Cell 1996 - Abstracts
| Cell 1996 | |||||
| Title | Subject | Authors | |||
|---|---|---|---|---|---|
| 2.0 angstrom crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region. (arginine-glysine-aspartic acid peptide chain) | Biological sciences | Harold P. Erickson, Daniel J. Leahy, Ikramuddin Aukhil | |||
| A 450 kb transgene displays properties of the mammalian X-inactivation center. | Biological sciences | Rudolf Jaenisch, Jeannie T. Lee, William M. Strauss, Jessica A. Dausman | |||
| A 700 bp cis-acting region controls mating-type dependent recombination along the entire left arm of yeast chromosome III. | Biological sciences | James E. Haber, XiaoHua Wu | |||
| Absconding with the chaperone: essential cyclophilin-Gag interaction in HIV-1 virions. (human immunodeficiency virus-1) | Biological sciences | Jeremy Luban | |||
| Absence epilepsy in tottering mutant mice is associated with calcium channel defects. | Biological sciences | Nancy A. Jenkins, Neal G. Copeland, Wayne N. Frankel, John D. Shaughnessy Jr., Colin F. Fletcher, Cathleen M. Lutz, T. Norene O'Sullivan, Rochard Hawkes | |||
| A CBP integrator complex mediates translational activation and AP-1 inhibition by nuclear receptors. (cAMP Response Binding Protein-Binding Protein) | Biological sciences | Christopher K. Glass, Michael G. Rosenfeld, Riki Kurokawa, David W. Rose, Richard A. Heyman, Sheng-Cai Lin, Thorsten Heinzel, Joseph Torchia, Bernd Gloss, Yasutomi Kamei, Lan Xu | |||
| Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. | Biological sciences | Zvi Fuks, Edward H. Schuchman, Carlos Cordon-Cardo, Richard Kolesnick, Adriana Haimovitz-Friedman, Pino Santana, Louis A. Pena, Seamus Martin, Douglas Green, Maureen McLoughlin | |||
| A cluster of cytoplasmic histidine residues specifies pH dependence of the AE2 plasma membrane anion exchanger. | Biological sciences | Ron R. Kopito, Israel Sekler, Sumire Kobayashi | |||
| A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly. | Biological sciences | Don W. Cleveland, Andreas Merdes, Kasra Ramyar, Janet D. Vechio | |||
| Actin-based cell motility and cell locomotion. | Biological sciences | T.J. Mitchison, L.P. Cramer | |||
| Active and inactive protein kinases: structural basis for regulation. | Biological sciences | David J. Owen, Louise N. Johnson, Martin E.M. Noble | |||
| A defect in nurturing in mice lacking the immediate early gene fosB. | Biological sciences | Pieter Dikkes, Roderick T. Bronson, Michael E. Greenberg, Hong Ye, Jennifer R. Brown | |||
| A deubiquitinating enzyme interacts with SIR4 and regulates silencing in S. cerevisiae. (Saccharomyces cerevisiae) | Biological sciences | Alexander D. Johnson, Danesh Moazed | |||
| Adipogenesis and obesity: rounding out the big picture. | Biological sciences | Bruce M. Spiegelman, Jeffrey S. Flier | |||
| A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function. | Biological sciences | Hugo J. Bellen, Kendal Broadie, Judith A. Lengyel, Stefan Baumgartner, J. Troy Littleton, Andreas Prokop, Manzoor A. Bhat, Ruth Chiquet-Ehrismann, Ruth Harbecke | |||
| A dual-tropic primary HIV-1 isolate that uses Fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. | Biological sciences | Robert W. Doms, Marc Parmentier, Stephen C. Peiper, Benjamin J. Doranz, Joseph Rucker, Yanjie Yi, Robert J. Smyth, Michel Samson, Ronald G. Collman | |||
| Agrin acts via a MuSK receptor complex. (muscle-specific kinase) | Biological sciences | Steven J. Burden, George D. Yancopoulos, Thomas M. DeChiara, Czeslaw Radziejewski, Peter S. DiStefano, Trevor N. Stitt, David J. Glass, David M. Valenzuela, David R. Gies, Terence E. Ryan, David C. Bowen, JoAnne Bruno, Sonal Shah, Karen Mattson | |||
| A GTPase controlling nuclear trafficking: running the right way or walking RANdomly? | Biological sciences | Pamela A. Silver, Deanna M. Koepp | |||
| A hot topic: the origin of hyperthermophiles. | Biological sciences | Patrick Forterre | |||
| A kinesin-like protein is required for germ plasm aggregation in Xenopus. (Xenopus laevis) | Biological sciences | Janet Heasman, Chris Wylie, Jos Raats, Denise L. Robb | |||
| A license to kill. (apoptosis) | Biological sciences | Gerard Evan, Andrew Fraser | |||
| alphaLbeta2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule. | Biological sciences | Brian Seed, Waldemar Kolanus, Wolfgang Nagel, Britta Schiller, Lutz Zeitlmann, Samuel Godar, Hannes Stockinger | |||
| Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members. | Biological sciences | David J. Anderson, Nirao M. Shah, Andrew K. Groves | |||
| AML1, the target of multiple chromosomal translocation in human leukemia, is essential for normal fetal liver hematopoiesis. | Biological sciences | James R. Downing, Scott W. Hiebert, Tsukasa Okuda , Jan van Deursen, Gerard Grosveld | |||
| A molecular perspective on pollination in flowering plants. | Biological sciences | Peter N. Dodds, Adrienne E. Clarke, Ed Newbigin | |||
| A molecular switch in a replicating machine defined by an internal competition for protein rings. | Biological sciences | Mike O'Donnell, Jennifer Turner, Vytautas Naktinis | |||
| An activated form of notch influences the choice between CD4 and CD8 T cell lineages. | Biological sciences | Gerry Weinmaster, Dragana Cado, David Chang, Ellen Robey, Andrea Itano, Heather Alexander, Deborah Lans, Patrick Salmon | |||
| An alternatively spliced C. elegans ced-4 RNA encodes a novel cell death inhibitor. | Biological sciences | H. Robert Horvitz, Shai Shaham | |||
| Anatomy of a flexer-DNA complex inside a higher-order transposition intermediate. | Biological sciences | Brigitte D. Lavoie, George Chaconas, Gary S. Shaw, Anders Millner | |||
| An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments. | Biological sciences | Elaine Fuchs, Don W. Cleveland, James Dowling, Qian-Chun Yu, Yanmin Yang, Panos Kouklis | |||
| Anion exchanger 1 (band 3) is required to prevent erythrocyte membrane surface loss but not to form the membrane skeleton. | Biological sciences | Stuart H. Orkin, Carlo Brugnara, Samuel E. Lux, Kathryn M. John, Shih-Chun Liu, Babette Gwynn, Ramesh A. Shivdasani, Luanne L. Peters, Narla Mohandas, Manjit Hanspal, Jennifer M. Gonzalez, Seth L. Alper | |||
| An MII-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes. | Biological sciences | Terence H. Rabbitts, Javier Corral, Isabelle Lavenir, Helen Impey, Alan J. Warren, Alan Forster, Teresa A. Larson, Sarah Bell, Andrew N.J. McKenzie, Gareth King | |||
| A novel complex of nucleoporins, which includes Sec13p and a Sec13p homolog, is essential for normal nuclear pores. | Biological sciences | Valerie Doye, Alexandra Segref, Symeon Siniossoglou, Christian Wimmer, Michael Rieger, Hildegard Tekotte, Chris Weise, Sonja Emig, Edward C. Hurt | |||
| A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. | Biological sciences | Peter Walter, Jeffery S. Cox | |||
| A novel receptor-mediated nuclear protein import pathway. | Biological sciences | Fan Wang, Mikiko C. Siomi, W. Matthew Michael, Gideon Dreyfuss, Victoria W. Pollard, Sara Nakielny | |||
| A novel spliceosome containing U11, U12, and U5 snRNPs excises a minor class (AT-AC) intron in vitro. | Biological sciences | Joan A. Steitz, Woan-Yuh Tarn | |||
| Apoptosis meets signal transduction: elimination of a BAD influence. | Biological sciences | Craig B. Thompson, Thomas F. Gajewski | |||
| A pre-mRNA-binding protein accompanies the RNA from the gene through the nuclear pores and into polysomes. | Biological sciences | Neus Visa, Xin Sun, Alla T. Alzhanova-Ericsson, Elena Kiseleva, Birgitta Bjorkroth, Tilmann Wurtz, Bertil Daneholt | |||
| A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. | Biological sciences | Reinhold Forster, Martin Lipp, Elisabeth Kremmer, Anita E. Mattis, Eckhard Wolf, Gottfried Brem | |||
| Araucan and caupolican, two members of the novel iroquois complex, encode homeoproteins that control proneural and vein-forming genes. | Biological sciences | Ruth Diez del Corral, Dolors Ferres-Marco, Juan Modolell, Jose-Luis Gomez-Skarmeta, Elisa de la Calle-Mustienes | |||
| A signaling pathway to translational control. | Biological sciences | Eric J. Brown, Stuart L. Schreiber | |||
| A specialized nucleosome modulates transcription factor access to a C. glabrata metal responsive promoter. | Biological sciences | Dennis J. Thiele, Zhiwu Zhu | |||
| A structural model for the HIV-1 Rev-RRE complex deduced from altered-specificity rev variants isolated by a rapid genetic strategy. | Biological sciences | Chaitanya Jain, Joel G. Belasco | |||
| Asymmetric accumulation of Ash1p in postanaphase nuclei depends on a myosin and restricts mating-type switching to mother cells. | Biological sciences | Kim Nasmyth, Nicoletta Bobola, Ralf-Peter Jansen, Tae Ho Shin | |||
| A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(super Kip1)-deficient mice. | Biological sciences | James M. Roberts, Kenneth Kaushansky, Peggy Porter, Li-Huei Tsai, Kornelia Polyak, Roger M. Perlmutter, Eduardo Firpo, Matthew L. Fero, Micheal Rivkin, Michael Tasch, Catherine Carow E., Virginia Broudy | |||
| Atm-deficient mice: a paradigm of ataxia telangiectasia. | Biological sciences | Yosef Shiloh, Francis Collins, Thomas Ried, Carrolee Barlow, Anthony Wynshaw-Boris, Jacqueline N. Crawley, Michael Eckhaus, Shinji Hirotsune, Richard Paylor, Marek Liyanage, Danilo Tagle | |||
| ATP binding to the sigma54-dependent activator XylR triggers a protein multimerization cycle catalyzed by UAS DNA. (upstream activating sequence) | Biological sciences | Jose Perez-Martin, Victor de Lorenzo | |||
| A tyrosyl-tRNA synthetase recognizes a conserved tRNA-like structural motif in the group I intron catalytic core. (transfer ribonucleic acid) | Biological sciences | Alan M. Lambowitz, Eric Westhof, Mark G. Caprara, Valerie Lehnert | |||
| Autocatalytic subunit processing couples active site formation in the 20S proteasome to completion of assembly. | Biological sciences | Ping Chen, Mark Hochstrasser | |||
| Base-specific recognition of the nontemplate strand of promoter DNA by E. coli RNA polymerase. | Biological sciences | Jeffrey W. Roberts, Christine W. Roberts | |||
| Bcl-2 targets the protein kinase Raf-1 to mitochondria. | Biological sciences | John C. Reed, Ulf R. Rapp, Hong-Gang Wang | |||
| Beyond homing: competition between intron endonucleases confers a selective advantage on flanking genetic markers. | Biological sciences | Heidi Goodrich-Blair, David A. Shub | |||
| Biogenesis of polytopic membrane proteins: membrane segments assemble within translocation channels prior to membrane integration. | Biological sciences | Sanford M. Simon, Angela C. Borel | |||
| Blood vessel formation: what is its molecular basis? | Biological sciences | Patricia A. D'Amore, Judah Folkman | |||
| branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching. (fibroblast growth factor) | Biological sciences | Christos Samakovlis, Mark A. Krasnow, David Sutherland | |||
