Walsh, Ian Mohr | |||
| Phosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cells. | Biological sciences | Li Hoi-Yeung, Zheng Yixian | |||
| Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. | Biological sciences | Michael B. Kastan, Peter J. McKinnon, Christopher J. Bakkenist, Risa Kitagwa | |||
| Photoreceptor ubiquitination by COP1 E3 ligase desensitizes phytochrome A signaling. | Biological sciences | Nam-Hai Chua, Hak Soo Seo, Etsuku Watanake, Nagatani Akira, Satoru Tokutomi | |||
| Pol 12, the B subunit of DNA polymerase alpha, functions in both telomere capping and length regulation. | Biological sciences | Massimo Lopes, Simone Grossi, Andrea Puglisi, Petr V. Dmitriev, David Shore | |||
| Polybromo protein BAF180 functions in mammalian cardiac chamber maturation. | Biological sciences | James A. Richardson, Robert Tjian, Eric N. Olson, William C. Skarnes, Wang Zhong, Weiguo Zhai, Juanito J. Meneses, Meri T. Firpo, Chulho Kang | |||
| Positive and negative functions of the SAGA complex mediated through interaction of Spt 8 with TBP and the N-terminal domain of TFIIA. | Biological sciences | Steven Hahn, Jeffrey A. Ranish, Linda Warfiled | |||
| POTI-interacting protein PIP1 a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. | Biological sciences | Titia de Lange, Diego Loayza, Dirk Hockemeyer, Jeffrey Zheng-Sheng Ye, Andrew N. Krutchinsky, Sarah M. Hooper, Brain T. Chait | |||
| PPAR gamma signaling exacerbates mammary gland tumor development. | Biological sciences | Ronald M. Evans, Robert D. Cardiff, Michael Nelson, Enrique Seaz, Peter lson, Antonia Livolsi, John Rosenfeld, Eleuterio Lombardo, Ester Banayo, Juan Carlos Izpisua-Belmonte | |||
| Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling. | Biological sciences | Shoji Tsuji, Derek van der Kooy, Ichiro Kanazawa, Seiji Hitoshi, Raewyn M. Seaberg, Cheryl Koscik, Tania Alexson, Susumu Kusunoki | |||
| Prions: proteins as genes and infectious entities. | Biological sciences | Reed B. Wickner, B. Tibor Roberts, Eric D. Ross, Andreas Brachmann, Herman K. Edskes, Ulrich Baxa, Michael M. Pierce | |||
| Progesterone and insulin stimulation of CPEB-dependent polyadenylation is regulated by Aurora A and glycogen synthase kinase-3. | Biological sciences | Raul Mendez, Joel D. Richter, Madathia Sarkissian | |||
| Pyramus and thisbe: FGF genes that pattern the mesoderm of Drosophila embryos.. | Biological sciences | Manfred Frasch, Michael Levine, Angelike Stathopoulos, Bergin Tam, Matthew Ronshaugen | |||
| Rad54 and DNa Ligase IV cooperate to maintain mammalian chromatid stability. | Biological sciences | David O. Ferguson, Frederick W. Alt, Mark Eckersdorff, Kevin D. Mills, Jeroen Essers, Roland Kanaar | |||
| Rad6 plays a role in transcriptional activation through ubiquitylation of histone H2B. | Biological sciences | Shelley Berger, Mary Ann Osley, Cheng-fu Kao, Cory Hillyer, Toyoko Tsukuda, Karl Henry | |||
| Rapid accumulation of mutations during seed-to-seed propagation of mismatch-repair-defective Arabidopsis. | Biological sciences | Peter D. Hoffman, Jeffrey M. Leonard, Gerrick E. Lindberg, Stephanie R. Bollmann, John B. Hays | |||
| Recruitment of NIMA kinase show that maturation of the S.pombe spindle-pole body occurs over consecutive cell cycles and reveals a role for NIMA in modulating SIN activity. | Biological sciences | Agnes Grallert, Andrea Krapp, Steve Bagley, Viesturs Simanis, Iain M Hagan | |||
| Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. | Biological sciences | William G. Kaelin Jr., Ernst Hafen, Jan H. Reiling, James Brugarolos, Lee A. Witters, Kui Lei, Leif W. Ellisen, Rebecca L. Hurley, Brendan D. Manning | |||
| Regulation of multimers via truncated isoforms: a novel mechanism to control nitric-oxide signaling. | Biological sciences | Tim Tully, Grigori Enikolopov, Yuri Stasiv, Boris Kuzin, Michael Regulski | |||
| Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. | Biological sciences | Ronald A. DePinho, Nabeel Bardeesy, Ken Inoki, Michael N. Corradetti, Kun-Liang Guan | |||
| Regulatory circuit design and evolution using phase Lambda. | Biological sciences | John W. Little, Xing Wang Deng, Giuliana Gusmaroli, Setsuko Komatsu, Naoyuki Kataoka, Matsuhito Ohno, Shota Atsumi | |||
| Release of initiation factors from 48S complexes during ribosomal subunit joining and the link between establishment of codon-anticodon base-pairing and hydrolysis of elF2-bound GTP. | Biological sciences | Tatyana V. Pestova, Christopher U.T. Hellen, Anett Unbehaun, Sergei I. Borukhov | |||
| Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics. | Biological sciences | Raluca Verona, Jacqueline A. Lees, Aaron Aslanian, J. Phillip Iaquinta | |||
| Reprogramming of a melanoma genome by nuclear transplantation. | Biological sciences | Lynda Chin, Rudolf Jaenisch, Konrad Hochedlinger, Robert Blelloch, Cameron Brennan, Yasuhiro Yamada, Minjung Kim | |||
| Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation. | Biological sciences | Shideng Bao, Ambereen Ali, Ji Zhang, Irene Liu, Otterness, Diane; Dean, Nicholas M.; Abr | |||
| Requirement of yeast Rad1-Rad10 nuclease for the removal of 3'-blocked termini from DNA strand breaks induced by reactive oxygen species. | Biological sciences | Robert E. Johnson, Lajos Haracska, Satya Prakash, Louise Prakash, Sami N. Guzder, Carlos Torres-Ramos | |||
| RhoBTB2 is a substrate of the mammalian Cu13 ubiquitin ligase complex. | Biological sciences | Andrew Wilkins, Christopher L. Carpenter, Qinggong Ping | |||
| RISC is a 5' phosphomonoester-producing RNA endonuclease. | Biological sciences | Thomas Tuschi, Javier Martinez | |||
| RNA length defines RNA export pathway. | Biological sciences | Xing Wang Deng, Giuliana Gusmaroli, Setsuko Komatsu, Kaoru Masuyama, Ichiro Taniguchi, Naoyuki Kataoka, Matsuhito Ohno | |||
| RNA polymerase I transcriptional and pre-rRNA processing are linked by specific SSU processome components. | Biological sciences | Jennifer E.G Gallagher, Ann L. Beyer, David A. Dunbar, Susan J. Baserga, Sander Granneman, Brianna M. Mitchell, Yvonne Osheim | |||
| RNase-sensitive DNA modification(s) initiates S. pombe mating-type switching. | Biological sciences | Jacob Z. Dalgaard, Sonya Vengrova | |||
| Role of the Escherichia coli RecQ DNA helicase in SOS signaling and genome stabilization at stalled replication forksHishida, Takashi. | Biological sciences | Yoshizumi Ishino, Takashi Hishida, Yong-Woon Han, Tatsuya Shibata, Yoshin Kubota, Hiroshi Iwasaki, Hideo Shinagawa | |||
| Role of the processing pore of the ClpX AAA+ ATPase in the recognition and engagement of specific protein substrates. | Biological sciences | Robert T. Sauer, Tania A. Baker, Samia M. Siddiqui | |||
| Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction. | Biological sciences | Naoto Ueno, Hiroshi Shibuya, Kunihiro Matsumoto, Bisei Ohkawara, Kyoko Shirakabe, Junko Hyodo-Miura, Ritsuko Matsuo | |||
