| Genes & Development 1998 |
| Title | Subject | Authors |
|---|
| 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. | Biological sciences | Nahum Sonenberg, Anne-Claude Gingras, Nissim Hay, Scott G. Kennedy, Maura A. O'Leary |
| A bacterial ATP-dependent, enhancer binding protein that activates the housekeeping RNA polymerase. | Biological sciences | Robert G. Kranz, William C. Bowman |
| A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type. | Biological sciences | John M. Shelton, James A. Richardson, R. Sanders Williams, Eric N. Olson, Rhonda Bassel-Duby, Eva R. Chin, Quan Yang, Caroline Humphries, Hai Wu, Weiguang Zhu |
| A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegans. | Biological sciences | Yang Shi, Craig Mello |
| A coactivator of pre-mRNA splicing. | Biological sciences | Phillip A. Sharp, Benjamin J. Blencowe, Jeffrey A. Nickerson, Robbyn Issner |
| A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. | Biological sciences | Ronald A. DePinho, Harold E. Varmus, Eric C. Holland, Wendy P. Hively |
| A cooperative interaction between U2AF65 and mBBP/SF1 facilitates branchpoint region recognition. (branchpoint sequence binding protein)(mammalian splicing factor) | Biological sciences | Michael Rosbash, J. Andrew Berglund, Hadja Abovich |
| Activated transcription independent of the RNA polymerase II holoenzyme in budding yeast. | Biological sciences | David Bentley, J. Bryan McNeil, Helga Agah |
| Activiation of Rac1 by a Crk SH3-binding protein, DOCK180. | Biological sciences | Michiyuki Matsuda, Takeshi Kurata, Etsuko Kiyokawa, Yuko Hashimoto, Shin Kobayashi, Haruhiko Sigimura |
| Activin is an essential early mesenchymal signal in tooth development that is required for patterning of the murine dentition. | Biological sciences | Martin M. Matzuk, Paul T. Sharpe, Christine A. Ferguson, Abigail S. Tucker, Lars Christensen, Anthony L. Lau |
| A histone deacetylase corepressor complex regulates the Notch signal transduction pathway. | Biological sciences | Hung-Ying Kao, Michael Downes, Peter Ordentlich, Ronald M. Evans, Chris R. Kintner, Naoko Koyano-Nakagawa, Zhenyu Tang, Tom Kadesch |
| Allosteric interactions between capping enzyme subunits and the RNA polymerase II carboxy-terminal domain. | Biological sciences | Stephen Buratowski, Eun-Jung Cho, Toshimitsu Takagi, Christine R. Rodriguez |
| Altered DNA-binding specificity mutants of EKLF and Sp1 show that EKLF is an activator of the beta-globin locus control region in vivo. | Biological sciences | Fokke Lindeboom, Frank Grosveld, Sjaak Philipsen, Mark Wijgerde, Rita Tewari, Nynke Gillemans, Robbert Rottier, Ton de Wit |
| Amino acid-amino acid contacts at the coopertivity interface of the bacteriophage lambda and P22 repressors. | Biological sciences | Ann Hochschild, Frederick W. Whipple, Emmeline F. Hou |
| Analysis of a Caenorhabditis elegans Twist homolog identifies conserved and divergent aspects of mesodermal patterning. | Biological sciences | Jun Liu, Cynthia Kenyon, Andrew Fire, Brian D. Harfe, Michael Krause, Ana Vaz Gomes |
| A new NEDD8-ligating system for cullin-4A. | Biological sciences | Keiji Tanaka, Tomoki Chiba, Hiroshi Kawasaki, Fumio Osaka, Noriko Aida, Mihoro Saeki, Seiichi Kawashima, Seishi Kato |
| A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal. | Biological sciences | Haifan Lin, Lisa Chang, Daniel N. Cox, Anna Chao, Jeff Baker, Dan Qiao |
| A novel homeobox gene, dharma, can induce the organizer in a non-cell-autonomous manner. | Biological sciences | Cheol-Hee Kim, Toshio Hirano, Masahiko Hibi, Yoshiki Sasai, Yojiro Yamanaka, Hiroyuki Takeda, Toshiro Mizuno, Masashi Kishi |
| A novel homeobox gene mediates the Dpp signal to establish functional specificity within target cells. | Biological sciences | Yo-ichi Nabeshima, Hideki Nakagoshi, Fumio Matsuzaki, Minako Hoshi |
| A novel Myb homolog initiates Dictyostelium development by induction of adenylyl cyclase expression. | Biological sciences | Hideshi Otsuka, Peter J.M. Van Haastert |
| A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system. | Biological sciences | Leonard P. Freedman, Paul Tempst, Christophe Rachez, Zalman Suldan, Jeremy Ward, Betty Chao-Pei Chang, Darya Burakov, Heidye Erdjument-Bromage |
| A novel, putative MEK kinase controls developmental timing and spatial patterning in Dictyostelium and is regulated by ubiquitin-mediated protein degradation. | Biological sciences | Richard A. Firtel, Chang Y. Chung, R.B.K. Reddy, Kemin Zhou |
| Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor.(mitogen-activated protein) | Biological sciences | Riccardo Dalla-Favera, Huifeng Niu, Bihui H. Ye |
| A prokaryotic-like mode of cytoplasmic eukaryotic ribosome binding to the initiation codon during internal translation initiation of hepatitis C and classical swine fever virus RNAs. | Biological sciences | Tatyana V. Pestova, Christopher U.T. Hellen, Ivan N. Shatsky, Richard J. Jackson, Simon P. Fletcher |
| A protein-induced DNA bend increases the specificity of a prokaryotic enhancer-binding protein. | Biological sciences | Jonathan Dworkin, Alexander Ninfa, Peter Model |
| A requirement for NF-kB activation in Bcr-Abl-mediated transformation. | Biological sciences | David Cortez, Albert S. Baldwin Jr., Ann Marie Pendergast, Gary W. Reuther, Julie Y. Reuther |
| Arginine methylation facilitates the nuclear export of hnRNP proteins. (heterogeneous nuclear ribonucleoproteins) | Biological sciences | Sandro R. Valentini, Pamela A. Silver, Margaret S. Lee, Elisa C. Shen, Michael F. Henry, Valerie H. Weiss |
| A ribosomal function is necessary for efficient splicing of the T4 phage thymidylate synthase intron in vivo. | Biological sciences | Renee Schroeder, Katharina Semrad |
| A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting. | Biological sciences | Roderick T. Bronson, David M. Livingston, Geoffrey J. Lindeman, Stefan Gaubatz, Lina Dagnino, Yuhui Xu, Henry B. Warren |
| A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm. | Biological sciences | Javier F. Caceres, Adrian R. Krainer, Gavin R. Screaton |
| A splice variant of CD44 expressed in the apical ectodermal ridge presents fibroblast growth factors to limb mesenchyme and is required for limb outgrowth. | Biological sciences | Helmut Ponta, Peter Herrlich, Larry Sherman, David Wainwright |
| A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. | Biological sciences | Randal J. Kaufman, Witoon Tirasophon, Ajith A. Welihinda |
| A surface of Esherichia coli sigma super70 required for promoter function and antitermination by phage lambda Q protein. | Biological sciences | Jeffrey W. Roberts, Michael T. Marr, Dennis C. Ko, Jingshu Guo |
| Asymmetric cell division: from A to Z. | Biological sciences | Nancy Hawkins, Gian Garriga |
| Asymmetric segregation on spindle poles of the Schizosaccaromyces pombe septum-inducing protein kinase Cdc7p. | Biological sciences | Susanne Schmidt, Marc Sohrmann, Viesturs Simanis, Iain Hagan |
| Autocrine growth and anchorage independence: two complementing Jun-controlled genetic programs of cellular transformation. | Biological sciences | Peter Angel, Peter Herrlich, Hans Van Dam, Stephanie Huguier, Klaas Kooistra, Joel Baguet, Emmanuel Vial, Alex J. Van der Eb, Marc Castellazzi |
| Bacterial senescence: stasis results in increased and differential oxidation of cytoplasmic proteins leading to developmental induction of the heat shock regulon. | Biological sciences | Thomas Nystrom, Sam Dukan |
| Beadex encodes an LMO protein that regulates Apterous LIM-homeodomain activity in Drosophila wing development: a model for LMO oncogene function. | Biological sciences | Marco Milan, Stephen M. Cohen, Fernando J. Diaz-Benjumea |
| Beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. | Biological sciences | Helena Edlund, Jorgen Jonsson, Karin Simu, Ulf Ahlgren, Lena Jonsson |
| Binary sibling neuronal cell fate decisions in the Drosophila embryonic central nervous system are nonstochastic and require inscuteable-mediated asymmetry of ganglion mother cells. | Biological sciences | Xiaohang Yang, William Chia, Guy Tear, Marita Buescher, Su Ling Yeo, Gerald Udolph, Michael Zavortink |
| BMP4 is essential for lens induction in the mouse embryo. | Biological sciences | Brigid L.M. Hogan, Yasuhide Furuta |
| BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites. | Biological sciences | Ronald M. Evans, Bruce Blumberg, Heonjoong Kang, Tanya A. Moreno, Thomas Perlmann, Eddy M. De Robertis, Jack Bolado Jr., Hongwu Chen, A. Grey Craig, Kazuhiko Umesono |
| Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. | Biological sciences | Gary Ruvkun, Suzanne Paradis |