| Brassinosteroids rescue the deficiency of CYP90, a cytochrome P450, controlling cell elongation and de-etiolation in Arabidopsis. | Biological sciences | Csaba Koncz, Thomas Altmann, Jaideep Mathur, Ferenc Nagy, Miklos Szekeres, Kinga Nemeth, Zsuzsanna Koncz-Kalman, Annette Kauschmann, George P. Redei, Jeff Schell | |||
| Budding of rabies virus particles in the absence of the spike glycoprotein. | Biological sciences | Teshome Mebatsion, Matthias Konig, Karl-Klaus Conzelmann | |||
| Budding yeast SKP1 encodes an evolutionarily conserved kinetochore protein required for cell cycle progression. | Biological sciences | Philip Hieter, Carla Connelly | |||
| Calcium spiking in plant root hairs responding to Rhizobium nodulation signals. | Biological sciences | Sharon R. Long, David W. Ehrhardt, Rebecca Wais | |||
| CAR1, a TNFR-related protein, is a cellular receptor for cytopathic avian leukosis-sarcoma viruses and mediates apoptosis. | Biological sciences | John A.T. Young, John Naughton, Melissa M. Rolls, Jurgen Brojatsch, Kurt Zingler | |||
| CD4-independent infection by HIV-2 is mediated by fusin/CXCR4. | Biological sciences | Robert W. Doms, Timothy N.C. Wells, James A. Hoxie, Nathaniel R. Landau, Mark Marsh, Christine A. Power, Paul R. Clapham, Sunny Choe, Michael J. Endres, Mena Ahuja, Julie Davis Turner, Aine McKnight, Jill F. Thomas, Beth Stoebenau-Haggarty, Patricia J. Vance, Shaheen S. Sutterwala | |||
| Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway. | Biological sciences | Curt Wittenberg, Mike Tyers, Ryuji Kobayashi, Andrew R. Willems, Stefan Lanker, E. Elizabeth Patton, Karen L. Craig, Timothy F. Nason, Neal Mathias | |||
| Cdk2 kinase is required for entry into mitosis as a positive regulator of Cdc2-cyclin B kinase activity. | Biological sciences | Thomas M. Guadagno, John W. Newport | |||
| Cell adhesion: the molecular basis of tissue architecture and morphogenesis. | Biological sciences | Barry M. Gumbiner | |||
| Cell cycle control by an essential bacterial two-component signal transduction protein. | Biological sciences | Lucy Shapiro, Kim C. Quon, Gregory T. Marczynski | |||
| Cell migration: a physically integrated molecular process. | Biological sciences | Douglas A. Lauffenburger, Alan F. Horwitz | |||
| Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro. | Biological sciences | Mark S. Schlissel, Patricia Stanhope-Baker, Karen M. Hudson, Arthur L. Shaffer, Andrei Constantinescu | |||
| Characterization of the active intermediate of a GroEL-GroES-mediated protein folding reaction. | Biological sciences | Jonathan S. Weissman, Arthur L. Horwich, Wayne A. Fenton, Hays S. Rye, Joseph M. Beechem | |||
| Chemokine receptors and HIV-1: an attractive pair? (human immunodeficiency virus type 1) | Biological sciences | Paul Bates | |||
| Chromatid segregation at anaphase requires the barren product, a novel chromosome-associated protein that interacts with topoisomerase II. | Biological sciences | Hugo J. Bellen, David M. Glover, Manzoor A. Bhat, Alastair Philp Valentine | |||
| Chromatin assembly coupled to DNA repair: a new role for chromatin assembly factor 1. | Biological sciences | Bruce Stillman, Pierre-Henri L. Gaillard, Genevieve Almouzni, Paul D. Kaufman, Emmanuelle M.-D. Martini, Ethel Moustacchi | |||
| Chromatin structure and RNA polymerase II connection: implications for transcription. | Biological sciences | Kevin Struhl | |||
| Chromatin unfolds. | Biological sciences | Gary Felsenfeld | |||
| Chromosomal inheritance of epigenetic states in fission yeast during mitosis and meiosis. | Biological sciences | Amar J.S. Klar, Shiv I.S. Grewal | |||
| Civ1 (CAK in vivo), a novel Cdk-activating kinase. | Biological sciences | Jean-Yves Thuret, Jean-Gabriel Valay, Gerard Faye, Carl Mann | |||
| C-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions. | Biological sciences | Michael Karin, Masahiko Hibi, Tuula Kallunki, Tiliang Deng | |||
| Cleavage plane specification in C. elegans: how to divide the spoils. (Caenorhabditis elegans) | Biological sciences | John White, Susan Strome | |||
| Clustering membrane proteins: it's all coming together with the PSD-95/SAP90 protein family. | Biological sciences | Stephen N. Gomperts | |||
| Complementary and mutually exclusive activities of decapentaplegic and wingless organize axial patterning during Drosophila leg development. | Biological sciences | Jin Jiang, Gary Struhl | |||
| Contacts in context: promoter specificity and macromolecular interactions in transcription. | Biological sciences | Robert Tijian, James A. Goodrich, Gene Cutler | |||
| Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene. | Biological sciences | Jeffrey C. Hall, Barbara J. Taylor, Steven A. Wasserman, Bruce S. Baker, Diego H. Castrillon, Lisa C. Ryner, Stephen F. Goodwin, Anuranjan Anand, Adriana Villeta | |||
| Coordinated dual cleavages induced by the proteasome regulator PA28 lead to dominant MHC ligands. (major histocompatibility complex) | Biological sciences | Hansjorg Schild, Hans-Georg Rammensee, Marcus Groettrup, Stefan Stevanovic, Lothar Kuehn, Tobias P. Dick, Ulrich H. Koszinowski, Thomas Ruppert, Peter M. Kloetzel | |||
| Cortexillins, major determinants of cell shape and size, are actin-bundling proteins with a parallel coiled-coil tail. | Biological sciences | Ueli Aebi, Friedrich Lottspeich, John Murphy, Gunther Gerisch, Jan Faix, Michel Steinmetz, Heike Boves, Richard A. Kammerer, Ursula Mintert, Alexander Stock | |||
| Coupling of a replicative polymerase and helicase: a tau-DnaB interaction mediates rapid replication fork movement. | Biological sciences | Kenneth J. Marians, Charles S. McHenry, Sungsub Kim, H. Garry Dallmann | |||
| CREB phosphorylation and dephosphorylation: a Ca2+- and stimulus duration-dependent switch for hippocampal gene expression. (cyclic adenosine monophosphate-responsive element binding protein) | Biological sciences | Richard W. Tsien, Haruhiko Bito, Karl Deisseroth | |||
| Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1. (cyclin-dependent kinase 2) | Biological sciences | John A. Tainer, Steven I. Reed, Mark H. Watson, Yves Bourne, Michael J. Hickey, William Holmes, Warren Rocque | |||
| Crystal structure at 2.4 angstrom resolution of the complex of transduction betagamma and its regulator, phosducin. | Biological sciences | Paul B. Sigler, Rachelle Gaudet, Andrew Bohm | |||
| Crystal structure of an ATP-dependent DNA ligase from bacteriophage T7. | Biological sciences | Dale B. Wigley, Hosahalli S. Subramanya, Aidan J. Doherty, Stephen R. Ashford | |||
| Crystal structure of an IHF-DNA complex: a protein-induced DNA U-turn. (integration host factor-deoxyribonucleic acid) | Biological sciences | Phoebe A. Rice, Kiyoshi Mizuuchi, Shu-Wei Yang, Howard A. Nash | |||
| Crystal structure of a sigma70 subunit fragment from E. coli RNA polymerase. | Biological sciences | Seth A. Darst, Elena Severinova, Arun Malhotra | |||
| Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid. | Biological sciences | Christopher P. Hill, Wesley I. Sundquist, David K. Worthylake, Theresa R. Gamble, Felix F. Vajdos, Sanghee Yoo, Megan Houseweart | |||
| Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain. | Biological sciences | Brian T. Chait, John Kuriyan, Kalle Saksela, Urooj A. Mirza, Chi-Hon Lee | |||
| Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin-binding protein, EBNA1, bound to DNA. | Biological sciences | Richard A. Pfuetzner, Alexey Bochkarev, Lori Frappier, Aled M. Edwards, Jean A. Barwell, Elena Bochlareva | |||
| Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide. | Biological sciences | C.M. Rice, C. Lin, J.L. Kim, J.A. Landro, K.A. Morgenstern, T. Fox, M.D. Dwyer, S.P. Chambers, W. Markland, C.A. Lepre, E.T. O'Malley, S.L. Harbenson, M.A. Murcko, P.R. Caron, J.A. Thomson | |||
| Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ. | Biological sciences | John Lewis, Morgan Sheng, Roderick MacKinnon, Alice Lee, Declan A. Doyle, Eunjoon Kim | |||
| cul-1 Is required for cell cycle exit in C. elegans and identifies a novel gene family. (Caenorhabditis elegans) | Biological sciences | Edward M. Hedgecock, Edward T. Kipreos, Lois E. Lander, John P. Wing, Wei Wu He | |||
| Cyclin-dependent kinase inhibitor, dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesis. | Biological sciences | Iswar K. Hariharan, Joriene C. De Nooij, Mary Ann Latendre | |||
| Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid. | Biological sciences | Michael J. Welsh, E. Peter Greenberg, Jeffrey J. Smith, Sue M. Travis | |||
| Cytokinesis in higher plants. | Biological sciences | L. Andrew Staehelin, Peter K. Hepler | |||
| Cytokinesis in the Arabidopsis embryo involves the syntaxin-related KNOLLE gene product. | Biological sciences | Gerd Jurgens, Wolfgang Lukowitz, Ulrike Mayer | |||
| Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development. | Biological sciences | Harald Vaessin, Christian F. Lehner, Yuh Nung Jan, Mary Ellen Lane, Karsten Sauer, Kenneth Wallace | |||
| Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling. | Biological sciences | Michael A. Simon, Thomas Raabe, James Schilling, Ronald Herbst, Pamela M. Carroll, John D. Allard | |||
| Defective neuromuscular synaptogenesis in agrin-deficient mutant mice. | Biological sciences | Richard H. Scheller, Joshua R. Sanes, John P. Merlie, Peter G. Noakes, Medha Gautam, Lisa Moscoso, Fabio Rupp | |||
| Definitive hematopoiesis is autonomously initiated by the AGM region. (aorta-gonad-mesonephros region) | Biological sciences | Alexander Medvinsky, Elaine Dzierzak | |||
| Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. | Biological sciences | Marc Tessier-Lavigne, Joseph G. Culotti, Masayuki Masu, E. David Leonardo, Kazuko Keino-Masu, Lindsay Hinck, Shirley S.-Y. Chan | |||
| Die and let live: eliminating dangerous lymphocytes. | Biological sciences | Abul K. Abbas | |||
| Differential requirements for alpha-4 integrins during fetal and adult hematopoiesis. | Biological sciences | Richard O. Hynes, Helen Rayburn, Joy T. Yang, Alicia G. Arroyo | |||
| Direct and long-range action of a DPP morphogen gradient. (decapentaplegic) | Biological sciences | Konrad Basler, Gary Struhl, Denise Nellen, Richard Burke | |||
| Direct and long-range action of a wingless morphogen gradient. | Biological sciences | Konrad Basler, Gary Struhl, Myriam Zecca | |||
| Direct evidence of a role for heterochromatin in meiotic chromosome segregation. | Biological sciences | R. Scott Hawley, Abby F. Dernburg, John W. Sedat | |||
| Direct visualization of uridylate deletion in vitro suggests a mechanism for kinetoplastid RNA editing. | Biological sciences | Stefan Heidmann, Scott D. Seiwert, Kenneth Stuart | |||
| Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. (tumor necrosis factor; Jun N-terminal kinases) | Biological sciences | Michael Karin, Hailing Hsu, David V. Goeddel, Zheng-gang Liu | |||
| DNA demethylation in vitro: involvement of RNA. | Biological sciences | Howard Cedar, Alona Weiss, Ilana Keshet, Aharon Razin | |||
| DNA helicases: new breeds of translocating motors and molecular pumps. | Biological sciences | Stephen C. West | |||