| Role of Unc51.1 and its binding partners in CNS axon outgrowth. | Biological sciences | Mary E. Hatten, Toshifumi Tomoda, Jee Hae Kim, Caixin Zhan | |||
| Roles of Bifocal, Homer, and F-actin in anchoring Oskar to the posterior cortex of Drosophila oocytes. | Biological sciences | Yu Cai, William Chia, Kavita Babu, Sami Bahri, Xiaochang Yang | |||
| Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. | Biological sciences | Carolina A. Yoshida, Hiromitsu Yamamoto, Takashi Fujita, Tatsuya Furuichi, Ito, Kosei; Inoue, Ken-ichi, Takada, Kenji; Ito, Yoshiaki, Akira Zanma, Kei Yamana, Toshihisa Komori | |||
| Segmentation in vertebrates: clock and gradient finally joined. | Biological sciences | Yusuke Saijo, Bernhard G. Herrmann, Jian Wang, Xiaojiang S. Cheng, Seisuke Kimura, Xing Wang Deng, Giuliana Gusmaroli, Setsuko Komatsu, Alexander Aulehla | |||
| Selective assembly of a HIV-1 Vif-Cul5-ElonginB-Elongin-C E3 ubiquitin ligase complex through a novel SOCS box and upstream cysteines. | Biological sciences | Yunkai Yu, Zuoxiang Xiao, Elana S. Ehrlich, Xianghui Yu, Xiao-Fang Yu | |||
| SGS3 and SGS2/SDE1/RDR6 are required for juvenile development and the production of trans-acting siRNAs in Arabidopsis. | Biological sciences | R. Scott Poethig, Angela Peragine, Manabu Yoshikawa, Gang Wu, Heidi L. Albrecht | |||
| Signaling hierarchy downstream of retinoic acid that independently regulates vascular remodeling and endothelial cell proliferation. | Biological sciences | Pascal Dolle, Brenda L. Bohnsack, Lihua Lai, Karen K. Hirschi | |||
| Signaling to NF- (kappa)B. | Biological sciences | Matthew S. Hayden, Sankar Ghosh | |||
| Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27. | Biological sciences | Danny Reinberg, Antonis Kirmizis, Stephanie M. Bartley, Andrei Kuzmichev, Raphael Margueron, Roland Green, Peggy J. Farnham | |||
| siRNAs targeting an intronic transposon in the regulation of natural flowering behavior in Arabidopsis. | Biological sciences | Jun Liu, Richard Amasino, Yuehui He, Xuemei Chen | |||
| Skp2-dependent degradation of p27kip1 is essential for cell cycle progression. | Biological sciences | Michael P. Manns, Nisar P. Malek, Uta Kossatz, Nils Dietrich, Lars Zender, Jan Buer | |||
| Slik Sterile-20 kinase regulates Moesin activity to promote epithelial integrity during tissue growth. | Biological sciences | Stephen M. Cohen, David R. Hipfner, Nadine Keller | |||
| Smurf2 up-regulation activates telomere-dependent senescence. | Biological sciences | Stanley N. Cohen, Hong Zhang | |||
| Snail blocks the cell cycle and confers resistance to cell death. | Biological sciences | Sonia Vega, Aixa V. Morales, Oscar H. Ocana, Francisco Valdes, Isabel Fabregat, Angela M. Nieto | |||
| Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression. | Biological sciences | Daniel Metzger, Pierre Chambon, Seth G.N. Grant, Gordon W. McLean, Noboru H. Komoiyama, Hidefumi Asano, Francesco Conti, Margaret C. Frame, Kairbaan Hodivala-Dilke, Louise Reynolds, Bryan Serrels | |||
| Specificity of microRNA target selection in translational repression. | Biological sciences | Phillip A. Sharp, John G. Doench | |||
| Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization. | Biological sciences | David K. Han, Richard L. Proia, Ji-Hye Paik, Athanasia Skoura, Sung-suk Chae, Ann E. Cowan | |||
| Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae. | Biological sciences | ||||
