| Genes & Development 1999 |
| Title | Subject | Authors |
|---|
| A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development. | Biological sciences | Patricia Ducy, Michael Amling, Matthias Priemel, Jianhe Shen, Gerard Karsenty, Valerie Geoffroy, Michael Starbuck, Gerald Pinero |
| A cell-counting factor regulating structure size in Dictyostelium.(Statistical Data Included) | Biological sciences | Debra A. Brock, Richard H. Gomer |
| ACF consists of two subunits, Acf1 and ISWI, that function cooperatively in the ATP-dependent catalysis of chromatin assembly. | Biological sciences | Takashi Ito, James T. Kadonaga, Dmitry V. Fyodorov, Ryuji Kobayashi, Mark E. Levenstein, Alan K. Kutach |
| A cis-acting element in the 3'-untranslated region of human TNF-alpha mRNA renders splicing dependent on the activation of protein kinase PKR.(Statistical Data Included) | Biological sciences | Raymond Kaempfer, Yitzhak Ben-Asouli, Farhat Osman, Nayef Jarrous |
| Activation and centromeric localization of CCAAT/enhancer-binding proteins during the mitotic clonal expansion of adipocyte differentiation.(Statistical Data Included) | Biological sciences | Qi-Qun Tang, M. Daniel Lane |
| Activation of dormant origins of DNA replication in budding yeast.(Statistical Data Included) | Biological sciences | John F.X. Diffley, Corrado Santocanale, Karuna Sharma |
| Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress. | Biological sciences | Leroy F. Liu, Allen Y. Chen, Yong Mao, Tsai-Kun Li, Chiang Yu, Huimin Wang |
| A functional interaction between the histone deacetylase Rpd3 and the corepressor Groucho in Drosophila development.(Statistical Data Included) | Biological sciences | Albert J. Courey, Guoqing Chen, Joseph Fernandez, Sheenah Mische |
| A GATA-2/estrogen receptor chimera functions as a ligand-dependent negative regulator of self-renewal.(Statistical Data Included) | Biological sciences | Tariq Enver, Clare Heyworth, Karin Gale, Michael Dexter, Gillian May |
| A G-protein signaling network mediated by an RGS protein.(Statistical Data Included) | Biological sciences | Min Han, Kun-Liang Guan |
| A large-scale insertional mutagenesis screen in zebrafish.(Statistical Data Included) | Biological sciences | Nancy Hopkins, Zhaoxia Sun, Adam Amsterdam, Wenbiao Chen, Shawn Burgess, Gregory Golling, Karen Townsend, Sarah Farrington, Maryann Haldi |
| Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome.(Statistical Data Included) | Biological sciences | Christine Guthrie, Catherine A. Collins |
| Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4 (ital).(Statistical Data Included) | Biological sciences | Gary Ruvkun, Cornelia I. Bargmann, Alvaro Sagasti, Oliver Hobert, Emily R. Troemel |
| A mechanism of repression of TGFB/Smad signaling by oncogenic Ras.(cytokine) | Biological sciences | Joan Massague, Jacqueline Doody, Marcus Kretzschmar, Inna Timokhina |
| Amino-terminal sequences of sigma-N (sigma-54) inhibit RNA polymerase isomerization. | Biological sciences | Martin Buck, Paul Casaz, Wendy Cannon, Maria-Trinidad Gallegos |
| Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.(Statistical Data Included) | Biological sciences | Adrian Bird, Danny Reinberg, Yi Zhang, Hediye Erdjument-Bromage, Paul Tempst, Huck-Hui Ng |
| An HMG1-like protein facilitates Wnt signaling in 'Caenorhabditis elegans'. | Biological sciences | Paul W. Sternberg, Lily I. Jiang |
| A novel p34(super.cdc2)-binding and activating protein that is necessary and sufficient to trigger G2/M progression in Xenopus oocytes.(Statistical Data Included) | Biological sciences | |
| A novel property of the RecA nucleoprotein filament: activation of double-stranded DNA for strand exchange in trans(ital).(Statistical Data Included) | Biological sciences | Stephen C. Kowalczykowski, Alexander V. Mazin |
| An RNA thermometer. | Biological sciences | Gisela Storz |
| Antagonism between G(sub.o)alpha and G (sub.q)alpha in Caenorhabditis elegans: The RGS protein EAT-16 is necessary for G(sub.o)alpha signaling and regulates G (sub.q)alpha activity.(Statistical Data Included) | Biological sciences | Michael R. Koelle, Paul W. Sternberg, Yvonne M. Hajdu-Cronin, Wen J. Chen, Georgia Patikoglou |
| Antagonism between RSF1 and SR proteins for both splice-site recognition in vitro and Drosophila development. | Biological sciences | Henri-Marc Bourbon, Jamal Tazi, Emmanuel Labourier, Imed-eddine Gallouzi, Maggy Fostier, Eric Allemand |
| Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development. | Biological sciences | Raju Kucherlapati, Winfried Edelmann, Ray White, Riccardo Fodde, P. Meera Khan, Ron Smits, Menno F. Kielman, Cor Breukel, Chris Zurcher, Kristi Neufeld, Shantie Jagmohan-Changur, Nandy Hofland, Jaap van Dijk |
| A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. | Biological sciences | Gary Ruvkun, Alex Toker, James H. Thomas, Michael Ailion, Suzanne Paradis |
| A plethora of lesion-replicating DNA polymerases.(Statistical Data Included) | Biological sciences | Roger Woodgate |
| A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction. | Biological sciences | Min Han, Meera Sundaram, Derek S. Sieburth, Robyn M. Howard |
| A protein phosphatase functions to recycle RNA polymerase II. | Biological sciences | William S. Lane, Danny Reinberg, Helen Cho, Tae-Kyung Kim, Helena Mancebo, Osvaldo Flores |
| A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila.(Statistical Data Included) | Biological sciences | Hugo J. Bellen, Louise O'Keefe, Yuchun He, Robert Saint, Sergei N. Prokopenko, Anthony Brumby, Leanne Prior |
| A putative protein complex consisting of Ctf19, Mcm21, and Okp1 represents a missing link in the budding yeast kinetochore. | Biological sciences | Olaf Stemmann, Johannes Lechner, Jennifer Ortiz, Simone Rank |
| Arabidposis STERILE APETALA (ital), a multifunctional gene regulating inflorescence, flower, and ovule development. | Biological sciences | Mark G.M. Aarts, Marina V. Byzova, John Franken, Janice de Almeida-Engler, Gilbert Engler, Celestina Mariani, Michiel M. Lookeren Campagne, Gerco C. Angenent |
| A role for ATR in the DNA damage-induced phosphorylation of p53. | Biological sciences | Sheau-Yann Shieh, Yoichi Taya, Randal S. Tibbetts, Kathryn M. Brumbaugh, Robert T. Abraham, William A. Cliby, Josie M. Williams, Jann N. Sarkaria, Carol Preves |
| A role for RAD51 and homologous recombination in Trypanosoma brucei antigenic variation.(Statistical Data Included) | Biological sciences | Richard McCulloch, J. David Barry |
| A role for the Cdc7 kinase regulatory subunit Dbf4p in the formation of initiation-competent origins of replication.(Statistical Data Included) | Biological sciences | Susan M. Gasser, Philippe Pasero, Bernard P. Duncker, Etienne Schwob |
| A specific protein-protein interaction accounts for the in vivo substrate selectivity of Ptp3 towards the Fus3 MAP kinase.(Statistical Data Included) | Biological sciences | Kun-Liang Guan, Xiao-Li Zhan |
| Assembly of functionally active Drosophila origin recognition complex from recombinant proteins. | Biological sciences | Michael Botchan, Igor Chesnokov, Manfred Gossen, Dirk Remus |
| Assembly of the Escherichia coli RuvABC resolvasome directs the orientation of Holliday junction resolution.(Statistical Data Included) | Biological sciences | Alain J. van Gool, Andrzej Stasiak, Stephen C. West, Nasser M.A. Hajibagheri |
| Association of Chk1 with 14-3-3 proteins is stimulated by DNA damage. | Biological sciences | Lin Chen, Ting-Hsiu Liu, Nancy C. Walworth |
| Asymmetric and node-specific nodal (ital) expression patterns are controlled by two distinct cis-acting regulatory elements. | Biological sciences | Elizabeth J. Robertson, Dominic P. Norris |