| DNA polymerase III: running rings around the fork.(Minireview) | Biological sciences | Thomas J. Kelly, Daniel R. Herendeen | |||
| Do changes in chromosomes cause aging? | Biological sciences | Leonard Guarente | |||
| Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4. (bone morphogenetic proteins) | Biological sciences | Eddy M. De Robertis, Stefano Piccolo, Yoshiki Sasai, Bin Lu | |||
| DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras-1 in Drosophila. | Biological sciences | Ernst Hafen, Thomas Raabe, Peter Deak, Juan Riesgo-Escovar, Xiangdong Liu, Burkhard S. Bausenwein, Peter Maroy | |||
| Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein. | Biological sciences | Tony Pawson, S. Lawrence Zipursky, Paul A. Garrity, Yong Rao, Iris Salecker, Jane McGlade | |||
| Dual roles for patched in sequestering and transducing hedgehog. | Biological sciences | Yu Chen, Gary Struhl | |||
| E2F-1 functions in mice to promote apoptosis and suppress proliferation. | Biological sciences | Stuart H. Orkin, David M. Livingston, Michael E. Greenberg, William G. Kaelin Jr., Seth J. Field, Fong-Ying Tsai, Frank Kuo, Ana M. Zubiaga | |||
| E2F and cell proliferation: a world turned upside down. | Biological sciences | Robert A. Weinberg | |||
| E-cadherin is the receptor for internalin, a surface protein required for entry of L. monocytogenes into epithelial cells. | Biological sciences | Pierre Gounon, Pascale Cossart, Jerome Nengaud, Helene Ohayon, Rene-Marc Mege | |||
| E. coli SSB activates N4 virion RNA polymerase promoters by stabilizing a DNA hairpin required for promoter recognition. (single-stranded DNA-binding protein) | Biological sciences | Lucia B. Rothman-Denes, M. Alexandra Glucksmann-Kuis, Xing Dai, Peter Markiewicz | |||
| EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. (Caenorhabditis elegans) | Biological sciences | H. Robert Horvitz, Michael R. Koelle | |||
| Emerging understanding of translation termination. | Biological sciences | Koichi Ito, Yoshikazu Nakamura, Leif A. Isaksson | |||
| Emotion: systems, cells, synaptic plasticity. | Biological sciences | Michael T. Rogan, Joseph E. LeDoux | |||
| Ending the message is not so simple. | Biological sciences | Nicholas Proudfoot | |||
| Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(super Kip1). | Biological sciences | Lawrence A. Frohman, Adrian C. Hayday, Masao Ono, Hiroaki Kiyokawa, Rhonda D. Kineman, Katia O. Manova-Todorova, Vera C. Soares, Eric S. Hoffman, Dilruba Khanam, Andrew Koff | |||
| Eomesodermin, a key early gene in Xenopus mesoderm differentiation. | Biological sciences | Kenneth Ryan, J.B. Gurdon, Nigel Garrett, Andrew Mitchell | |||
| Epigenetic programming of developmental genome rearrangements in ciliates. | Biological sciences | Sandra Duharcourt, Eric Meyer | |||
| Epithelial M cells: gateways for mucosal infection and immunization. | Biological sciences | Marian R. Neutra, Andreas Frey, Jean-Pierre Kraehenbuhl | |||
| Evidence for a new step in telomere maintenance. | Biological sciences | Virginia A. Zakian, Raymund J. Wellinger, Katia Ethier, Pascale Labrecque | |||
| Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. | Biological sciences | Louis A. Tartaglia, Elizabeth A. Woolf, Jay P. Morgenstern, Xun Weng, Janice Culpepper, Karen J. Moore, Robert I. Tepper, Hong Chen, Olga Charlat, Stephen J. Ellis, Nathan D. Lakey, Roger E. Breitbart, Geoffrey M. Duyk | |||
| Evolution of chlorophyll biosynthesis - the challenge to survive photooxidation. | Biological sciences | Klaus Apel, Steffen Reinbothe, Christiane Reinbothe, Nikolai Lebedev | |||
| Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. | Biological sciences | Stephen W. Davies, Gillian P. Bates, Hans Lehrach, Yvon Trottier, Laura Mangiarini, Kirupa Sathasivam, Mary Seller, Barbara Cozens, Alex Harper, Colin Hetherington, Martin Lawton | |||
| Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor. (cell-derived) | Biological sciences | Christopher C. Goodnow, Richard A. Flavell, Jeffrey C. Rathmell, Sarah E. Townsend, Jiachao C. Xu | |||
| Facilitated recycling pathway for RNA polymerase III. | Biological sciences | Andre Sentenac, Giorgio Dieci | |||
| Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11. | Biological sciences | Francis Collins, Anthony Wynshaw-Boris, Lucio H. Castilla, Michael Eckhaus, Cisca Wijmenga, Qing Wang, Terryl Stacy, Nancy A. Speck, Miguel Marin-Padilla, Pu P. Liu | |||
| Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4. (calcium) | Biological sciences | Gisela M. Terwindt, Michel D. Ferrari, Roel A. Ophoff, Rune R. Frants, Dick Lindhout, Monique N. Vergouwe, Ronald Van Eijk, Peter J. Oefner, Susan M.G. Hoffman, Jane E. Lamerdin, Harvey W. Mohrenweiser, Dennis E. Bulman, Maurizio Ferrari, Joost Haan, Gert-Jan B. Van Ommen, Marten H. Hofker | |||
| FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase. | Biological sciences | Katja Wiegmann, Martin Kronke, Waldemar Kolanus, Sabine Adam-Klages, Dieter Adam, Sandra Struve, Jens Schneider-Mergener | |||
| Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation of Cdk2 inhibitors. | Biological sciences | James M. Roberts, Russell Ross, Elaine W. Raines, Hidenori Koyama, Karin E. Bornfeldt | |||
| Fibroblast growth factor receptor 3 is a negative regulator of bone growth. | Biological sciences | Philip Leder, Anthony Wynshaw-Boris, Ann Kuo, Chuxia Deng, Fen Zhou | |||
| Fifty ways to love your lever myosin motors. | Biological sciences | Steven M. Block | |||
| FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. | Biological sciences | Matthias Mann, Jian Ni, Peter H. Krammer, Arul M. Chinnaiyan, Reiner Gentz, Marcus E. Peter, Andrej Shevchenko, Karen O'Rourke, Vishva M. Dixit, Marta Muzio, Frank C. Kischkel, Carsten Scaffidi, James D. Bretz, Mei Zhang | |||
| Form and function in protein dephosphorylation. | Biological sciences | John M. Denu, Jack E. Dixon, Jeanne A. Stuckey, Mark A. Saper | |||
| For protein misassembly, it's the "I" decade. | Biological sciences | Ronald Wetzel | |||
| frazzled encodes a Drosophila member if the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance. (deleted in colorectal cancer; central nervous system) | Biological sciences | Lily Yeh Jan, Corey S. Goodman, Kevin J. Mitchell, Peter A. Kolodziej, Leslie C. Timpe, Sharon R. Fried, Yung Nung Jan | |||
| From form to function: signaling by protein tyrosine phosphatases. | Biological sciences | Benjamin G. Neel, Nicholas K. Tonks | |||
| From glycogen to amylopectin: a model for the biogenesis of the plant starch granule. | Biological sciences | Paul Colonna, Jack Preiss, Steven Ball, Han-Ping Guan, Martha James, Alan Myers, Peter Keeling, Gregory Mouille, Alain Buleon | |||
| From transcript to protein.(scientific workshop on mRNA processing, translation and transport) | Biological sciences | Angus I. Lamond, Gideon Dreyfuss, Matthias Hentze | |||
| Function of E. coli RNA polymerase sigma factor sigma70 in promoter-proximal pausing. | Biological sciences | Jeffrey W. Roberts, Brian Z. Ring, William S. Yarnell | |||
| GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits. | Biological sciences | David M. Berman, Alfred G. Gilman, Thomas M. Wilkie | |||
| GASPing for life in stationary phase. (growth advantage in stationary phase phenotype) | Biological sciences | Roberto Kolter, Maria Mercedes Zambrano | |||
| GDNF-induced activation of the Ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF.(glial cell line-derived neurotrophic factor) | Biological sciences | Zheng Hu, Yi Luo, Sylvia Hu, Shuqian Jing, Duanzhi Wen, Yanbin Yu, Paige L. Holst, Mei Fang, Rami Tamir, Laarni Antonio, Rod Cupples, Jean-Claude Louis, Bruce W. Altrock, Gary M. Fox | |||
| Genetic analysis of autoimmune disease. | Biological sciences | John A. Todd, Timothy J. Vyse | |||
| Gene transpositions in the HoxD complex reveal a hierarchy of regulatory controls. | Biological sciences | Jozsef Zakany, Denis Duboule, Frank van der Hoeven | |||
| Getting membrane flow and the cytoskeleton to cooperate in moving cells. | Biological sciences | Mark S. Bretscher | |||
| G protein heterodimers: new structures propel new questions. | Biological sciences | Eva J. Neer, Temple F. Smith | |||
| G proteins are required for spatial orientation of early cell cleavages in C. elegans embryos. (Caenorhabditis elegans) | Biological sciences | Julie Ahringer, Ronald H.A. Plasterk, Richard R. Zwaal, Henri G.A.M. Luenen, Alice Rushforth, Phil Anderson | |||
| H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection. | Biological sciences | H. Earl Ruley, Luc Van Kaer, W. David Martin, Geoffrey G. Hicks, Sanjeev K. Mendiratta, Hitesh I. Leva | |||
| Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain. | Biological sciences | Amina S. Woods, Robert J. Cotter, Philip A. Beachy, Eugene V. Koonin, Stephen C. Ekker, Jeffery A. Porter, Doris P. von Kessler, Keith E. Young, Woo-Jin Park, Chien-Huan Chen, Yong Ma | |||
| Hedgehog, transmitted along retinal axons, triggers neurogenesis in the developing visual centers of the Drosophila brain. | Biological sciences | Zhen Huang, Samuel Kunes | |||
| Helicase-contrahelicase interaction and the mechanism of termination of DNA replication. | Biological sciences | Stephen W. White, Deepak Bastia, Adhar C. Manna, Karnire S. Pai, Dirksen E. Bussiere, Christopher Davies | |||
| Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome. | Biological sciences | Michelle Hadchouel, Marco Pontoglio, Jacqueline Barra, Antonia Doyen, Chantal Kress, Josephine Poggi Bach, Charles Babinet, Moshe Yaniv | |||
| Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. (tumor necrosis factor; nerve growth factor) | Biological sciences | Patricia G. Spear, Rebecca I. Montgomery, Morgyn S. Warner, Brian J. Lum | |||
| Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription. (locus control region) | Biological sciences | Eric Milot, An Langeveld, Frank Grosveld, Peter Fraser, Mark Wijgerde, John Strouboulis, Ernie de Boer, Tolleiv Trimborn, Kian Tan-Un, Wilma Vergeer, Nikos Yannoutsos | |||
| Heterochronic genes control cell cycle progress and developmental competence of C. elegans vulva precursor cells. (nematode Caenorhabditis elegans) | Biological sciences | Victor Ambros, Susan Euling | |||
| High frequency retrotransposition in cultured mammalian cells. | Biological sciences | Haig H. Kazazian Jr., Jef D. Boeke, John V. Moran, Ralph J. DeBerardinis, Susan E. Holmes, Thierry P. Naas | |||
| Hijacking the cell: parasites in the driver's seat. | Biological sciences | Stephen M. Beverley | |||
| His-Asp phosphorelay: two components or more? | Biological sciences | Masayori Inouye | |||
| Histone acetylation and chromatin assembly: a single escort, multiple dances? | Biological sciences | C. David Allis, Sharon Y. Roth | |||
| Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. | Biological sciences | Richard A. Koup, Richard Horuk, Marcy E. MacDonald, Nathaniel R. Landau, Rong Liu, Heidi Stuhlmann, Sunny Choe, Scott R. Martin, William A. Paxton, Daniel Ceradini | |||
