Nature Medicine 2007 - Abstracts
| Nature Medicine 2007 | |||||
| Title | Subject | Authors | |||
|---|---|---|---|---|---|
| 27-hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. | Health | David J. Mangelsdorf, Ivan S. Yuhanna, Philip W. Shaul, Carolyn L. Cummins, Michihisa Umetani, Kenneth S. Korach, Hideharu Domoto, Andrew K. Gormley, Norman B. Javitt | |||
| Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia. | Health | Jeffrey Milbrandt, Michael Andreeff, Orla M. Conneely, Shuo Zhang, Shannon E. Mullican, Marian Konopleva, Vivian Ruvolo | |||
| A call to arms. | Health | Joanna Owens | |||
| ACE inhibitor bulks up muscle. | Health | Jeffrey S. Chamberlain | |||
| Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system. | Health | Angela Vincent, Michael J. Welsh, Lars Fugger, John A. Wemmie, Manuel A. Friese, Matthew J. Craner, Ruth Etzensperger, Sandra Vergo | |||
| A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1. | Health | Klaus Piontek, Gregory G. Germino, Luis F. Menezes, Miguel A. Garcia-Gonzalez, David L. Huso | |||
| Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis. | Health | Charles T. Esmon, Angelika Bierhaus, Bruce Gerlitz, Brian W. Grinnell, Berend Isermann, Hartmut Weiler, Ilya A. Vinnikov, Thati Madhusudhan, Stefanie Herzog, Kashif, Muhammed;, Janusch Blautzik, Marcus A. F. Corat, Martin Zeier, Erwin Blessing, Jun Oh, David T. Berg, Triantafyllos Chavakis, Peter P. Nawroth | |||
| Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial.(Clinical report) | Health | Lu Zhang, Sandeep T. Patil, Stephen L. Lowe, Ferenc Martenyi, Kimberley A. Jackson, Boris V. Andreev, Alla S. Avedisova, Leonid M. Bardenstein, Issak Y. Gurovich, Margarita A. Morozova, Bryan G. Johnson, James A. Monn, Darryle D. Schoepp, Sergey N. Mosolov, Alexander M. Reznik, Anatoly B. Smulevich, Vladimir A. Tochilov, Nikolai G. Neznanov | |||
| Adaptive immune cells temper initial innate responses. | Health | Jie Zhao, Kwang Dong Kim, Sogyong Auh, Xuanming Yang, Peishuang Du, Hong Tang, Yang-Xin Fu | |||
| A deer in the headlights: BAMBI meets liver fibrosis. | Health | Scott L. Friedman | |||
| Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure. | Health | Walter J. Koch, Anastasios Lymperopoulos, Giuseppe Rengo, Hajime Funakoshi, Andrea D. Eckhart | |||
| After decades of drought, new drug possibilities flood TB pipeline. | Health | Erica Check | |||
| A GABAergic system in airway epithelium is essential for mucus overproduction in asthma.(gamma aminobutyric acid) | Health | Paul M. O'Byrne, Mingyao Liu, Margaret M. Kelly, Yun-Yan Xiang, Shuhe Wang, Jeremy A. Hirota, Li Jingxin, William Ju, Yijun Fan, Bin Ye, Beverly Orser, Wei-Yang Lu, Mark D. Inman | |||
| Aggressive drug marketing tactics trigger backlash. | Health | Emily Singer | |||
| Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer. | Health | Joseph Keane, Gang Liu, Timothy Anderson, Avrum Spira, Jennifer E. Beane, Vishal Shah, Katrina Steiling, Frank Schembri, Sean Gilman, Yves-Martine Dumas, Paul Calner, Paola Sebastiani, Sriram Sridhar, John Beamis, Carla Lamb, Norman Gerry, Marc E. Lenburg, Jerome S. Brody | |||
| Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity. | Health | Joseph Loscalzo, Bertram Pitt, Ronglih Liao, Jane A. Leopold, Aamir Dam, Bradley A. Maron, Anne W. Scribner, Diane E. Handy, Robert C. Stanton | |||
| A ligand-receptor fusion of growth hormone forms a dimer and is a potent long-acting agonist. | Health | Peter J. Artymiuk, Christian J. Strasburger, Richard J. Ross, Ian R. Wilkinson, Eric Ferrandis, Marc Teillot, Chantal Soulard, Caroline Touvay, Sarbendra L. Pradhananga, Sue Justice, Zida Wu, Kin C. Leung, Jon R. Sayers | |||
| Aligning pharmaceutical innovation with medical need. | Health | Carl Nathan | |||
| [Alpha.sub.1][beta.sub.1] integrin is crucial for accumulation of epidermal T cells and the development of psoriasis. | Health | Frank O. Nestle, Humphrey Gardner, Curdin Conrad, Onur Boyman, Guilia Tonel, Adrian Tun-Kyi, Ute Laggner, Antonin De Fougerolles, Victor Kotelianski | |||
| Altered recognition of antigen is a mechanism of CD8+T cell tolerance in cancer. | Health | Kapil Gupta, Dmitry I. Gabrilovich, Donna L. Herber, Loveleen Kang, Simon Sherman, Leo Kinarsky, Vladamir Pisarev, Srinivas Nagaraj, Jonathan Schneck | |||
| A MSC-ing link in metastasis?(mesenchymal stem cells ) | Health | Douglas R. Hurst, Danny R. Welch | |||
| A new link to airway obstruction in asthma. | Health | David B. Corry, Farrah Kheramand | |||
| A new way to regulate the NMJ. | Health | Kay E Davies, Tejvir S Khurana | |||
| Angiogenic inhibition reduces germinal matrix hemorrhage. | Health | Maiken Nedergaard, Steven A. Goldman, Praveen Ballabh, Nanhong Lou, Hongmin Xu, Zoltan Ungvari, Furong Hu, Anna Csiszar, Alex Braun, Kira Smith, Aracelie Rivera | |||
| Angiotensin II type 1 receptor blockade attenuates TGF-[beta]-induced failure of muscle regeneration in multiple myopathic states. | Health | Harry C. Dietz, Francesco Ramirez, Ronald D. Cohn, Daniel P. Judge, Christel van Erp, Jennifer P. Habashi, Arshia A. Soleimani, Erin C. Klein, Matthew T. Lisi, Colette M. ap Rhys, Tammy M. Holm, Bart L. Loeys, Christopher W. Ward | |||
| Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals. | Health | Gerald I. Shulman, Sabrina Diano, Tamas L. Horvath, Ingo Bechmann, Csaba Leranth, Qiao Gao, Gabor Mezei, Yongzhan Nie, Yan Rao, Cheol Soo Choi, Dominique Toran-Allerand, Catherine A. Priest, James L. Roberts, Xiao-Bing Gao, Charles Mobbs | |||
| A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14. | Health | Karl Welte, Jan Buer, Bodo Grimbacher, Cornelia Zeidler, Georg Bohn, Anna Allroth, Gudrun Brandes, Jens Thiel, Erik Glocker, Alejandro A. Schaffer, Chozhavendan Rathinam, Nicole Taub, David Teis, Ricardo A. Dewey, Robert Geffers, Lukas A. Huber, Christoph Klein | |||
| Antibacterial discovery and development-the failure of success? | Health | Prabhavathi Fernandes | |||
| Antibiotics- An investment worth making? | Health | Ralph E. Christoffersen | |||
| Antibiotics au naturel.(natural products research ) | Health | Cormac Sheridan | |||
| Antidepressant actions of the exercise-regulated gene VGF. | Health | Joshua G. Hunsberger, Samuel S. Newton, Alicia H. Bennett, Catherine H. Duman, David S. Russell, Stephen R. Salton, Roland S. Duman | |||
| Antielastin autoimmunity in tobacco smoking-induced emphysema. | Health | Sheila Goodnight-White, Linda Green, Seung-Hyo Lee, Farrah Kheradmand, Sangeeta Goswami, Ariel Grudo, Li-zhen Song, Venkata Bandi, Joan Hacken-Bitar, Joseph Huh, David B Corry, Faisal Bakaeen, Harvey O Coxson, Sebastian Cogswell, Claudine Storness-Bliss | |||
| Anti-infective antibodies: Finding the path forward. | Health | Monya Baker | |||
| Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. | Health | Robert E.W. Hancock, Hans-Georg Sahl | |||
| APC and colon cancer: two hits for one.(mutation in adenomatous polyposis coli tumor suppressor genes control cancer) | Health | Leonard I. Zon, David Pellman, Craig J. Ceol | |||