| ATP-dependent remodeling and acetylation as regulators of chromatin fluidity. | Biological sciences | Robert E. Kingston, Geeta J. Narlikar |
| atSRp30, one of two SF2/ASF-like proteins from Arabidopsis thaliana, regulates splicing of specific plant genes. | Biological sciences | Adrian R. Krainer, Ryuji Kobayashi, Silke Dorner, Sergiy Lopato, Maria Kalyna, Andrea Barta |
| A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedeghog signaling pathways. | Biological sciences | Tom Maniatis |
| Axis determination by inhibition of Wnt signaling in Xenopus.(Statistical Data Included) | Biological sciences | Sergei Y. Sokol, Keiji Itoh |
| A zinc-binding site in the largest subunit of DNA-dependent RNA polymerase is involved in enzyme assembly.(Statistical Data Included) | Biological sciences | Konstantin Severinov, Arkady Mustaev, Dmitriy Markov, Tatyana Naryshkina |
| Bacterial promoter architecture: subsite structure of UP elements and interactions with the carboxy-terminal domain of the RNA polymerase alpha subunit.(upstream elements and interactions)(Statistical Data Included) | Biological sciences | Richard H. Ebright, Wilma Ross, Richard L. Gourse, Tamas Gaal, Wei Niu, Shawn T. Estrem, Z.W. Susan Chen |
| Balancing import and export in development. | Biological sciences | Markus Affolter, Thomas Marty, M. Alessandra Bigano |
| BCL-2 family members and the mitochondria in apoptosis.(Statistical Data Included) | Biological sciences | Stanley J. Korsmeyer, Atan Gross, James M. McDonnell |
| Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25. | Biological sciences | Akiko Kumagai, William G. Dunphy |
| Binding of hnRNP H to an exonic splicing silencer is involved in the regulation of alternative splicing of the rat beta-tropomyosin gene. | Biological sciences | David M. Helfman, Ryuji Kobayashi, Charlie Degui Chen |
| Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.(Statistical Data Included) | Biological sciences | Anton Berns, Maarten van Lohuizen, Jacqueline J.L. Jacobs, Karin Kieboom, Blanca Scheijen, Jan-Willem Voncken |
| Bmp4 is required for the generation of primordial germ cells in the mouse embryo. | Biological sciences | Christopher V.E. Wright, N. Ray Dunn, Brigid L.M. Hogan, Kirstie A. Lawson, Bernard A.J. Roelen, Laura M. Zeinstra, Angela M. Davis, Jeroen P.W.F.M. Korving |
| Brachyury downstream notochord differentiation in the ascidian embryo.(ST) | Biological sciences | Michael Levine, Hiroki Takahashi, Nori Satoh, Robert W. Zeller, Kohji Hotta, Albert Erives, Anna Di Gregorio |
| c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF.(platelet-derived growth factor)(Statistical Data Included) | Biological sciences | Andrius Kazlauskas, Ann Marie Pendergast, Lisa Kadlec, Rina Plattner, Kris A. DeMali |
| Caspase-9 and APAF-1 form an active holoenzyme.(Statistical Data Included) | Biological sciences | Yuri Lazebnik, Joe Rodriguez |
| Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc23. | Biological sciences | Raymond J. Deshaies, Marta Galova, Kim Nasmyth, Yong Chi, Anna Shevchenko, Andrej Shevchenko, Wolfgang Zachariae, Craig C. Correll, Jae Hong Seol, R.M.Renny Feldman, Jonathan Claypool, Suzanne Sandmeyer, Svetlana Lyapina |
| CDK inhibitors: positive and negative regulators of G(sub.1)-phase progression.(first gap phase)(ST) | Biological sciences | James M. Roberts, Charles J. Sherr |
| Cell cycle-regulated histone acetylation required for expression of the yeast HO gene. | Biological sciences | C. David Allis, Jocelyn E. Krebs, Craig L. Peterson, Min-Hao Kuo |
| Cellular survival: a play in three Akts.(Statistical Data Included) | Biological sciences | Sandep Robert Datta |
| Characterization of the Imitation Switch subfamily of ATP-dependent chromatin-remodeling factors in Saccaromyces cerevisiae. | Biological sciences | Carl Wu, Toshio Tsukiyama, Joseph Shiloach, Jeffrey Palmer, Carolyn C. Landel |
| Chromatin remodeling and activation of chromosomal DNA replication by an acidic transcriptional activation domain from BRCA1. | Biological sciences | Rong Li, Ya-Fen Hu, Zhong Lin Hao |
| Cleavage of the death domain kinase RIP by Caspase-8 prompts TNF-induced apoptosis. | Biological sciences | Yong Lin, Anne Devin, Yolanda Rodriguez, Zheng-gang Liu |
| c-Myb is essential for early T cell development. | Biological sciences | Robert D. Allen III, TImothy P. Bender, Gerald Siu |
| c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release. | Biological sciences | Trevor Littlewood, Philippe Juin, Gerard Evan, Anne-Odile Hueber |
| Collisions between yeast chromosomal loci in vivo are governed by three layers of organization.(Statistical Data Included) | Biological sciences | Nancy Kleckner, Sean M. Burgess |
| Comparative synteny cloning of zebrafish you-too: mutations in the Hedgehog target gli2 affect ventral forebrain patterning. | Biological sciences | Alexander F. Schier, William S. Talbot, Rolf O. Karlstrom |
| Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion.(Statistical Data Included) | Biological sciences | Philippe Soriano, Nicholas W. Gale, Richard A. Klinghoffer, Alice Davy, Elizabeth W. Murray, Claude Feuerstein, Stephen M. Robbins |
| Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle.(Statistical Data Included) | Biological sciences | Raymond J. Deshaies, Ellen Freed, Peter K. Jackson, Tim Stearns, Kathleen R. Lacey, Philip Huie, Svetlana A. Lyapina |
| Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation. | Biological sciences | Alexander F. Schier, Michael M. Shen, William S. Talbot, Rebecca D. Burdine, Kira Gristman, Yu-Ting Yan, Jixiang Ding, JoMichelle D. Corrales, Sandy M. Price |
| Control of cell cycle progression by c-Jun is p-53 dependent. | Biological sciences | Michael Karin, Erwin F. Wagner, Axel Szabowski, Andrea Kolbus, Martin Schreiber, Fabrice Piu, Uta Mohle-Steinlein, Jianmin Tian, Angel Peter |
| Control of the nuclear localization of Extradenticle by competing nuclear import and export signals. | Biological sciences | Richard S. Mann, Muna Abu-Shaar, Hyung Don Ryoo |
| Core promoter elements can regulate transcription on a separate chromosome in trans. | Biological sciences | James R. Morris, Pamela K. Geyer, Chao-ting Wu |
| "Cre"-ating mouse mutants - a meeting review on conditional mouse genetics.(review at National Cancer INsitute-sponsored workshop on Conditional genetic Technologies in the Mouse and contains Web address) | Biological sciences | Janet Rossant, Andrew McMahon |
| Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survivial and patterning of the first branchial arch.(Statistical Data Included) | Biological sciences | John L.R. Rubenstein, Gail R. Martin, J. Michael Bishop, Andreas Trumpp, Michael J. Depew |
| Critical role for Atm in suppressing V(D)J (ital) recombination-driven thymic lymphoma. | Biological sciences | Terry Van Dyke, Mai-Jing Liao |
| Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface.(d)(Statistical Data Included) | Biological sciences | Phillip A. Sharp, Carl O. Pabo, Daniel Chasman, Karyn Cepek |
| Crystal structure of the conserved core of the herpes simplex virus transcriptional regulatory protein VP16.(Statistical Data Included) | Biological sciences | Winship Herr, Xiaodong Cheng, Yu Liu, Weimin Gong, C. Chris Huang |
| Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding. | Biological sciences | H. Eric Xu, Wenqing Xu, Jonathan A. Epstein, Carl O. Pabo, Richard L. Maas, Mark A. Rould |
| Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNA. | Biological sciences | Adrian R. Krainer, Rui-Ming Xu, Ying Zhang, Jianzhong Ding, Mariko K. Hayahsi, Manche Lisa |
| Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery.(chromosome transmission fidelity) | Biological sciences | Philip Hieter, Doug Koshland, Robert V. Skibbens, Laura B. Corson |
| Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells.(Statistical Data Included) | Biological sciences | James M. Roberts, Bruce Clurman, Jeffrey D. Singer, Mark Guirian-West |
| Culprits in the degradation of cyclin E apprehended.(Cullin genes)(Statistical Data Included) | Biological sciences | J. Wade Harper, Jeffrey T. Winston, Claire Chu |
| Cyclin-dependent kinase and Cks/Suc1 interact with the proteasome in yeast to control proteolysis of M-phase targets. | Biological sciences | Peter Kaiser, Steven I. Reed, Mark H. Watson, Eric Bailly, Duncan J. Clarke, Bonnie L. Bertolaet, Vincent Momcollin |
| Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta. | Biological sciences | Sudhansu K. Dey, Jason D. Morrow, David E. Moller, Rajnish A. Gupta, James M. Trzaskos, Hyunjung Lim, Bibhash C. Paria, Wen-ge Ma, Raymond N. DuBoise |
| Cytosine methylation and mammalian development. | Biological sciences | Timothy H. Bestor, Colum P. Walsh |
| Defects in Saccharomyces cerevisiae protein phosphatase type I activate the spindle/kinetochore checkpoint. | Biological sciences | Kelly Tatchell, Andrew Bloecher |
| Dephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases.(Statistical Data Included) | Biological sciences | Mark J. Solomon, Karen E. Ross, Philipp Kaldis, Aiyang Cheng |
| Determination of left-right asymmetric expression of nodal (ital) by a left side-specific enhancer with sequence similarity to a lefty-2 (ital) enhancer. | Biological sciences | Yukio Saijoh, Kyoko Mochida, Hiroshi Hamada, Sachiko Ohishi, Hitoshi Adachi, Akiko Hirao, Hiromi Hashiguchi |
| Developmental regulation of SR protein phosphorylation and activity.(ST) | Biological sciences | Jeremy R. Sanford, James P. Bruszik |
| Different upstream transcriptional activators have distinct coactivator requirements.(Statistical Data Included) | Biological sciences | John T. Lis, Dong-ki Lee, Soyoun Kim |
| Direct interaction of hematopoietic transcription factors PU-1 and GATA-1: functional antagonism in erythroid cells. | Biological sciences | Arthur I. Skoultchi, Natasha Rekhtman, Farshid Radparvar, Todd Evans |
| Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis.(Statistical Data Included) | Biological sciences | John L. Cleveland, Martine F. Roussel, Charles J. Sherr, Christine M. Eischen, Jason Weber D. |
| Distinct transcriptional regulatory mechanisms underlie left-right asymmetric expression of lefty-1 and lefty-2. | Biological sciences | Yukio Saijoh, Kyoko Mochida, Hiroshi Hamada, Sachiko Ohishi, Hitoshi Adachi, Akiko Hirao |
| Dorsoventral patterning in plants. | Biological sciences | Martin F. Yanofsky, Allen Sessions |
| Double-strand-break repair recombination in Escherichia coli: physical evidence for a DNA replication mechanism in vivo.(Statistical Data Included) | Biological sciences | |
| Double-strand end repair via the RecBC pathway in Escherichia coli primes DNA replication. | Biological sciences | Franklin W. Stahl, Andrei Kuzminov |
| Drosophila ORC specifically binds to ACE3, an origin of DNA replication control element.(origin recognition complex)(Statistical Data Included) | Biological sciences | Terry L. Orr-Weaver, Stephen P. Bell, Richard J. Austin |
| Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway.(Statistical Data Included) | Biological sciences | Marek Mlodzik, Nuria Paricio, Clive Wilson, Deborah C.I. Goberdhan, Emma C. Goodman |
| ebi regulates epidermal growth factor receptor signaling pathways in Drosophila. | Biological sciences | Michael Lin, Kenton H. Zavitz, Xinzhong Dong, S. Lawrence Zipursky, Leo Tsuda, Richard W. Carthew, Songui Li |
| ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway.(Statistical Data Included) | Biological sciences | Ruslan Medzhitov, Charles A. Janeway, Sankar Ghosh, Changchun Xiao, Elizabeth Kopp, James Carothers, Iris Douglas |
| ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system. | Biological sciences | Jack D. Keene, Jeffrey Wilusz, Lance P. Ford, Janice Watson |
| ELAV tumor antigen, Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human teratocarcinoma cells. | Biological sciences | Jack D. Keene, Dragana Antic, Ning Lu |
| Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants.(Statistical Data Included) | Biological sciences | Thomas Cech, Katherine L. Friedman |
| Excision of micronuclear-specific DNA requires parental expression of Pdd2p and occurs independently from DNA replication in Tetrahymena thermophila.(Statistical Data Included) | Biological sciences | C. David Allis, James F. Smothers, Martin A. Gorovsky, Mikhail A. Nikiforov |
| FGF signaling inhibits chrondrocyte proliferation and regulates bone development through the STAT-1 pathway. | Biological sciences | David Levy, Claudio Basilico, Alka Mansukhani, Malika Sahni, Davide-Carlo Ambrosetti, Rachel Gertner |
| FILAMENTOUS FLOWER (ital), a meristem and organ identity gene of Arabidopsis, encodes a protein with a zinc finger and HMG-related domains. | Biological sciences | Koji Goto, Kiyotaka Okada, Shinichiro Sawa, Keiro Watanabe, Eiko Kanaya, Eugene Hayato Morita |
| Fission yeast condensin complex: essential roles of non-SMC subunits for condensation and Cdc2 phosphorylation of Cut3/SMC4.(Statistical Data Included) | Biological sciences | Mitsuhiro Yanagida, Naoshi Dohmae, Koji Takio, Takeshi Tomonaga, Tatsuro Yuasa, Takashi Sutani |
| From insect eye to vertebrate muscle: redeployment of a regulatory network.(Statistical Data Included) | Biological sciences | Margaret Buckingham, Frederic Relaix |
| Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation.(Statistical Data Included) | Biological sciences | Julie Lessard, Guy Sauvageau, Maarten van Lohuizen, Terry Magnuson, Armin Schumacher, Unnur Thorsteindottir |
| Functional interactions between a phage histone-like protein and a transcriptional factor in regulation of phi29 early-late transcriptional switch. | Biological sciences | Margarita Salas, Montserrat Elias-Arnanz |
| Functional interactions of Prp8 with both splice sites at the spliceosomal catalytic center.(Statistical Data Included) | Biological sciences | Maria M. Konarska, Miroslawa Siatecka, Jose L. Reyes |
| Functional requirement of p23 and Hsp90 in telomerase complexes.(molecular chaperones) | Biological sciences | Jerry W. Shay, David O. Toft, Woodring E. Wright, Michael A. White, Shawn E. Holt, Dara L. Aisner, Joseph Bauer, Valerie M. Tesmer, Marife Dy, Michel Ouellette, James B. Trager, Gregg B. Morin |
| Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. | Biological sciences | Andrew L. Kung, David M. Livingston, Shoumo Bhattacharya, Man-Kit Leung, Zoltan P. Arany, Catherine L. Michels |
| GalR mutants defective in repressosome formation. | Biological sciences | Sankar Adhya, Mark Geanocopoulos, George Vasmatzis, Dale E.A. Lewis, Siddartha Roy, Byungkook Lee |
| Gata5 is required for the development of the heart and endoderm in zebrafish.(Statistical Data Included) | Biological sciences | Jeremy F. Reiter, Jonathan Alexander, Deborah Yelon, Didier Y.R. Stainier, Adam Rodaway, Roger Patient, Nigel Holder |
| Genes regulating dendritic outgrowth, branching, and routing in Drosophila. | Biological sciences | Jay E. Brenman, Fen-Biao Gao, Lily Yeh Jan, Yuh Nung Jan |
| Gene targeting in the silkworm by use of a baculovirus. | Biological sciences | Hajime Mori, Masafumi Yamao, Nagakazu Katayama, Hiroshi Nakazawa, Minoru Yamakawa, Yoshiyuki Hayashi, Saburo Hara, Kaeko Kamei |
| Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, Angiopoietins, and ephrins in vascular development. | Biological sciences | George D. Yancopoulos, Nicolas W. Gale |
| Heat shock-induced activation of stress MAP kinase is regulated by threonine and tyrosine-specific phosphatases.(Statistical Data Included) | Biological sciences | Kazuhiro Shiozaki, Aaron Ngocky Nguyen |
| Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis. | Biological sciences | Masayuki Komada, Philippe Soriano |
| Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing. | Biological sciences | Robin Reed, Katrin Chua |
| IAP family proteins - suppressors of apoptosis.(inhibitor of Apoptosis) | Biological sciences | John C. Reed, Quinn L. Deveraux |
| Identification of a novel mechanism of regulation of Ah (dioxin) receptor function. | Biological sciences | Masatsugu Ema, Junsei Mimura, Kazuhiro Sogawa, Yoshiaki Fujii-Kuryama |
| Identification of an SCF ubiquitin-ligase complex required for auxin response in Arabidposis thaliana.(Statistical Data Included) | Biological sciences | Mark Estelle, William M. Gray, Ming Yang, William L. Crosby, Hong Ma, Lawrence Hobbie, J. Carlos Del Pozo, Loni Walker, Eddy Risseeuw, Travis Banks |
| Identification of eight proteins that cross-link to pre-mRNA in the yeast commitment complex. | Biological sciences | Michael Rosbash, Dong Zhang |
| IKK1-deficient mice exhibit abnormal development of skin and skeleton. | Biological sciences | Qiutang Li, Inder M. Verma, Dirk Buscher, Kuo-Fen Lee, Juan Carlos Izpisua-Belmonte, Qingxian Lu, Jason Y. Hwang |
| Inactivation of the winged helix transcription factor HNF3 alpha affects glucose homeostasis and islet glucagon gene expression in vivo. | Biological sciences | Klaus H. Kaestner, Gunther Schutz, Daniel J. Drucker, Jonathan Katz, Yuanfang Liu |
| Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation.(Statistical Data Included) | Biological sciences | Andrew P. McMahon, Benoit St-Jacques, Matthias Hammerschmidt |
| Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. | Biological sciences | Douglas Hanahan, Zena Werb, Lisa M. Coussens, Gabriele Bergers, Wilfred W. Raymond, Marion Laig-Webster, Ole Beherndtsen, George H. Caughey |
| Initial recognition of U12-dependent introns requires both U11/5' splice-site and U12/branchpoint interactions. | Biological sciences | Joan A. Steitz, Mikko J. Frilander |
| INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.(Statistical Data Included) | Biological sciences | Mila E. McCurrach, Scott W. Lowe, Clemens A. Schmitt, Elisa de Stanchina, Rachel R. Wallace-Brodeur |
| INNER NO OUTER regulates abaxial-adaxial patterning in Arabidopsis ovules.(Statistical Data Included) | Biological sciences | Jacinto M. Villanueva, Jean Broadhvest, Bernard A. Hauser, Robert J. Meister, Kay Schneitz, Charles Gasser |
| Interaction between FGF and BMP signaling pathways regulates development of metanephric mesenchyme. | Biological sciences | Elizabeth J. Robertson, Andrew T. Dudley, Robert E. Godin |
| Interaction of the U1 snRNP with nonconserved intronic sequences affects 5' splice site selection. | Biological sciences | Patrizia Fabrizio, Bertrand Seraphin, Oscar Puig, Alexander Gottschalk |
| Intermediates in formation and activity of the RNA polymerase II preinitiation complex: holoenzyme recruitment and a postrecruitment role for the TATA box and TFIIB. | Biological sciences | Steven Hahn, Natalya Yudkovsky, Jeffrey A. Ranish |
| Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. | Biological sciences | James Douglas Engel, Masayuki Yamamoto, Kazuhiko Igarashi, Tetsuro Ishii, Ken Itoh, Nobunao Wakabayashi, Yasutake Katoh |
| Linking asymmetric division to cell fate: teaching an old microbe new tricks. | Biological sciences | Richard Losick, Jonathan Dworkin |
| Localization of Bud2p, a GTPase-activating protein necessary for programming cell polarity in yeast to the presumptive bud site.(Statistical Data Included) | Biological sciences | Ira Herskowitz, Hay-Oak Park, Anthony Sanson |
| Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion. | Biological sciences | Qin Yu, Ivan Stamenkovic |
| Looping versus linking: toward a model for long-distance gene activation. | Biological sciences | Mark Groudine, Michael Bulger |
| Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development.(Statistical Data Included) | Biological sciences | Philip Leder, Christine Kozak, Jennifer S. Michaelson, Debra Bader, Frank Duo |
| Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras(ital) transgene or nullizygosity for p53 (ital). | Biological sciences | Kouetsu Ogasawara, Motoya Katsuki, Tadatsugu Taniguchi, Nobuyuki Tanaka, Taeko Yokochi, Eri Oda, Kazuki Nakao, Masahiko Ishihara, Yoko Nakatsuru, Takatoshi Ishikawa, Hiroaki Nozawa, Seiji Ueda, Seiichiro Shimizu, Yoshikazu Ohira, Kyoji Hioki, Sinichi Aizawa, Tetsuichiro Muto |
| Luc7p, a novel yeast U1 snRNP protein with a role in 5' splice site recognition.(Statistical Data Included) | Biological sciences | Iain W. Mattaj, Guillaume Rigaut, Bertrand Seraphin, Maarten Fornerod, Puri Fortes, Daniel Bilbao-Cortes, Wendy Raymond |
| Maintenance of genomic imprinting at the Arabidopsis medea locus requires zygotic DDM1 activity.(Statistical Data Included) | Biological sciences | Jean-Philippe Vielle-Calzada, Charles Spillane, Juli Thomas, Alison Coluccio, Marilu A Hoeppner, Ueli Frossniklaus |
| Mammalian sex determination: a molecular drama. | Biological sciences | Robin Lovell-Badge, Amanda Swain |
| Mechanism of corepressor binding and release from nuclear hormone receptors.(Statistical Data Included) | Biological sciences | Hung-Ying Kao, Ronald M. Evans, Laszlo Nagy, Chuan Li, Ester Banayo, John W.R. Schwabe, James D. Love, John T. Gooch, V. Krishna, K. Chatterjee |
| Mechanisms of developmental control of transcription in the murine alpha- and beta-globin loci. | Biological sciences | Joost Gribnau, Frank Grosveld, Peter Fraser, Tolleiv Trimborn |
| Meiotic DNA replication checkpoint control in fission yeast. | Biological sciences | Paul M. Nurse, Hiroshi Murakami |
| Metal ion catalysis during group II intron self-splicing: parallels with the spliceosome.(Statistical Data Included) | Biological sciences | Joseph A. Piccirilli, Erik J. Sontheimer, Peter M. Gordon |
| Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation. | Biological sciences | Bjorn Vennstrom, Claes Ohlsson, Sten Gothe, Zhendong Wang, Lily Ng, Jenny M. Kindblom, Angel Campos Barros, Douglas Forrest |
| Mice lacking both presenilin genes exhibit early embryonic patterning defects.(Statistical Data Included) | Biological sciences | Hui Zheng, Alan Bernstein, Dorit B. Donoviel, Ann-Katerina Hadjantonakis, Masaki Ikeda, Peter St. George Hyslop |
| Molecular determinants of nuclear receptor-compressor interaction.(Statistical Data Included) | Biological sciences | Christopher K. Glass, Michael G. Rosenfeld, Riki Kurokawa, David W. Rose, Anna Krones, Valentina Perissi, Eileen M. McInerney, Lena M. Staszewski, Mill H. Lambert, Michael V. Milburn |
| Molecular mechanism of nucleotide excision repair. | Biological sciences | Jan H.J. Hoeijmakers, Nicolaas G.J. Jaspers, Wouter L. de Laat |
| Mos positively regulates Xe-Wee1 to lengthen the first mitotic cell cycle of Xenopus. | Biological sciences | Terry D. Copeland, Monica S. Murakami, George F. Vande Woude |
| Mouse MutS-like protein Msh5 is required for proper chromosome synapsis in male and female meiosis. | Biological sciences | Marleen Dekker, Hein te Riele, Sandra S. de Vries, Esther B. Baart, Ariaan Siezen, Dirk G. de Rooij, Peter de Boer |
