Cell 2005 - Abstracts
| Cell 2005 | |||||
| Title | Subject | Authors | |||
|---|---|---|---|---|---|
| 24p3 and its receptor: Dawn of a new iron age? | Biological sciences | ||||
| A beta-catenin identified by functional rather than sequence criteria and its role in Wnt/MAPK signaling. | Biological sciences | Judith Kimble, Ambrose R. Kidd III, Jennifer A. Miskowski, Kellee R. Siegfried, Hitoshi Sawa | |||
| A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. | Biological sciences | Michael R. Green, Laxminarayana R. Devireddy, Claude Gazin, Xiaochun Zhu | |||
| Acetylation in histone H3 globular domain regulates gene expression in yeast. | Biological sciences | Michael Grunstein, Feng Xu, Kangling Zhang | |||
| Activation-loop autophosphorylation is mediated by a novel transitional intermediate form of DYRKs. | Biological sciences | Pamela A. Lochhead, Gary Sibbet, Nick Morrice, Vaughn Cleghon | |||
| Adam meets Eph: An ADAM substrate recognition module acts as a molecular switch for Ephrin cleavage in trans. | Biological sciences | Dimitar B. Nikolov, Peter W. Janes, Nayanendu Saha, William A. Barton, Momchil V. Kolev, Sabine H. Wimmer-Kleikamp, Eva Nievergall, Juha-Pekka Himanen, Carl P. Blobel, Martin Lackmann | |||
| A disulfide relay system in mitochondria. | Biological sciences | Kostas Tokatlidis | |||
| A disulfide relay system in the intermembrane space of mitochondria that mediates protein import. | Biological sciences | Walter Neupert, Kai Hell, Nikola Mesecke, Nadia Terziyska, Johannes M. Herrmann, Christian Kozany, Frank Baumann | |||
| A dual inhibitory mechanism restricts msl-2 mRNA translation for dosage compensation in Drosophila. | Biological sciences | Matthias W. Hentze, Karsten Beckmann, Marica Grskovic, Fatima Gebauer | |||
| Advocating asymmetry and the POP-1 paradox: Noncanonical Wnt signaling in C. elegans.(Caenorhabditis elegans ) | Biological sciences | Bruce Bowerman | |||
| A genetic screen for candidate tumor suppressors identifies REST. | Biological sciences | Stephen J. Elledge, Ronald A. DePinho, Gregory J. Hannon, Lynda Chin, Thomas M. Roberts, Thomas F. Westbrook, Yumei Leng, Jean J. Zhao, Galil Mandel, Eric S. Martin, Michael R. Schlabach, Anthony C. Liang, Bin Feng | |||
| A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenecity. | Biological sciences | Katrien Berns, Jasper Mullenders, Reuven Agami, Roderick L. Beijersbergen, Ingrid G.M. Kolfschoten, P. Mathijs Voorhoeve, Bart van Leeuwen, V | |||
| A genomic and functional inventory of deubiquitinating enzymes. | Biological sciences | Titia K. Sixma, Thijn R. Brummelkamp, Arno Velds, Sebastian M.B. Nijam, Mark P.A. Luna-Vargas, Annette M.G. Dirac | |||
| A Hox regulatory network establishes motor neuron pool identity and target-muscle connectivity. | Biological sciences | Thomas M. Jessell, Jeremy S. Dasen, Bonnie C. Tice, Susan Brenner-Morton | |||
| A human protein-protein interaction network: A resource for annotating the proteome. | Biological sciences | Walter Birchmeier, Hans Lehrach, Felix H. Brembeck, Ulrich Stelzl, Uwe Worm, Maciej Lalowski, Christian Haenig, Heike Goehler, Martin Stroedicke, Martina Zenkner, Anke Schoenherr, Susanne Koeppen, Jan Timm, Claudia Abraham, Sascha Mintzlaff, Nicole Bock, Silvia Kietzmann, Astrid Goedde, Anja Droege, Engin Toksoz, Bernhard Korn, Sylvia Krobitsch, Erich E. Wanker | |||
| A humble bacterium sweeps this year's Nobel Prize. | Biological sciences | Francis Megraud | |||
| Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins. | Biological sciences | Tahir H. Tahirov, Dmitry G. Vassylyev, Irina Artsimovitch, Marina N. Vassylyeva, Anna Perederina, Vladimir Svetlov, Naohiro Matsugaki, Dmitri Svetlov, NoriyukI Igarashi, Soichi Wakatsuki | |||
| Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. | Biological sciences | William I. Weis, W. James Nelson, Soichiro Yamada, Sabine Pokutta, Frauke Drees | |||
| Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. | Biological sciences | Sreeganga Chandra, Rafael Fernandez-Chacon, Thomas C. Sudhof, Gilbert Gallardo, Oliver M. Schluter | |||
| Alternative slicing regulation impacts heart development. | Biological sciences | Thomas A. Cooper | |||
| A microRNA meditates EGF receptor signaling and promotes photoreceptor differentiation in the drosophila eye. | Biological sciences | Richard W. Carthew, Xin Li | |||
| A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBP alpha regulates human granulopoiesis. | Biological sciences | Vania Gelmetti, Francesco Fazi, Alessandro Fatica, Alessandro Rosa, Maria Laura De Marchis | |||
| A modular design for the clathrin- and actin-mediated endocytosis machinery. | Biological sciences | Marko Kaksonen, David G. Drubin, Christopher P. Toret | |||
| An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. | Biological sciences | Raul R. Gainetdinov, Robert J. Lefkowitz, Marc G. Caron, Jean-Martin Beaulieu, Tatyana D. Sotnikova, Sebastien Marion | |||
| Anchors away! Fos Fosters anchor-cell invasion. | Biological sciences | Denise J. Montell | |||
| And the noise played on: Stochastic gene expression and HIV-I infection. | Biological sciences | James J. Collins, William J. Blake | |||
| An E-MAP of the ER. | Biological sciences | Elizabeth Conibear | |||
| A neuropeptide courier for sigma-opioid receptors. | Biological sciences | Allan I. Basbaum, David Julius | |||
| A new class of transcription factors mediates brassinosteroid-regulated gene expression in arabidopsis. | Biological sciences | Joanne Chory, Tadao Asami, Yanhai Yin, Dionne Vafeados, Yi Tao, Shigeo Yoshida | |||
| A new FronTIR in targeted protein degradation and plant development. | Biological sciences | Joanne Chory, Jennifer L. Nemhauser | |||
| A new map for navigating the yeast epigenome. | Biological sciences | Dirk Schubeler, Byran M. Turner | |||
| A new paradigm for translational control: Inhibition via 5'-3' mRNA tethering by Biocoid and the elF4E cognate 4EHP. | Biological sciences | Paul Lasko, Nahum Sonenberg, Francis Poulin, Park F. Cho, Yoon Andrew Cho-Park, Ian B. Cho-Park, Jarred D. Chicoine | |||
| A new view of an old pore. | Biological sciences | Sandra Bajjalieh | |||
| Animal microRNAs confer robustness to gene expression and have a significant impact on 3'UTR evolution. | Biological sciences | Stephen M. Cohen, Julius Brennecke, Robert B. Russell, Alexander Stark, Natascha Bushati | |||
| An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. | Biological sciences | Dennis L. Kasper, Arthur O. Tzianabos, Sarkis K. Mazmanian, Cui Hua Liu | |||
| A nose by any other names (should smell as sweetly). | Biological sciences | David J. Anderson, Gloria B. Choi | |||
| A novel human p53 isoform is an essential element of the ATR-intra-S phase checkpoint. | Biological sciences | Wolfgang Deppert, Gabor Rohaly, Jan Chemnitz, Silke Dehde, Alejandro Mena Nunez, Jochen Heukeshoven, Irena Dornreiter | |||