| A pivotal role for galectin-1 in fetomaternal tolerance. | Health | Julia Szekeres-Bartho, Mariana Garcia, Burghard F. Klapp, Sandra M. Blois, Juan M. Ilarregui, Mareike Tometten, Arif S. Orsal, Rosalia Cordo-Russo, Marta A. Toscano, German A. Bianco, Peter Kobelt, Bori Handjiski, Irene Tirado, Udo R. Markert, Francoise Poirier, Gabriel A. Rabinovich, Petra C. Arck | |||
| A plague upon fibrin: A surface protease helps Yersinia pestis plow its way through the body during pneumonic plague. | Health | Richard W. Titball, Petra C.F. Oyston | |||
| A prize catch for diabetic retinopathy. | Health | Thomas W. Gardner, David A. Antonetti | |||
| Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging. | Health | Ho-Geun Yoon, Jung-wook Seo, Young-wook Jun, Jinwoo Cheon, Jae-Hyun Lee, Yong-Min Huh, Jung-tak Jang, Ho-Taek Song, Sungjun Kim, Eun-Jin Cho, Jin-Suck Suh | |||
| ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor. | Health | Hiroshi Miyamoto, Gen Sobue, Zhiming Yang, Yu-Jia Chang, I-Chen Yu, Shuyuan Yeh, Cheng-Chia Wu, Diane E. Merry, Lu-Min Chen, Shu-Shi Chang, Chawnshang Chang | |||
| Ashok Alexander.(Interview) | Health | Paroma Basu | |||
| A skeleton key to metabolism. | Health | T. John Martin | |||
| A spatially and temporally restricted mouse model of soft tissue sarcoma.(Clinical report) | Health | Stanley J. Korsmeyer, Tyler Jacks, Roderick T. Bronson, G. Petur Nielsen, Ralph Weissleder, Osamu Takeuchi, Denise Crowley, Daniela M. Dinulescu, John B. Miller, David G. Kirsch, Jan Grimm, Sam S. Yoon, Philip M. Santiago, Nathan P. Young, Bradley J. Quader, Christopher J. Chaber, Christian P. Schultz, Francis J. Hornicek | |||
| AstraZeneca announces discovery of a new class of antibiotic. | Health | ||||
| Australia set to test insulin 'vaccine' for juvenile diabetes. | Health | Simon Grose | |||
| Autism: Highly heritable but not inherited. | Health | Arthur L Beaudet | |||
| Bad signals jam organelle traffic. | Health | Esteban C. Dell'Angelica | |||
| [beta]-Cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment. | Health | James D. Johnson, Michael R. Hayden, John S. Parks, Brian Rodrigues, Liam R. Brunham, Janine K. Kruit, Terry D. Pape, Jenelle M. Timmins, Anne Q. Reuwer, Zainisha Vasanji, Brad J. Marsh, C. Bruce Verchere | |||
| Biomarkers trump behavior in mental illness diagnosis. | Health | Amanda Leigh Haag | |||
| Bird flu almighty.(research on the genetic causes and transmission of bird flue) | Health | Kate Jeffrey | |||
| Blocking HDACs boosts regulatory T cells.(histone deacetylase ) | Health | Weiping Zou, Pavan Reddy | |||
| B lymphocyte-directed immunotherapy promotes long-term islet allograft survival in nonhuman primates. | Health | Brigitte Koeberlein, Ali Naji, John E. Tomaszewski, Clyde F. Barker, Chengyang Liu, Hooman Noorchashm, Taryn Green, Jennifer A. Sutter, Mina Naji, Eline Luning Prak, Michael R. Rickels, Zhonglin Wang, Michelle E. Paessler, Ergun Velidedeoglu, Susan Y. Rostami, Ming Yu, Jean Boyer | |||
| Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance. | Health | Alan R. Saltiel, Jerrold M. Olefsky, Shian-Huey Chiang, Mohammad Pashmforoush, Lisa A. Lesniewski, Sarah E. Hosch, Jaap G. Neels, Carl de Luca, Carey N. Lumeng, Miriam Scadeng | |||
| Bone marrow transplant paper revives contentious debate on fertility. | Health | Kendall Powell | |||
| Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins. | Health | Luciano Rossetti, Tony K.T. Lam, Roger Gutierrez-Juarez, Gary J. Schwartz, Alessandro Pocai, Sanjay Bhanot, Patrick Tso | |||
| Bring the magic back to the bullets. | Health | ||||
| Broad HIV-1 neutralization mediated by CD4-binding site antibodies. | Health | John R. Mascola, Mark K. Louder, George M. Shaw, Yuxing Li, Stephen A. Migueles, Brent Welcher, Krisha Svehla, Adhuna Phogat, Xueling Wu, Mark Connors, Richard T. Wyatt | |||
| Bugs vs drugs: In the ongoing battle between bacteria and antibiotics strains of staphylococcus aureus are emerging the winners. | Health | Douglas Braaten | |||
| Building the bionic T cell. | Health | Drew M. Pardoll | |||
| Calreticulin exposure dictates the immunogenicity of cancer cell death. | Health | Guido Kroemer, Laurence Zitvogel, Lionel Apetoh, Didier Metivier, Francois Ghiringhelli, Michel Obeid, Antoine Tesniere, Gian Maria Fimia, Jean-Luc Perfettini, Maria Castedo, Gregoire Mignot, Theoharis Panaretakis, Noelia Casares, Peter van Endert, Fabiola Ciccosanti, Mauro Piacentini | |||
| Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans? | Health | Lisa Schnell, John Martin, Mary Bartlett Bunge, Thierry Wannier, Gregoire Courtine, Roger Lemon, Eric M Rouiller, Irin Maier, James W Fawcett, Robert G Grossman, Randolph J Nudo, Martin E Schwab, Jon H Kaas, Almundena Ramon-Cueto, Reggie V Edgerton | |||
| Cardiac aid to the injured but not the elderly?(Clinical report) | Health | Charles E. Murry | |||
| C[a.sup.2+] channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1. | Health | Matthias W. Hentze, Martina U. Muckenthaler, Guenter Weiss, Suzanne Ludwiczek, Milan Theurl, Judit Kiss, Igor Theurl, Markus Paulmichl, Martin Jakab, Markus Ritter, Sabine M. Mair | |||
| Catching bird flu in a droplet. | Health | Yi Zhang, Juergen Pipper, Masafumi Inoue, Lisa F-P Ng, Pavel Neuzil, Lukas Novak | |||
| Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. | Health | Andrew D. Luster, Terry K. Means, Joseph El Khoury, Michelle Toft, Suzanne E. Hickman, Kinya Terada, Changiz Geula | |||
| CD16 promotes Escherichia coli sepsis through an FcR[gamma] inhibitory pathway that prevents phagocytosis and facilitates inflammation. | Health | J. Sjef Verbeek, Antoine Andremont, Fabiano Pinheiro da Silva, Meryem Aloulou, David Skurnik, Marc Benhamou, Renato C. Monteiro, Inrineu T. Velasco, Chiamolera. Murilo, Peirre Launay | |||
| CD[8.sup.+] T cell responses to adeno-associated virus capsid in humans. | Health | Margaret V. Ragni, Glenn F. Pierce, Marcela V. Maus, Katherine A. High, Catherine S. Manno, Federico Mingozzi, Hildegund C.J. Ertl, Daniel J. Hui, Jurg Sommer, Haiyan Jiang, Denise E. Sabatino, Samuel L. Murphy, John E.J. Rasko | |||
| CD8.sup.} T-cell responses to different HIV proteins have discordant associations with viral load. | Health | Hoosen Coovadia, James I. Mullins, Bruce D. Walker, Christian Brander, Photini Kiepiela, Christina Thobakgale, Isobella Honeyborne, Zenele Mncube, Kholiswa Ngumbela, Dhanwanthie Ramduth, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, David Nickle, Christine Rousseau, David Heckerman, Philip Goulder | |||
| [CD8.sup.+] T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes. | Health | Fidel Zavala, Sumana Chakravarty, Ian A. Cockburn, Salih Kuk, Michael G. Overstreet, John B. Sacci | |||
| Cellular microRNAs contribute to HIV-1 latency in resting primary [CD4.sup.} T lymphocytes. | Health | Kathleen Squires, Wenlin Huang, Hui Zhang, Jialing Huang, Fengxiang Wang, Elias Argyris, Keyang Chen, Zhihui Liang, Heng Tian, Gwen Verlinghieri | |||