| Multilineage embryonic hematopoiesis requires hypoxic ARNT activity. | Biological sciences | David M. Adelman, Emin Maltepe, M.Celeste Simon |
| Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase. | Biological sciences | Dave Jacobs, Anthony J. Muslin, Kerry Kornfeld, Denielle Glossip, Heming Xing |
| Mutant mice with scrambled brains: understanding the signaling pathways that control cell positioning in the CNS.(central nervous system)(Statistical Data Included) | Biological sciences | Tom Curran, Dennis S. Rice |
| Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)j recombination.(Statistical Data Included) | Biological sciences | David B. Roth, Mark A. Landree, Jamie A. Wibbenmeyer |
| Mutations of acidic residues in RAG1 define the active site of the V(D)j recombinase.(Statistical Data Included) | Biological sciences | Wei Yang, Marjorie A. Oettinger, Deok Ryong kim, Yan Dai, Cynthia L. Mundy |
| Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the MRe11/Rad50 complex.(Nijmegen breakage syndrome gene product, adenosine triphosphate) | Biological sciences | Martin Gellert, Tanya T. Paull |
| Negative regulation of male development in Caenorhabditis elegans by a protein-protein interaction between TRA-2A and FEM-3. | Biological sciences | Patricia E. Kuwabara, Andrew M. Spence, Arum Mehra, Jeb Gaudet, Linda Heck |
| NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus.(Statistical Data Included) | Biological sciences | Takaki Muyata, Tomoko Maeda, Jacqueline E. Lee |
| NEUROGENIN1 and NEUROGENIN2 control two distinct waves of neurogenesis in developing dorsal root ganglia.(Statistical Data Included) | Biological sciences | Carol Fode, Qiufu Ma, David J. Anderson, Francois Guillemot |
| Nim1-related kinases coordinate cell cycle progression with the organization of the peripheral cytoskeleton in yeast. | Biological sciences | Michael Snyder, Yves Barral, Macarena Parra, Scott Bidlingmaier |
| Nuclear export of Far1p in response to pheromones requires the export receptor Msn5p/Ste21p.(Statistical Data Included) | Biological sciences | Gustav Ammerer, Matthias Peter, Paula M. Alepuz, Shai Shaham, Marc Blondel, Linda S. Huang |
| Nuclear export of the small ribosomal subunit requires the Ran-GTPase cycle and certain nucleoporins.(Statistical Data Included) | Biological sciences | Pamela Silver, Terence I. Moy |
| Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation. | Biological sciences | Ruth Steward, Eric A. Drier, Leslie H. Huang |
| Nuclear matrix attachment regions antagonize methylation-dependent repression of long-range enhancer-promoter interactions.(Statistical Data Included) | Biological sciences | Luis A. Fernandez, William C. Forrester, Rudolf Frosschedl |
| Nucleoin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation. | Biological sciences | Michael Karin, Matthias Mann, Ching-Yi Chen, Roberto Gherzi, Jens S. Andersen, Guido Gaietta, Karsten Jurchott, Hans-Dieter Royer |
| Oppositely imprinted genes p57(sup)Kip2 and Igf2 interact in a mouse model for Beckwith-Wiedemann syndrome.(Statistical Data Included) | Biological sciences | Stephen J. Elledge, Shirley M. Tilghman, Michele A. Cleary, Pumin Zhang, Tamara Caspary, Elizabeth J. Perlman |
| ORC binding, gene amplification, and the nature of metazoan replication origins.(origin recognition complex)(Statistical Data Included) | Biological sciences | |
| ORC localization in 'Drosophila' follicle cells and the effects of mutations in dE2F and dDp.(protein) | Biological sciences | Irena Royzman, Terry L. Orr-Weaver, Stephen P. Bell, Richard J. Austin, Giovanni Bosco |
| Organization and dynamics of the Mu transpososome: recombination by communication between two active sites.(Statistical Data Included) | Biological sciences | ERica L. Jackson, Tania A. Baker, Tanya Williams, Amanda Carritte |
| p21CIP1 and p57KIP2 control muscle differentiation at the myogenin step. | Biological sciences | Stephen J. Elledge, J. Wade Harper, Dou Liu, Pumin Zhang, Calvin Wong, Milton Finefold |
| p27(super.Kip1) induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells.(Statistical Data Included) | Biological sciences | Martin Gottlicher, Siva Kumar Kolluri, Andrew Koff, Carsten Weiss |
| p53-mediated apoptosis is attenuated in Werner syndrome cells. | Biological sciences | Curtis C. Harris, Xin Wei Wang, Gerard D. Schellenberg, Ana I. Robles, Elisa A. Spillare, Jiang-Cheng Shen, Chang-Eu Yu |
| Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage.(Statistical Data Included) | Biological sciences | David O. Morgan, Rachel L. Tinker-Kulberg |
| Pds1p of budding yeast has dual roles: inhibition of anaphase initiation and regulation of mitotic exit.(Statistical Data Included) | Biological sciences | Doug Koshland, Orna Cohen-Fix |
| Periodic repression of Notch pathway genes governs the segmentation of Xenopus embryos. | Biological sciences | Chris Kintner, Volker Gawantka, Nicolas Pollet, Christof Niehrs, Wui-Chuong Jen |
| Peripheral nervious system defects in erbB2 mutants following genetic rescue of heart development. | Biological sciences | Stefan Britsch, Dieter Riethmacher, Carmen Birchmeier, Lan Xu, Pico Caroni, Richard Harvey, Eva Sonnenberg-Riethmacher, Masresha T. Woldeyesus, Faikah Abou-Rebyeh |
| Phosphorylated RNA polymerase II stimulates pre-mRNA splicing. | Biological sciences | Yutaka Hirose, James L. Manley, Roland Tacke |
| Polarity determination in the Drosophila eye: a novel role for Unpaired and JAK/STAT signaling. | Biological sciences | Norbert Perrimon, Martin P. Zeidler, David I. Strutt |
| PRDI-BFI/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins. | Biological sciences | Tom Maniatis, Bing Ren, Kerlen J. Chee, Tai Hoon Kim |
| Pre-mRNA splicing of IgM exons M1 and M2 is directed by a juxtaposed splicing enhancer and inhibitor. | Biological sciences | Michael R. Green, Julie L.C. Kan |
| Progressive impairment of developing neuroendocrine cell lineages in the hypothalamus of mice lacking the Orthopedia gene.(Statistical Data Included) | Biological sciences | Antonio Simeone, Dario Acampora, Flora M. Vaccarino, Jacques Michaud, Maria Pia Postiglione, Virginia Avantaggiato, Maria Di Bonito |
| Proper metaphase spindle length is determined by centromere proteins Mis12 and Mis6 required for faithful chromosome segregation.(Statistical Data Included) | Biological sciences | Gohta Goshima, Mitsuhiro Yanagida, Shigeaki Saitoh |
| Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus.(Statistical Data Included) | Biological sciences | Jin Jiang, Bing Wang, Gelin Wang |
| RANK is essential for osteoclast and lymph node development.(Statistical Data Included) | Biological sciences | Philip J. Morrissey, Dirk Anderson, David Cosman, Victor Shen, Jacques J. Peschon, Jeffery Smith, Mark E. Tometsko, William C. Dougall, Moira Glaccum, Keith Charrier, Kathy Rohrbach, Kenneth Brasel, Thibaut De Smedt, Elizabeth Daro, Charles R. Maliszewski, Allison Armstrong, Steven Bain, JoAnn Schuh |
| Reconstitution of a minimal RNA degradosome demonstrates functional coordination between a 3' exonuclease and a DEAD-box RNA helicase. | Biological sciences | Glen A. Coburn, George A. Mackie, Xin Miao, Douglas J. Briant |
| Recruitment of Nanos to hunchback mRNA by Pumilio.(Statistical Data Included) | Biological sciences | Junichiro Sonoda, Robin P. Wharton |
| Recruitment of the SWI/SNF chromatin remodeling complex by transcriptional activators.(Statistical Data Included) | Biological sciences | Steven Hahn, Craig L. Peterson, Natalya Yudkovsky, Colin Logie |
| Reelin-induced tryosine phosphorylation of Disabled 1 during neuronal positioning. | Biological sciences | Jonathan A. Cooper, Brian W. Howell, Tara M. Herrick |
| Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. | Biological sciences | Ruedi Aebersold, Nahum Sonenberg, Robert T. Abraham, Anne-Claude Gingras, Brian Raught, Steven P. Gygi, Roberto D. Polakiewicz, Merl F. Hoekstra |
| Regulation of CDK4 activity by a novel CDK4-binding protein, p34(super.SEI-1).(Statistical Data Included) | Biological sciences | Yoichi Taya, Ko Okumura, Takeshi Nakamura, Masatak Sugimoto, Naoko Ohtani, Lynne Hampson, Ian N. Hampson, Akira Shimamoto, Yasuhiro Furuichi, Shinichiro Niwa, Eiji Hara |
| Regulation of homologous recombination: Chi inactivates RecBCD enzyme by disassembly of the three subunits. | Biological sciences | Gerald R. Smith, Andrew F. Taylor |
| Regulation of Saccharomyces cerevisiae kinetochores by the type 1 phosphatase Glc7p. | Biological sciences | Peter K. Sorger, Anthony A. Hyman, Michael J.R. Stark, Fedor F. Severin, Ingrid Sassoon, Paul D. Andrews, Maria-Rita Taba, Ken B. Kaplan, Anthony Ashford |
| Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis. | Biological sciences | Steve Gerondakis, Raelene Grumont, Ian J. Rourke |
| Role of Nr13 in regulation of programmed cell death in the bursa of Fabricius. | Biological sciences | |
| Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development. | Biological sciences | Michael G. Rosenfeld, Concepcion Rodriguez-Esteban, Juan Carlos Izpisua-Belmonte, Forrest Liu, Aimee K. Ryan, Shawn M. O'Connell, Anatoli S. Gleiberman, Doniel P. Szeto, Chrissa Kioussi |
| Roles for Nkx3.1 (ital) in prostate development and cancer. | Biological sciences | Michael M. Shen, Christine R. Norton, Thomas Gridley, Peter Young, Cory Abate-Shen, Robert D. Cardiff, Minjung Kim, Nishita Desai, Rajula Bhatia-Gaur, Annemarie A. Donjacour, Peter J. Sciavolino, Gerland R. Cunha |
| Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. | Biological sciences | Nicholas W. Gale, Rudiger Klein, Ralf H. Adams, Francesca Diella, Urban Deutsch, Werner Risau, George A. Wilkinson, Cornelia Weiss |
| Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein. | Biological sciences | Anton Berns, Els Robanus-Maandag, Michiko Niwa-Kawakita, Laurence Goutebroze, James M. Woodruff, Gilles Thomas, Philippe Merel, Marco Giovannini, Martin van der Valk |
| Septation, dephosphorylation, and the activation of sigma(super.F) during sporulation in Bacillus subtilis. | Biological sciences | Richard Losick, Nicole King, Kit Pogliano, Patrick Stragier, Oliver Dreesen |
| SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival.(inositol 5-phosphatase, serine/threonine protein kinase B) | Biological sciences | Ivona Kozieradzki, Annick Itie, Josef Penninger, Andrew Wakeham, Takehiko Sasaki, Qiurong Liu, Daniel J. Dumont |
| Signal-induced ubiquitination of I(kappa)B(alpha) by the F-box protein slimb/beta-TrCP. | Biological sciences | Erika Spencer, Zhijian J. Chen, Jin Jiang |
| Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. | Biological sciences | Michael Karin, Veronique Baud, Zheng-Gang Liu, Ying Xia, Brydon Bennett, Nobutaka Susuki |
| Signaling for germ cells. | Biological sciences | Anne McLaren |
| Six3 overexpression initiates the formation of ectopic retina. | Biological sciences | Joachim Wittbrodt, Felix Loosli, Sylke Winkler |
| Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor. | Biological sciences | Teruaki Nomura, Md Matiullah Khan, Sunil C. Kaul, Hai-Dong Dong, Renu Wadhwa, Clemencia Colmenares, Isao Kohno, Sunsuke Ishii |
| SMC-mediated chromosome mechanics: a conserved scheme from bacteria to vertebrates? | Biological sciences | Tatsuya Hirano |
| SNAP(sub.c): a core promoter factor with a built-in DNA-binding damper that is deactivated by the Oct-1 POU domain.(snRNA activating protein complex)(Statistical Data Included) | Biological sciences | Nouria Hernandez, Vivek Mittal, Beicong Ma |
| Somatic pairing of homologs in budding yeast: existence and modulation. | Biological sciences | Beth M. Weiner, Nancy Kleckner, Sean M. Burgess |
| Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signaling. | Biological sciences | Andrew B. Lassar, L. Charles Murtaugh, Jay H. Chyung |
| Specific isoforms of squid, a 'Drosophila' hnRNP, perform distinct roles in gurken localization during oogenesis.(melanogaster gene, heterogeneous nuclear RNA-binding proteins) | Biological sciences | Richard L. Kelley, Trudi Schupbach, Kristina Wehr, Amanda Norvell |
| Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. | Biological sciences | Randal J. Kaufman |
| Structural basis of DNA recognition by the heterodimeric cell cycle transcription factore E2F-DP. | Biological sciences | Ning Zheng, Nikola P. Pavletich, Ernest Fraenkel, Carl O. Pabo |
| Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3.(signal transducer and activator of transcription) | Biological sciences | Kiyoshi Takeda, Shizuo Akira, Alan R. Clarke, Rachel S. Chapman, Paula C. Lourenco, Elizabeth Tonner, David J. Flint, Stefan Selbert, Christine J. Watson |
| Switching on the notochord.(Statistical Data Included) | Biological sciences | Philip W. Ingham, Vincent T. Cunliffe |
| Synapsis and chiasma formation in Caenorhabditis elegans require HIM-3, a meiotic chromosome core component that functions in chromosome segregation.(Statistical Data Included) | Biological sciences | Susan Strome, Fritz Muller, Ichiro Kawasaki, Monique C. Zetka |
| Synergistic regulation of vertebrate muscle development by Dach2, Eya2, and Six1, homologs of genes required for Drosophila eye formation.(Statistical Data Included) | Biological sciences | Andrew B. Lassar, Clifford J. Tabin, Guillermo Oliver, Graeme Mardon, Ram Reshef, Tiffany A. Heanue, Richard J. Davis, Stanislav Tomarev |
| Tagging chromatin with retrotransposons: target specificity of the Saccharomyces Ty5 retrotransposon changes with the chromosomal localization of Sir3p and Sir4p.(Statistical Data Included) | Biological sciences | David A. Wright, Daniel F. Voytas, Yunxia Zhu, Sige Zou |
| Targeted mRNA degradation by double-stranded RNA in vitro.(Statistical Data Included) | Biological sciences | Thomas Tuschl, David P. Bartel, Phillip D. Zamore, Phillip A. Sharp, Ruth Lehmann |
| Targeting disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo.(Statistical Data Included) | Biological sciences | Gail R. Martin, Xin Sun, Erik N. Meyers, Mark Lewandoski |
| Targeting genes for self-excision in the germ line.(ST) | Biological sciences | Joy M. Greer, Kirk R. Thomas, Mario R. Capecchi, Michaeline Bunting, Kenneth E. Bernstein |
| TATA element recognition by the TATA box-binding protein has been conserved throughout evolution.(Statistical Data Included) | Biological sciences | Stephen K. Burley, Georgia A. Patikoglou, Thomas Kodadek, Joseph L. Kim, Liping Sun, Yang Sang-Hwa |
| T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification.(Statistical Data Included) | Biological sciences | Andrew P. McMahon, Shinji Takada, Terry P. Yamaguchi, Yoshiaki Yoshikawa, Nongying Wu |
| Telomerase RNA function in recombinant Tetrahymena telomerase. | Biological sciences | Kathleen Collins, Jill D. Licht |
| Telomeres and telomerase.(Statistical Data Included) | Biological sciences | Susan M. Gasser, Maria A. Blasco, Joachim Lingner |
| Telomere shortening and apoptosis in telomerase-inhibited human tumor cells.(Statistical Data Included) | Biological sciences | Wen Zhou, Lea Harrington, Xiaoling Zhang, Vernon Mar, Murray O. Robinson |
| Telomeric chromatin modulates replication timing near chromosome ends. | Biological sciences | Daniel E. Gottschling, Jeffery B. Stevenson |
| TFIID - specific yeast TAF40 is essential for the majority of RNA polymerase II-mediated transcription in vivo. | Biological sciences | Stephen Buratowski, Philip B. Komarnitsky, Bertha Michel |