| Splicing enhances translation in mammalian cells: an additional function of the exon junction complex. | Biological sciences | Herve Le Hir, Melissa J. Moore, Ajit Nott | |||
| SUMO and ubiquitin in the nucleus: different functions, similar mechanism?. | Biological sciences | Grace Gill, Yusuke Saijo, Jian Wang, Ryan J. Fletcher, Xiaojiang S. Cheng, Seisuke Kimura, Xing Wang Deng, Giuliana Gusmaroli, Setsuko Komatsu | |||
| Suppression of mitochondrial respiration through recruitment of p160myb binding protein to PGC-1 gamma: modulation by p38 MAPK. | Biological sciences | James Rhee, Melina Fan, Julie St-Pierre, Christoph Handschin, Puigserver, Pere; Lin, Jiandie; Jaeger, Si | |||
| Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila. | Biological sciences | Thomas Jenuwein, Gunter Reuter, Gunnar Schotta, Anja Ebert, Sandro Lein, Veiko Krauss, Stefan Kubicek | |||
| SV40 T antigen interacts with Nbs1 to disrupt DNA replication control. | Biological sciences | David Livingston, Xiaohua Wu, Dror Avni, Takuya Chiba, Feng Yan, Qiping Zhao, Henry Heng, Yafang Lin | |||
| synMuv verite-Myb comes into focus. | Biological sciences | Joseph S. Lipsick | |||
| Systematic analysis and nomenclature of mammalian F-box proteins. | Biological sciences | J. Wade Harper, Michele Pagano, Jianping Jin, Timothy Cardozo, C. Ruth Lovering, J. Stephen Elledge | |||
| Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding. | Biological sciences | Yuval Reiss, Ido Amit, Mina D. Marmor, Yaara Zwang, Menachem Katz, Liat Yakir, Keren Shtiegman, Ami Citri, Iris Alroy, Shmuel Tuvia, Eli Roubini, Ron Wides, Maya Cohen, Eran Bacharach, Yosef Yarden, Ullrich Schubert | |||
| Targeting of TAK1 by the NF-kappaB protein relish regulates the JNK-mediated immune response in Drosophila. | Biological sciences | Steven A. Wasserman, Jin Mo Park, Maria Grazia Ruocco, Helen Brady, Huaiyu Sun, Susan J. Lee, Williams DeeAnn, Kato, Tomohisa; Richards, Normand; Chan, Kyle, Mercurio, Frank; Karin, Michael | |||
| Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. | Biological sciences | Yuko Fujiwara, Stuart Orkin, Peter J.M. Valk, Hanno Hock, Eliza Meade, Sarah Medeiros, Jeffery W. Schindler | |||
| Telomerase- and recombination-independent immortalization of budding yeast. | Biological sciences | Laura Maringele, David Lydall | |||
| Tethering of eIF4G to adenoviral mRNAs by viral 100k protein drives ribosome shunting. | Biological sciences | Robert J. Schneider, Rafael Cuesta, Qiaoran Xi | |||
| The action of ARGONAUTE1 in the miRNA pathway and its regulation by the miRNA pathway are crucial for plant development. | Biological sciences | Herve Vaucheret, David P. Bartel, Franck Vazquez, Patrice Crete | |||
| The active spatial organization of the beta-globin locus requires the transcription factor EKLF. | Biological sciences | Frank Grosveld, Sjaak Philipsen, Wouter de Laat, Roy Drissen, Robert-Jan Palstra, Nynke Gillemans, Erik Splinter | |||
| The activity of the Nodal antagonist cerl-2 in the mouse node is required for correct L/R body axis. | Biological sciences | Sara Marques, Ana Cristina Borges, Ana Cristina Silva, Sandra Freitas, Jose Antonio Belo, Michelanglo Cordenonsi | |||
| The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. | Biological sciences | Javier Apfeld, Greg O'Connor, Tom McDonagh, Peter S. DiStefano, Rory Curtis | |||