| Antagonizing Wnt and FGF receptors: An enemy from within (the ER).(frizzled serpentine receptors ) | Biological sciences | Xi He | |||
| Antisense-Mediated depletion reveals essential and specific functions of MicroRNAs in Drosophila development. | Biological sciences | Michael Pearce, Thomas Tuschl, Abdullah Yalcin, Chris Sander, Po Yu Chen, Dan Leaman, Debora S. Marks, John Fak, Ulrike Gaul, Ulrich Unnerstall | |||
| A nuclear function of beta-arrestin 1 in GPCR signaling: Regulation of histone acetylation and gene transcription. | Biological sciences | Min Zhu, Bin Xiang, Min Zhang, Jiuhong Kang, Bin Qu, Wenjuan Su, Guobin Bao, Feifei Wang, Rongxi Yang, Fengjuan Fan, Xiaoquing Zhang, Xiaoqing Chen, Gang Pe | |||
| An unexpected role for ubiquitylation of a transcriptional activator. | Biological sciences | Fred Winston, Karen Arndt | |||
| AP-3 directs the intracellular trafficking of HIV-1 Gag and plays a key role in particle assembly. | Biological sciences | Terence S. Dermody, Hua Li, Xinhong Dong, Paul Spearman, Aaron Derdowski, Lingmei Ding, Atuhani Burnett, Xuemin Chen, Timothy R. Peters, Elvin Woodruff, Jaang-Jiun Wang | |||
| Apoptotic pathways: Ten minutes to dead. | Biological sciences | Douglas R. Green | |||
| Arabidopsis interdigitating cell growth requires two antagonistic pathways with opposing action on cell morphogenesis. | Biological sciences | Ying Fu, Ying Gu, Zhiliang Zheng, Geoffrey Wasteneys, Yang Zhenbiano | |||
| A Rae1- containing ribonucleoprotein complex is required for mitotic spindle assembly. | Biological sciences | Rebecca Heald, Karsten Weis, Michael D. Blower, Maxence Nachury | |||
| A ratchet mechanism of transcription elongation and its control. | Biological sciences | Arkady Mustaev, Gil Bar-Nahum, Evgeny Nudler, Vitaly Epshtein, Andrei E. Ruckenstein, Ruslan Rafikov | |||
| ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. | Biological sciences | Wei Gu, Jun Qin, Delin Chen, Ning Kon, Muyang Li, Wenzhu Zhang | |||
| Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation. | Biological sciences | Xiaodong Wang, Fenghe Du, Tim A. Rand, Sean Petersen | |||
| A role for proapoptotic BID in the DNA-damage response. | Biological sciences | Stanley J. Korsmeyer, Atan Gross, Sandra S. Zinkel, Kristen E. Hurov, Christy Ong, Farvardean M. Abtahi | |||
| A series of ubiquitin binding factors connects CDC48/p97 to substrate multiubiquitylation and proteasomal targeting. | Biological sciences | Michael Rape, Stefan Jentsch, Holger Richly, Siguard Braun, Sebastin Rumpf, Carsten Hoege | |||
| ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle. | Biological sciences | James L. Manley, Ju Chen, Xiangdong Xu, Jian-Hua Ding, Dongmei Yang, Wang Wang, Nancy D. Dalton, Pao-Hsien Chu, Huan-You Wang, Zhen Ye, John R. Jr. Bermingham, Forrest Liu, John Jr. Ross, Michael G. Rosenfield, Fu Xiang-Dong, Heping Cheng, Rui-Ping Xiao | |||
| A skeleton of the human protein interactome. | Biological sciences | Gerard Cagney, Andrew Emili, Ata Ghavidel | |||
| A slowed classical pathway rather than kiss-and-run mediates endocytosis at synapses lacking synaptojanin and endophilin. | Biological sciences | Thomas L. Schwarz, Ian A. Meinertzhagen, Dion K. Dickman, Jane Anne Horne | |||
| Assembly of the SIR complex and its regulation by O-acetyl-ADP-ribose, a product of NAD-Dependent histone deacetylation. | Biological sciences | Thomas Walz, Danesh Moazed, Gunn-Guang Liou, Ryan G. Kruger, Jason C. Tanny | |||