| Central control of bone remodeling by neuromedin U. | Health | Shu Takeda, Shigeaki Kato, Takahiro Matsumoto, Seiji Fukumoto, Yasuhiro Takeuchi, Reiko Hanada, Kenji Kangawa, Takanori Ida, Toshiro Fujita, Shingo Sato, Ayako Kimura, Tomomi Abe, Makiko Iwasaki, Hiroyuki Inose, Michihiro Mieda, Masayasu Kojima, Ken-ichi Shinomiya | |||
| Challenges in tuberculosis drug research and development. | Health | Ann M. Ginsberg, Melvin Spigelman | |||
| Changing funding patterns in tuberculosis. | Health | Stefan H.E. Kaufmann, Shreemanta K. Parida | |||
| Chromosome 5q deletion and epigenetic suppression of the gene encoding [alpha]-catenin (CTNNA1) in myeloid cell transformation. | Health | A. Thomas Look, Clara D. Bloomfield, Richard M. Stone, Daniel J. DeAngelo, Michael F. Clarke, Michael W. Becker, Wen-Shu Wu, Min Deng, Ting Xi Liu, Jaroslav Jelinek, Natallia Mikhalkevich, Karl Hsu, Ilene A. Galinsky, Jean-Pierre Issa | |||
| Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins. | Health | Robert Tibshirani, Tony Wyss-Coray, Marek Jutel, Bruce L. Miller, Jerome A. Yesavage, William H. Robinson, Joseph F. Quinn, Douglas R. Galasko, Kaj Blennow, Sandip Ray, Markus Britschgi, Charles Herbert, Yoshiko Takeda-Uchimura, Adam Boxer, Leah F. Friedman, Anna Karydas, Jeffery A. Kaye, Jerzy Leszek, Lennart Minthon, Gil D. Rabinovici, Marwan Sabbagh, Yuen T. So, D. Larry Sparks, Massimo Tabaton, Jared Tinklenberg | |||
| Clearance of amyloid-[beta] by circulating lipoprotein receptors. | Health | Alison Goate, Rashid Deane, Zhenhua Wu, Abhay Sagare, Robert D. Bell, Zhihui Zhong, Bradley Johnson, Katie Hamm, Ronan Pendu, Andrew Marky, Peter J. Lenting, Troy Zarcone, Kevin Mayo, David Perlmutter, Mireia Coma, Berislav V. Zlokvic | |||
| Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease. | Health | Dirk Roos, Dominik Hartl, Philipp Latzin, Peter Hordijk, Veronica Marcos, Carsten Rudolph, Markus Woischnik, Susanne Krauss-Etschmann, Barbara Koller, Dietrich Reinhardt, Adelbert A. Roscher, Matthias Griese | |||
| Cluster busters.(hallucinogenic drugs) | Health | Arran Frood | |||
| Cracking the cytokine code in psoriasis. | Health | Brian J. Nickoloff | |||
| Critical link between TRAIL and CCL20 for the activation of [T.sub.H]2 cells and the expression of allergic airway disease. | Health | Mark J. Smyth, Hideo Yagita, Markus Weckmann, Adam Collison, Jodie L. Simpson, Matthias V. Kopp, Peter A. B. Wark, Jeorg Mattes, Klaus I. Matthaei, Nicole Hansbro, Bruce Whitehead, Peter G. Gibson, Paul S. Foster, Joerg Mattes | |||
| Critics slam Russian trial to test pig pancreas for diabetics. | Health | Simon Grose | |||
| Cross-presentation of caspase-cleaved apoptic self antigens in HIV infection. | Health | Alessandro Sette, Antonella Propato, Vincenzo Barnaba, John Sidney, Pisana Moroni Rawson, Caroline Molette, Melissa Videtta, Laura Altieri, Debora Franceschini, Tiziana Donato, Luigi Finocchi, Marino Paroli, Francesca Meloni, Claudio M. Mastroianni, Gabriela d'Ettorre | |||
| Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance. | Health | Takashi Yamamoto, Yoshimi Nakagawa, Hitoshi Shimano, Hiroaki Suzuki, Noriyuki Inoue, Hirohito Sone, Takashi Matsuzaka, Hideo Toyoshima, Akimitsu Takahashi, Alyssa H. Hasty, Naoya Yahagi, Nobuhiro Yamada, Toyonori Kato, Ayaka Atsumi, Mayumi Ishikawa, Sumiyo Okada, Naomi Ishigaki, Hitoshi Iwasaki, Yuko Iwasaki, Tadayoshi Karasawa, Shin Kumadaki, Toshiyuki Matsui, Motohiro Sekiya, Ken Ohashi, Sigeru Yatoh, Jun-ichi Osuga | |||
| Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells. | Health | Guojie Li, Brian L Bishop, Mathew J. Duncan, Jeongmin Song, David Zaas, Soman N Abraham | |||
| Deacetylase inhibition promotes the generation and function of regulatory T cells. | Health | Eric N. Olson, Laurence A. Turka, Bin Li, Wayne W. Hancock, Mark I. Greene, Ran Tao, Edwin F. de Zoeten, Engin Ozkaynak, Chunxia Chen, Liqing Wang, Paige M. Porrett, Andrew D. Wells | |||
| Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand apo2L/TRAIL. | Health | Avi Ashkenazi, Guy Cavet, Klaus W. Wagner, Elizabeth A. Punnoose, Thomas Januario, David A. Lawrence, Robet M. Pitti, Kate Lancaster, Dori Lee, Melissa von Goetz, Sharon Fong Yee, Klara Totpal, Ling Huw, Viswanatham Katta, Sarah G. Hymowitz, Lukas Amler | |||
| Defining the 'survivasome' of Mycobacterium tuberculosis. | Health | William Bishai, Gyanu Lamichhane | |||
| Dendritic cells: versatile controllers of the immune system. | Health | Ralph M. Steinman | |||
| Derivation of engraftable skeletal myoblasts from human embryonic stem cells. | Health | Lorenz Studer, Georgia Panagiotakos, Tiziano Barberi, Michelle Bradbury, Zehra Dincer, Nicholas D Socci | |||
| Detecting tumor response to treatment using hyperpolarized [13.sup.C] magnetic resonance imaging and spectroscopy. | Health | Mikko I. Kettunen, Kevin M. Brindle, Sam E. Day, Ferdia A. Gallagher, De-En Hu, Mathilde Lerche, Jan Wolber, Klaes Golman, Jan Henrik Ardenkjaer-Larsen | |||
| Dickkopf-1 is a master regulator of joint remodeling. | Health | Markus Hoffmann, William G. Richards, Georg Schett, Josef Smolen, Clemens Scheinecker, Daniella Diarra, Marina Stolina, Karin Polzer, Jochen Zwerina, Michael S. Ominsky, Denise Dwyer, Adelheid Korb, Desiree van der Heijde, Robert Landewe, Dave Lacey | |||
| Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor C[B.sub.1] on neurons and C[B.sub.2] on auto reactive T cells. | Health | David Baker, Gareth Pryce, Roger G. Pertwee, Takashi Yamamura, Beat Lutz, Catherine Ledent, Gavin Giovannoni, Katarzyna Maresz, Leah P. Shriver, Eugene D. Ponomarev, Xiaodong Cheng, Erica J. Carrier, Giovanni Marsicano, Ludovic J. Croxford, Monica K. Mann, Bonnie N. Dittel, Nancy E. Buckley, Cecilia J. Hillard | |||
| Diseased red blood cells topple iron balance. | Health | Mitchell J. Weiss, Stella T. Chou | |||
| Disruption of methylarginine metabolism impairs vascular homeostasis. | Health | Caroline Smith, Patrick Vallance, Neil Q. McDonald, James Leiper, Manasi Nandi, Belen Torondel, Judith Murray-Rust, Mohammed Malaki, Bernard O'Hara, Sharon Rossiter, Shelagh Anthony, Melanie Madhani, David Selwood, Beata Wojciak-Stothard, Alain Rudiger, Ray Stidwill | |||
| DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection.(Clinical report) | Health | Victor Nizet, Mark J. Walker, Andrew Hollands, Martina L. Sanderson-Smith, Jason N. Cole, Joshua K. Kirk, Anna Henningham, Jason D. McArthur, Katrin Dinkla, Ramy K. Aziz, Rita G. Kansal, Amelia J. Simpson, John T. Buchanan, Gursharan S. Chhatwal, Malak Kotb | |||
| Drugs for bad bugs: Confronting the challenges of antibacterial discovery. | Health | David J. Holmes, David J. Payne, Michael N. Gwynn, David L. Pompliano | |||
| Dying T cells trigger autoimmunity in HIV. | Health | Sarah Rowland-Jones, Tao Dong | |||
| E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury.(Clinical report) | Health | Kurt Bachmaier, Sophie Toya, Thomas Triantafillou, Sean Garrean, Xiaopei Gao, Gye Young Park, Randall S. Frey, Stephen Vogel, Richard Minshall, John W. Christman, Chinnaswamy Tiruppathi, Asrar B. Malik | |||