| HOOKLESS1, an ethylene response gene, is required for differential cell elongation in the Arabidopsis hypocotyl. | Biological sciences | Joseph R. Ecker, Anne Lehman, Robert Black | |||
| How do bacteria decide where to divide? | Biological sciences | Lawrence I. Rothfield, Chun-Rui Zhao | |||
| How fission yeast fission in the middle. | Biological sciences | Paul M. Nurse, Fred Chang | |||
| Human L1 retrotransposon encodes a conserved endonuclease required for retrotransposition. | Biological sciences | Haig H. Kazazian Jr., Jef D. Boeke, John V. Moran, Qinghua Feng | |||
| Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro. | Biological sciences | Peter Baumann, Stephen C. West, Fiona E. Benson | |||
| Human TAFII105 is a cell type-specific TFIID subunit related to hTAFII130. | Biological sciences | Sharleen Zhou, Robert Tjian, Rivka Dikstein | |||
| Hydration and DNA recognition by homeodomains. | Biological sciences | Kurt Wuthrich, Peter Guntert, Peter Luginbuhl, Martin Billeter | |||
| Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family. | Biological sciences | Wei Fan, Elizabeth A. Woolf, George A. Carlson, John J. Lee, Janice Culpepper, Jim Deeds, Karen J. Moore, M. Alexandra Glucksmann-Kuis, Hong Chen, Olga Charlat, Nathan D. Lakey, Geoffrey M. Duyk, Patrick W. Kleyn, Steve G. Kovats, Jacqueline C. Pulido, Ye Wu, Lucy R. Berkemeier, Don J. Misumi, Lisa Holmgren, Olga Tayber, Thomas Brody, Pei Shu, Fiona Hawkins, Brenda Kennedy, Linda Baldini, Chris Ebeling, Geoffrey D. Alperin | |||
| Identification of an asymmetrically localized determinant, Ash1p, required for lineage-specific transcription of the yeast HO gene. | Biological sciences | Ira Herskowitz, Anita Sil | |||
| Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules. | Biological sciences | Timothy J. Mitchison, Lisa D. Belmont | |||
| Identification of a Stat gene that functions in Drosophila development. | Biological sciences | Claude Desplan, James E. Darnell Jr., Riqiang Yan, Stephen Small, Charles R. Dearolf | |||
| Identification of neurogenin, a vertebrate neuronal determination gene. | Biological sciences | Qiufu Ma, David J. Anderson, Chris Kintner | |||
| Identification of the cell fate gene stalky in Dictyostelium. | Biological sciences | Wen-Tsan Chang, Peter C. Newell, Julian D. Gross | |||
| I-mf, a novel myogenic repressor, interacts with members of the MyoD family. | Biological sciences | Mark Groudine, Norbert Kraut, Harold Weintraub, C.-M. Amy Chen | |||
| Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. (interferon consensus sequence binding protein) | Biological sciences | Rolf M. Zinkernagel, Keiko Ozato, Jurgen Lohler, Thomas Holtschke, Yuka Kanno, Thomas Fehr, Nathalia Giese, Frank Rosenbauer, Jing Lou, Klaus-Peter Knobeloch, Lucia Gabriele, Jeffrey F. Waring, Martin F. Bachmann, Herbert C. Morse III, Ivan Horak | |||
| Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice. (N-methyl-D-aspartate) | Biological sciences | Susumu Tonegawa, Joe Z. Tsien, Matthew A. Wilson, Thomas J. McHugh, Kenneth I. Blum | |||
| Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice. | Biological sciences | Pamela S. Ohashi, Josef Penninger, Andrew Wakeham, Tak W. Mak, Arda Shahinian, Toshifumi Matsuyama, Thomas M. Kundig, Anne Hakem, Ryuichi Amakawa, John J.L. Simard, Emma Timms, Hans-Will Mittruecker, Henrik Griesser, Hiroaki Takimoto, Rudolf Schmits | |||
| Importin provides a link between nuclear protein import and U snRNA export. | Biological sciences | Iain W. Mattaj, Ronald A. Laskey, Elisa Izaurralde, Enno Hartmann, Susanne Kostka, Dirk Gorlich, Frank Vogel, Regine Kraft | |||
| Inactivation of NMDA receptors by direct interaction of calmodulin with the NR1 subunit. | Biological sciences | Su Zhang, Richard L. Huganir, Michael D. Ehlers, Jeffrey P. Bernhardt | |||
| Inactivation of the HR6B ubiquitin-conjugating DNA repair enzyme in mice causes male sterility associated with chromatin modification. | Biological sciences | D. Bootsma, J.H.J. Hoeijmakers, H.P. Roest, J. Van Klaveren, J. De Wit, C.G. Van Gurp, M.H.M. Koken, M. Vermey, J.H. Van Roijen, J.W. Hoogerbrugge, J.T.M. Vreeburg, W.M. Baarends, J.A. Grootegoed | |||
| Induction of apoptotic program in cell-free extracts: requirement for dATP and Cytochrome c. | Biological sciences | Xiaodong Wang, Jie Yang, Xuesong Liu, Caryn Naekyung Kim, Ronald Jemmerson | |||
| Induction of large DNA palindrome formation in yeast: implications for gene amplification and genome stability in eukaryotes. (deoxyribonucleic acid) | Biological sciences | Meng-Chao Yao, David K. Butler, Lauren E. Yasuda | |||
| Influence of PAX6 gene dosage on development: overexpression causes severe eye abnormalities. | Biological sciences | Nicholas D. Hastie, Andreas Schedl, Veronica van Heyningen, Dieter Engelkamp, Allyson Ross, Muriel Lee, Penny Rashbass | |||
| Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor. | Biological sciences | Zaverio M. Ruggeri, Brian Savage, Enrique Saldivar | |||
| Inositol triphosphate and cyclic ADP-ribose-mediated release of Ca2+ from single isolated pancreatic zymogen granules. | Biological sciences | Oleg V. Gerasimenko, Julia V. Gerasimenko, Ole H. Petersen, Pavel V. Belan | |||
| Insulin-dependent diabetes mellitus. | Biological sciences | Hugh McDevitt, Roland Tisch | |||
| Integrin activation by R-ras. | Biological sciences | John C. Reed, Erkki Ruoslahti, Zhuohua Zhang, Kristiina Vuori, Hong-Gang Wang | |||
| Interaction between the origin recognition complex and the replication licensing system in Xenopus. | Biological sciences | J. Julian Blow, Gerard I. Evan, Alison Rowles, James J.P. Chong, Lamorna Brown, Mike Howell | |||
| Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine. | Biological sciences | Anthony J. Muslin, Paul M. Allen, J. William Tanner, Audrey S. Shaw | |||
| Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha 1-syntrophin mediated by PDZ domains. | Biological sciences | David S. Bredt, Jay E. Brenman, Daniel S. Chao, Houhui Xia, Stanley C. Froehner, Stephen H. Gee, Aaron W. McGee, Sarah E. Craven, Daniel R. Santillano, Ziqiang Wu, Fred Huang, Matthew F. Peters | |||
| Interchromosomal transfer of epigenetic states in Ascobolus: transfer of DNA methylation is mechanistically related to homologous recombination. | Biological sciences | Vincent Colot, Jean-Luc Rossignol, Laurent Maloisel | |||
| Invariant chain structure and MHC class II function. | Biological sciences | Peter Cresswell | |||
| Inversion of the membrane topology of SecG coupled with SecA-dependent preprotein translocation. | Biological sciences | Takashi Suzuki, Ken-ichi Nishiyama, Hajime Tokuda | |||
| Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. | Biological sciences | David Wallach, Mark P. Boldin, Tanya M. Goncharov, Yury V. Goltsev | |||
| Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. | Biological sciences | George D. Yancopoulos, Samuel Davis, Czeslaw Radziejewski, Vivek Jain, Joanne Bruno, Pamela F. Jones, Terence E. Ryan, Ann Acheson, Debra L. Compton, Thomas H. Aldrich, Peter C. Maisonpierre | |||
| Kinesin-related proteins at mitotic spindle poles: function and regulation. | Biological sciences | Timothy J. Mitchison, Claire E. Walczak | |||
| Know your neighbors: three phenotypes in null mutants of the myogenic bHLH gene MRF4. (basic helix-loop-helix) | Biological sciences | E.N. Olson, H.-H. Arnold, P.W.J. Rigby, B.J. Wold | |||
| Ku-86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. | Biological sciences | Dae-Sik Lim, David B. Roth, Molly A. Bogue, Chengming Zhu, Paul Hasty | |||
| Lateral and axial signals involved in avian somite patterning: a role for BMP4. | Biological sciences | Marc Tessier-Lavigne, Christiane Breant, Chen-Ming Fan, Olivier Pouquie, Monique Coltey, Estelle Hirsinger, Yuji Watanabe, Philippa Francis-West, Paul Brickell, Nicole M. Le Douarin | |||
| Lessons from hereditary colorectal cancer. | Biological sciences | Kenneth W. Kinzler, Bert Vogelstein | |||
| LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction. (Caenorhabditis elegans) | Biological sciences | Stuart K. Kim, Susan M. Kaech, Jeffrey S. Simske, Stacey A. Harp | |||
| LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition. | Biological sciences | Mark Noble, Shannon J. Odelberg, Mark T. Keating, Eric D. Green, Donald L. Atkinson, Amanda K. Ewart, Colleen A. Morris, Carolyn B. Mervis, Christoph Proschel, J. Michael Frangiskakis, Jacquelyn Bertrand, Byron F. Robinson, Bonita P. Klein, Gregory J. Ensing, Lorraine A. Everett, Nick J. Gutowski | |||
| Linker histone H1 regulates specific gene expression but not global transcription in vivo. | Biological sciences | Xuetong Shen, Martin A. Gorovsky | |||
| Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha-v-beta-3. | Biological sciences | David A. Cheresh, William G. Stetler-Stevenson, Peter C. Brooks, James P. Quigley, Staffan Stromblad, Luraynne C. Sanders, Tami L. Von Schalscha, Ronald T. Aimes | |||
| Long-term potentiation is reduced in mice that are doubly mutant in endothelial and neuronal nitric oxide synthase. | Biological sciences | Eric R. Kandel, Mark C. Fishman, Robert D. Hawkins, Michael Kiebler, Paul L. Huang, Hyeon Son, Kelsey Martin | |||
| Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiency. | Biological sciences | Jay L. Degen, Thomas H. Bugge, Keith W. Kombrinck, Matthew J. Flick, Cynthia C. Daugherty, Mary Jo S. Danton | |||
| Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae. | Biological sciences | Leonard Guarente, James Claus, Brian Kennedy, Tod Smeal, Francesca Cole | |||
| Lymphoid potential, probed before circulation in mouse, is restricted to caudal intraembryonic splanchnopleura. | Biological sciences | Francoise Dieterlen-Lievre, Ana Cumano, Isabelle Godin | |||
| MADR1, a MAD-related protein that functions in BMP2 signaling pathways. (Mothers against dpp)(bone morphogenic proteins) | Biological sciences | Jeffrey L. Wrana, Michael B. O'Connor, Pamela A. Hoodless, Liliana Attisano, Theo Haerry, Shirin Abdollah, Mark Stapleton | |||
| MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling. (Mothers against dpp-related proteins)(tumor growth factor) | Biological sciences | Jeffrey L. Wrana, Pamela A. Hoodless, Liliana Attisano, Shirin Abdollah, Rosa Pirone, Marina Macias-Silva | |||
| MADR2 maps to 18q21 and encodes a TGF beta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. (TGF) | Biological sciences | Hyeja Kim, Steven Gallinger, Jeffrey L. Wrana, Stephen W. Scherer, Liliana Attisano, Lap-Chee Tsui, Gerald H. Thomsen, Bharati Bapat, Irene L. Andrulis, Kolja Eppert, Hilmi Ozcelik, Rosa Pirone, Pamela Hoodless | |||
| MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation. | Biological sciences | Thomas Graf, Hildegard Tekotte, Michael H. Sieweke, Jonathan Frampton | |||
| Mammalian SH2-containing protein tyrosine phosphatases.(Letter to the Editor) | Biological sciences | Tony Pawson, Axel Ullrich, Kohzoh Imai, Matthew Thomas, Masaaki Adachi, Edmond H. Fischer, James Ihle, Frank Jirik, Ben Neel, Shi-Hsiang Shen, Zhizhuang Zhao | |||
| marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs. (signal transducers and activators of transcription) | Biological sciences | Norbert Perrimon, Michael B. Melnick, Xianyu Steven Hou | |||
| Maturation pathways for E. coli tRNA precursors: a random multienzyme process in vivo. | Biological sciences | Zhongwei Li, Murray P. Deutscher | |||
| MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. | Biological sciences | Alfred H. Schinkel, Hein Sprong, Piet Borst, Alexander J. Smith, Ardy Van Helvoort, Ingo Fritzsche, Gerrit Van Meer | |||
| Meiotic pachytene arrest in MLH1-deficient mice. | Biological sciences | Paula E. Cohen, Raju Kucherlapati, Jeffrey W. Pollard, Winfried Edelmann, Richard D. Kolodner, Giorgio Cattoretti, Bernice Morrow, Michael Kane, Kirkland Lau, Samuel Bennett, Asad Umar, Thomas Kunkel, Raju Chaganti | |||
| Meiotic recombination in yeast: coronation of the double-strand-break repair model. | Biological sciences | Frank Stahl | |||
| Meiotic transvection in fungi. | Biological sciences | Robert L. Metzenberg, Rodolfo Aramayo | |||
| Membrane dynamics in endocytosis. | Biological sciences | Marino Zerial, Colin Watts, Margaret S. Robinson | |||
| Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament. (vasodilator-stimulated phosphoprotein) | Biological sciences | Philippe Soriano, Jurgen Wehland, Frank B. Gertler, Kirsten Niebuhr, Matthias Reinhard | |||
| MEX-3 is a KH domain protein that regulates blastomere identity in early C. elegans embryos. | Biological sciences | Craig C. Mello, Bruce Bowerman, Jeff Hardin, James R. Priess, Bruce W. Draper | |||
| Mg2+ as an extracellular signal: environmental regulation of Salmonella virulence. (magnesium ions) | Biological sciences | Eduardo A. Groisman, Eleonora Garcia Vescovi, Fernando C. Soncini | |||
| Mice expressing activated CaMKII lack low frequency LTP and do not form stable place cells in the CA1 region of the hippocampus. (long-term potentiation)(Ca2+/calmodulin-dependent protein kinase II) | Biological sciences | Eric R. Kandel, Robert D. Hawkins, Mark Mayford, Alexander Rotenberg, Robert U. Muller | |||
| Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway. | Biological sciences | Andree Dierich, Christophe Benoist, Diane Mathis, Hidde Ploegh, Caroline Waltzinger, Toru Miyazaki, Paula Wolf, Sylvie Tourne, Nicolas Barois | |||
| Mice lacking p27(super Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. | Biological sciences | Kei-ichi Nakayama, Dennis Y. Loh, Keiko Nakayama, Noriko Ishida, Michiko Shirane, Akira Inomata, Tomoaki Inoue, Nobuyuki Shishido, Ikuo Horii | |||
| Migraines in mice? | Biological sciences | Ellen J. Hess | |||
| Mixed mechanisms in yeast pre-mRNA splicing? | Biological sciences | Michael Rosbash | |||
| Modulation of horizontal gene transfer in pathogenic bacteria by in vivo signals. | Biological sciences | John J. Mekalanos, Stephen F. Mel | |||
| Modulation of Neisseria porin (PorB) by cytostolic ATP (Adenosine Triphosphate)/GTP (Guanine Triphosphate) of target cells: parallels between pathogen accommodation and mitochondrial endosymbiosis. | Biological sciences | Roland Benz, Thomas Meyer, Florian Lang, Thomas Rudel, Angela Schmid, Hans-Albert Kolb | |||
| Molecular glue: kinase anchoring and scaffold proteins. | Biological sciences | John D. Scott, Maree C. Faux | |||
| Molecular mimicry in development: identification of ste11+ as a substrate and mei3+ as a pseudosubstrate inhibitor of ran1+ kinase. | Biological sciences | Peng Li, Maureen McLeod | |||
| Morphogenetic properties of microtubules and mitotic spindle assembly. | Biological sciences | Eric Karsenti, Anthony A. Hyman | |||
| Morphogens, compartments, and pattern: lessons from Drosophila? | Biological sciences | Gary Struhl, Peter A. Lawrence | |||
| Mother and daughter are doing fine: asymmetric cell division in yeast. | Biological sciences | Angelika Amon | |||
| Mother cell-specific HO expression in budding yeast depends on the unconventional Myosin Myo4p and other cytoplasmic proteins. | Biological sciences | Marta Galova, Kim Nasmyth, Christine Michaelis, Ralf-Peter Jansen, Celia Dowzer | |||
| Moving membrane up to the front migrating cells. | Biological sciences | Mark S. Bretscher | |||
| Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. | Biological sciences | Lawrence Steinman | |||
| Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. | Biological sciences | Allen E. Bale, Michael Dean, Alisa M. Goldstein, Bernard Gerrard, Igor Vorechovsky, Ian Smyth, Carol Wicking, David J. Leffell, Heidi Hahn, Peter G. Zaphiropoulos, Mae R. Gailani, Susan Shanley, Abirami Chidambaram, Erika Holmberg, Anne Birgitte Unden, Susan Gillies, Kylie Negus, Carol Pressman, Rune Toftgard, Georgia Chenevix-Trench, Brandon Wainwright | |||
| Mu transpositional recombination: donor DNA cleavage and strand transfer in trans by the Mu transposase. | Biological sciences | Kiyoshi Mizuuchi, Harri Savilahti | |||
| Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability. | Biological sciences | Brian Popko, Timothy Coetzee, Nobuya Fujita, Jeffrey Dupree, Riyi Shi, Andrew Blight, Kinuko Suzuki, Kunihiko Suzuki | |||
| Nerve growth factor is an autocrine survival factor for memory B lymphocytes. | Biological sciences | Maria Torcia, Luisa Bracci-Laudiero, Maria Lucibello, Lucia Nencioni, Danilo Labardi, Anna Rubartelli, Federico Cozzolino, Luigi Aloe, Enrico Garaci | |||
| Netrin-1 is required for commisural axon guidance in the developing vertebrate nervous system. | Biological sciences | Marc Tessier-Lavigne, Wang Hao, William C. Skarnes, Sophia A. Colamarino, Rosa Beddington, Tito Serafini, E. David Leonardo | |||
| NF-kappaB: ten years after. | Biological sciences | David Baltimore, Patrick A. Baeuerle | |||
| Nitric oxide acts directly in the presynaptic neuron to produce long-term potentiation in cultured hippocampal neurons. | Biological sciences | Eric R. Kandel, Robert D. Hawkins, Roger Y. Tsien, Michael Kiebler, Ottavio Arancio, C. Justin Lee, Varda Lev-Ram | |||
| Nitric oxide regulates cell proliferation during Drosophila development. | Biological sciences | Ian Roberts, Natalia Peunova, Grigori Enikolopov, Boris Kuzin | |||
| Nitrosative stress: activation of the transcription factor OxyR. | Biological sciences | Jonathan S. Stamler, Alfred Hausladen, Christopher T. Privalle, Teresa Keng, Joseph DeAngelo | |||
| Nonsense mutations inhibit RNA splicing in a cell-free system: recognition of mutant codon is independent of protein synthesis. (Ribonucleic acid) | Biological sciences | Cesar Milstein, Said Aoufouchi, Jose Yelamos | |||
| Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4. | Biological sciences | Bruce Stillman, Paul D. Kaufman, Alain Verreault, Ryuji Kobayashi | |||
| Nuk controls pathfinding of commissural axons in the mammalian central nervous system. | Biological sciences | Tony Pawson, Rudiger Klein, Mark Henkemeyer, Donata Orioli, Jeffrey T. Henderson, Tracy M. Saxton, John Roder | |||
| odr-10 encodes a seven transmembrane domain receptor required for response for responses to the odorant diacetyl. | Biological sciences | Piali Sengupta, Cornelia I. Bargmann, Joseph H. Chou | |||
| Oligomeric rings of the Sec61p complex induced by ligands required for protein translocation. | Biological sciences | Tom A. Rapoport, Kathrin Plath, Berit Jungnickel, Dorit Hanein, Kent E.S. Matlack, Kai-Uwe Kalies, Kenneth R. Miller, Christopher W. Akey | |||
| Operating under a Gag order: a block against incoming virus by the Fv1 gene. | Biological sciences | Stephen P. Goff | |||
| Organelle inheritance. | Biological sciences | Graham Warren, William Wickner | |||
| Organ-specific disease provoked by systemic autoimmunity. | Biological sciences | Claude Degott, Christophe Benoist, Diane Mathis, Valerie Kouskoff, Anne-Sophie Korganow, Veronique Duchatelle | |||
| Origins of cell polarity. | Biological sciences | W. James Nelson, David G. Drubin | |||
| p53 protein exhibits 3'-to-5' exonuclease activity. | Biological sciences | Wolfgang Deppert, Torsten Mummenbrauer, Friedemann Janus, Beate Muller, Lisa Wiesmuller, Frank Grosse | |||
| Pathogenicity islands: bacterial evolution in quantum leaps. | Biological sciences | Howard Ochman, Eduardo A. Groisman | |||
| Pathway leading to correctly folded beta-tubulin. | Biological sciences | Joel Vandekerckhove, Guoling Tian, Yi Huang, Heidi Rommelaere, Christophe Ampe, Nicholas J. Cowan | |||
| Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. | Biological sciences | Douglas Hanahan, Judah Folkman | |||
| Pddp1p, a novel chromodomain-containing protein, links heterochromatin assembly and DNA elimination in tetrahymena. | Biological sciences | C. David Allis, Meng-Chao Yao, James F. Smothers, Malavi T. Madireddi, Robert S. Coyne, Katherine M. Mickey | |||
| PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. | Biological sciences | John K. Heath, Mats Hellstrom, Per Lindahl, Christer Betsholtz, Per Leveen, Hans Bostrom, Karen Willetts, Milos Pekny, Hakan Hedstrand, Marcela Pekna, Samuel Gebre-Medhin, Martin Schalling, Mia Nilsson, Siri Kurland, Jan Tornell | |||
| Peptide-surface association: the case of PDZ and PTB domains. | Biological sciences | Stephen C. Harrison | |||
| Perturbation of nuclear architecture by long-distance chromosome interactions. | Biological sciences | Abby F. Dernburg, John W. Sedat, David A. Agard, Jennifer C. Fung, Karl W. Broman, Wallace F. Marshall, Jennifer Philips | |||
| PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface.(pleckstrin homology) | Biological sciences | Joseph Schlessinger, Mark A. Lemmon, Kathryn M. Ferguson | |||
| Plant cells contain two functionally distinct vacuolar compartments. | Biological sciences | John C. Rogers, Nardine Paris, C. Michael Stanley, Russell L. Jones | |||
| Polypeptide translocation: a pretty picture is worth a thousand words. | Biological sciences | Randy Schekman | |||
| Ponce d'elegans: genetic quest for the fountain of youth. | Biological sciences | Cynthia Kenyon | |||
| Positional information within the Mu transposase tetramer: catalytic contributions of individual monomers. | Biological sciences | Jin-Ying Yang, Makkuni Jayaram, Rasika M. Harshey | |||
| Principles of viral pathogenesis. | Biological sciences | Michael B.A. Oldstone | |||
| Promoter proximal sequences modulate RNA polymerase II elongation by a novel mechanism. | Biological sciences | Thadd C. Reeder, Diane K. Hawley | |||
| Protein degradation or regulation: Ub the judge. (ubiquitin) | Biological sciences | Mark Hochstrasser | |||
| Quality control in Mu DNA transposition. | Biological sciences | Robert Craigie | |||
| Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65(super PAK) and the JNK/SAPK MAP kinase cascade. | Biological sciences | Alan Hall, Lisa Stowers, John Chant, Pontus Aspenstrom, Nathalie Lamarche, Nicholas Tapon, Peter D. Burbelo, Tina Bridges | |||
| RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination. (recombination activating gene-1; variable(diversity)joining) | Biological sciences | Michael J. Difilippantonio, David G. Schatz, Quinn M. Eastman, Catherine J. McMahan, Eugenia Spanopoulou | |||
| Receptor tyrosine phosphatases are required for motor axon guidance in the Drosophila embryo. | Biological sciences | Lawrence S.B. Goldstein, Joseph G. Gindhart Jr., Chand J. Desai, Kai Zinn | |||
| Recognition of the bacterial avirulence protein AvrBs3 occurs inside the host plant cell. | Biological sciences | Eric Marois, Guido Van den Ackerveken, Ulla Bonas | |||
| Recombination by replication. | Biological sciences | Tokio Kogoma | |||
| Reconstruction in vitro of the motile apparatus from the amoeboid sperm of Ascaris shows that filament assembly and bundling move membranes. | Biological sciences | Murray Stewart, Thomas M. Roberts, Joseph E. Italiano Jr., Carolyn A. Fontana | |||
| Regions in beta-chemokine receptors CCR5 and CCR2b that determine HIV-1 cofactor specificity. | Biological sciences | Robert W. Doms, Gilbert Vassart, Marc Parmentier, Benjamin J. Doranz, Joseph Rucker, Yanjie Yi, Robert J. Smyth, Michel Samson, Ronald G. Collman, Frederick Libert, Joanne F. Berson, Christopher C. Broder | |||
| Regions responsible for the assembly of inwardly rectifying potassium channels. | Biological sciences | Lily Yeh Jan, Yuh Nung Jan, Andrew Tinker | |||
| Regulating S phase: CDKs, licensing and proteolysis. (cyclin dependent kinases) | Biological sciences | Paul M. Nurse, Jerome Wuarin | |||
| Regulation of organelle biogenesis. | Biological sciences | Peter Walter, Jodi Nunnari | |||
| Regulation of the Drosophila protein timeless suggests a mechanism for resetting the circadian clock by light. | Biological sciences | Amita Sehgal, Melissa Hunter-Ensor, Andrea Ousley | |||
| Regulatory circuits controlling photosynthesis gene expression. | Biological sciences | Carl E. Bauer, Terry H. Bird | |||
| Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. (epidermal growth factor) | Biological sciences | Matthew Freeman | |||
| Replicative senescence: an old lives' tale? | Biological sciences | Judith Campisi | |||
| Replisome assembly reveals the basis for the asymmetric function in leading and lagging strand replication. | Biological sciences | Mike O'Donnell, Jennifer Turner, Alexander Yuzhakov | |||
| Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation. | Biological sciences | Thomas M. Jessell, Samuel L. Pfaff, Colin L. Stewart, Thomas Edlund, Monica Mendelsohn | |||
| Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis. | Biological sciences | Thomas A. Kunkel, Alan B. Clark, David C. Thomas, Jeffrey A. Simon, Asad Umar, Andrew B. Buermeyer, R. Michael Liskay | |||
| Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. | Biological sciences | George D. Yancopoulos, Samuel Davis, Pamela F. Jones, Chitra Suri, Thomas N. Sato, Peter C. Maisonpierre, Sybill Patan, Sona Bartunkova | |||
| Retrohoming: cDNA-mediated mobility of group II introns requires a catalytic RNA.(Minireview) | Biological sciences | Marlene Belfort, M. Joan Curcio | |||
| Rheumatoid arthritis. | Biological sciences | Marc Feldmann, Ravinder N. Maini, Fionula M. Brennan | |||
| RNA polymerase II holoenzyme contains SWI/SNF regulators involved in chromatin remodeling. | Biological sciences | Richard A. Young, Anthony N. Imbalzano, Robert E. Kingston, David M. Chao, Gavin R. Schnitzler, Christopher J. Wilson | |||
| RNase III cleaves eukaryotic preribosomal RNA at a U3 snoRNP-dependent site. | Biological sciences | Manuel Ares Jr., Haller Igel, Sherif Abou Elela | |||
| Role of band 3 in homeostasis and cell shape. (erythrocyte anion exchange protein) | Biological sciences | Daniel G. Jay | |||
| Role of the INK4a locus in tumor suppression and cell mortality. | Biological sciences | Han-Woong Lee, Manuel Serrano, Ronald A. DePinho, Lynda Chin, David Beach, Carlos Cordon-Cardo | |||
| Role of tim23 as voltage sensor and presequence receptor in protein import into mitochondria. | Biological sciences | Matthias F. Bauer, Walter Neupert, Michael Brunner, Christian Sirrenberg | |||
| Roles for FGF8 in the induction, initiation, and maintenance of chick limb development. | Biological sciences | Gail R. Martin, Philip H. Crossley, George Minowada, Craig A. MacArthur | |||
| RSC, an essential, abundant chromatin-remodeling complex. | Biological sciences | Roger D. Kornberg, Hediye Erdjument-Bromage, Paul Tempst, Bradley R. Cairns, Yang Li, Yahli Lorch, Mincheng Zhang, Lynne Lacomis, Jian Du, Brehon Laurent | |||
| Sec18p(NSF)-driven release of Sec17p(alpha-SNAP) can precede docking and fusion of yeast vacuoles. (N-ethylmaleimide-sensitive fusion, soluble NSF attachment proteins) | Biological sciences | Andreas Mayer, William Wickner, Albert Haas | |||
| Self/nonself recognition in fungi: old mysteries and simple solutions. | Biological sciences | Michael Bolker, Regine Kahmann | |||
| Self-promotion? Intimate connections between APC and prostaglandin H synthase-2. | Biological sciences | Raymond L. White, Stephen M. Prescott | |||
| Separation of sister chromatids in mitosis requires the Drosophila pimples product, a protein degraded after the metaphase/anaphase transition. | Biological sciences | Christian F. Lehner, Rembert Stratmann | |||
| Septin scaffolds and cleavage planes in Saccharomyces. | Biological sciences | John Chant | |||
| Sequence-specific alteration of the ribosome-membrane junction exposes nascent secretory proteins to the cytosol. | Biological sciences | Vishwanath R. Lingappa, Ramanujan S. Hegde | |||
| Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not Bcl-X(sub L). | Biological sciences | Stanley J. Korsmeyer, Jiping Zha, Elizabeth Yang, Jennifer Jockel, Hisashi Harada | |||
| Serpentine proteins slither into the Wingless and Hedgehog fields. | Biological sciences | Norbert Perrimon | |||
| Short-range signaling by candidate morphogens of the TGFbeta family and evidence for a relay mechanism of induction. | Biological sciences | Douglas A. Melton, Karlyne M. Reilly | |||
| Signal sequences: the same yet different. | Biological sciences | Lila M. Gierasch, Ning Zheng | |||
| Signal transduction via the multi-step phosphorelay: not necessarily a road less traveled. | Biological sciences | John S. Parkinson, Jeryl L. Appleby, Robert B. Bourret | |||
| Similar structural models of the transmembrane proteins of Ebola and avian sarcoma viruses.(Letter to the Editor) | Biological sciences | William R. Gallaher | |||
| Site-specific phosphorylation of I(kappa)B(alpha) by a novel ubiquitination-dependent protein kinase activity. | Biological sciences | Zhijian J. Chen, Tom Maniatis, Lana Parent | |||
| Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs. | Biological sciences | Tamas Kiss, Zsuzsanna Kiss-Laszlo, Yves Henry, Jean-Pierre Bachellerie, Michele Caizergues-Ferrer | |||
| Size control: the regulation of cell numbers in animal development. | Biological sciences | Martin C. Raff | |||
| SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. | Biological sciences | Stephen J. Elledge, J. Wade Harper, Mark Goebl, Kay Hofmann, Chang Bai, Partha Sen, Lei Ma | |||
| SNARE-mediated retrograde traffic from the Golgi complex to the endoplasmic reticulum. | Biological sciences | Hugh R.B. Pelham, Michael J. Lewis | |||
| Solution structure of a pair of calcium-binding epidermal growth factor-like domains: implications for the Marfan syndrome and other genetic disorders. | Biological sciences | A.K. Downing, V. Knott, C.M. Cardy, I.D. Campbell, P.A. Handford, J.M. Werner | |||
| Solution structure of the link module: a hyaluronan-binding domain involved in extracellular matrix stability and cell migration. | Biological sciences | Daisuke Kohda, Iain D. Campbell, Craig J. Morton, Ashfaq A. Parkar, Hideki Hatanaka, Fuyuhiko M. Inagaki, Anthony J. Day | |||
| Spatial and temporal controls target pal-1 blastomere-specification activity to a single blastomere lineage in C. elegans embryos. (partial loss of function) | Biological sciences | Cynthia Kenyon, Craig P. Hunter | |||
| Spatial learning and memory: the beginning of a dream. | Biological sciences | Charles F. Stevens | |||
| Spindle orientation and asymmetric localization in Drosophila: both Inscuteable? | Biological sciences | Chris Q. Doe | |||
| STATs: signal transducers and activators of transcription. | Biological sciences | James N. Ihle | |||
| Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment.(sterol regulatory element binding protein) | Biological sciences | Michael S. Brown, Robert B. Rawson, Joseph L. Goldstein, Juro Sakai, Elizabeth A. Duncan, Xianxin Hua | |||
| Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein. (Chinese hamster ovary; sterol regulatory element binding proteins) | Biological sciences | Michael S. Brown, Joseph L. Goldstein, Axel Nohturfft, Xianxin Hua | |||
| Structural basis for the autoinhibition of calcium/calmodium-dependent protein kinase I. | Biological sciences | Jonathan Goldberg, Angus C. Nairn, John Kuriyan | |||
| Structural basis for the excision repair of alkylation-damaged DNA. | Biological sciences | Gregory L. Verdine, Orlando D. Scharer, Jorg Labahn, Alexander Long, Khosro Ezaz-Nikpay, Tom E. Ellenberger | |||
| Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid. | Biological sciences | Michael D. Sintchak, Mark A. Fleming, Paul R. Caron, Olga Futer, Scott A. Raybuck, Stephen P. Chambers, Mark A. Murcko, Keith P. Wilson | |||
| Structure of bacteriophage T4 RNase H, a 5' to 3' RNA-DNA and DNA-DNA exonuclease with sequence similarity to the RAD2 family of eukaryotic proteins. | Biological sciences | Timothy C. Mueser, Nancy G. Nossal, C. Craig Hyde | |||
| Structure of the C-terminal region of p21WAF1/CIP1 complexed with human PCNA. (proliferating cell nuclear antigen) | Biological sciences | Mike O'Donnell, John Kuriyan, Jerard Hurwitz, Jacqueline M. Gulbis, Zvi Kelman | |||
| Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism. (fibroblast growth factor) | Biological sciences | Joseph Schlessinger, Stevan R. Hubbard, Moosa Mohammadi | |||
| Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor.(insulin receptor substrate-1, phosphotyrosine binding) | Biological sciences | Michael J. Eck, Steven E. Shoelson, Thomas Trub, Sirano Dhe-Paganon, Robert T. Nolte | |||
| Subregion- and cell type-restricted gene knockout in mouse brain. | Biological sciences | David J. Anderson, Eric R. Kandel, Susumu Tonegawa, Joe Z. Tsien, Mark Mayford, Dong Feng Chen, David Gerber, Cindy Tom, Eric H. Mercer | |||
| Suppression of intestinal polyposis in APCdelta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). | Biological sciences | Jilly F. Evans, Masanobu Oshima, Makoto M. Taketo, Joseph E. Dinchuk, James M. Trzaskos, Stacia L. Kargman, Hiroko Oshima, Bruno Hancock, Elizabeth Kwong | |||
| Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins. | Biological sciences | Richard O. Hynes, Paul S. Frenette, Tanya N. Mayadas, Denisa D. Wagner, Helen Rayburn | |||
| Systemic lupus erythematosus. | Biological sciences | Brian L. Kotzin | |||