| A structure-based model for the synthesis and hydrolysis of ATP by F(sub 1)-ATPase. | Biological sciences | Martin Karplus, Wei Yang, Yi Qin Gao | |||
| Asymmetric interactions of ATP with the AAA+ ClpX(sub 6) unfoldase: Allosteric control of a protein machine. | Biological sciences | Robert T. Sauer, Tania A. Baker, Daniel N. Bolon, Randall E. Burton, Greg L. Hersch | |||
| Asymmetric Rab11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous system. | Biological sciences | Juergen A. Knoblich, Gregory Emery, Andrea Hutterer, Daniela Berdnik, Bernd Mayer, Frederik Wirtz-Peitz, Marcos-Gonzalez Gaitan | |||
| A topological interaction between cohesion rings and a circular minichromosome. | Biological sciences | Kim Nasmyth, Dmitri Ivanov | |||
| ATP hydrolysis-dependent disassembly of the 26S proteasome is part of the catalytic cycle. | Biological sciences | Hediye Erdjument-Bromage, Paul Tempst, Andrew E. Deffenbaugh, Tione Buranda, Larry A. Sklar, Dorota Skowyra, Shalon E. Babbitt, Alexi Kiss, Yie-Hwa Chang, Eric Bailly, Jennifer Baumler, Edward Gogol | |||
| A transforming principle. | Biological sciences | Gerald R. Fink | |||
| A transient cell cycle shift in Drosophila imaginal disc cells precedes multipotency. | Biological sciences | Gerold Schubiger, Anne Sustar | |||
| A transient cell cycle shift in Drosophila imaginal disc cells precedes multipotency. | Biological sciences | Gerold Schubiger, Anne Sustar | |||
| A unique RNA fold in the RumA-RNA-cofactor ternary complex contributes to substrate selectivity and enzymatic function. | Biological sciences | Robert M. Stroud, Tom T. Lee, Sanjay Agarewalla | |||
| Autophagy regulates programmed cell death during the plant innate immune response. | Biological sciences | Beth Levine, Kirk Czymmek, Michael Schiff, Yule Liu, Zsolt Talloczy, S. P. Dinesh-Kumar | |||
| Auxin distribution and plant pattern formation: How many angels can dance on the point of PIN? | Biological sciences | Ottoline Leyser | |||
| A wakeup call for science faculty. | Biological sciences | Bruce Alberts | |||
| Axis formation- beta-catenin catches a Wnt. | Biological sciences | Jason R. Jessen, Lila Solnica-Krezel | |||
| Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. | Biological sciences | Michael D. Schneider, Beth Levine, Milton Packer, Noboru Mizushima, Sophie Pattingre, Amina Tassa, Xueping Qu, Rita Garuti, Xiao Huan Liang | |||
| Beta-Arrestin goes nuclear. | Biological sciences | Marc G. Caron, Jean-Martin Beaulieu | |||
| Big pharma's commedia.(pharmaceutical industry forecast) | Biological sciences | Fintan R. Steele | |||
| Bioscience in India: Times are changing. | Biological sciences | Inder M. Verma, Rajesh S. Gokhale, Jyotsna Dhawan | |||
| Birth of a prion: Spontaneous generation revisited. | Biological sciences | Charles Weissmann | |||
| Bmp signaling: Turning a half into a whole. | Biological sciences | David Kimelman, Ujwal J. Pyati | |||
| Both the establishment and the maintenance of neuronal polarity require active mechanisms: Critical roles of GSK-3beta and its upstream regulators. | Biological sciences | Yi Rao, Hui Jiang, Wei Guo, Xinhua Liang | |||
| "Bound" to work: The free hormone hypothesis revisited. | Biological sciences | John S. Adams | |||
| C2 can do it, too.(serine/threonine protein kinase Cdelta is a phosphotyrosine binding domain) | Biological sciences | H. Sondermann, J. Kuriyan | |||
| Calibrated measurement of gating-charge arginine displacement in the KvAP voltage-dependent K(super +) channel. | Biological sciences | Vanessa Ruta, Jiyayun Chen, Roderick Mackinnon | |||