| The Arabidopsis MutS homolog AtMSH4 functions at an early step in recombination: Evidence for two classes of recombination in Arabidopsis. | Biological sciences | Gareth H. Jones, James D. Higgins, Susan J. Arnstrong, Christopher Franklin F. | |||
| The biology of hypoxia: The role of oxygen sensing in development, normal function, and disease. | Biological sciences | Amato J. Giaccia, Randall Johnson, M. Celeste Simon | |||
| The C. elegans microRNA let-7 binds to imperfect let-7 complimentary sites from lin-41 3'UTR. | Biological sciences | Frank J. Slack, Monica C. Vella, Eun-Young Choi, Shin-Yi Lin, Kristy Reinert | |||
| The Drosha-DGCR8 complex in primary microRNA processing. | Biological sciences | Yoontae Lee, Jinju Han, Young-Kook Kim, Kyu-Hyun Yeom, Hua Jin, V. Narry Kim | |||
| The geminivirus nuclear shuttle protein is a virulence factor that suppresses transmembrane receptor kinase activity. | Biological sciences | Joanne Chory, Elizabeth P.B. Fontes, Anesia A. Santos, Alessandro J. Wacalwovsky, Dirce F. Luz | |||
| The generation of antibody diversity through somatic hypermutation and class switch recombination. | Biological sciences | Matthew D. Scharff, Ziqiang Li, Caroline J. Woo, Maria D. Iglesias-Ussel, Diana Ronai | |||
| The generation of proper constitutive G-tails on yeast telomeras is dependent on the MRX complex. | Biological sciences | Michel Larrivee, Catherine LeBel, Raymond J. Wellinger | |||
| The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher erkaryote . | Biological sciences | Dirk Schubeler, Mark Groudine, Bryan M. Turner, Daniel E. Gottschling, Charles Kooperberg, David M. MacAlpine, David Scalzo, Christiane Wirbelauer, Delrow Jeffrey, Stephen P. Bell, Laura P. O'Neill, Leeuwen Fred van | |||
| The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila. | Biological sciences | Ernst Hafen, Jan H. Reiling | |||
| The induction of sexual development and virulence in the smut fungus Ustilago maydis depends on Crk1, a novel MAPK protein. | Biological sciences | Elia Garrido, Ute Vob, Philip Muller, Sonia Castillo-Lluva, Regine Kahmann, Jose Perez-Martin | |||
| The loss of circadian PAR bZip transcription factors results in epilepsy. | Biological sciences | Jozsef Zakany, Denis Duboule, Ueli Schibler, Tohru Kodama, Frederic Gachon, Philippe Fonjallaz, Francesa Damiola, Pascal Gos, Brice Petit, Mehdi Tafti | |||
| The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation. | Biological sciences | Janet Rossant, Leonard C. Schalkwyk, Karin Schuster-Gossler, Achim Gossler, Heiko Lickert, Hanaa Ben Abdelkhalek, Anja Beckers, Maria N. Pavlova, Hannelore Burkhardt, Richard Reinhardt, Ines Miller, Marcelo Ceolin, Bernhard G. Herrmann, Rolando Rivera-Pomar | |||
| The MTE, a new core promoter element for transcription by RNA polymerase II. | Biological sciences | James T. Kadonaga, Chin Yan Lim, Buyung Santoso, Thomas Boulay, Emily Dong, Uwe Ohler | |||
| The Mus81 solution to resolution: generating meiotic crossovers without holliday junctions. | Biological sciences | Steven J. Brill, Nancy M. Hollingsworth | |||
| The NAD(super+)-dependent Sir2p histone deacetylase is a negative regulator of chromosomal DNA replication. | Biological sciences | Donald L. Pappas Jr., Ryan Frisch, Michael Weinreich | |||
| The notch target genes Hey1 and Hey2 are required for embryonic vascular development. | Biological sciences | Manfred Gessler, Michael Sendtner, Andreas Fischer, Nina Schumacher, Manfred Maier | |||