| TAF,250 is a bipartite protein kinase that phosphorylates the basal transcription factor RAP74. | Biological sciences | Siegfried Ruppert, Rivka Dikstein, Robert Rjian | |||
| TAFIIS mediate activation of transcription in the Drosophila embryo. | Biological sciences | Gerald M. Rubin, Robert Tjian, Frank Sauer, David A. Wassarman | |||
| Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. | Biological sciences | David E. Levy, M. Celeste Simon, Renee Hackenmiller, Joan E. Durbin | |||
| Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. | Biological sciences | J. Michael White, Robert D. Schreiber, Raymond N. DuBois, Michel Aguet, Scott J. Rodig, Marco A. Meraz, Kathleen C.F. Sheehan, Erika A. Bach, Anand S. Dighe, Daniel H. Kaplan, Joan K. Riley, Andrew C. Greenlund, Dayle Campbell, Karen Carver-Moore, Ross Clark | |||
| Targeting chromatin disruption: transcription regulators that acetylate histones. | Biological sciences | Alan P. Wolffe, Dmitry Pruss | |||
| Telomeres and telomerase: a simple picture becomes complex. | Biological sciences | Victoria Lundblad, Woodring E. Wright | |||
| Tertiary structure of destrin and structural similarity between two actin-regulating protein families. | Biological sciences | H. Hatanaka, F. Inagaki, K. Ogura, K. Moriyama, S. Ichikawa, I. Yahara | |||
| Testing the Agrin Hypotheses. | Biological sciences | Robin J. Kleiman, Louis F. Reichhardt | |||
| Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation. | Biological sciences | C. David Allis, Sharon Y. Roth, Ryuji Kobayashi, Jianxin Zhou, James E. Brownell, Tamara Ranalli, Diane G. Edmonson | |||
| TGF beta 1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. (transforming growth factor) | Biological sciences | Allan Balmain, Rosemary J. Akhurst, Wei Cui, Deborah J. Fowlis, Sheila Bryson, Elizabeth Duffie, Hazel Ireland | |||
| TGF-beta signaling: receptors, transducers, and Mad proteins.(transforming growth factor, Mothers against decapentaplegic) | Biological sciences | Joan Massague | |||
| The 1.85 angstrom structure of vaccinia protein VP39: a bifunctional enzyme that participates in the modification of both mRNA ends. | Biological sciences | Alec E. Hodel, Paul D. Gershon, Xuenong Shi, Florante Quiocho | |||
| The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1. | Biological sciences | Margaret M. Chou, John Blenis | |||
| The adaptor protein Shc couples a class of integrins to the control of cell cycle progression. | Biological sciences | Filippo G. Giancotti, Kishore K. Wary, Fabrizio Mainiero, Steven J. Isakoff, Eugene E. Marcantonio | |||
| The alpha(1,3)Fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-,E-, and P-selectin ligand biosynthesis. | Biological sciences | Ulrich H. von Andrian, Ole Hindsgaul, John B. Lowe, Sally A. Camper, Thomas L. Saunders, Petr Maly, Aron D. Thall, Bronislawa Petryniak, Clare E. Rogers, Peter L. Smith, Rory M. Marks, Robert J. Kelly, Kevin M. Gersten, Guiying Cheng, Ray T. Camphausen, Francis X. Sullivan, Yukihiro Isogai | |||
| The alpha-galactosyl epitope: a sugar coating that makes viruses and cells unpalatable. | Biological sciences | Russell P. Rother, Stephen P. Squinto | |||
| The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. | Biological sciences | Michael Farzan, Joseph Sodroski, Charles R. Mackay, Craig Gerard, Ying Sun, Hyeryun Choe, Nancy Sullivan, Barrett Rollins, Paul D. Ponath, Lijun Wu, Gregory LaRosa, Walter Newman, Norma Gerard | |||
| The CBF(beta) subunit is essential for CBF(alpha)2 (AML1) function in vivo. | Biological sciences | Frederick W. Alt, Michael Binder, Anthony Wynshaw-Boris, Arlene H. Sharpe, Qing Wang, Jean-Christophe Bories, Terryl Stacy, Nancy A. Speck, Miguel Marin-Padilla, Janelle D. Miller, Amy F. Lewis, Ting-Lei Gu, Xuemei Huang, John H. Bushweller, Gabriella Ryan, Pu Paul Liu | |||
| The Cdk-activating kinase (CAK) from budding yeast. | Biological sciences | Mark J. Solomon, Ann Sutton, Philipp Kaldis | |||
| The chaperonin ATPase cycle: mechanism of allosteric switching and movements of substrate-binding domains in GroEL. (adenosine triphosphatase) | Biological sciences | Helen R. Saibil, Alan M. Roseman, Helen White, Shaoxia Chen, Kerstin Braig | |||
| The COP9 complex, a novel multisubunit nuclear regulator involved in light control of a plant developmental switch. | Biological sciences | Mark T. Osterlund, Ning Wei, Minami Matsui, Xing-Wang Deng, Daniel A. Chamovitz, Albrecht G. von Arnim, Jeffrey M. Staub | |||
| The cotranslational integration of membrane proteins into the phospholipid bilayer is a multistep process. | Biological sciences | David W. Andrews, Arthur E. Johnson, Hung Do, Domina Falcone, Jialing Lin | |||
| The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site. | Biological sciences | Hans E. Parge, Ellen W. Moomaw, Noriyuki Habuka, Robert A. Love, John A. Wickersham, Zdenek Hostomsky, Tsuyoshi Adachi, Zuzana Hostomska | |||
| The crystal structure of the DNA-binding domain of yeast RAP1 in complex with telomeric DNA. | Biological sciences | Peter Konig, Daniela Rhodes, Rafael Giraldo, Lynda Chapman | |||
| The DExH box protein Suv3p is a component of a yeast mitochondrial 3'-to-5' exoribonuclease that suppresses group I intron toxicity. | Biological sciences | Ronald A. Butow, Steven P. Margossian, Huilin Li, Hans Peter Zassenhaus | |||
| The dorsoventral regulatory gene cassette spatzle/Toll/Cactus controls the potent antifungal response in the Drosophila adults. | Biological sciences | Emmanuelle Nicolas, Bruno Lemaitre, Jean-Marc Reichhart, Lydia Michaut, Jules A. Hoffman | |||
| The Drosophila beaten path gene encodes a novel secreted protein that regulates defasciculation at motor axon choice points. | Biological sciences | Corey S. Goodman, Douglas Fambrough | |||
| The Drosophila light-activated conductance is composed of the two channels TRP and TRPL.(transient receptor potential, TRP-like) | Biological sciences | Charles S. Zuker, Kristin Scott, Barbara A. Niemeyer, Emiko Suzuki, Kees Jalink | |||
| The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. | Biological sciences | Joan E. Hooper, Joy Alcedo, Marina Ayzenzon, Tonia Von Ohlen, Markus Noll | |||
| The emerging field of receptor-mediated inhibitory signaling: SHP or SHIP? | Biological sciences | Jean-Pierre Kinet, Andew M. Scharenberg | |||
| The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. (N-methyl-D-aspartate receptors) | Biological sciences | Susumu Tonegawa, Joe Z. Tsien, Patricio T. Huerta | |||
| The Fc-epsilon-RI-beta subunit functions as an amplifier of Fc-epsilon-RI-gamma-mediated cell activation signals.(high affinity immunoglobulin E receptor) | Biological sciences | Jean-Pierre Kinet, Andrew M. Scharenberg, Siqi Lin, Claudia Cicala | |||
| The FHIT gene at 3p14.2 is abnormal in lung cancer. (fragile histidine triad) | Biological sciences | Ugo Pastorino, Carlo M. Croce, Raffaele Baffa, Kay Huebner, Hiroshi Inoue, Massimo Negrini, Gabriella Sozzi, Maria Luisa Veronese, Maria Grazia Cotticelli, Silvana Tornielli, Silvana Pilotti, Laura De Gregorio, Marco A. Pierotti, Masataka Ohta | |||
| The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. | Biological sciences | Carlo M. Croce, Raffaele Baffa, Kay Huebner, Masaki Mori, Peter McCue, Hiroshi Inoue, Maria Grazia Cotticelli, Masataka Ohta, Kumar Kastury, Juan Palazzo, Zurab Siprashvili, Teresa Druck | |||
| The gap junction communication channel. | Biological sciences | Norton B. Gilula, Nalin M. Kumar | |||
| The homedomain region of Rag-1 reveals the parallel mechanisms of bacterial and V(D)J recombination. (variable(diversity)joining, recombination activating gene-1) | Biological sciences | David Baltimore, George Panayotou, Eugenia Spanopoulou, Florina Zaitseva, Fu-Huo Wang, Sandro Santagata | |||
| The homeotic target gene centrosomin encodes an essential centrosomal component. | Biological sciences | Thomas C. Kaufman, Kaijun Li | |||
| The human cytomegalovirus US11 gene product dislocates MHC class 1 heavy chains from the endoplasmic reticulum to the cytosol. | Biological sciences | Hidde L. Ploegh, Hans J. Geuze, Emmanual J.H.J. Wiertz, Thomas R. Jones, Lei Sun, Matthew Bogyo | |||
| The human p62 cDNA encodes Sam68 and not the RasGAP-associated p62 protein. | Biological sciences | Stefano Fumagalli, Paul Polakis, Frank McCormick, Sara A. Courtneidge, Peter Lock | |||
| The immunophilin FKBP12 functions as a common inhibitor of the TGFbeta family type I receptors. | Biological sciences | Jennifer Martin, Robert J. Lechleider, Tongwen Wang, Patricia K. Donahoe, Bi-Yu Li, Paul D. Danielson, Paresh C. Shah, Sybil Rockwell, Thomas Manganaro | |||
| The interwoven architecture of the Mu transposase couples DNA synapsis to catalysis. | Biological sciences | Tania A. Baker, Hector Aldaz, Eugene Schuster | |||
| The invariant U5 snRNA loop 1 sequence is dispensable for the first catalytic step of pre-mRNA splicing in yeast. | Biological sciences | Andrew J. Newman, Raymond T. O'Keefe, Christine Norman | |||
| The major cytoplasmic histone acetyltransferase in yeast: links to chromatin replication and histone metabolism. | Biological sciences | Daniel E. Gottschling, Jonathan Widom, Mark R. Parthun | |||
| The making of a compound leaf: genetic manipulation of leaf architecture in tomato. | Biological sciences | Yuval Eshed, Dana Hareven, Tamar Gutfinger, Ania Parnis, Eliezer Lifschitz | |||
| The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte. (mitogen-activated protein) | Biological sciences | Michael J. Owen, Tessa Crompton, Kimberly C. Gilmour | |||
| The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type I. | Biological sciences | Feng Qian, Gregory G. Germino, Terry J. Watnick, Luiz F. Onuchic | |||
| The molecules of mammalian fertilization. | Biological sciences | William J. Snell, Judith M. White | |||
| The no apical meristem gene of Petunia is required for pattern formation in embryos and flowers and is expressed at meristem and primordia boundaries. | Biological sciences | Erik Souer, Adele van Houwelingen, Daisy Kloos, Jos Mol, Ronald Koes | |||
| The origin and early evolution of life: prebiotic chemistry, the pre-RNA world, and time. | Biological sciences | Stanley L. Miller, Antonio Lazcano | |||
| The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation. | Biological sciences | James L. Manley, Yoshio Takagaki, Rebecca L. Seipelt, Martha L. Peterson | |||
| The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C. | Biological sciences | Jose Lozano, Maria T. Diaz-Meco, Maria M. Municio, Sonia Frutos, Pilar Sanchez, Laura Sanz, Jorge Moscat | |||
| The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4. | Biological sciences | Laurie H. Glimcher, John W. Rooney, I-Cheng Ho, Martin R. Hodge | |||
| The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination. | Biological sciences | Martin Gellert, Dik C. van Gent, Dale A. Ramsden | |||