| c-Cbl/Sli-1 regulates endocytic sorting and ubiquination of the epidermal growth factor receptor. | Biological sciences | Yosef Yarden, Benjamin Geiger, Gil Levkowitz, Hadassa Waterman, Eli Zamir, Zvi Kam, Shlomo Oved, Wallace Y. Langdon, Laura Berguinot |
| Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1. | Biological sciences | Peter Kaiser, Steven I. Reed, Rey A.L. Sia, Elaine F.S. Bardes, Daniel J. Lew |
| Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box protein complexes that regulate cell division and methionine biosynthesis in yeast. | Biological sciences | Mike Tyers, Dominique Thomas, Andrew R. Willems, E. Elizabeth Patton, Karen L. Craig, Danne Sa, Laurent Kuras |
| Cdc7 is required throughout the yeast S phase to activate replication origins. | Biological sciences | Anne D. Donaldson, Bonita J. Brewer, Walton L. Fangman |
| Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity. | Biological sciences | Helen K. Salz, Stephane Larochelle, Beat Suter, Judit Pandur, Tovert P. Fisher |
| CDK inhibitors p18INK4c and p27Kip1 mediate two separate pathways to collaboratively suppress pituitary tumorigenesis. (cyclin-dependent kinase) | Biological sciences | Lishan Su, Selina Chen-Kiang, David S. Franklin, Yue Xiong, Virginia L. Godfrey, Hayyoung Lee, Grigoriy I. Kovalev, Robert Schoonhoven |
| C/EBP-beta, but not C/EBP-alpha, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland. (CCAAT-enhancer binding protein) | Biological sciences | Brian Raught, Tiffany N. Seagroves, Gretchen J. Darlington, Susanne Krnacik, Jason Gay, Bonnie Burgess-Beusse, Jeffrey M. Rosen |
| Cell cycle control of chorion gene amplification. | Biological sciences | Allan C. Spradling, Brian R. Calvi, Mary A. Lilly |
| Cell cycle-dependent transcriptional and proteolytic regulation of FtsZ in Caulobacter. (cell-division-initiation protein) | Biological sciences | Aaron J. Kelly, Marcella J. Sackett, Neena Din, Ellen Quardokus, Yves V. Brun |
| Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1x. | Biological sciences | Gregg L. Semenza, Ann M. Lawler, Narayan V. Iyer, Lori E. Kotch, Faton Agani, Sandra W. Leung, Erik Laughner, Roland H. Wenger, Max Gassmann, John D. Gearhart, Aimee Y. Yu |
| Characterization of a prokaryotic SMC protein involved in chromosome partitioning. | Biological sciences | Alan D. Grossman, Robert A. Britton, Daniel Chi-Hong Lin |
| CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. | Biological sciences | David Ron, Masahiko Kuroda, Helene Zinszner, XiaoZhong Wang, Nikoleta Batchvarova, Richard T. Lightfoot, Helen Remotti, James L. Stevens |
| Chromatin assembly factor I contributes to the maintenance , but not the re-establishment, of silencing at the yeast silent mating loci. | Biological sciences | Shinichiro Enomoto, Judith Berman |
| Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro. (TBP-associated factors) | Biological sciences | Robert Tjian, James T. Kadonaga, Anders M. Naar, Pierre A. Beaurang, Karen M. Robinson, Jon D. Oliner, Daina Avizonis, Sigrid Scheek, Jork Zwicker |
| Chromosome methylation patterns during mammalian preimplantation development. | Biological sciences | Alain Niveleau, Deborah Bourc'his, Nathalie Rougier, Denise Molina Gomes, Michelle Plachot, Andras Paldi, Evani Viegas-Pequignot |
| CLB5 and CLB6 are required for premeiotic DNA replication and activation of the meiotic S/M checkpoint. | Biological sciences | Curt Wittenberg, David Stuart |
| Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the alpha v beta3 integrin receptor. | Biological sciences | Brigid L.M. Hogan, Yasuhisa Matsui, Thomas Quertermous, Chiaki Hidai, Thomas Zupancic, Kalyani Penta, Adel Mikhail, Masatoshi Kawana, Elena E. Quertermous, Yoshikazu Aoka, Masafumi Fukagawa, Doros Platika, Robert Auerbach, Ralph Snodgrass |
| clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans. | Biological sciences | H. Robert Horvitz, Leslie DeLong, Michelle Kokel, Michael J. Stern, Christina Z. Borland |
| c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targets. | Biological sciences | Michael Cole, Andrew Bush, Kerri Dugan, Alvaro Obaya, Susumu Adachi, John Sedivy, Maria Mateyak |
| Combinatorial signaling codes for the progressive determination of cell fates in the Drosophila embryonic mesoderm. | Biological sciences | Ana Carmena, Stephen Gisselbrecht, Alan M. Michelson, Jacob Harrison, Fernancdo Jimenez |
| Communication between Hin recombinase and Fis regulatory subunits during coordinate activation of Hin-catalyzed site-specific DNA inversion. | Biological sciences | Reid C. Johnson, Stacy K. Merickel, Michael J. Haykinson |
| Complete inhibition of Cdk/cyclin by one molecule of p21 (super Cip1). | Biological sciences | Steven Reed, Hilal A. Lashuel, Ludger Hengst, Ulrich Gopfert |
| Control of cell lineage-specific development and transcription by bHLH-PAS proteins. | Biological sciences | Stephen T. Crews |
| Control of Cyclin B1 localization through regulated binding of the nuclear export factor CRM1. | Biological sciences | Jennifer Brennan, Jing Yang, Sally Kornbluth, Maureen A. Powers, ELaine S.G. Bardes, Jonathan D. Moore |
| Control of distal antennal identity and tarsal development in Drosophila by spineless-aristapedia, a homolog of the mammalian dioxin receptor. | Biological sciences | Dianne M. Duncan, Ian Duncan, Elizabeth A. Burgess |
| Control of MAP kinase signaling specificity or how not to go HOG wild. (mitogen-activated protein kinase) | Biological sciences | George F. Sprague Jr. |
| Conversion of the omega subunit of Escherichia coli RNA polymerase into a transcriptional activator or an activation target. | Biological sciences | Ann Hochschild, Simon L. Dove |
| Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development. | Biological sciences | Stephen J. Elledge, Ronald A. DePinho, J. Wade Harper, Pumin Zhang, Calvin Wong |
| Cooperative interactions between the central spindle and the contractile ring during Drosophila cytokinesis. | Biological sciences | Silvia Bonaccorsi, Maurizio Gatti, Maria Grazia Giansanti, Byron Williams, Erika V. Williams, Carlo Santolamazza, Michael L. Goldberg |
| Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo. (Spt, Ada, Gcn5 acetyltransferase) | Biological sciences | Shelley L. Berger, Lian Wang, Lin Liu |
| Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct Jak kinase signaling pathways. | Biological sciences | James N. Ihle, John L. Cleveland, Gerard P. Zambetti, Frederick W. Quelle, Demin Wang, JinLing Wang, Jian Feng |
| Defective peroxisomal catabolism of branched fatty acyl coenzyme A in mice lacking the sterol carrier protein-2/sterol carrier protein-x gene function. | Biological sciences | Thomas Engel, Gerd Assmann, Ronald J.A. Wanders, Nobuyo Maeda, Udo Seedorf, Martin Raabe, Peter Ellinghaus, Frank Kannenberg, Manfred Fobker, Simone Denis, Fred Wouters, Karel W.A. Wirtz |
| Defective potassium currents in ataxia telangiectasia fibroblasts. | Biological sciences | Michael B. Kastan, Yael Ziv, Yosef Shiloh, David G. Kirsch, Theresa D'Souza, Nelson Rhodes, Christine D. Foster, Peter H. Reinhart, Tona M. Gilmer |
| Defective trophoblast function in mice with a targeted mutation of Ets2. | Biological sciences | Robert G. Oshima, Hideyuki Yamamoto, Margaret L. Flannery, Sergey Kupriyanov, Jonathan Pearce, Scott R. McKercher, Gregory W. Henkel, Ricahrd A. Maki, Sena Werb |
| Defects in limb, craniofacial, and thymic development in Jagged2 mutnt mice. | Biological sciences | Gerry Weinmaster, Christine R. Norton, Thomas Gridley, Yu Lan, Rulang Jiang, Harry D. Chapman, Carrie Shawber, David V. Serreze |
| Defects in regulation of apoptosis in caspase-2-deficient mice. | Biological sciences | Gloria I. Perez, Jonathan L. Tilly, Andrea Jurisicova, Michael A. Moskowitz, Jodi A. Flaws, En Li, Keith E. Latham, Yi Sun, Louise Bergeron, Glen Macdonald, Lianfa Shi, Sue Varmuza, Jessica C.M. Salter, Hideaki Hara, Arnold Greenberg, Junying Yuan |
| Degradation of carboxy-terminal-tagged cytoplasmic proteins by the Escherichia coli protease HflB (FtsH). | Biological sciences | Graham C. Walker, Christophe Herman, Richard D'Ari, Danielle Thevenet, Philippe Bouloc |
| Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2. | Biological sciences | Joanne L. Thorvaldsen, Marisa S. Bartolomei, Kristen L. Duran |
| Delta and Serrate are redundant Notch ligands required for asymmetric cell divisions within the Drosophila sensory organ lineage. | Biological sciences | Yuh Nung Jan, Lily Y. Jan, Chaoyang Zeng, Susan Younger-Shepherd |