| The Arabidopsis det3 mutant reveals a central role for the vacuolar H(sup)+-ATPase in plant growth and development.(Statistical Data Included) | Biological sciences | Joanne Chory, Karin Schumacher, Dionne Vafeados, Melissa McCarthy, Heven Sze, Thea Wilkins |
| The balance between isoforms of the Prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs.(Statistical Data Included) | Biological sciences | John Roote, David Gubb, Clare Green, David Huen, Darin Coulson, Glynnis Johnson, David Tree, Simon Collier |
| The bHLH gene Hes1 (ital) is essential for expansion of early T cell precursors. | Biological sciences | Shigetada Nakanishi, Ryoichiro Kageyama, Nagahiro Minato, Koichi Tomita, Masakazu Hattori, Eijiro Nakamura |
| The boundaries of the silenced HMR domain in Saccharomyces cerevisiae. | Biological sciences | |
| The Caenorhabditis elegans gene ham-2 links Hox patterning to migration of the HSN motor neuron. | Biological sciences | Gian Garriga, Paul D. Baum, Catherine Guenther, C. Andrew Frank, Binh V. Pham |
| The cAMP receptor protein CRP can function as an osmoregulator of transcription in Escherichia coli.(Statistical Data Included) | Biological sciences | Reid C. Johnson, Lenore Landis, Jimin Xu |
| The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast. | Biological sciences | Andrew W. Murray, Anthony A. Hyman, Sue Biggins, Needhi Bhalla, Fedor F. Severin, Ingrid Sassoon |
| The control of trunk Hox specificity and activity by Extradenticle.(Statistical Data Included) | Biological sciences | Richard S. Mann, Hyung Don Ryoo |
| The coronin-like protein POD-1 is required for anterior-posterior axis formation and cellular architecture in the nematode Caenorhabditis elegans.(Statistical Data Included) | Biological sciences | Raffi V. Aroian, Chad A. Rappleye, Alexander R. Paredez, Carol W. Smith, Kent L. McDonald |
| The cytoplasmic Purkinje onconeural antigen cdr2 down-regulates c-Myc function: implications for neuronal and tumor cell survival.(Statistical Data Included) | Biological sciences | Robert B. Darnell, Hirotaka J. Okano, Woong-Y. Park, John P. Corradi |
| The DNA-dependent protein kinase. | Biological sciences | Stephen P. Jackson, Graeme C.M. Smith |
| The Drosophila Activin receptor Baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development. | Biological sciences | Jeffrey L. Wrana, Michael B. O'Connor, Mary Jane Shimell, Shirin Abdollah, Ted Brummel, Theodor E. Haerry, John Merriam, Laurel Raftery |
| The Drosophila p38 MAPK pathway is required during oogenesis for egg asymmetric development.(mitogen-activated protein kinase) | Biological sciences | Kunihiro Matsumoto, Stephane Noselli, Bruno Glise, Kenji Irie, Magali Suzanne, Francois Agnes, Eiji Mori |
| The Drosophila Pkn protein kinase is a Rho/Rac effector target required for dorsal closure during embryogenesis. | Biological sciences | Jeffrey Settleman, Yu Lu |
| The Escherichia coli sigma(super.E)-dependent extracytoplasmic stress response is controlled by the regulated proteolysis of an anti-sigma factor.(Statistical Data Included) | Biological sciences | Carol A. Gross, Benjamin M. Alba, Sarah E. Ades, Lynn E. Connolly |
| The FAR1 (ital) locus encodes a novel nuclear protein specific to phytochrome A signaling.(Statistical Data Included) | Biological sciences | Peter H. Quail, Christoph Ringli, Matthew Hudson, Margaret T. Boylan |
| The genetic transformation of bone biology.(review) | Biological sciences | Gerard Karsenty |
| The glucocorticoid receptor is required for stress erythropoiesis.(Statistical Data Included) | Biological sciences | Harmut Beug, Anton Bauer, Gunther Schutz, Francois Tronche, Christoph Kellendonk, Holger M. Reichardt, Oliver Wessely, Peter Steinlein |
| The homeodomain protein Vax1 is required for axon guidance and major tract formation in the developing forebrain.(Statistical Data Included) | Biological sciences | Greg Lemke, Robert Hindges, Dennis D.M. O'Leary, Stina H. Mui, Stefano Bertuzzi |
| The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences. | Biological sciences | Bryan R. Cullen, Yibin Kang |
| The interface of sigma with core RNA polymerase is extensive, conserved, and functionally specialized.(Statistical Data Included) | Biological sciences | Konstantin Severinov, Chi Zen Lu, Carol A. Gross, Jeffrey W. Roberts, Michael T. Marr, Cathleen L. Chan, Meghan Sharp, Sergei Nechaev, Ernest W. Merritt |
| The Iroquois homeodomain proteins are required to specify body wall identity in Drosophila.(Statistical Data Included) | Biological sciences | Juan Modolell, Ruth Diez del Corral, Pilar Aroca, Jose Luis Gomez-Skarmeta, Florencia Cavodeassi |
| The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development. | Biological sciences | Fred A. Pereira, Ming-Jer Tsai, Sophia Y. Tsai, Ge Zhou, Yuhong Qiu |
| The perianthia gene encodes a bZIP protein involved in the determination of floral organ number in Arabidopsis thaliana. | Biological sciences | Elliot M. Meyerowitz, Robert W. Williams, Chiou-Fen Chuang, Mark P. Running |
| The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappa B that blocks TNFalpha-induced apoptosis. | Biological sciences | |
| The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2.(Statistical Data Included) | Biological sciences | Joan Weliky Conaway, Ronald C. Conaway, Qin Yan, Takumi Kamura, Michael N. Conrad |
| The RecBC enzyme loads RecA protein onto ssDNA asymmetrically and independently of x, resulting in constitutive recombination activation. | Biological sciences | Stephen C. Kowalczykowski, Daniel G. Anderson, Jason J. Churchill |
| The RING finger/B-Box factor TAM-1 and a retinoblastoma-like protein LIN-35 modulate context-dependent gene silencing in Caenorhabditis elegans.(Statistical Data Included) | Biological sciences | Jing Liu, Andrew Fire, Paul W. Sternberg, Jenny Hsieh, Stephen A. Kostas, Chieh Chang |
| The SCF(beta-TRCP)-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in I(kappa)B(alpha) and beta-catenin and stimulates I(kappa)B(alpha) ubiquitination in vitro. | Biological sciences | Stephen J. Elledge, J.Wade Harper, Peggy Beer-Romero, Jeffrey T. Winston, Peter Strack, Claire Y. Chu |
| The SIR2/3/4 complex and 2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.(silent information regulator) | Biological sciences | Matt Kaeberlein, Leonard Guarente, Mitch McVey |
| The Ski oncoprotein interacts with the Smad proteins to repress TGF beta signaling.(Statistical Data Included) | Biological sciences | Sharleen Zhou, Wang Wei, Kunxin Luo, Qiang Zhou, Shannon L. Stroschein, Dan Chan, Eric Martens |
| The Something About Silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAF(sub.II)30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc(sub.68)/Pob(sub.3))-FACT complex. | Biological sciences | Sam John, LeAnn Howe, Stefan T. Tafrov, Patrick A. Grant, Rolf Sternglanz, Jerry L. Workman |
| The SPOROCYTELESS gene of Arabidopsis is required for initiation of sporogenesis and encodes a novel nuclear protein.(Statistical Data Included) | Biological sciences | Venkatesan Sundaresan, Jian Xu, Wei-Cai Yang, De Ye |
| The Spt componenet of SAGA facilitate TBP binding to a promoter at a post-activator-binding step in vivo.(Statistical Data Included) | Biological sciences | Claire Rougeulle, Aimee M. Dudley, Fre Winston |
| The steroid receptor coactivator, GRIP-1, is necessary for MEF-2C-dependent gene expression and skeletal muscle differentiation. | Biological sciences | Shen Liang Chen, Dennis H. Dowhan, Brett M. Hosking, George E.O. Muscat |