| Eating bone or adding it: The Wnt pathway decides. | Health | Steven R. Goldring, Mary B. Goldring | |||
| Emergency trials of blood substitutes skirt ethical questions. | Health | Andrea Anderson | |||
| Endothelial-to-mesenchymal transition contributes to cardiac fibrosis.(Clinical report) | Health | Seigo Izumo, Mohamed H. Sayegh, Anita B. Roberts, Eric G. Neilson, Michael Zeisberg, Raghu Kalluri, Elisabeth M. Zeisberg, Oleg Tarnavski, Adam L. Dorfman, Julie R. McMullen, Erika Gustafsson, Anil Chandraker, Xueli Yuan, William T. Pu | |||
| Engineering functional two-and three-dimensional liver systems in vivo using hepatic tissue sheets. | Health | Kazuo Ohashi, Takashi Yokoyam, Mayayuki Yamato, Hiroyuki Kuge, Hiromichi Kanehiro, Masahiro Tsutsumi, Toshihiro Amanuma, Hiroo Iwata, Joseph Yang, Terou Okano, Yoshiyuki Nakajima | |||
| Essential role of stromally induced hedgehog signaling in B-cell malignancies.(Clinical report) | Health | Christine Dierks, Jovana Gbric, Katja Zirlik, Ronak Beigi, Nathan P. Englund, Gui-Rong Guo, Hendrik Veelken, Monika Engelhardt, Roland Mertelsmann, Joseph F. Kelleher, Peter Schultz, Markus Warmuth | |||
| Ethicists balk at new emergency trials that skip informed consent. | Health | Andrea Anderson | |||
| Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury.(Clinical report) | Health | Jeffrey Robbins, Jeffrey D. Molkentin, Richard T. Lee, Michael E. Davis, Patrick C.H. Hsieh, Vincent F.M. Sergers, Catherine MacGillivray, Joseph Gannon | |||
| Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation. | Health | Lloyd Paul Aiello, James G. Fujimoto, Ben-Bo Gao, Allen Clermont, Susan Rook, Stephanie J. Fonda, Vivek J. Srinivasan, Maciej Wojtkowski, Robert L. Avery, Paul G. Arrigg, Sven-Erik Bursell, Edward P. Feener | |||
| Extralymphatic virus sanctuaries as a consequence of potent T-cell activation. | Health | Rolf M. Zinkernagel, Lukas Hunziker, Hans Hengartner, Bernhard Odermatt, Karl S. Lang, Mike Recher, Stefan Freigang, Philipp A. Lang, Lars Hangartner, Katja Fink, Alexander Navarini, Panco Georgiev, Rapahel Zellweger, Andreas Bergthaler, Ahmed N. Hegazy, Bruno Eschli, Alexandre Theocharides, Lukas T. Jeker, Doron Merkler, Martin Hersberger | |||
| Fen1 mutations result in autoimmunity, chronic inflammation and cancers. | Health | Purnima Singh, Li Zheng, Mian Zhou, Huifang Dai, Dongxin Lin, Xuemei Zhang, Kernstine Kemp, Qin Huang, Walter Tsark, Junzhuan Qui, Bingshui Shen | |||
| Fertility clinics cashing in on risky immune tests, expert warns. | Health | Michael Hopkin | |||
| From magic bullets back to the Magic Mountain: The rise of extensively drug-resistant tuberculosis. | Health | Richard E. Chaisson, Susan E. Dorman | |||
| Genital transmission of HPV in a mouse model is potentiated in nonoxynol-9 and inhibited by carrageenan. | Health | John T. Schiller, Douglas R. Lowy, Jeffrey N. Roberts, Christopher D. Buck, Cynthia D. Thompson, Rhonda Kines, Marcelino Bernardo, Peter L. Chokye | |||
| Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3[beta] activity.(histone deacetylase) | Health | Wolfgang Wurst, Jonathan A. Epstein, Maozhen Zhang, Tao Wang, Chinmay M. Trivedi, Yang Luo, Zhan Yin, Wenting Zhu, Thomas Floss, Martin Goettlicher, Patricia Ruiz Noppinger, Victor A. Ferrari, Charles S. Abrams, Peter J. Gruber | |||
| Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. | Health | Kazuo Kinoshita, Tasuku Honjo, Yuko Matsumoto, Hiroyuki Marusawa, Yoko Endo, Tadayuki Kou, Toshiyuki Morisawa, Takeshi Azuma, Il-Mi Okazaki, Tsutomu Chiba | |||
| Heme moves to center stage in cerebral malaria. | Health | Roland Stocker, Nicholas Hunt H. | |||
| Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria. | Health | Miguel P. Soares, Maria M. Mota, Ana Pamplona, Ana Ferreira, Jozsef Balla, Viktoria Jeney, Sabrina Epiphanio, Gyorgy Balla, Angelo Chora, Cristina D. Rodrigues, Isabel Pombo Gregoire, Margarida Cunha-Rodrigues, Silvia Portugal | |||
| HER3 and mutant EGFR meet MET. | Health | Carlos L. Arteaga | |||
| High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. | Health | Richard Childs, Susan F. Leitman, Tomas Ganz, Suthat Fucharoen, Naomi L.C. Luban, Toshihiko Tanno, Natarajan V. Bhanu, Patricia A. Oneal, Sung-Ho Goh, Pamela Staker, Y. Terry Lee, John W. Moroney, H. Christopher Reed, Rui-Hong Wang, Thomas E. Eling, Jeffrey L. Miller | |||
| Hope in sight for retinoblastoma. | Health | Julien Sage | |||
| Humanization of autoantigen.(to prevent bullous pemphigoid) | Health | Kim B. Yancey, Hiroshi Shimizu, Wataru Nishie, Daisuke Sawamura, Maki Goto, Kei Ito, Akihiko Shibaki, James R. McMillan, Kaori Sakai, Hideki Nakamura, Edit Olasz, Masashi Akiyama | |||
| Human [T.sub.17] lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. | Health | Burkhard Becher, Hania Kebir, Katharina Kreymborg, Igal Ifergan, Aurore Dodelet-Devillers, Romain Cayrol, Monique Bernard, Fabrizio Giuliani, Nathalie Arbour, Alexandre Prat | |||
| Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. | Health | Ikuroh Ohsawa, Masahiro Ishikawa, Kumiko Takahashi, Megumi Watanabe, Kiyomi Nishimaki, Kumi Yamagata, Ken-ichiro Katsura, Yasuo Katayama, Sadamitsu Asoh, Shigeo Ohta | |||
| Identification of a key pathway required for the sterile inflammatory response triggered by dying cells.(myeloid differentiation primary response gene) | Health | Hajime Kono, Kenneth L. Rock, George Reed, Chun-Jen Chen, Douglas Golenbock, Shuzuo Akira | |||
| Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. | Health | Min Li, Andreas Peschel, Rong Wang, Frank R. DeLeo, Michael Otto, Kevin R. Braughton, Dorothee Kretschmer, Thanh-Huy L. Bach, Shu Y. Queck, Adam D. Kennedy, David W. Dorward, Seymour J. Klebanoff | |||
| Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche. | Health | Li Zhang, Li Li, Songtao Shi, Yanming Bi, Driss Ehirchiou, Tina M. Kilts, Colette A. Inkson, Mildred C. Embree, Wataru Sonoyama, Arabella I. Leet, Byoung-Moo Seo, Marian F. Young | |||
| IFN-[gamma] mediates [CD4.sup.+] T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy. | Health | Bruce R. Blazar, William J. Murphy, Dan L. Longo, Haiyan Liu, Qing Zhou, Vanessa Berner, Kory L. Alderson, Kai Sun, Jonathan M. Weiss, Timothy C. Back, Robert H. Wiltrout, Lisbeth A. Welnaik, Doug Redelman | |||
| IL-15 constraints mast cell-dependent antibacterial defences by suppressing chymase activities.(Clinical report) | Health | Marcus Maurer, Martin Metz, Ralf Paus, Silvia Bulfone-Paus, Elena Bulanova, Vadim Budagian, Zane Orinska, Farhadbulanova Mirghomizadeh, Natalia Nashkevich, Florian Schiemann, Jan Schulmistrat, Julien Giron-Michel, Ernst Brandt | |||
| IL-1alpha responds to necrotic cell death. | Health | Keith B. Elkon | |||
| IL-23: A master regulator in Crohn disease. | Health | Markus F. Neurath | |||
| Incapacitating the immune system in cystic fibrosis. | Health | Ian Sabroe, Moira K.B. Whyte | |||