| The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo. (muscle-specific kinase) | Biological sciences | Steven J. Burden, George D. Yancopoulos, Thomas M. DeChiara, Susan Thomas, Peter S. DiStefano, David J. Glass, John S. Park, David M. Valenzuela, William T. Poueymirou, David C. Bowen, Mary V. Simmons, Erika Kinetz, Debra L. Compton, Eduardo Rojas, Cynthia Smith | |||
| The repertoire of T cells shaped by a single MHC/peptide ligand. | Biological sciences | Philippa Marrack, John Kappler, Leszek Ignatowicz | |||
| The RNA world of the nucleolus: two major families if small RNAs defined by different box elements with related functions. | Biological sciences | ||||
| The role of the genome project in determining gene function: insights from model organisms. | Biological sciences | Gerald M. Rubin, George L. Gabor Miklos | |||
| The SCARECROW gene regulates an asymmetric cell division that is essential for generating the radial organization of the Arabidopsis root. | Biological sciences | Yrjo Helariutta, Joanna Wysocka-Diller, Philip N. Benfey, Kenneth A. Feldmann, Laura Di Laurenzio, Jocelyn E. Malamy, Leonard Pysh, Glenn Freshour, Michael G. Hahn | |||
| The signal-dependent coactivator CBP is a nuclear target for pp90RSK. (CREB-binding protein) | Biological sciences | Fred H. Gage, Akiyoshi Fukamizu, Toshihiro Nakajima, John Blenis, Jun Takahashi, Tracy Fisher, Marc R. Montminy | |||
| The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. | Biological sciences | Richard M. Harland, Lyle B. Zimmerman, Jose M. De Jesus-Escobar | |||
| The TAFII250 subunit of TFIID has histone acetyltransferase activity. (transcription-activating factor) | Biological sciences | C. David Allis, Tony Kouzarides, Yoshihiro Nakatani, Shelley L. Berger, Tom Owen-Hughes, Andrew J. Bannister, Craig A. Mizzen, Tetsuro Kokubo, James E. Brownell, Xiang-Jiao Yang, Jerry Workman, Lian Wang | |||
| The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. | Biological sciences | Stuart H. Orkin, Frederick W. Alt, Yuko Fujiwara, Wojciech Swat, Catherine Porcher, Karen Rockwell | |||
| The three chemical steps of Tn10/IS10 transposition involve repeated utilization of a single active site. | Biological sciences | Nancy Kleckner, Silvia Bolland | |||
| The tomato Cf-2 disease resistance locus comprises two functional genes encoding leucine-rich repeat proteins. | Biological sciences | David A. Jones, Colwyn M. Thomas, Jonathan D.G. Jones, Kate Harrison, Mark S. Dixon, James S. Keddie | |||
| The transcriptional coactivators p300 and CBP are histone acetyltransferases. | Biological sciences | Yoshihiro Nakatani, Vasily V. Ogryzko, Bruce H. Howard, R. Louis Schiltz, Valya Russanova | |||
| The transmembrane tyrosine phosphatase DLAR controls motor axon guidance in Drosophila. | Biological sciences | Corey S. Goodman, Haruo Saito, William M. Gelbart, Neil X. Krueger, David Van Vactor, Hong Wan I. | |||
| The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. | Biological sciences | Andrew Wakeham, Julia Potter, Tak W. Mak, Janet Rossant, Razqallah Hakem, Armin Reitmair, Christian Sirard, Anne Hakem, Jim Roberts, Jose Luis De la Pompa, Rong Mo, Minna Woo, Filio Billia, Eduardo Firpo, Chi Chung Hui | |||
| The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts. | Biological sciences | William G. Dunphy, Thomas R. Coleman, Phillip B. Carpenter | |||
| The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor. | Biological sciences | Jeffrey L. Wrana, Scott A. Holley, Eddy M. De Robertis, Michael B. O'Connor, Liliana Attisano, Yoshiki Sasai, Edwin L. Ferguson, Jeffrey L. Neul | |||
| The yeast CDC16 and CDC27 genes restrict DNA replication to once per cell cycle. | Biological sciences | James M. Roberts, Karen A. Heichman | |||
| The YTA10-12 complex, an AAA protease with chaperone-like activity in the inner membrane of mitochondria. | Biological sciences | Walter Neupert, Thomas Langer, Heike Arlt, Raimund Tauer, Horst Feldmann | |||
| Three-dimensional structure and stability of the KH domain: molecular insights into the fragile X syndrome. | Biological sciences | Giovanna Musco, Gunter Stier, Catherine Joseph, Maria Antonietta Castiglione Morelli, Michael Nilges, Toby J. Gibson, Annalisa Pastore | |||
| Three-dimensional structure of a DNA repair enzyme, 3-methyladenine DNA glycosylase II, from Escherichia coli. | Biological sciences | Satoshi Fujii, Yuriko Yamagata, Masato Kato, Kyoko Odawara, Yoshiteru Tokuno, Yoko Nakashima, Nobuko Matsushima, Kohei Yasumura, Ken-ichi Tomita, Kenji Ihara, Yoshimitsu Fujii, Yusaku Nakabeppu, Mutsuo Sekiguchi | |||
| Three-site synapsis during Mu DNA transposition: a critical intermediate preceding engagement of the active site. (deoxyribonucleic acid) | Biological sciences | George Chaconas, Mark A. Watson | |||
| Tomato Prf is a member of the leucine-rich repeat class of plant disease resistance genes and lies embedded within the Pto kinase gene cluster. | Biological sciences | John M. Salmeron, Brian J. Staskawicz, Steven R. Scofield, Giles E.D. Oldroyd, Caius M.T. Rommens, Han-Suc Kim, Daniel T. Lavelle, Douglas Dahlbeck | |||
| Topographically specific effects of ELF-1 on retinal axon guidance in vitro and retinal axon mapping in vivo. | Biological sciences | Hwai-Jong Cheng, John G. Flanagan, Dennis D.M. O'Leary, Todd McLaughlin, Masaru Nakamoto, Glenn C. Friedman, Michael J. Hansen, Cliff H. Yoon | |||
| Toxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasite. | Biological sciences | L. David Sibley, Janice M. Dobrowolski | |||
| TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. | Biological sciences | Hailing Hsu, David V. Goeddel, Hong-Bing Shu, Ming-Gui Pan | |||
| Transcription activation at class II CAP-dependent promoters: two interactions between CAP and RNA polymerase. (catabolite activator protein)(ribonucleic acid) | Biological sciences | Richard H. Ebright, Tomasz Heyduk, Wei Niu, Younggyu Kim, Gregory Tau | |||
| Transcripts that increase the processivity and elongation rate of RNA polymerase. | Biological sciences | Ding Jun Jin, Robert A. Weisberg, Rodney A. King, Sarbani Banik-Maiti | |||
| Translational recoding induced by G-rich mRNA sequences that form unusual structures. | Biological sciences | Donald M. Coen, Brian C. Horsburgh, Heike Kollmus, Hansjorg Hauser | |||
| tRNA ligase is required for regulated mRNA splicing in the unfolded protein response. | Biological sciences | Peter Walter, Jeffrey S. Cox, Carmela Sidrauski | |||
| %% trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. | Biological sciences | Lutz Birnbaumer, Enrico Stefani, Michael Peyton, Chu Hsi, Meisheng Jiang, Guylain Boulay, Raymond Hurst | |||
| TRP: its role in phototransduction and store-operated Ca2+ entry. | Biological sciences | David D Friel | |||
| tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells. | Biological sciences | Stanley N. Cohen, Limin Li | |||
| Tumor induction and tissue atrophy in mice lacking E2F-1. (transcription factors) | Biological sciences | Roderick Bronson, Tyler Jacks, Ed Harlow, Nicholas J. Dyson, Lili Yamasaki, Evelyne Goillot | |||
| Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity. | Biological sciences | Thomas M. Jessell, Johan Ericson, Atsushi Kawakami, Henk Roelink, Susan Morton | |||
| Two-dimensional crystallography of TFIIB- and IIE-RNA polymerase II complexes: implications for start site selection and initiation complex formation.(transcription factors IIB) | Biological sciences | Roger D. Kornberg, Kerstin K. Leuther, David A. Bushnell | |||
| Tyrosine phosphorylation of IkappaB-alpha, activates NF-kappaB without proteolytic degradation of IkappaB-alpha. | Biological sciences | Antonia Livolsi, Patrick Auberger, Veronique Imbert, Rudolf A. Rupec, Heike L. Pahl, E. Britta-Mareen Traenckner, Christoph Mueller-Dieckmann, Dariush Farahifar, Bernard Rossi, Patrick A. Baeuerie, Jean-Francois Peyron | |||
| Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis. | Biological sciences | Howard Riezman, Linda Hicke | |||
| UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues. | Biological sciences | H. Zheng, S.S.-Y. Chan, M.-W. Su, R. Wilk, M.T. Killeen, E. M. Hedgecock, J.G. Culotti | |||
| Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development. | Biological sciences | Rudiger Klein, Antonio Simeone, Paolo M. Comoglio, Carola Ponzetto, Franca Casagranda, Flavio Maina, Enrica Audero | |||
| Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. | Biological sciences | Bjorn R. Olsen, Laurence M. Boon, Matthew L. Warman, Douglas A. Marchuk, John B. Mulliken, Lewis C. Cantley, Miikka Vikkula, Kermit L. Carraway III, Jennifer T. Calvert, A. John Diamonti, Boyan Goumnerov, Krystyna A. Pasyk | |||
| Visualizing an olfactory sensory map. | Biological sciences | Catherine Dulac, Richard Axel, Peter Mombaerts, Adriana Nemes, Fan Wang, Monica Mendelsohn, Steve K. Chao, James Edmondson | |||
| Visualizing the spatial relationships between defined DNA sequences and the axial region of extracted metaphase chromosomes. | Biological sciences | Wendy A. Bickmore, Kathy Oghene | |||
| Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. | Biological sciences | Frank McCormick, Uta Francke, Arie Abo, Marc Symons, Jonathan M.J. Derry, Brian Karlak, Sharon Jiang, Vanessa Lemahieu | |||
| Worm sperm and advances in cell locomotion. | Biological sciences | Julie A. Theriot | |||
| X chromosome inactivation, XIST, and pursuit of the X-inactivation center. | Biological sciences | Huntington F. Willard | |||
| Xenopus Mad proteins transduce distinct subsets of signals for the TGFbeta superfamily. (transforming growth factor beta) | Biological sciences | Douglas A. Melton, Jonathan M. Graff, Anu Bansal | |||
| Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease. | Biological sciences | Richard D. Wood, Jan H.J. Hoeijmakers, Nicolaas G.J. Jaspers, Elizabeth Evans, Maureen Biggerstaff, Anneke M. Sijbers, Wouter L. De Laat, Rafael R. Ariza, Ying-Fei Wei, Jonathan G. Moggs, Kenneth C. Carter, Brenda K. Shell, Mariska C. De Jong, Suzanne Rademakers, Johan De Rooij | |||
| XKCM1: a Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly. | Biological sciences | Timothy J. Mitchison, Arshad Desai, Claire E. Walczak | |||
| Xklp2, a novel Xenopus centrosomal kinesin-like protein required for centrosome separation during mitosis. | Biological sciences | Eric Karsenti, Isabelle Vernos, Haralabia Boleti | |||
| X-MyT1, a Xenopus C2HC-type zinc finger protein with a regulatory function in neuronal differentiation. | Biological sciences | Qiufu Ma, David J. Anderson, Chris Kintner, Tomas Pieler, Eric J. Bellefroid, Catherine Bourguignon, Thomas Hollemann | |||
| XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos. | Biological sciences | Mariette Oosterwegel, Hans Clevers, Marc van de Wetering, Miranda Molenaar, Josi Peterson-Maduro, Susan Godsave, Vladimir Korinek, Jeroen Roose, Oliver Destree | |||
| Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor. | Biological sciences | Haruo Saito, Francesc Posas, Susannah M. Wurgler-Murphy, Tatsuya Maeda, Elizabeth A. Witten, Tran Cam Thai | |||
| Zebrafish make a big splash. | Biological sciences | Judith S. Eisen | |||
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