| The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex. | Biological sciences | Lynne E. Maquat, Shang-Yi Chiu, Fabrice Lejeune, Aparna C. Ranganathan | |||
| The polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation. | Biological sciences | Giuseppina Caretti, Monica Di Padova, Bruce Micales, Gary E. Lyons, Vittorio Sartorelli | |||
| The promoter of the Chinese hamster ovary dihydrofolate reductase gene regulates the activity of the local origin and helps define its boundaries. | Biological sciences | Joyce L. Hamlin, Swati Saha, Yujie Shan, Larry D. Mesner | |||
| The promoter targeting sequence mediates epigenetically heritable mediates epigenetically heritable transcription memory. | Biological sciences | Qing Lin, Qi Chen, Lan Lin, Jumin Zhou | |||
| The small ubiquitin-like modifier (SUMO) is required for gonadal and uterine-vulval morphogenesis in Caenorhabditis elegans. | Biological sciences | Benjamin Podbilewicz, Anindita Bhoumik, Limor Broday, Irina Kolotuev, Christine Didier, Ze' ev Ronai, Bhagwati P. Gupta, Pual W. Sternberg | |||
| The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments. | Biological sciences | Karin Schuster-Gossler, Achim Gossler, Markus Bussen, Marianne Petry, Michael Leitges, Andreas Kispert | |||
| The viral protein Apoptin associates with the anaphase-promoting complex to induce G2/M arrest and apoptosis in the absence of p53. | Biological sciences | Michael R. Green, Jose G. Teodoro, Destin W. Heilman, Albert E. Parker | |||
| The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2. | Biological sciences | James M. Berger, Michael R. Botchan, Eric A. Abbate | |||
| Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130. | Biological sciences | Leontine Schuijff, Jan-Hermen Dannenberg, Marleen Dekker, Martin van der Valk, Hein te Riele | |||
| TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival.. | Biological sciences | Fang-Tsyr Lin, Kang Liu, Yuhong Luo, Wee-Chin Lin | |||
| Topological domain structure of the Escherichia coli chromosome. | Biological sciences | Nicholas R. Cozzarelli, Lisa Postow, Christine D. Hardy, Javier Arsuaga | |||
| Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. | Biological sciences | Daniel P. Kelly, Richard C. Scarpulla | |||
| Translation repression by GLD-1 protects its mRNA targets from nonsense-mediated mRNA decay in C.elegans. | Biological sciences | Min-Ho Lee, Tim Schedl | |||
| Tsc2 is not a critical target of Akt during normal Drosophila development. | Biological sciences | Jixin Dong, Duojia Pan | |||
| Two heads are better than one: regulation of DNA replication by hexameric helicases. | Biological sciences | Robert A. Sclafani, Yusuke Saijo, Jian Wang, Ryan J. Fletcher, Xiaojiang S. Cheng, Seisuke Kimura, Xing Wang Deng, Giuliana Gusmaroli, Setsuko Komatsu | |||
| Two modes of DNA double-strand break repair are reciprocally regulated through the fission yeast cell cycle. | Biological sciences | Miguel Godinho Ferreira, Julia Promisel Cooper | |||
| U2AF homology motifs: protein recognition in the RRM world. | Biological sciences | Michael R. Green, Clara L. Kielkopf, Stephan Lucke | |||
| UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant. | Biological sciences | Akio Yamashita, Tsung-Cheng Chang, Chyi-Ying A. Chen, Yukiko Yamashita, Wenmiao Zhu; Durdan, Simon; Kahvejian, Avak; Sonenberg, Nahum; Shyu, Ann-Bin | |||
| Upstream and downstream of mTOR. | Biological sciences | Nahum Sonenberg, Nissim Hay | |||
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