| Determinants of coactivator LXXLL motif specificty in nuclear receptor transcriptional activation. | Biological sciences | Christopher K. Glass, Michael G. Rosenfeld, Michael V. Milburn, David W. Rose, Nuria Assa-Munt, Anna Krones, Stefan Westin, Joseph Torchia, Robert T. Nolte, Sarah E. Flynn, Tina-Marie Mullen, Juan Inostroza, Eileen M. McInerney |
| Determinants of specificity in TGF-beta signal transduction. | Biological sciences | Akiko Hata, Joan Massague, Roger S. Lo, Yigong Shi, David Wotton, Nikola Pavletich, Y-Guang Chen |
| Developmentally programmed assembly of higher order telomerase complexes with distinct biochemical and structural properties. | Biological sciences | Dorothy E. Shippen, Eric C. Greene |
| Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1. | Biological sciences | Jacques L. Michaud, Chen-Ming Fan, Thomas Rosenquist, Noah R. May |
| Different core promoters possess distinct regulatory activities in the Drosophila embryo. | Biological sciences | Michael Levine, Sumio Ohtsuki, Haini N. Cai |
| Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways. | Biological sciences | Randall T. Moon, Norbert Perrimon, Joshua M. Shulman, Jeffrey R. Miller, Jeffrey Axelrod D. |
| Distinct C/EBP functions are required for eosinophil lineage commitment and maturation. | Biological sciences | Thomas Graf, Claus Nerlov, Elisabeth Kowenz-Leutz, Kelly M. McNagny, Gabriele Doderlein |
| DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair. | Biological sciences | Jan H.J. Hoeijmakers, Kaoru Sugasawa, Esther Appeldoorn, Nicolaas G.J. Jaspers, Wouter L. de Laat, Eric Weterings |
| DNA damage activates p53 through a phosphorylation-acetylation cascade. (tumor suppressor) | Biological sciences | Ettore Appella, Michael Bustin, Alex Vassilev, Toru Miki, Carl W. Anderson, Kazuyasu Sakaguchi, Julio E. Herrera, Sin'ichi Saito |
| DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D. | Biological sciences | Stephen P. Jackson, Graeme C.M. Smith, Ugur Yavuzer, Tonya Bliss, Dieter Werner |
| Dorsoventral patterning in the Drosophila central nervous system: the intermediate neuroblasts defective homeobox gene specifies intermediate column identity. | Biological sciences | Matthew P. Scott, Chris Q. Doe, Dervla M. Mellerick, Joseph G. Weiss, Tonia Von Ohlen, Gregory Dressler |
| Dorsoventral patterning in the Drosophila central nervous system: the vnd homeobox gene specifies ventral column identity. | Biological sciences | Takako Isshiki, Scott Holbrook, Chris Q. Doe, Joseph Weiss, Jocelyn A. McDonald, Dervla M. Mellerick |
| Double-strand break repair by interchromosomal recombination: suppression of chromosomal translocations. | Biological sciences | Christine Richardson, Maria Jasin, Mary Ellen Moynahan |
| Down-regulation of transcription factor CF2 by Drosophila Ras/MAP kinase signaling in oogenesis: cytoplasmic retention and degradation. | Biological sciences | Tien Hsu, Ekaterina Yu. Mantrova |
| DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in Drosophila. | Biological sciences | Norbert Perrimon, Udo Hacker |
| Drosophila Cyclin B3 is required for female fertility and is dispensable for mitosis like Cyclin B. | Biological sciences | Christian F. Lehner, Jurgen A. Knoblich, Henning W. Jacobs |
| Drosophila myb is required for the G2/M transition and maintenance of diploidy. (gene, stages of differentiation of cells) | Biological sciences | J. Michael Bishop, Alisa L. Katzen, Jean Jackson, Brian P. Harmon, Siau-Min Fung, Gary Ramsay |
| Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway. | Biological sciences | Norbert Perrimon, Michael Gilman, Douglas A. Harrison, Patricia E. McCoon, Richard Binari |
| DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs. (DRB sensitivity-inducing factor) | Biological sciences | Stephen Buratowski, Fred Winston, Yuki Yamaguchi, Tadashi Wada, Hiroshi Handa, Susumu Hirose, Toshiyuki Takagi, Anwarul Ferdous, Takeshi Imai, Grant A. Hartzog, Seiji Sugimoto, Keiichi Yano |
| DWnt-2, a Drosophila Wnt gene required for the development of the male reproductive tract, specifies a sexually dimorphic cell fate. | Biological sciences | Roel Nusse, Cindy Harryman Samos, Karen M. Kozopas |
| E1A signaling to p53 involves the p19ARF tumor suppressor. | Biological sciences | Mila E. McCurrach, Scott W. Lowe, Sheau-Yann Shieh, Carol Prives, Martine F. Roussel, Charles J. Sherr, Gerardo Ferbeyre, Elisa De Stanchina, Frederique Zindy, Andrew V. Samuelson |
| E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. | Biological sciences | R. Sanders Williams, Joseph R. Nevins, Gustavo Leone, Zhen Yan, James DeGregori, Laszlo Jakoi, Seiichi Ishida |
| EGF domain swap converts a Drosophila EGF receptor activator into an inhibitor. | Biological sciences | Amanda Simcox, Ronen Schweitzer, Ben-Zion Shilo, Bruce Schnepp, Timothy Donaldson, Gary Grumbling, Stephen Ostrowski |
| eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange. | Biological sciences | Alan G. Hinnebusch, Scot R. Kimball, Graham Pavitt, Kolluru V.A. Ramaiah |
| EIR1, a root-specific protein involved in auxin transport, is required for gravitropism in Arabidopsis thaliana. | Biological sciences | Gerald R. Fink, Paula Grisafi, Christian Luschnig, Roberto A. Gaxiola |
| Enhancer control of V(D)J recombination at the TCR-beta locus: differential effects on DNA cleavage and joining. | Biological sciences | Mark S. Schlissel, William M. Hempel, Patricia Stanhope-Baker, Noelle Mathieu, Fang Huang, Pierre Ferrier |
| Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses. | Biological sciences | Robert L. Van Etten, Elke Stein, Andrew A. Lane, Douglas Pat Cerretti, Harald O. Schoecklmann, Alfred D. Schroff, Thomas O. Daniel |
| Eph signaling is required for segmentation and differentiation of the somites. | Biological sciences | Nigel Holder, Lindsey Durbin, Caroline Brennan, Kensuke Shiomi, Julie Cooke, Arantza Barrios, Shantha Shanmugalingam, Brenda Guthrie, Rick Lindberg |
| Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. | Biological sciences | Razqallah Hakem, Arda Shahinian, Gordon S. Duncan, Anne Hakem, Min Woo, Maria S. Soengas, David Kagi, Mila McCurrach, Wilson Khoo, Stephen A. Kaufman |
| Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiae. | Biological sciences | Fred Winston, Tadashi Wada, Hiroshi Handa, Grant A. Hartzog |
| Exit from mitosis in Drosophila syncytial embryos requires proteolysis and cyclin degradation, and is associated with localized dephosphorylation. | Biological sciences | Patrick H. O'Farrell, Frank Sprenger, Tin Tin Su, Paul J. DiGregorio, Shelagh D. Campbell |
| Expansion and contraction of ribosomal DNA repeats in Saccharomyces cerevisiae: requirment of replication fork blocking (Fob1) Protein and the role of RNA polymerase I. | Biological sciences | Takashi Horiuchi, Takehiko Kobayashi, Masayasu Nomura, Denis J. Heck |
| Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry. | Biological sciences | Ed Harlow, Takashi Imai, Jiyong Zhai, Brian Dynlackt, Tada-aki Hori |
| Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG. | Biological sciences | Stuart H. Orkin, Yuko Fujiwara, Dennis B. Hom, Alice P. Tsang |
| Faithful anaphase is ensured by Mis4, a sister chromatid cohesion molecule required in S phase and not destroyed in G(sub)1 phase. | Biological sciences | Mitsuhiro Yanagida, Kanji Furuya, Kohta Takahashi |
| Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. | Biological sciences | W. Scott Simonet, Dimitry M. Danilenko, Hosung Min, Sheila A. Scully, Bolon. Brad, Brian D. Ring, John E. Tarpley, Margaret DeRose |
| Formation and specification of ventral neuroblasts is controlled by vnd in Drosophila neurogenesis. | Biological sciences | Fernando Jimenez, Kalpana White, Carlos Parras, Hsin Chu |
| Functional analysis of the secretory precursor processing machinery of Bacillus subtilis: identification of a eubacterial homolog of archaeal and eukaryotic signal peptidases. | Biological sciences | Sierd Bron, Gerard Venema, Harold Tjalsma, Albert Bolhuis, Jan Maarten van Dijl, Wim J. Quax, Wolfgang Schumann, Maarten L. van Roosmalen, Thomas Wiegert, Cees P. Broekhuizen |
| Functional and regulatory interactions between Hox and extradenticle genes. | Biological sciences | Gines Morata, Natalia Azipiazu |
| Functional intertwining of Dpp and EGFR signaling during Drosophila endoderm induction.(Decapentaplegic)(epidermal growth factor receptor) | Biological sciences | Mariann Bienz, Salih Eresh, David Szuts |
| GAGA mediates the enhancer blocking activity of the "eve" promoter in the Drosophila embryo.(even-skipped promoter) | Biological sciences | Michael Levine, Sumio Ohtsuki |
| GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo. | Biological sciences | Min Min Lu, Edward E. Morrisey, Azhihua Tang, Kirsten Sigrist, Fang Jiang, Hon S. Ip, Michael S Parmacek |
| Genetic analysis of the SR protein ASF/SF2: interchangeability of RS domains and negative control of splicing. | Biological sciences | James L. Manley, Jin Wang, Shou-Hua Xiao Xiao |
| Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. | Biological sciences | Martine F. Roussel, Charles J. Sherr, J. Alan Diehl, Mangeng Cheng |
| Groucho proteins: transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebrates. | Biological sciences | Alfred L. Fisher, Michael Caudy |
| Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin. | Biological sciences | Irving Weissman, Robert Lee, Bradley S. Cobb, Amanda G. Fisher, Stephen T. Smale, Kyungmin Hahm, Christopher A. Klug, Aaron S. McCarty, Karen D. Brown, Kochi Akashi |
| High mobility group protein-1 (HMG-1) is a unique activator of p53. | Biological sciences | Carol Prives, James L. Manley, Michael Bustin, Kanneganti G.K. Murthy, Lata Jayaraman, Narayani Chandra Moorthy |
| Histone acetylation and transcriptional regulatory mechanisms. | Biological sciences | Kevin Struhl |
| Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo. | Biological sciences | C. David Allis, Min-Hao Kuo, Mair E.A. Churchill, Jianxin Zhou, Per Jambeck |
| Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo. (protein) | Biological sciences | Kevin Struhl, David Kadosh |
| HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection. | Biological sciences | Pamela A. Silver, Michael Emerman, Deanna M. Koepp, Marie A. Vodicka |
| Hoxc13 mutant mice lack external hair. | Biological sciences | Mario R. Capecchi, Alan R. Godwin |
| Hox is in the hair: a break in colinearity? | Biological sciences | Denis Duboule |
| HSP101 functions as a specific translational regulatory protein whose activity is regulated by nutrient status. | Biological sciences | Douglas R. Wells, Robert L. Tanguay, Hanh Le, Daniel R. Gallie |
| Human and mouse homologs of Schizosaccharomyces pombe rad1+ and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis. | Biological sciences | Noel F. Lowndes, Stephen P. Jackson, Peter B. Moens, Raimundo Freire, Jose R. Murguia, Madalina Tarsounas |
| Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity. | Biological sciences | Alla Y. Karpova, Peter M. Howley, Lucienne V. Ronco, Marc Vidal |
| ICP27 mediates HSV RNA export by shuttling through a leucine-rich nuclear export signal and binding viral intronless RNAs through an RGG motif.(regulatory protein) | Biological sciences | Rozanne M. Sandri-Goldin |
| Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53. | Biological sciences | Lois Resnick-Silverman, Selvon St. Clair, Matthew Maurer, Kathy Zhao, James J. Manfredi |
| Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites. (abasic) | Biological sciences | Tadahide Izumi, Sankar Mitra, Robert E. Johnson, Satya Prakash, Louise Prakash, Carlos A. Torres-Ramos |
| Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins. | Biological sciences | Adrian R. Krainer, Michael Zhang, Hong-Xiang Liu |
| Identification of multiple cyclin subunits of human P-TEFb. (transcription elongation factor b) | Biological sciences | David H. Price, Junmin Peng, Yuerong Zhu, Jeffrey T. Milton |
| Identification of Xenopus SMC protein complexes required for sister chromatid cohesion.(structural maintenance of chromosomes) | Biological sciences | Ana Losada, Michiko Hirano, Tatsuya Hirano |
| Igf2 imprinting does not require its own DNA methylation of H19RNA. | Biological sciences | John M. Levorse, Shirley M. Tilghman, Beverly K. Jones |
| Impaired megakaryopoiesis and behavioral defects in mafG-null mutant mice. | Biological sciences | James Douglas Engel, Hozumi Motohashi, Jordan A. Shavit, Masayuki Yamamoto, Ko Onodera, Jun-etsu Akasaka |
| Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70. | Biological sciences | Robert T. McCluskey, Daniel A. Haber, James A. DeCaprio, Sean Bong Lee, Christoph Englert, Shyamala Maheswaran, Gang Zheng, Jenise Wong, D. Paul Harkin, James Bean, Robert Ezzell, A. Julian Garvin |
| Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase progression. (retinoblastoma tumor suppressor protein) | Biological sciences | James R. Feramisco, Jean Y.J. Wang, Erik S. Knudsen, Carolan Buckmaster, Tung-Ti Chen |
| Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress.(phosphoinositide-3 kinase) | Biological sciences | Wayne Zundel, Amato Giaccia |
| Inorganic pyrophosphatase is a component of the Drosophila nucleosome remodeling factor complex. | Biological sciences | Carl Wu, Toshio Tsukiyama, Vincent Ossipow, David A. Gdula, Raphael Sandaltzopoulos |
| inscuteable and numb mediate asymmetric muscle progenitor cell divisions during Drosophila myogenesis. | Biological sciences | William Chia, Ana Carmena, Fernando Jimenez, Bernadette Murugasu-Oei, Devi Menon |
| Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. | Biological sciences | Michael S. Brown, Joseph L. Goldstein, Yuriy Bashmakov, Iichiro Shimomura, Robert E. Hammer, JAmes A. Richardson, Sinji Ikemoto |
| Interaction of Agouti protein with the melanocortin 1 receptor in vitro and in vivo. | Biological sciences | Gregory Barsh, Michael M. Ollmann, M. Lynn Lamoreux, Brent D. Wilson |
| Interaction of a nascent RNA structure with RNA polymerase is required for hairpin-dependent transcriptional pausing but not for transcript release. | Biological sciences | Robert Landick, Irina Artsimovitch |
| Interaction of recombinant Tetrahymena telomerase proteins p80 and p95 with telomerase RNA and telomeric DNA substrates. | Biological sciences | Leena Gandhi, Kathleen Collins |
| Ironing out the kinks: splicing and translation in bacteria. | Biological sciences | Sarah A. Woodson |
| JNKK1 organizes a MAP kinase model through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension. | Biological sciences | Michael Karin, Zhenguo Wu, Ying Xia, Bing Su, Brion Murray |
| JNK targets p53 ubiquitination and degradation in nonstressed cells. (tumor suppressor protein) | Biological sciences | Thomas Buschmann, Serge Y. Fuchs, Ze'ev Ronai, Stephen N. Jones, Xiangwei Wu, Victor Adler, Zhimin Yin |
| Kappa chain monoallelic demethylation and the establishment of allelic exclusion. | Biological sciences | Raul Mostoslavsky, Nandita Singh, Andrew Chess, Howard Cedar, Yehudit Bergman, Roberta Pelanda, Andrei Kirillov |
| Knockout and knockin of the beta-1 exon D define distinct roles for integrin splice variants in heart function and embryonic development. | Biological sciences | Christine Mummery, Christian Baudoin, Marie-Jose Goumans, Arnoud Sonnenberg |
| Life without white fat: a transgenic mouse. | Biological sciences | |
| Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1. | Biological sciences | Rene Bernards, E. Marielle Hijmans, Renate M.L. Zwigsen, Robin S. Buckle, Cindy J.M. Loomans |
| Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos. | Biological sciences | Michael W. Young, Simon Kidd, Toby Lieber |
| LIN-12/Notch signaling: lessons from worms and flies. | Biological sciences | Iva Greenwald |
| LMO T-cell translocation oncogenes typify genes activated by chromosomal translocations that alter transcription and developmental processes. | Biological sciences | Terence H. Rabbitts |
| Localization-dependent translation requires a functional interaction between the 5' and 3' ends of oskar mRNA. | Biological sciences | Anne Ephrussi, Niki Gunkel, Tamaki Yano, Finn-Hugo Markussen, Lisbeth C. Olsen |
| Lon-mediated proteolysis of the Escherichia coli UmuD mutagenesis protein: in vitro degradation and identification of residues required for proteolysis. | Biological sciences | Roger Woodgate, Ekaterina G. Frank, Arthur S. Levine, Martin Gonzalez |
| Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators. | Biological sciences | Gary Felsenfeld, Michael J. Pikaart, Felix Recillas-Targa |
| Maintenance of sister-chromatid cohesion at the centromere by the Drosophila MEI-S332 protein. | Biological sciences | Terry L. Orr-Weaver, Tracy Tzu-Ling Tang, Sharon E. Bickel, Lynn M. Young |
| Malignant melanoma: modern black plague and genetic black box. | Biological sciences | Ronald A. De Pinho, Lynda Chin, Glenn Merlino |
| Masking, unmasking, and regulated polyadenylation cooperate in the translational control of a dormant mRNA in mouse oocytes. | Biological sciences | Beatrice Conne, Andre Stutz, Jean-Dominique Vassalli, Joachim Huarte, Pascale Gubler, Valerie Volkel, Pierre Flandin |