| Increased dietary intake of [omega]-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis. | Health | Charles N. Serhan, Jing Chen, Lois E.H. Smith, Kip M. Connor, Jing X. Kang, John Paul SanGiovanni, Chatarina Lofqvist, Christopher M. Aderman, Akiko Higuchi, Song Hong, Elke A. Pravda, Sharon Majchrzak, Deborah Carper, Ann Hellstrom, Emily Y. Chew, Norman Salem Jr. | |||
| Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea.(Clinical report) | Health | Richard L. Gallo, Kenshi Yamasaki, Anna De Nardo, Antonella Bardan, Masamoto Murakami, Takaaki Ohtake, Robert A. Dorschner, Chrystelle Bonnart, Pascal Descargues, Alain Hovnanian, Vera B. Morhenn | |||
| Infrastructure, biotech top African science summit agenda.(Conference news) | Health | Christina Scott | |||
| Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC. | Health | J. Michael Bishop, David O. Morgan, Aaron D. Tward, Dun Yang, Andrei Goga | |||
| Inhibition of Fc[epsilon]RI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes. | Health | Alirio J. Melendez, Margaret M. Harnett, Peter N. Pushparaj, W. S. Fred Wong, Hwee Kee Tay, Charles P. McSharry, William Harnett | |||
| In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice. | Health | Wolfgang Hillen, Sabine Ehrt, Dirk Schnappinger, Sheetal Gandotra, Mercedes Monteleone | |||
| In vivo imaging of siRNA delivery and silencing in tumors. | Health | Anna Moore, Zdravka Medarova, Wellington Pham, Christian Farrar, Victoria Petkova | |||
| In vivo magnetic resonance imaging of acute brain inflammation using microparticles of iron oxide. | Health | Jurgen E. Schneider, Daniel C. Anthony, Martina A. McAteer, Nicola R. Sibson, Constantin von zur Muhlen, Andrew S. Lowe, Nicholas Warrick, Keith M. Channon, Robin P. Choudhury | |||
| It's what you do with the fat that matters! | Health | Mark A. Febbraio, Clinton R. Bruce | |||
| Keeping quiet: microRNAs in HIV-1 latency. | Health | Robert F. Siliciano, Yefei Han | |||
| Lack of Fas antagonism by Met in human fatty liver disease. | Health | Stephen Strom, Xue Wang, Carla J. Johnson, Chunbin Zou, Amamda E. Eaker, Lida Guo, John Stoops, Zhenqi Zhu, Jihong Ma, George K. Michalopoulos, Marie C. DeFrances, Reza Zarnegar | |||
| Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors. | Health | Mathias Chamaillard, Christel Rousseaux, Xavier Thuru, Agathe Gelot, Nicolas Barnich, Christel Neut, Laurent Dubuquoy, Caroline Dubuquoy, Emilie Merour, Karen Geboes, Arthur Ouwehand, Greg Leyer, Didier Carcano, Jean-Frederic Colombel, Denis Ardid, Pierre Desreumaux | |||
| Langerhans cells lap up HIV-1. | Health | Olivier Schwartz | |||
| Langerin is a natural barrier to HIV-1 transmission by Langerhans cells. | Health | Teunis B.H. Geijtenbeek, Lot de Witte, Alexey Nabatov, Marjorie Pion, Donna Fluitsma, Marein A.W.P. de Jong, Tanja de Gruijl, Vincent Piguet, Yvette van Kooyk | |||
| LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. | Health | Blake Pepinsky, Li Wang, Yi Luo, Sha Mi, Bing Hu, Kyungmin Hahm, Edward Sai Kam Hui, Qiuju Yuan, Wai Man Wong, Huanxing Su, Tak-Ho Chu, Jiasong Guo, Wenming Zhang, Kwok-Fai So, Zhaohui Shao, Christilyn Graff, Ellen Garber, Vincent Jung, Ed Xuekui Wu, Wutian Wu | |||
| Linking calcineurin activity to leukemogenesis. | Health | Anjana Rao, Martin R. Muller | |||
| Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide. | Health | Klaus Mann, Andreas Erhardt, Dieter Haussinger, Florian Lang, Erich Gulbins, Philipp A. Lang, Marcus Schenck, Jan P. Nicolay, Jan Ulrich Becker, Daniela S. Kempe, Adrian Lupescu, Saisudha Koka, Kerstin Eisele, Barbara A. Klarl, Herbert Rubben, Kurt W. Schmid, Sibylle Hildenbrand, Harald Hefter, Stephan M. Huber, Thomas Wieder | |||
| London hospital launches infectious disease 'biobank'.(Organization overview) | Health | Narelle Towie | |||
| Long-distance affair with adrenal GRK2 hangs up heart failure. | Health | Stephen B. Liggett | |||
| Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma.(phosphatase and tensin homolog) | Health | David Stokoe, Michael C. Jensen, Andrew T. Parsa, Ian F. Parney, Paul S. Mischel, James S. Waldron, Amith Panner, Courtney A. Crane, Jeffrey J. Barry, Kristine E. Cachola, Joseph C. Murray, Tarik Tihan, Russell O. Pieper | |||
| Lung turns to AA (adenosine analogues) to dry out. | Health | James L Kreindler, Steven D Shapiro | |||
| Magnetic resonance-guided, real-time targeted delivery and imaging of magnetocapsules immunoprotecting pancreatic islet cells.(Clinical report) | Health | Matthias Stuber, Jeff W.M. Bulte, Piotr Walczak, Brad P. Barnett, Aravind Arepally, Parag V. Karmarkar, Di Qian, Wesley D. Gilson, Valerie Howland, Leo Lawler, Cal Lauzon, Dara L. Kraitchman | |||
| Malaria's journey through the lymph node. | Health | Michael F. Good, Denise L. Doolan | |||
| Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors. | Health | Gerard I. Evan, Elizabeth R. Lawlor, Laura Soucek, Darya Soto, Ksenya Shchors, Lamorna Brown Swigart | |||
| Mast cells promote antherosclerosis by releasing proinflammatory cytokines. | Health | Peter Libby, Paul J. Wolters, Jiusong Sun, Galina K. Sukhova, Min Yang, Shiro Kitamoto, Lindsey A. MacFarlane, Jon Mallen-St Clair, Guo-Ping Shi | |||
| Merging mitochondria for neuronal survival. | Health | M. Flint Beal, Giovanni Manfredi | |||
| Microarrays: retracing steps.(research on human cancer cell lines) | Health | Jing Wang, Keith A. Baggerly, Kevin R. Coombs | |||
| MicroRNA-133 controls cardiac hypertrophy. | Health | Pilar Ruiz-Lozano, Yusu Gu, Oyvind Ellingsen, Cesare Peschle, Gianluigi Condorelli, Morten Hoydal, Alessandra Care, Daniele Catalucci, Gerald W Dorn II, Marie-Louise Bang, Kirk L Peterson, Carlo M Croce, Federica Felicetti, Desiree Bonci, Antonio Addario, Patrizia Segnalini, Paolo Gallo, Matteo A Russo, Nancy D Dalton, Leonardo Elia, Camillo Autore, Michael V G Latronico | |||
| Microscopes made from bamboo bring biology into focus. | Health | Paroma Basu | |||
| MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. | Health | Richard Bucala, Jurgen Bernhagen, Teake Kooistra, Andreas Schober, Christian Weber, Regina Krohn, Shaun R McColl, Hongqi Lue, Julia L Gregory, Michael J Hickey, Alma Zernecke, Rory R Koenen, Robert Kleeman, Manfred Dewor, Ivan Georgiev, Pietro Ghezzi, Lin Leng, Gunter Fingerle-Rowson | |||
| Molecular engineering approaches to peptide, polyketide and other antibiotics. | Health | Richard H. Baltz | |||
| Molecular imaging of Akt kinase activity. | Health | Eric C. Holland, Limin Zhang, Mahaveer S. Bhojani, Amjad P. Khan, Kuei C. Lee, Alla Shilman, Brian D. Ross, Alnawaz Rehemtulla | |||
| Molecular imaging of VEGF receptors in angiogenic vasculature with single-chain VEGF-based probes.(vascular endothelial growth factor) | Health | Francis G. Blankenberg, Marina V. Backer, Vimalkumar Patel, Zoya Levashova, Brian T. Jehning, Kevin Claffey, Joseph M. Backer | |||
| MRI detection of transcriptional regulation of gene expression in transgenic mice. | Health | Michal Neeman, Laura E. Benjamin, Batya Cohen, Keren Ziv, Vicki Plaks, Tomer Israely, Vyacheslav Kalchenko, Alon Harmelin | |||
| Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. | Health | Tom van der Poll, Thomas Vogl, Klaus Tenbrock, Stephan Ludwig, Nadja Leukert, Christina Ehrhardt, Marieke A.D. van Zoelen, Wolfgang Nacken, Dirk Foell, Clemens Sorg, Johannes Roth | |||
| Multifunctional [T.sub.H]1 cells define a correlate of vaccine mediated protection against Leishmania major. | Health | Robert A. Seder, Mario Roederer, Peter Andersen, Patricia A. Darrah, Dipti T. Patel, Paula M. De Luca, Ross W.B. Lindsay, Dylan F. Davey, Barbara J. Lynn, Soren T. Hoff, Steven G. Reed, Sheldon L. Morris | |||
| 'Multipurpose oxidase' in atherogenesis. | Health | Daniel J. Rader, Harry Ischiropoulos | |||
| Multi-targeting by monotherapeutic antibacterials. | Health | Lynn L. Silver | |||
| Muscle growth learns new tricks from an old dog. | Health | Gustavo A. Nader | |||
| Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-Cell leukemia. | Health | Juan Carlos Zuniga-Pflucker, Maria Dominguez, Carlos Cordon-Cardo, Ramon Parsons, Teresa Palomero, Maria Cortina, Pedro J. Real, Kelly Barnes, Maria Ciofani, Esther Caparros, Jean Buteau, Kristy Brown, Sherrie L. Perkins, Govind Bhagat, Archana M. Agarwal, Giuseppe Basso, Mireia Castillo, Satoru Nagase, Adolfo A. Ferrando | |||
| Mycobacterial virulence and specialized secretion: Same story, different ending. | Health | David R. Sherman, Marcel A. Behr | |||
| Mycobacterium tuberculosis virulence: Lipids inside and out. | Health | Sabine Ehrt, Dirk Schnappinger | |||
| Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. | Health | Terry B. Strom, Kai W. Wucherpfennig, Raymond A. Sobel, Vijay K. Kuchroo, Amit Awasthi, Estelle Bettelli, Wenda Gao, Thomas Korn, Mohamed Oukka, Troels R. Petersen, Jayagopala Reddy, Thomas B. Backstrom | |||
| Netting bacteria in sepsis. | Health | Arturo Zychlinsky, Constantin Urban | |||
| Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome. | Health | Michael D. Johnson, Stephen B. Baker, Lijun Li, Jason U. Tilan, Joanna B. Kitlinska, Lydia E. Kuo, Edward W. Lee, Mary Susan Burnett, Stanley T. Ficke, Zofia Zukowska, Herbert Herzog, Richard Kvetnansky | |||
| Neutralization of staphylococcal enterotoxin B by soluble, high-affinity receptor antagonists. | Health | Patrick M. Schlievert, Rebecca A. Buonpane, Hywyn R.O. Churchill, Beenu Moza, Sundberg Eric J., Marnie L. Peterson, David M. Kranz | |||
| New antibiotics from bacterial natural products. | Health | Jon Clardy, Christopher T. Walsh, Michael A. Fischbach | |||
| NF-[kappa]B in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF. | Health | Richard J. Zarbo, Bae Keun Park, Honglai Zhang, Qinghua Zeng, Jinlu Dai, Evan T. Keller, Thomas Giordano, Keni Gu, Veena Shah, Lei Pei, Laurie McCauley, Songtao Shi, Shaoqiong Chen, Cun-Yu Wang | |||
| Nifty transport device doubles durability of donor organs.(The LifePort) | Health | Alan Dove | |||
| Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography. | Health | Ronald Gordon, Valentin Fuster, Fabien Hyafil, Jean-Chritophe Cornily, Jonathan E Feig, Esad Vucic, Vardan Amirbekian, Edward A Fisher, Laurent J Feldman, Zahi A Fayad | |||
| Not so fast: adaptive suppression of innate immunity. | Health | Ruslan Medzhitov, Noah W. Palm | |||
| Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human. | Health | Andrea Superti-Furga, Tatsuya Furuichi, Nobuhiro Ishida, Kyoichi Isono, Haruhiko Koseki, Shiro Ikegawa, Hidenao Toyoda, David L. Rimoin, Shuichi Hiraoka, Gen Nishimura, Shunichi Shibata, Masaki Yanagishita, Peter G. Nikkels, Minako Ogawa, Kayoko Katsuyama, Akiko Kinoshita-Toyoda, Yutaka Sanai, Daniel H. Cohn | |||
| Orexins: Looking forward to sleep, back to addition. | Health | Clifford B. Saper, Thomas E. Scammell | |||
| Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets. | Health | Georgina Xanthou, Themis Alissafi, Maria Semitekolou, Davina C M Simoes, Vily Panoutsakopoulou, Erasmia Economidou, Mina Gaga, Bart N Lambrecht, Clare M Lloyd | |||
| Paging all doctors. | Health | Tinker Ready | |||
| Pathogens cooperate in lymphomagenesis.(Clinical report) | Health | David A. Thorley-Lawson, Karen A. Duca | |||
| Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair.(Clinical report) | Health | Mark T. Keating, Bernhard Kuhn, Federica del Monte, Roger J. Hajjar, Yuh-Shin Chang, Djamel Lebeche, Shima Arab | |||
| Peroxiredoxin-2 links Cdk5 to neurodegeneration. | Health | Serge Przedborski | |||
| Phosphoinositides' link to neurodegeneration. | Health | Laura Daley-Volpcelli, Pietro De Camili | |||
| Pim-1 regulates cardiomyocyte survival downstream of Akt. | Health | Anton Berns, Piero Anversa, Jan Kajstura, Annarosa Leri, Marcello Rota, Steven R. Houser, John A. Muraski, Yu Misao, Jenna Fransioli, Christopher Cottage, Natalie Gude, Grazia Esposito, Francesca Delucchi, Michael Arcarese, Roberto Alvarez, Sailay Siddiqi, Gregory N. Emmanuel, Weitao Wu, Kimberlee Fischer, Joshua J. Martindale, Christopher C. Glembotski, Nancy Magnuson, Remus M. Beretta, Erik M. Schaefer, Mark A. Sussman | |||
| Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection. | Health | Kypros H. Nicolaides, Charles R. Cantor, Tse N. Leung, Y.M. Dennis Lo, Nancy B.Y. Tsui, Rossa W.K. Chiu, Tze K. Lau, Macy M.S. Heung, Ageliki Gerovassili, Yongjie Jin, Chunming Ding | |||
| Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype. | Health | Maria Febbraio, Roy L. Silverstein, Brian R. Curtis, Stanley L. Hazen, Tatiana V. Byzova, Eugene A. Podrez, Robert G. Salomon, Yi Ma, Manojkumar Valiyqveettil, Eugenia Poliakov, Mingjiang Sun, Paula J. Finton, Juhua Chen, Renliang Zhang | |||
| Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. | Health | Paul Kubes, Stephen R. Clark, Adrienne C. Ma, Samantha A. Tavener, Braedon McDonald, Zahra Goodarzi, Margaret M. Kelly, Kamala D. Patel, Subhadeep Chakrabarti, Erin McAvoy, Gary D. Sinclair, Elizabeth M. Keys, Emma Allen-Vercoe, Rebekah DeVinney, Christopher J. Doig, Francis H.Y. Green | |||
| Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants. | Health | Bruce D. Walker, Norman L. Letvin, Robert Funkhouser, Beatrice H. Hahn, James Theiler, Carla Kuiken, Bette T. Korber, Will Fischer, Simon Perkins, Tanmoy Bhattacharya, Karina Yusim, Barton Haynes | |||
| Poring over pores: [alpha]-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia. | Health | Olaf Schneewind, Frank R. DeLeo, Juliane Bubeck Wardenburg, Taeok Bae, Michael Otto | |||
| Potti et al. reply:.(research on cancer cell lines) | Health | Joseph R. Nevins, Anil Potti | |||
| PPAR-[gamma] regulates osteoclastogenesis in mice. | Health | Ronald M. Evans, Yihong Wan, Ling-Wa Chong | |||
| Practical malaria tests promise results in remote regions. | Health | Emily Waltz | |||
| Premature poking: Impulsivity, cocaine and dopamine. | Health | George Uhl | |||
| Preventing kidney cell suicide.(antiapoptotic protein C to counteract kidney damage) | Health | Michael Brownlee | |||
| Pricey cancer genome project struggles with sample shortage.(Cancer Genome Atlas Project ) | Health | Emily Waltz | |||