| The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH. | Biological sciences | Fulvio Mavilio, Francesco Blasi, Jens Berthelsen, Charlotte Kilstrup-Nielsen, Vincenzo Zappavigna |
| The TOR signaling cascade regulates gene expression in response to nutrients.(Statistical Data Included) | Biological sciences | Joseph Heitman, Michael C. Lorenz, Maria E. Cardenas, N. Shane Cutler, Charles J. Di Como |
| The trials and travels of tRNA. | Biological sciences | Sandra L. Wolin, A. Gregory Matera |
| The type 2C Ser/Thr phosphatase PP2C gamma is a pre-mRNA splicing factor. | Biological sciences | Adrian R. Krainer, Ryuji Kobayashi, Michael V. Murray |
| The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity.(Statistical Data Included) | Biological sciences | Joanna Lisztwan, Wilhelm Krek, Christiane Wirbelauer, Matthias Gstaiger, Georges Imbert |
| The yeast exosome and human PM-Sc1 are related complexes of 3' --> 5' exonucleases.(Statistical Data Included) | Biological sciences | Alexandre Podtelejnikov, Matthias Mann, David Tollervey, Elisabeth Petfalski, Philip Mitchell, Christine Allmang |
| The Zw5 protein, a component of the scs chromatin domain boundary, is able to block enhancer-promoter interaction.(Statistical Data Included) | Biological sciences | Paul Schedl, Miklos Gaszner, Julio Vazquez |
| Toll receptor-mediated 'Drosophila' immune response requires Dif, an NF-kB factor.(gene) | Biological sciences | Y. Tony Ip, Xiangjun Meng, Bhupinder S. Khanuja |
| TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. | Biological sciences | Annick Itie, Ildiko Sarosi, Josef Penninger, Wen-Chen Yeh, Andrew Wakeham, Tak W. Mak, Takehiko Sasaki, David L. Lacey, William J. Boyle, Alexandra Ho, Gordon S. Duncan, David V. Goeddel, Sean Morony, Zhaodan Cao, Wilson Khoo, Colin R. Dunstan, Casey Capparelli, Gwyneth Van, Mark A. Lomaga, Caren Furlonger, Stephen Kaufman, Annette van der Heiden, Christopher J. Paige |
| Transcriptional repression by the Caenorhabditis elegans germ-line protein PIE-1. | Biological sciences | Melanie A. Dunn, Geraldine Seydoux, T. Keith Blackwell, Eun Yong Shim, Craig Mello, Ceri Batchelder, Bob Choy, Yong Suh, Conrad Cassie, Tae Ho Shin |
| Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a. | Biological sciences | Ronald M. Evans, Arnold J. Levine, Maureen Murphy, Donna L. George, Kristen K. Walker, Jaimo. Ahn, William H Hoffman |
| Transcription elongation factor hSPT5 stimulates mRNA capping.(Statistical Data Included) | Biological sciences | Aaron J. Shatkin, Yingexia Wen |
| Transient gene asymmetry during sporulation and establishment of cell specificity in Bacillus subtilis. | Biological sciences | Patrick Stragier, Niels Frandsen, Imrich Barak, Celine Karmazym-Capelli |
| Translational induction of heat shock transcription factor sigma (super) 32: evidence for a built-in RNA thermosensor. | Biological sciences | Hideki Yanagi, Takashi Yura, Yoshimasa Kyogoku, Miyo Terao Morita, Yoshiyuki Tanaka, Takashi S. Kodama |
| twist (ital) is a potential oncogene that inhibits apoptosis.(Statistical Data Included) | Biological sciences | Gregory J. Hannon, David H. Beach, Roberta Maestro, Claudio Doglioni, Larry Kedes, Yasuo Hamamori, Angelo P. Dei Tos, Svetlana Krasnokutsky, Vittorio Satorelli |
| Two protein tyrosine phosphatases, Ptp2 and Ptp3, modulate the subcellular localization of the Hog1 MAP kinase in yeast. | Biological sciences | Christopher P. Mattison, Irene M. Ota |
| UAS(sub.rpg) can function as a heterochromatin boundary element in yeast. | Biological sciences | James R. Broach, Xin Bi |
| Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. | Biological sciences | Avram Hershko, Michele Pagano, Giulio F. Draetta, Alessia Montagnoli, Francesca Fiore, Esther Eytan, Andrea C. Carrano |
| Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit Srb7 in mice.(Statistical Data Included) | Biological sciences | Richard A. Young, Rudolf Jaenisch, Peter J. Murray, Matthew Tudor, Christina Onufryk |
| UNC-4/UNC-37-dependent repression of motor neuron-specific genes controls synaptic choice in Caenorhabditis elegans.(Statistical Data Included) | Biological sciences | Monica Driscoll, Nektarios Tavernarakis, Angela R. Winnier, James Y.-J. Meir, Jennifer M. Ross, Takeshi Ishihara, Isao Katsura, David M. Miller III |
| Uncoupling integrin adhesion and signaling: the beta(sub)ps cytoplasmic domain is sufficient to regulate gene expression in the Drosophila embryo. | Biological sciences | Maria D. Martin-Bermudo, Nicholas H. Brown |
| Uncoupling of the hnRNP Np13p from mRNAs during the stress-induced block in mRNA export.(Statistical Data Included) | Biological sciences | Heike Krebber, Pamela A. Silver, Margaret S. Lee, Tetsuya Taura |
| unr, a cellular cytoplasmic RNA-binding protein with five cold-shock domains, is required for internal initiation of translation of human rhinovirus RNA. | Biological sciences | Richard J. Jackson, Sarah L. Hunt, Justin J. Hsuan, Nicholas Totty |
| Unraveling a cytoplasmic role for hnRNP D in the in vivo mRNA destabilization directed by the AU-rich element.(Statistical Data Included) | Biological sciences | Ann-Bin Shyu, Paul Loflin, Chyi-Ying A. Chenm |
| Vax1, a novel homeobox-containing gene, directs development of the basal forebrain and visual system.(Statistical Data Included) | Biological sciences | Peter Gruss, Thomas Hollemann, Marc Hallonet, Thomas Pieler |
| Vein expression is induced by the EGF receptor pathway to provide a positive feedback loop in patterning the Drosophila embryonic ventral ectoderm. | Biological sciences | Ben-Zion Shilo, Myriam Golembo, Talia Yarnitzky, Talila Volk |
| Whose end is destruction: cell division and the anaphase-promoting complex.(Statistical Data Included) | Biological sciences | Kim Nasmyth, Wolfgang Zachariae |
| Wnt3a (minus/minus)-like phenotype and limb deficiency in Lef1(minus/minus)Tcf1(minus/minus) mice. | Biological sciences | Hans Clevers, Rudolf Grosschedl, Juan Galceran, Michael J. Depew, Isabel Farinas |
| Wnt-induced dephosphorylation of Axin releases beta-catenin from the Axin complex.(Statistical Data Included) | Biological sciences | Roel Nusse, Karl Willert, Sayumi Shibamoto |
| Wnt pathway components orient a mitotic spindle in the early Caenorhabditis elegans embryo without requiring gene transcription in the responding cell.(Statistical Data Included) | Biological sciences | Christopher A. Shelton, Bruce Bowerman, Marc Meneghini, Ann Shlesinger, Julin N Maloof |
| Wnt signaling in Xenopus embryos inhibits Bmp4 expression and activates neural development.(Statistical Data Included) | Biological sciences | Richard M. Harland, Rosa S.P. Beddington, Julie C. Baker |
| X-inactivation by chromosomal pairing events.(Statistical Data Included) | Biological sciences | York Marahrens |
| XRCC3 promotes homology-directed repair of DNA damage in mammalian cells.(Statistical Data Included) | Biological sciences | Maria Jasin, Andrew J. Pierce, Roger D. Johnson, Larry H. Thompson |
| Yeast autonomously replicating sequence binding factor is involved in nucleotide excision repair.(Statistical Data Included) | Biological sciences | Bruce Stillman, Errol C. Friedberg, Simon H. Reed, Masahiro Akiyama |
| Yeast calcineurin regulates nuclear localization of the Crz1p transcription factor through dephosphorylation.(ionized calcium protein phosphatase) | Biological sciences | Angelike Stathopoulos-Gerontides, Jim Jun Guo, Martha S. Cyert |
| Yeast Cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication. | Biological sciences | Alexander Schleiffer, Attila Toth, Marta Galova, Kim Nasmyth, Frank Uhlmann, Rafal Ciosk |
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