| Maternal IL-11R-alpha function is required for normal decidua and fetoplacental development in mice. | Biological sciences | Achim Gossler, Petra Bilinski, Derry Roopenian |
| Mcm1 regulates donor preference controlled by the recombination enhancer in Saccharomyces mating-type switching. | Biological sciences | Carol S. Newlon, James E. Haber, Cherry Wu, Kerstin Weiss, Chen Yang, Midori A. Harris, Bik-Kwoon Tye, Robert T. Simpson |
| Mei-W68 in Drosophila melanogaster encodes a Spo11 homolog: evidence that the mechanism for initiating meiotic recombination is conserved. | Biological sciences | Kim S. McKim, Aki Hayashi-Hagihara |
| Membrane recruitment of the kinase cascade scaffold protein Ste5 by the G-beta-gamma complex underlies activation of the yeast pheromone response pathway. | Biological sciences | Peter M. Pryciak, Frederick A. Huntress |
| Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors. | Biological sciences | Tyler Jacks, Roderick T. Bronson, Kim Mercer, Denise Crowley, James F. Gusella, Andrea I. McClatchey, Ichiko Saotome |
| Miranda as a multidomain adapter linking apically localized Inscuteable and basally localized Staufen and Prospero during asymmetric cell division in Drosophila. | Biological sciences | Lily Yeh Jan, Yuh Nung Jan, Juergen A. Knoblich, Chun-Pyn Shen, Yee-Ming Chan, Ming-Ming Jiang |
| Miranda mediates asymmetric protein and RNA localization in the developing nervous system. | Biological sciences | Andrea H. Brand, Daniel St Johnston, Alison J. Schuldt, Jan H.J. Adams, Catherine M. Davidson, David R. Micklem, Jim Haseloff |
| Mismatch repair, molecular switches, and signal transduction. | Biological sciences | Richard Fishel |
| Mitotic inactivation of a human SWI/SNF chromatin remodeling complex. (protein family) | Biological sciences | Marc W. Kirschner, Said Sif, Robert E. Kingston, P. Todd Stukenberg |
| Modeling mutations in the G1 arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a-ARF induces hyperploidy in cultured mouse astrocytes. | Biological sciences | Harold E. Varmus, Eric C. Holland, Wendy P. Hively, Vittorio Gallo |
| Modification of yeast Cdc53p by the ubiquitin-related protein Rub1p affects function of the SCF Cdc4 complex. | Biological sciences | Mark Estelle, Mark Goebl, Yun Liu, Jose M. Laplaza, Judy Callis, Neal Mathias, Doug Lammer, Weidong Jiang |
| Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha. | Biological sciences | Thomas Cech, Stacie J. Froelich-Ammon, Brent A. Dickinson, Joanne M. Bevilacqua, Steve C. Schultz |
| Molecular chaperones as HSF1-specific transcriptional repressors. (heat shock factor) | Biological sciences | Yanhong Shi, Richard I. Morimoto, Dick D. Mosser |
| Molecular genetic analysis of the heterodimeric splicing factor U2AF: the RS domain on either the large or small Drosophila subunit is dispensable in vivo. | Biological sciences | Donald C. Rio, David Z. Rudner, Kevin S. Breger |
| Molecular interactions between Vestigial and Scalloped promote wing formation in Drosophila. | Biological sciences | Kenneth D. Irvine, Andrew J. Simmonds, Henry M. Krause, John B. Bell, Xiaofeng Liu, Kelly H. Soanes |
| mRNA stabilization by poly(A) binding protein is independent of poly(A) and requires translation. | Biological sciences | Nicola K. Gray, Marvin P. Wickens, Jeffery M. Coller |
| Multistep signaling requirements for pituitary organogenesis in vivo. | Biological sciences | Andrew P. McMahon, Michael G. Rosenfeld, Jill A. McMahon, Mathias Treier, Daniel P. Szeto, Shawn M. O'Connell, Anatoli S. Gleiberman |
| Myc activates telomerase. | Biological sciences | Jing Wang, Gregory J. Hannon, David Beach, Lin Ting Xie, Susan Allan |
| Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. | Biological sciences | John L. Cleveland, Martine F. Roussel, Charles J. Sherr, David H. Randle, Frederique Zindy, Takehiko Kamijo, Christine M. Eischen |
| Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes. | Biological sciences | Jeffrey Settleman, Kathy Barrett, Katherine M. Nolan, Yu Lu, Kang-Quan Hu, Sylvie Vincent |
| Negative control of replication initiation by a novel chromosomal locus exhibiting exceptional affinity for Escherichia coli DnaA protein. | Biological sciences | Shigeki Moriya, Toru Ozaki, Risa Kitagawa, Tohru Ogawa |
| Negative regulation of the heat shock transcriptional response by HSBP1.(heat shock binding protein 1) | Biological sciences | Richard I. Morimoto, James M. Kramer, Sanjeev H. Satyal, Dayue Chen, Susan G. Fox |
| Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord. | Biological sciences | Thomas M. Jessell, Kevin J. Lee, Monica Mendelsohn |
| New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor IIB. | Biological sciences | Richard H. Ebright, Danny Reinberg, Achillefs N. Kapanidis, Thierry Lagrange, Hong Tang |
| New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2. | Biological sciences | Gerrit Vriend, Hans R. Scholer, Valerie Botquin, Heike Hess, Guy Fuhrmann, Constantinos Anastassiadis, Michael K. Gross |
| Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. (bone morphogenetic protein) | Biological sciences | Richard M. Harland, Andrew P. McMahon, Jill A. McMahon, Shinji Takada, Chen-Ming Fan, Lyle B. Zimmerman |
| Not just scaffolding: plectin regulates actin dynamics in cultured cells. | Biological sciences | Kerstin Andra, Branislav Nikolic, Markus Stocher, Detlev Drenckhahn, Gerhard Wiche |
| Notochord repression of endodermal Sonic hedgehog permits pancreas development. | Biological sciences | Seung K. Kim, Matthias Hebrok, Douglas A. Melton |
| Nuclear events in ethylene signaling: a transcriptional cascade mediated by ETHYLENE-INSENSITIVE3 and ETHYLENE-RESPONSE-FACTOR1. | Biological sciences | Joseph R. Ecker, Roberto Solano, Qimin Chao, Anna Stepanova |
| Nuclear localization of the C2H2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity. | Biological sciences | Gustav Ammerer, Francisco Estruch, Barbara Hamilton, Wolfram Gorner, Erich Durchschlag, Maria Teresa Martinez-Pastor, Helmut Ruis, Christoph Schuller |
| Nuclear RNA export. | Biological sciences | Michael Rosbash, Francoise Stutz |
| Nucleolar localization of early tRNA processing. | Biological sciences | Edouard Bertrand, Robert H. Singer, Felicia Houser-Scott, Ann Kendall, David R. Engelke |
| Nucleosome positioning by the winged helix transcription factor HNF3. | Biological sciences | Kenneth S. Zaret, Eun Yong Shim, Christopher Woodcock |
| Nucleotide excision repair and photolyase preferentially repair the nontranscribed strand of RNA polymerase III-transcribed genes in Saccharomyces cerevisiae. | Biological sciences | Abdelilah Aboussekhra, Fritz Thoma |
| okra and spindle-B encode components of the RAD52 DNA repair pathway and affect meiosis and patterning in Drosophila oogenesis. | Biological sciences | Amin Ghabrial, Robert P. Ray, Trudi Schupback |
| Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway. | Biological sciences | David Cortez, Ann Marie Pendergast, Zonghan Dai, Robert C. Quackenbush, Kevin D. Courtney, Matthew Grove, Gary W. Reuther |
| Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos. | Biological sciences | Janet Rossant, Juha Partanen, Lois Schwartz |
| osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. | Biological sciences | Ildiko Sarosi, Sheila Scully, David L. Lacey, William J. Boyle, W. Scott Simonet, Sean Morony, Nathan Bucay, Colin R. Dunstan, John Tarpley, Casey Capparelli, Hong Lin Tan, Weilong Xu |
| Overcoming cellular senescence in human cancer pathogenesis. | Biological sciences | Kennedy W. Gilchrist, Reginald Bruskewitz, Thomas R. YEager, Sandy DeVries, David F. Jarrard, Chinghai Kao, Stepehn Y. Nakada, Timothy D. Moon, Walter M. Stadler, Lorraine F. Meisner, Michael A. Newton, Frederic M. Waldman, Catherine A. Reznikoff |
| p107 is a suppressor of retinoblastoma development in pRb-deficient mice. | Biological sciences | Anton Berns, Els Robanus-Maandag, Martin van der Valk, Hein te Riele, Jan-Hermen Dannenberg, Marleen Dekker, Maria-Luisa Carrozza, Jean-Claude Jeanny |
| p300 and ATF-2 are components of the DRF complex, which regulates retinoic acid- and E1A-mediated transcription of the c-jun gene in F9 cells. | Biological sciences | Yang Shi, Hiroaki Kawasaki, Robert Chiu, Kazunari Taira, Kazunari K. Yokoyama, Richard Eckner, Nic Jones, Jun Song, Hideyo Ugai |
| p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation. | Biological sciences | W. Lee Kraus, James T. Kadonaga |
| pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis. (gene pavarotti, Drosophila) | Biological sciences | Hugo J. Bellen, David M. Glover, Adi Salzberg, Richard R. Adams, Alvaro A.M. Tavares |
| Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities. | Biological sciences | Rudi Balling, Annette Neubuser, Heiko Peters, Klaus Kratochwil |
| pha-4, an HNF-3 homolog, specifies pharyngeal organ identity in Caenorhabditis elegans. | Biological sciences | Judith Kimble, Susan E. Mango, Michael A. Horner, Sophie Quintin, Mary Ellen Domeier, Michel Labouesse |
| Phosphorylation and association with the transcription factor Atf1 regulate localization of Spc1/Sty1 stress-activated kinase in fission yeast. | Biological sciences | Paul Russell, Genevieve Degols, Kazuhiro Shiozaki, Frederique Gaits |
| Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysis. | Biological sciences | Robin Reed, Or Gozani, Emma Lees, Katrin Chua, Changyu Wang, Wolfgang Seghezzi |
| Phosphorylation regulates association of the transcription factor Pho4 with its import receptor Pse1/Kap121. | Biological sciences | Erin K. O'Shea, Arie Kaffman, Nicole Miller Rank |
| Pleiotropic control of glucose and hormone responses by PRL1, a nuclear WD protein, in Arabidopsis. | Biological sciences | Csaba Koncz, Jaideep Mathur, Mark Stitt, Kinga Nemeth, Zsuzsanna Koncz-Kalman, George P. Redei, Jeff Schell, Klaus Salchert, Peter Putnoky, Rishikesh Bhalerao, Biljana Stankovic-Stangeland, Laszlo Bako, Laszlo Okresz, Sylvia Stabel, Peter Geigenberger |
| Pointing roots in the right direction: the role of auxin transport in response to gravity. | Biological sciences | Liam Dolan |
| Polar localization of the MinD protein of Bacillus subtilis and its role in selection of the mid-cell division site. | Biological sciences | Jeffery Errington, Helena B. Thomaides, Adele L. Marston, David H. Edwards, Michaela E. Sharpe |
| Polar localization of the replication origin and terminus in Escherichia coli nucleoids during chromosome partitioning. | Biological sciences | Hironori Niki, Sota Hiraga |
| Polo-like kinases: a team that plays throughout mitosis. | Biological sciences | Iain M. Hagan, Alvaro A.M. Tavares, David Glover M. |
| Pom1p, a fission yeast protein kinase that provides positional information for both polarized growth and cytokinesis. | Biological sciences | Jurg Bahler, John R. Pringle |
| Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. | Biological sciences | Manuel Serrano, Scott W. Lowe, Athena W. Lin, Marta Barradas, James C. Stone, Linda van Aelst |
| Prespore-specific gene expression in Bacillus subtilis is driven by sequestration of SpoIIE phosphatase to the prespore side of the asymmetric septum. | Biological sciences | Jeffery Errington, Ling Juan Wu, Andrea Feucht |
| Proneural gene self-stimulation in neural precursors: an essential mechanism for sense organ development that is regulated by Notch signaling. | Biological sciences | Joaquim Culi, Juan Modolell |
| Proteases to die for. | Biological sciences | Vincent Cryns, Yuan Junying |
| Proteasomal regulation of nuclear receptor corepressor-mediated repression. | Biological sciences | Jinsong Zhang, Matthew G. Guenther, Mitchell A. Lazar, Richard W. Carthew |
| PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors. | Biological sciences | Thomas Graf, Claus Nerlov |
| 'Puckered' encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila. | Biological sciences | Nikolai Kirov, Enrique Martin-Blanco, Alexandra Gampel, Jenny Ring, Kanwar Virdee, Aviva M. Tolkovsky, Alfonso Martinez-Arias |
| Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. | Biological sciences | William S. Lane, David R. Engelke, Joel R. Chamberlain, Yoon Lee |
| pX, the HBV-encoded coactivator, suppresses the phenotypes of TBP and TAFII250 mutants. (hepatitis B virus, TATA-binding protein, TBP-associated factor) | Biological sciences | Yosef Shaul, Izhak Haviv, Yehuda Matza |
| Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway. (Janus-family protein tyrosine kinases) | Biological sciences | Joseph Schlessinger, Tadatsugu Taniguchi, Akinori Takaoka, Ivan Dikic, Tadaaki Miyazaki, Leonor Nogueira, Hodaka Fujii, Shiho Tsujino, Yukiko Mitani, Michiyuki Maeda |
| Rad52 associates with RPA and functions with Rad55 and Rad57 to assemble meiotic recombination complexes. | Biological sciences | Douglas K. Bishop, Stephen L. Gasior, Anthony K. Wong, Yoshiteru Kora, Akira Shinohara |
| RadA protein is an archaeal RecA protein homolog that catalyzes DNA strand exchange. | Biological sciences | Steven J. Sandler, Stephen C. Kowalczykowski, Erica M. Seitz, Joel P. Brockman, A. John Clark |
| Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway. | Biological sciences | Stephen J. Elledge, Annette A. Alcasabas, Brian A. Desany, Jeffrey B. Bachant |
| RecQ helicase, in concert with RecA and SSB proteins, initiates and disrupts DNA recombination. | Biological sciences | Stephen C. Kowalczykowski, Frank G. Harmon |
| Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo. | Biological sciences | Piotr Sicinski, Carol Trempus, Stuart H. Yuspa, Claudio J. Conti, Laura Hansen, Ana I. Robles, Marcelo L. Rodriguez-Puebla, Adam B. Glick, Raymond W. Tennant, Tovert A. Weinberg |
| Regulation of dorsal somitic cell fates: BMPs and Noggin control the timing and pattern of myogenic regulator expression. | Biological sciences | Andrew B. Lassar, Miguel Maroto, Ram Reshef |
| Regulation of gene expression by TBP-associated proteins. | Biological sciences | Tong Ihn Lee, Richard A. Young |
| Regulation of POU genes by castor and hunchback establishes layered compartments in the Drosophila CNS. | Biological sciences | Ward F. Odenwald, Ravi Kambadur, Keita Koizumi, Chad Stivers, James Nagle, Stephen J. Poole |
| Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (exportin) and the stress-activated MAP kinase Sty1/Spc1. | Biological sciences | Brian A. Morgan, Takashi Toda, Nic Jones, W. Mark Toone, Shusuke Kuge, Michael Samuels |
| Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase. | Biological sciences | Valerie A. Wilson, Rosa S.P. Beddington, Simon L. Bullock, Judy M. Fletcher |
| Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK. (mitogen-activated protein kinase)(MAPK/ERK kinase) | Biological sciences | Lee Bardwell, Jeremy Thorner, Jeanette G. Cook, Deepak Noora, Daniel M. Baggott, Anthony R. Martinez |
| Reprogramming of early embryonic blastomeres into endodermal progenitors by a Caenorhabditis elegans GATA factor. | Biological sciences | Joel H. Rothman, Tetsunari Fukushige, James D. McGhee, Jiangwen Zhu |
| Ribonuclease E organizes the protein interactions in the Escherichia coli RNA degradosome. | Biological sciences | Christopher F. Higgins, Agamemnon J. Carpousis, Beatrice Py, Henry M. Krisch, Nathalie F. Vanzo, Yeun Shan Li, Erwin Blum, Lelia C. Raynal |
| RNA-binding protein conserved in both microtubule- and microfilament-based RNA localization. | Biological sciences | Nancy Standart, Karina Yaniv, Leora Havin, Anna Git, Zichrini Elisha, Froma Oberman, Sigal Pressman Schwartz, Joel K. Yisraeli |
| Saccharomyces cerevisiae cAMP-dependent protein kinase controls entry into stationary phase through the Rim 15p protein kinase. | Biological sciences | Thomas Boller, Andres Wiemken, Anke Reinders, Niels Burckert, Claudio de Virgilio |
| SAPKs and transcription factors do the nucleocytoplasmic tango. (stress-activated mitogen-activated protein kinase) | Biological sciences | Jonathan B.A. Millar, Marc G. Wilkinson |
| SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish. | Biological sciences | Stephen J. Pratt, Barry H. Paw, Leonard I. Zon, John H. Postlethwait, Eric C. Liao, Andrew C. Oates |
| Selective regulation of Bcl-XL by a Jak kinase-dependent pathway is bypassed in murine hematopoietic malignancies. | Biological sciences | James N. Ihle, John L. Cleveland, Hui Yang, Gabriel Nunez, Evan Parganas, Christine M. Eischen, Graham Packham, Elsie White, Didier A.M. Grillot, Ferard P. Zambetti |
| Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. | Biological sciences | Austin Smith, Ian Chambers, Hitoshi Niwa, Tom Burdon |
| Senescence of human fibroblasts induced by oncogenic Raf. | Biological sciences | Douglas Woods, Martin McMahon, J. Michael Bishop, Jiyue Zhue |
| Sequence and DNA structural determinants of N4 virion RNA polymerase-promoter recognition. | Biological sciences | Xing Dai, Lucia B. Rothman-Denes |
| Seven-up, the Drosophila homolog of the COUP-TF orphan receptors, controls cell proliferation in the insect kidney. | Biological sciences | Michael Hoch, Birgit Kerber, Sonja Fellert |
| Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases. | Biological sciences | W. Tony Parks, Robert J. Lechleider, Anita B. Roberts, Donald P. Bottaro, Mark P. de Caestecker, Chistopher J. Frank, Paola Castagnino |
| Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. | Biological sciences | Ali Hemmati-Brivanlou, Joan Massague, Akiko HAta, Giorgio LAgna |
| Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm. | Biological sciences | Manfred Frasch, Edwin L. Ferguson, Xiaolei Xu, Zhizhang Yin, John B. Hudson |
| Smads and early developmental signaling by the TGF-beta superfamily. (transforming growth factor beta) | Biological sciences | Malcom Whitman |
| SNAP19 mediates the assembly of a functional core promoter complex (SNAPc) shared by RNA polymerases II and III. | Biological sciences | Nouria Hernandez, Vivek Mittal, Ryuji Kobayashi, R. William Henry, Beicong Ma |
| Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice. (transcription factor) | Biological sciences | Vasso Episkopou, Hisato Kondoh, Robin Lovell-Badge, Heather Wood, Seiji Nishiguchi |
| Spalten, a protein containing G(alpha)-protein-like and PP2C domains, is essential for cell-type differentiation in Dictyostelium. | Biological sciences | Richard A. Firtel, Laurence Aubry |
| Specific telomerase RNA residues distant from the template are essential for telomerase function. | Biological sciences | Jagoree Roy, Tracy B. Fulton, Elizabeth H. Brackburn |
| S-phase specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe. | Biological sciences | Antony M. Carr, Fekret Osman, Nancy Walworth, Howard D. Lindsay, Dominic J.F. Griffiths, Rhian F. Edwards, Per U. Christensen, Johanne Murray |
| Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth. | Biological sciences | William G. Kaelin Jr, Andrew B. Lassar, Frederic J. Kaye, William R. Sellers, Bennett G. Novitch, Satoshi Miyake, Agnieszka Heith, Gregory A. Otterson |
| Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted distruption in the murine Bloom's syndrome gene. | Biological sciences | Philip Leder, Frank Kuo, Nicholas Chester, Christine Kozak, Cathie D. O'Hara |
| Structure and specificity of nuclear receptor-coactivator interactions. | Biological sciences | Keith R. Yamamoto, Robert J. Fletterick, John D. Baxter, Michael R. Stallcup, Richard L. Wagner, James W. Apriletti, Beatrice D. Darimont, Peter J. Kushner |
| Suppression of crossing-over by DNA methylation in Ascobolus. | Biological sciences | Jean-Luc Rossignol, Laurent Maloisel |
| Suppression of the p300-dependent mdm2 negative-feedback loop induces the p53 apoptotic function.(murine double minute 2) | Biological sciences | Eileen White, Anju Thomas |
| Switch from translation to RNA replication in a positive-stranded RNA virus. | Biological sciences | Raul Andino, Andrea V. Gamarnik |
| SXR, a novel steroid and xenobiotic-sensing nuclear receptor. | Biological sciences | Ronald M. Evans, Bruce Blumberg, Estelita S. Ong, Henry Juguilon, Jack Bolado Jr., Walid Sabbagh Jr., Casey M. van Meter |
| Synapse-specific and neuregulin-induced transcription require an Ets site that binds GABP alpha/GABP beta. | Biological sciences | Steven J. Burden, Larry Fromm |
| Synaptonemal complex morphogenesis and sister-chromatid cohesion require Mek1-dependent phosphorylation of a meiotic chromosomal protein. | Biological sciences | Julie M. Bailis, G. Shirleen Roeder |
| Synergistic cooperation of TFE3 and Smad proteins in TGF-beta-induced transcription of the plasminogen activator inhibitor-1 gene. | Biological sciences | Harvey F. Lodish, Dominic O. Ansari, Xianxin Hua, Xuedong Liu |
| Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span. | Biological sciences | R. Keith Humphries, Anita Borowski, Cheryl D. Helgason, Jacqueline E. Damen, Patty Rosten, Rewa Grewal, Poul Sorensen, Suzanne M. Chappel, Frank jirik, Gerald Krystal |
| Telomere-mediated chromosome pairing during meiosis in budding yeast. | Biological sciences | G. Shirleen Roeder, Beth Rockmill |
| TGF-beta-stimulated cooperation of Smad proteins with the coactivators CBP/p300. | Biological sciences | Tony Hunter, Ralf Janknecht, Nicholas J. Wells |
| The ATP-dependent PIM1 protease is required for the expression of intron-containing genes in mitochondria. | Biological sciences | Walter Neupert, Thomas Langer, Luc Van Dyck |
| The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells.(protein, coactivator) | Biological sciences | Ming-Jer Tsai, Hiroyujki Mutoh, Francisco J. Naya, Andrew B. Leiter |
| The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. | Biological sciences | Kurt Burki, Andrea Krapp, Martin Knofler, Birgit Ledermann, Catherine Berney, Nicole Zoerkler, Otto Hagenbuchle, Peter K. Wellauer |
| The box H + ACA snoRNAs carry Cbf5p, the putative rRNA pseudouridine synthase. | Biological sciences | David Tollervey, Yves Henry, Michele Caizergues-Ferrer, Denis L.J. Lafontaine, Cecile Bousquet-Antonelli |
| The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development. | Biological sciences | James Keller, Michael O. Hengartner, Nicholas K. Tonks, Michael J. Gutch, Andrew J. Flint |
| The Cdc7 protein kinase is required for origin firing during S phase. | Biological sciences | John F.X. Diffley, Kristine Bousset |
| The C/EBP-beta transcription factor regulates epithelial cell proliferation and differentiation in the mammary gland. (CCAAT-enhancer binding protein) | Biological sciences | Gertraud W. Robinson, Peter F. Johnson, Lothar Hennighausen, Esta Sterneck |
| The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. | Biological sciences | Marc W. Kirschner, Guowei Fang, Hongtao Yu |
| The ClpXP and ClpAP proteases degrade proteins with carboxy-terminal peptide tails added by the SsrA-tagging system. | Biological sciences | Susan Gottesman, Robert T. Sauer, Eric Roche, YanNing Zhou |
| The competence transcription factor of Bacillus subtilis recognizes short A/T-rich sequences arranged in a unique flexible pattern along the DNA helix. | Biological sciences | Gerard Venema, Leendert W. Hamoen, David Dubnau, Jetta J.E. Bijlsma, Aske F. Van Werkhoven |
| The complexity of p53 modulation: emerging patterns from divergent signals. | Biological sciences | Michael B. Kastan, Amato J. Giaccia |
| The compulsion of chirality: toward an understanding of left-right asymmetry. | Biological sciences | Mark Mercola, Michael Levin |
| The control of maize spikelet meristem fate by the APETALA2-like gene indeterminate spikelet1. | Biological sciences | Sarah Hake, Robert B. Meeley, George Chuck |
| The DNA methylation locus DDM1 is required for maintenance of gene silencing in Arabidopsis. | Biological sciences | Judith Bender, Eric J. Richards, Jeffrey A. Jeddeloh |
| The Drosophila Ste20-related kinase misshapen is required for embryonic dorsal closure and acts through a JNK MAPK module on an evolutionarily conserved signaling pathway. (Jun amino-terminal kinase)(mitogen-activated protein kinase) | Biological sciences | Jessica E. Treisman, Edward Y. Skolnik, Yi-Chi Su |
| The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families. | Biological sciences | William G. Kaelin Jr., Joan Weliky Conaway, Ronald C. Conaway, Takumi Kamura, Li Liu, Shigeo Sato, Dewan Haque |
| The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system. | Biological sciences | Stefan Britsch, Dieter Riethmacher, Carmen Birchmeier, Volker Brinkmann, Li Li, Susanne Kirchhoff, Franz Theuring |
| The essential Gcd10p-Gcd14p nuclear complex is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA. | Biological sciences | Rafael Cuesta, James Anderson, Katsura Asano, Alan G. Hinnebusch, Lon Phan, Bradley A. Carlson, Marie Pak, Glenn R. Bjork, Mercedes Tamame |
| The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins. | Biological sciences | Marc W. Kirschner, Kun Ping Lu, Minhui Shen, P. Todd Stukenberg |
| The fission yeast SPB component Cut12 links bipolar spindle formation to mitotic control. | Biological sciences | Iain M. Hagan, Alan J. Bridge, Mary Morphew, Rachel Bartlett |
| The flagellar anti-sigma factor FlgM actively dissociates Salmonella typhimurium sigma28 RNA polymerase holoenzyme. | Biological sciences | Joyce E. Karlinsey, Kelly T. Hughes, Meggen S. Chadsey |
| The formation of neuromuscular synapses. | Biological sciences | Steven J. Burden |
| The guanosine nucleotide (p)ppGpp initiates development and A-factor production in Myxococcus xanthus. | Biological sciences | Dale Kaiser, Baruch Z. Harris, Mitchell Singer |
| The histone acetylase PCAF is a nuclear receptor coactivator. | Biological sciences | Ronald M. Evans, Yoshihiro Nakatani, Saverio Minucci, Keiko Ozato, Hongwu Chen, Jorge C. G. Blanco, Jianming Lu, Xiang-Jiao Yang, Kristen K. Walker |