| Promotion of sleep by targeting the orexin system in rats, dogs and humans. | Health | Catherine Brisbare-Roch, Jasper Dingemanse, Ralf Koberstein, Petra Hoever, Hamed Aissaoui, Susan Flores, Celia Muellar, Oliver Nayler, Joop van Gerven, Sanne L. de Haas, Patrick Hess, Changbin Qiu, Stephan Buchmann, Michael Scherz, Thomas Weller, Walter Fischli, Martine Clozel, Francois Jenck | |||
| Prospects for plant-derived antibacterials. | Health | Kim Lewis, Frederick M. Ausubel | |||
| Protein carbamylation links inflammation, smoking, uremia and atherogenesis. | Health | Eric J. Topol, Stanley L. Hazen, E. Rene Rodriguez, Sohvi Horkko, Stephen J. Nicholls, John Barnard, Zeneng Wang, Outi Kummu, Wanda F. Reynolds, Joseph A. DiDonato | |||
| Pulmonary barriers to pneumonia and sepsis. | Health | Michael A. Matthay, Xiao Su | |||
| Putting the heat on cancer.(role of heat shock factor in cancer) | Health | Paul Workman, Emmanuel de Billy | |||
| Real-time measurement of free [Ca.sup.2+] changes in CNS myelin by two photon microscopy. | Health | Ileana Micu, Andrew Rodsdale, Lingqing Zhang, John Woulfe, Jeff McClintock, Christine A. Brantner, S.Brian Andrews, Peter K. Stys | |||
| Receptor feasts on sugar and cholesterol. | Health | Pere Puigserver, Joseph T. Rodgers | |||
| Reformed US malaria program garners critics' approval. | Health | Charlotte Schubert | |||
| Regulatory T-cell development: Is Foxp3 the decider? | Health | Tyler J. Curiel | |||
| Reinventing phage therapy: Are the parts greater than the sum? | Health | Vincent A. Fischetti, Daniel Nelson, Raymond Schuch | |||
| Reply to 'Arsenic patent keeps drug for rare cancer out of reach for many'. | Health | Raymond P. Warrell Jr. | |||
| Reply to 'Must maternity medicine be reborn?'(Viewpoint essay) | Health | Jennifer Block | |||
| Reply to 'Poor trial design leaves gene therapy death a mystery'.(Jolee Mohr's death in gene therapy trial) | Health | H. Stewart Parker | |||
| Restoration of cone vision in a mouse model of achromatopsia. | Health | Bo Chang, Norman L. Hawes, John J. Alexander, Umino Yumiko, Drew Everhart, Seok H. Min, Qiuhong Li, Adrian M. Timmers, Ji-Jing Pang, Robert B. Barlow, William W. Hauswirth | |||
| Retinaldehyde: More than meets the eye. | Health | Beatrice Desvergne | |||
| Retinaldehyde represses adipogenesis and diet-induced obesity. | Health | Ouliana Ziourenkova, Gabriela Orasanu, Molly Sharlach, Taro E. Akiyama, Joel P. Berger, James A. Hamilton, Jason Viereck, Guangwen Tang, Gregory G. Dolnikowski, Silke Vogel, Jorge Plutzky, Gregg Duester | |||
| Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy. | Health | Ursula Grohmann, Claudia Volpi, Francesco Bistoni, Francesca Fallarino, Silvia Bozza, Maria C Fioretti, Roberta Bianchi, Carmine Vacca, Luigina Romani, Ciriana Orabona, Maria L Belladonna, Carlo Riccardi, Paolo Puccetti, Emira Ayroldi, Giuseppe Nocentini, Louis Boon | |||
| Rhesus monkey TRIM5[alpha] restricts HIV-1 production through rapid degradation of viral Gag polyproteins. | Health | Yasuhiro Ikeda, Ryuta Sakuma, Seiga Ohmine, Josh A Noser | |||
| Riboswitches as antibacterial drug targets. | Health | Ronald R. Breaker, Kenneth F. Blount | |||
| Rosacea: skin innate immunity gone awry?(Clinical report) | Health | Charles L. Bevins, Fu-Tong Liu | |||
| Schizophrenia drug says goodbye to dopamine.(Clinical report) | Health | Daniel R. Weinberger | |||
| Scientists stir the pot for the right to grow marijuana. | Health | Arran Frood | |||
| Secrets of a superbug.(research on pathogenesis of Staphylococcus) | Health | Franklin D. Lowy | |||
| Seeing what Alzheimer saw. | Health | Mony J. de Leon, Lisa Mosconi, Jean Logan | |||
| Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein. | Health | Amit Bar-Or, David A. Hafler, Lawrence Steinman, Kai W. Wucherpfennig, Vijay K. Kuchroo, Brenda Banwell, William H. Robinson, Estelle Bettelli, Chenqi Xu, Kevin C. O'Connor, Katherine A. McLaughlin, Philip L. De Jager, Tanuja Chitnis, Sunil V. Cherry, Hikoaki Fukaura, Toshiyuki Fukazawa, Silvia Tenembaum, Susan J. Wong, Norma P. Tavakoli, Zhannat Idrissova, Vissia Viglietta, Kevin Rostasy, Daniela Pohl, Russell C. Dale, Mark Freedman, Guy J. Buckle | |||
| Sema3a maintains normal heart rhythm through sympathetic innervation patterning. | Health | Satoshi Ogawa, Masahiko Taniguchi, Fumiyuki Hattori, Keiichi Fukuda, Keisuke Matsumura, Kensuke Kimura, Masaki Ieda, Hideaki Kanazawa, Yasuyo Ieda, Jong-Kook Lee, Yuichi Tomita, Shunichiro Miyoshi, Kouji Shimoda, Shinji Makino, Motoaki Sano, Itsuo Kodama | |||
| Sensitive cilia set up the kidney.(role of cilia in the protection of kidney) | Health | Emily Kim, Gerd Walz | |||
| Signaling out heart cells. | Health | Michael Basson | |||
| SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes. | Health | Marc Montminy, Hiroshi Takemori, Rebecca Berdeaux, Naomi Goebel, Laura Banaszynski, Thomas Wandless, Diane S Shelton | |||
| Skeletal remodeling in health and disease. | Health | Mone Zaidi | |||
| Spat over firing threatens medical school at US-Mexico border.(dismissal of Robert Suskind affects management of Texas Tech University) | Health | Brendan Borrell | |||
| STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression. | Health | Qian Zhang, Hong Y. Wang, Xiaobin Liu, Mariusz A. Wasik | |||
| Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease. | Health | Evan Y. Snyder, Terry D. Butters, Raymond A. Dwek, Frances M. Platt, Stuart A. Lipton, Jean-Pyo Lee, Jonathan Clarke, Gang Tong, Mylvaganam Jeyakumar, David Wenger, Rodolfo Gonzalez, Hiroto Takahashi, Pei-Jen Lee, Thomas N. Seyfried, Rena C. Baek, Dan Clark, Heather Rose, Philip Schwartz, Gerald Fu, Scott McKercher, Jennifer Meerloo, Franz-Josef Muller, Kook In Park | |||
| Straight talk from...Bruce Psaty.(Interview) | Health | Emma Morris | |||
| Straight talk from ... Victoria Hale.(founder of Institute for OneWorld Health - Victoria Hale)(Interview) | Health | Erika Check Hayden | |||
| Streptococcus pyogenes under pressure. | Health | Shiranee Sriskandan, Claire Turner | |||
| Stress, diet and abdominal obesity: Y? . | Health | James P. Warne, Mary F. Dallman | |||
| Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. | Health | Masaki Kobayashi, Kazuyuki Tobe, Takashi Kadowaki, Philippe Froguel, Toshimasa Yamauchi, Junji Kamon, Yusuke Ito, Atsushi Tsuchida, Masaki Tsunoda, Ryozo Nagai, Tomohiro Ide, Yasunori Nio, Toshiyuki Maki, Takeshi Takazawa, Masato Iwabu, Miki Okada-Iwabu, Sachiko Kawamoto, Naoto Kubota, Tetsuya Kubota, Katsuyoshi Kumagai, Hideki Kozono, Yusuke Hada, Hitomi Ogata, Kumpei Tokuyama, Kouji Murakami, Motoharu Awazawa, Iseki Takamoto, Hara Kazuo, Ueki Kohjiro | |||
| Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemia. | Health | Hugues de The, Hind Medyyouf, Caroline Berthier, Marie Claude Guillemin, Helene Alcalde, Nuno R. dos Santos, Anne Janin, Didier Decaudin, Jacques Ghysdael | |||
| Targeting the NF-[kappa]B signaling pathway in Notch1-induced T-cell leukemia. | Health | Lucio Miele, Maria-Luisa Alegre, Tomas Vilimas, Joaquina Mascarenhas, Teresa Palomero, Malay Mandal, Silvia Buonamici, Fanyong Meng, Benjamin Thompson, Christina Spaulding, Sami Macaroun, Barbara L. Kee, Adolfo Ferrando, Iannis Aifantis | |||
| T cell-encoded CD80 and 4-1 BBL induce auto- and transcostimulation, resulting in potent tumor rejection. | Health | Michel Sadelain, Glenn Heller, Renier J. Brentjens, Vladimir Ponomarev, Alex H. Chang, Mattthias T. Stephan, Konstantin V. Dobrenkov | |||
| Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment. | Health | Hong Jiang, Andreas Trumpp, Chozhavendan Rathinam, Christoph Klein, Zhenyu Ju, Maike Jaworski, Anne Gompf, Lenhard K. Rudolph | |||
| The ABCs of [beta]-cell dysfunction in type 2 diabetes. | Health | Clay F. Semenkovich, Manu V. Chakravarthy | |||
| The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas. | Health | Nicholas D. Socci, Carlos Cordon-Cardo, Li Ma, Eva Hernando, Nille Behrendt, Robert G. Maki, Elizabeth Charytonowicz, Maria E. Dudas, Silvia Menendez, Igor Matushansky, Joslyn Mills, Paolo Pandolfi | |||
| The antibacterial drugs market. | Health | Hedwig Kresse, Holger Rovini, Mark J. Belsey | |||
| The artificial heart valve. | Health | Albert Starr | |||
| The business of developing antibacterials.(Drug overview) | Health | Jeffrey L. Fox | |||
| The clot thickens - oxidized lipids and thrombosis. | Health | Shaun P. Jackson, Anna C. Calkin | |||
| The clot thickens - oxidized lipids and thrombosis. | Health | Shaun P. Jackson, Anna C. Calkin | |||
| The curiosity of IL-15.(Clinical report) | Health | Peter A. Ward | |||
| The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers. | Health | Shane Cronin, Josef M. Penninger, Peter P. Liu, Teiji Wada, Hiromitsu Hara, Renu Sarao, Liyong Zhang, Michael S. Anglesio, Maureen O'Sullivan, Fan Zhang, Ge Yang, Mai P. Nghiem, Nataliya Melnyk, Liheng Li, Jason Farrar, Robert J. Arceci, Poul H. Sorensen | |||
| The expanding global health agenda: a welcome development. | Health | Anthony S. Fauci | |||
| The hydrogen highway to reperfusion therapy. | Health | Mark T. Gladwin, Katherine C. Wood | |||
| The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2. | Health | Ying Zhang, Baofeng Yang, Huixian Lin, Jiening Xiao, Yanjie Lu, Xiaobin Luo, Baoxin Li, Chaoqian Xu, Yunlong Bai, Huizhen Wang, Guohao Chen, Zhiguo Wang | |||
| The open book of infectious diseases. | Health | Eric J. Rubin, Christopher M. Sassetti | |||
| The problem with upward mobility.(psoriasis )(Disease/Disorder overview) | Health | James T. Elder, Johann E. Gudjonnson | |||
| Therapeutic differentiation and maturation of lymphatic vessels after node dissection and transplantation. | Health | Seppo Yla-Herttuala, Kari Alitalo, Tuomas Tammela, Tatiana V. Petrova, Anne Saaristo, Tanja Holopainen, Johannes Lyytikka, Anna Kotronen, Miia Pitkonen, Usama Abo-Ramadan | |||
| Therapeutic targeting of innate immunity with toll-like receptor agonists and antagonists. | Health | Holger Kanzler, Franck J Barrat, Edith M Hessel, Robert L Coffman | |||
| The role of autophagy in cardiomyocytes in the basal state and in response to homodynamic stress. | Health | Masatsugu Hori, Noboru Mizushima, Osamu Yamaguchi, Kinya Otsu, Atsuko Nakai, Toshihiro Takeda, Yoshiharu Higuchi, Michio Asahi, Kazuhiko Nishida, Shungo Hikoso, Masayuki Taniike, Shigemiki Omiya, Isamu Mizote, Yasushi Matsumura | |||
| The surprising rise of nonthrombogenic valvular surgery. | Health | Alain Carpentier | |||
| The survival kit of Mycobacterium tuberculosis. | Health | Valerie Mizrahi, Digby F. Warner | |||
| The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation. | Health | Allan M. Weissman, Chand Khanna, Stephen M. Hewitt, Arnulfo Mendoza, Ming Zhou, Lee J. Helman, Yien Che Tsai, Jennifer M. Mariano, Zlatka Kostova, Bo Chen, Timothy Veenstra | |||
| The US pandemic influenza implementation plan at six months. | Health | Stephen S. Morse | |||
| TLR4 enhances TGF-beta signaling and hepatic fibrosis. | Health | Ekihiro Seki, Samuele De Minicis, Christoph H. Osterreicher, Johannes Kluwe, Yosuke Osawa, David A. Brenner, Robert F. Schwabe | |||
| TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity. | Health | Bruce Beutler, Kasper Hoebe, Roberto Baccala, Dwight H Kono, Argyrios N Theofilopoulos | |||
| Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy.(Clinical report) | Health | Guido Kroemer, Paul Saftig, Thomas Tursz, Sebastian Amigorena, Laurence Zitvogel, Virginie Joulin, Huan Yang, Patrick Saulnier, Francoise Clavel-Chapelon, Catherine Nogues, Lionel Apetoh, Evelyn Ullrich, Francois Ghiringhelli, Bernard Ryffel, Michel Obeid, Antoine Tesniere, Gregoire Mignot, Carla Ortiz, Alfredo Cariollo, M. Chiara Maiuri, Franck J. Barrat, Francis Levi, Rosette Lidereau, Jean Bourhis, Jean-Paul Mira, Agnes Chompret, Fabrice Andre, Suzette Delaloge | |||
| Trials race rashly ahead for regulatory immune cells. | Health | Douglas Braaten | |||
| [T.sub.H]17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. | Health | Robert B. Nussenblatt, Ahjoku Amadi-Obi, Cheng-Rong Yu, Xuebin Liu, Rashid M. Mahdi, Grace Levy Clarke, Igal Gery, Yun Sang Lee, Charles E. Egwuagu | |||
| Tuberculosis, a neglected opportunity? | Health | Claire Harper | |||
| Tumor-induced anorexia and weight loss are mediated by the TGF-[beta] superfamily cytokine MIC-1. | Health | Mark Hunter, Samuel N. Breit, David A. Brown, Matthew J. During, Herbert Herzog, Heiko Johnen, Shu Lin, Tamara Kuffner, Vicky Wang-Wei Tsai, Asne R. Bauskin, Liyun Wu, Greg Pankhurst, Lele Jiang, Simon Junankar, W. Douglas Fairlie, Nicola J. Lee, Ronaldo F. Enriquez, Paul A. Baldock, Eva Corey, Fred S. Apple, MaryAnn M. Murakami, En-Ju Lin, Chuansong Wang, Amanda Sainsbury | |||
| Turning skin into embryonic stem cells. | Health | Howard Y. Chang, George Cortsarelis | |||
| Type II monocytes modulate T cell-mediated central nervous system autoimmune disease.(Clinical report) | Health | Linda Lee, Lawrence Steinman, Scott S. Zamvil, Martin S. Weber, Thomas Prod'homme, Sawsan Youssef, Shannon E. Dunn, Cynthia D. Rundle, Juan C. Patarroyo, Olaf Stuve, Raymon A. Sobel | |||
| Uninformed consent? | Health | ||||
| Vaccine leads to memory loss. | Health | John B.A.G. Haanen, Ton N.M. Schumacher | |||
| Waltzing transporters and 'the dance macabre' between humans and bacteria. | Health | Olga Lomovskaya, Helen I. Zgurskaya, Maxim Totrov, William J. Watkins | |||
| Waltzing transporters and 'the dance macabre' between humans and bacteria. | Health | J.S.M. Peiris, Y. Guan, J.M. Nicholls, M.C.W. Chan, W.Y. Chan, H.K. Wong, C.Y. Cheung, D.L.W. Kwong, M.P. Wong, W.H. Chui, I.I.M. Poon, S.W. Tsao | |||
| Where have all the antibiotic patents gone?(decrease in antibiotic research are examined ) | Health | Martin L. Katz, Lisa V. Mueller, Mark Polyakov, Steven F. Weinstock | |||
| Where lies the blame for resistance-tumor or host? | Health | Charles L. Sawyers | |||
| Worms tame mast cells.(activation of mast cells is controlled by roundworm protein) | Health | Edward J. Pearce | |||
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