| The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor. | Biological sciences | Michael R. Green, Xiao-Yong Li |
| The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiae. (mitogen-activated protein kinase) | Biological sciences | Ira Herskowitz, Sean M. O'Rourke |
| The Homothorax homeoprotein activates the nuclear localization of another homeoprotein, Extradenticle, and suppresses eye development in Drosophila. | Biological sciences | Adi Salzberg, Chi-Yun Pai, Tung-Sheng Kuo, Thomas J. Jaw, Estee Kurant, Cheng-Tse Chen, Dmitri Bessarab, Y. Henry Sun |
| The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. | Biological sciences | Robert E. Hammer, Steven L. McKnight, Alvin M. Matsumoto, David W. Russell, Hui Tian |
| The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein. | Biological sciences | Vineet N. KewalRamani, Dan R. Littman, Ping Wei, Katherine A. Jones, Andrew P. Rice, Mitchell E. Garber, Timothy P. Mayall, Christine H. Herrmann |
| The maize gene liguless2 encodes basic leucine zipper protein involved in the establishment of the leaf blade-sheath boundary. | Biological sciences | Michael Freeling, Justine Walsh, Cynthia A. Waters |
| The mammalian transcriptional repressor RBP (CBF1) targets TFIID and TFIIA to prevent activated transcription. | Biological sciences | Danny Reinberg, Ivan Olave, Lynne D. Vales |
| The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain. | Biological sciences | Roger D. Kornberg, Hediye Erdjument-Bromage, Paul Tempst, David A. Bushnell, Claes M. Gustafsson, Lawrence C. Myers, Mary Lui |
| The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7. | Biological sciences | Danny Reinberg, Sasha Akoulitchev |
| The myogenic regulatory gene Mef2 is a direct target for transcriptional activation by Twist during Drosophila myogenesis. | Biological sciences | Eric N. Olson, Brian L. Black, Bin Zhao, Richard M. Cripps, Robert A. Schulz, Ching-Ling Lien |
| The Oct-1 POU domain activates snRNA gene transcription by contacting a region in the SNAP sub c largest subunit that bears sequence similarities to the Oct-1 coactivator OBF-1. | Biological sciences | Nouria Hernandez, Ethan Ford, Michel Sturbin |
| The ovo gene required for cuticle formation and oogenesis in flies is involved in hair formation and spermatogenesis in mice. | Biological sciences | Elaine Fuchs, Linda Degenstein, Xing Dai, Christopher Schonbaum, Wenyu Bai, Anthony Mahowald |
| The regulation of E2F by pRB-family proteins. (retinoblastoma tumor suppressor gene) | Biological sciences | Nicholas Dyson |
| There's the rub: a novel ubiquitin-like modification linked to cell cycle regulation. | Biological sciences | Mark Hochstrasser |
| The RNA cleavage activity of RNA plymerase III is mediated by an essential TFIIS-like subunit and is important for transciption termination. | Biological sciences | Patrick Schultz, Andre Sentenac, Michel Riva, Christophe Carles, Stephane Chedin |
| The role of Cdk7 in CAK function, a retro-retrospective. (protein) | Biological sciences | Stephen J. Elledge, J. Wade Harper |
| The role of FGFs in the early development of vertebrate limbs. | Biological sciences | Gail R. Martin |
| The ROOT HAIRLESS 1 gene encodes a nuclear protein required for root hair initiation in Arabidopsis. | Biological sciences | Brian Wells, Keith Roberts, Kurt Boudonck, Liam Dolan, Jaideep Mathur, Katharina Schneider |
| The ROTUNDIFOLIA3 gene of Arabidopsis thaliana encodes a new member of the cytochrome P-450 family that is required for the regulated polar elongation of leaf cells. | Biological sciences | Hirokazu Tsukaya, Gyung-Tai Kim, Hirofumi Uchimiya |
| The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs. | Biological sciences | Maria J. Ruiz-Echevarria, Stuart W. Peltz, Harry C. Dietz, Michael D. Ter-Avanesyan, Sergey V. Paushkin, Kevin Czaplinski, Xia Han, Youmin Weng, Haley A. Perlick |
| The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow. | Biological sciences | Stuart H. Orkin, Laurie Davidson, Yuko Fujiwara, Todd R. Golub, Jane Visvader, D. Gary Gilliland, Wojciech Swat, Frank Kuo, Li Chun Wang, Fred W. Alt |
| The telomerase reverse transcriptase: components and regulation. | Biological sciences | Victoria Lundblad, Constance I. Nugent |
| The TIR1 protein of Arabidopsis functions in auxin response and is related to human SKP2 and yeast Grr1p. | Biological sciences | Mark Estelle, Elizabeth Dewey, William M. Gray, Jocelyn Turner, Max Ruegger, Lawrence Hobbie |
| The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. | Biological sciences | Annick Itie, Andrew Wakeham, Tak W. Mak, Janet Rossant, Andrew Elia, Christian Sirard, Scott E. Kern, Christine Mirtsos, Jose Luis De la Pompa, Lois Schwartz, Alison Cheung, Stephan Hahn |
| The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-beta-induced transcriptional activation. | Biological sciences | Rik Derynck, Ying Zhang, Xin-Hua Feng, Rui-Yun Wu |
| The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse. | Biological sciences | En Li, Patricia K. Donahoe, Hong Lei, Masatoshi Nomura, Zhenyu Gu, Brenda B. Simpson, Alie Feijen, Janny van den Eijnden-van Raaij |
| The upstream sequence element of the C2 complement poly(A) signal activates mRNA 3' end formation by two distinct mechanisms. | Biological sciences | James L. Manley, Yoshio Takagaki, Alexandra Moreira, Simon Brackenridge, Matthew Wollerton, Nicholas J. Proudfoot |
| The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in Drosophila. | Biological sciences | Sean Carroll, Jaeseob Kim, Georg Halder, Mary Ellen Kraus, Allen Laughon, Angela Hudson, Patricia Polaczyk |
| The yeast Ada complex mediates the ligand-dependent activation function AF-2 of retinoid X and estrogen receptors. | Biological sciences | Pierre Chambon, Regine Losson, Elmar vom Baur, Matthias Harbers, Soo-Jung Um, Arndt Benecke |
| Think globally, act locally: the making of a mouse mammary gland | Biological sciences | Gertraud W. Robinson, Lothar Henninghausen |
| Transactivation-defective c-MycS retains the ability to regulate proliferation and apoptosis. | Biological sciences | Jingyu Shi, Susumu Adachi, John Sedivy, Qiurong Xiao, Gisela Claassen, Stephen R. Hann |
| Transcriptional termination in the Balbiani ring 1 gene is closely coupled to 3'-end formation and excision of the 3'-terminal intron. | Biological sciences | Goran Bauren, Sergey Belikov, Lars Wieslander |
| Transcription factor CREM coordinates the timing of hepatocyte proliferation in the regenerating liver. | Biological sciences | Paolo Sassone-Corsi, Giuseppe Servillo, Maria Agnese Della Fazia |
| Transcription occurs in pulses in muscle fibers. | Biological sciences | Vanessa R.M. Hodgson, Edna C. Hardeman, Sarah Newlands, Linda K. Levitt, C. Stephen Robinson, A.B. Carmen Karpf, Robert P. Wade |
| Translational readthrough in the hdc mRNA generates a novel branching inhibitor in the Drosophila trachea. | Biological sciences | Christos Samakovlis, Camilla Englund, Par Steneberg, Jesper Kronhamn, Thomas A. Weaver |
| Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death. | Biological sciences | Craig B. Thompson, Robert H. Arch, Richard W. Gedrich |
| Ultrabithorax regulates genes at several levels of the wing-patterning hierarchy to shape the development of the Drosophila haltere. | Biological sciences | Sean Carroll, Jaeseob Kim, Georg Halder, Scott D. Weatherbee, Angela Hudson |
| Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development. | Biological sciences | Stuart H. Orkin, Yuko Fujiwara, Jane E. Visvader |
| Vaccinia NPH-I, a DExH-box ATPase, is the energy coupling factor for mRNA transcription termination. | Biological sciences | Stewart Shuman, Liang Deng |
| WAT-free mice: diabetes without obesity. | Biological sciences | Steven L. McKnight |
| windbeutel, a gene required for dorsoventral patterning in Drosophila, encodes a protein that has homologies to vertebrate proteins of the endoplasmic reticulum. | Biological sciences | Trudi Schupbach, Mary Konsolaki |
| WTI interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes. | Biological sciences | Nicholas D. Hastie, Angus I. Lamond, Stefan H. Larsson, Rachel C. Davies, Cinzia Calvio, Eva Bratt |
| Xe-p9, a Xenopus Suc1/Cks protein, is essential for the Cdc2-dependent phosphorylation of the anaphase-promoting complex at mitosis. | Biological sciences | William G. Dunphy, Debabrata Patra |
| Yeast telomeres exert a position effect on recombination between internal tracts of yeast telomeric DNA. | Biological sciences | Virginia A. Zakian, Jeffrey B. Stavenhagen |
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