| Calorie restriction - the SIR2 connection. | Biological sciences | Leonard Guarente, Frederic Picard | |||
| CaMKll structure-An elegant design. | Biological sciences | Tony Hunter, Howard Schulman | |||
| Can 1000 reviews be wrong? Actin, alpha-catenin, and adherens junctions. | Biological sciences | Mark Peifer, Julie Gates | |||
| Canadian stem cells scientists take the prize.(Lasker Award for Basic Medical Research in 2005) | Biological sciences | Saul J. Sharkis | |||
| Cdk 1-dependent regulation of the mitotic inhibitor Wee1. | Biological sciences | Steven P. Gygi, Wilhelm Haas, Stacy L. Harvey, Alyson Charlet, Douglas R. Kellogg | |||
| CDKs give Cdc6 a license to drive into S phase. | Biological sciences | Nagi G. Ayad | |||
| CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis. | Biological sciences | Niels Mailand, John F.X. Diffley | |||
| Cell-surface calreticulin initiates clearance of viable or apopotic cells through trans-activation of LRP on the phagocyte. | Biological sciences | Peter M. Henson, Shyra J. Gardai, William J. Janssen, Donna L. Bratton, marek Michalak, Kathleen A. McPhillips, S.Courtney Frasch, Anna Starefeldt, Joanne E. Murphy-Ullrich, Per-Arne Oldenborg | |||
| Cellular and molecular signatures of muscle regeneration: Current concepts and controversies in adult myogenesis. | Biological sciences | Amy J. Wagers, Irina M. Conboy | |||
| Centriolin anchoring of Exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission. | Biological sciences | Adam Gromley, Charles Yeaman, Jack Rosa, Sambra Redick, Chun-Ting Chen, Stephanie Mirabelle, Minakshi Guha, James Sillibourne, Stephen J. Doxsey | |||
| Chemical conditionality: A genetic strategy to probe organelle assembly. | Biological sciences | Natividad Ruiz, Thomas J. Silhavy, Daniel Kahne, Brian Falcone | |||
| Chemicals call bacteria, and a new membrane protein machine answers. | Biological sciences | Kevan M. Shokat | |||
| Chipping away at the embryonic stem cell network. | Biological sciences | Stuart H. Orkin | |||
| Chromosomal translocations in yeast induced by low levels of DNA polymerase: A model for chromosome fragile sites. | Biological sciences | Francene J. Lemoine, Natasha P. Degtyareva, Kirill Lobachev, Thomas Petes | |||
| Chromosome and replisome dynamics in E.coli: Loss of sister cohesion triggers global chromosome movement and mediates chromosome segregation. | Biological sciences | Nancy Kleckner, David Bates | |||
| Chromosome morphogenesis: Condensin-dependent cohesin removal during meiosis. | Biological sciences | Douglas Koshland, Hong-Guo Yu | |||
| Chromosome sites play dual roles to establish homologous synapsis during meiosis in C. elegans. | Biological sciences | Abby F. Dernburg, Anne M. Villeneuve, Amy J. MacQueen, Carolyn M. Phillips | |||
| Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the Forkhead protein FoxA1. | Biological sciences | Myles Brown, Pamela A. Silver, Wenlin Shao, Wei Li, Jason S. Carroll, Shirley X. Liu, Alexander S. Brodsky, Clifford A. Meyer, Anna J. Szary, Jerome Eeckhoute, Eli V. Hestermann, Timothy R. Geistlinger, Edward A. Fox | |||
| Cleavage of the plasma membrane Na+/Ca(super 2)+ exchanger in excitotoxicity. | Biological sciences | Nancy J. Rothwell, Kenneth W. Young, Daniele Bano, Christopher J. Guerin, Ros LeFeuvre, Naldini Luigi, Rosario RIzzuto, Ernesto Carafoli, Pierluigi Nicotera | |||
| Coexpressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane domains. | Biological sciences | Tony Hunter, Samuel L. Pfaff, Till Marquardt, Ryuichi Shirasaki, Sourav Ghosh, Shane E. Andrews, Nigel Carter | |||
| Cohesin and the maternal age effect. | Biological sciences | R. Scott Hawley, William D. Gilliland | |||
| Common molecular pathways mediate long-term potentiation so synaptic excitation and slow synaptic inhibition. | Biological sciences | Robert B. Darnell, Yuh Nung Jan, Cindy Shen Huang, Song-Hai Shi, Jernej Ule, Matteo Ruggiu, Laura A. Barker, Lily Yeh Jan | |||
| Complicated tails: Histone modifications and the DNA damage response. | Biological sciences | David P. Toczyski, Genevieve M. Vidanes, Carla Y. Bonilla | |||
| Connecting mitochondria and innate immunity. | Biological sciences | Tom Maniatis, Sarah M. McWhirter, Benjamin R. tenOever | |||
| Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. | Biological sciences | David P. Bartel, Christopher B. Burge, Benjamin P. Lewis | |||
| Contribution of the endoplasmic reticulum to peroxisome formation. | Biological sciences | Ineke Braakman, Dominic Hoepfner, Danny Schildknegt, Peter Philippsen, Henk F. Tabak | |||
| Control of cell proliferation and apoptosis by Mob as tumor suppressor, Mats. | Biological sciences | Ying Li, Zhi-Chun Lai, Xiaomu Wei, Takeshi Shimizu, Edward Ramos, Margaret Rohrbaugh, Nikolas Noklaidis, Li-Lun Ho | |||
| Control of transcription through intragenic patterns of nucleosome composition. | Biological sciences | Jason D. Lieb, Neil D. Clarke | |||
| Coordinated remodeling of cellular metabolism during iron deficiency through targeted mRNA degradation. | Biological sciences | Sergi Puig, Dennis J. Thiele, Eric Askeland | |||
| Core transcriptional regulatory circuitry in human embryonic stem cells. | Biological sciences | Matthew G. Guenther, Richard A. Young, Douglas A. Melton, David K. Gifford, Rudolf Jaenisch, Tong Ihn Lee, Laurie A. Boyer, Megan F. Cole, Sarah E. Johnstone, Saurt S. Levine, Roshan M. Kumar, Heather L. Murray, Richard G. Jenner | |||
| Cotranscriptional Set2 methylation of histone H3 kysine 36 recruits a repressive Rpd3 complex. | Biological sciences | Jonathan S. Weissman, Stephen Buratowski, Michael Grunstein, Timothy R. Hughes, Charles Boone, Nevan J. Krogan, Andrew Emili, Jack F. Greenblatt, Sean R. Collins, Siavash K. Kurdistani, Maya Schuldiner, Thanuja Punna, Michael-Christopher Keogh, Stephaine A. Morris, Kayu Chi, Seong R. Ahn, Vladimir Podolny, Natalie Thompson, Brain D. Strahl | |||
| Coupling between clathrin-coated-pit invagination, cortactrin recruitment, and membrane scission observed in live cells. | Biological sciences | Christien J. Merrifield, David Perrais, David Zenisek | |||
| Cre-ating somatic cell genetic mosaics in the mouse. | Biological sciences | Nathaniel Heintz, Todd E. Anthony | |||
| Cryptic pol II transcripts are degraded by a nuclear quality control pathway involving a new poly(A) polymerase. | Biological sciences | Domenico Libri, Bertrand Seraphin, Alain Jacquier, Francoise Wyers, Mathieu Rougemaille, Gwenael Badis, Jean-Claude Rousselle, Marie-Elisabeth Dufour, Jocelyne Boulay, Beatrice Regnault, Frederic Devaux, Abdelkader Namane | |||
| Crystal structure of mitochondrial respiratory membrane protein complex II. | Biological sciences | Fei Sun, Dan Su, Xia Huo, Mark Bartlam, Yujia Zhai, Zihe Rao, Aojin Wang, Jianxing Xu | |||
| Crystal structures of RNase H bound to an RNA/DNA hydrid: Substrate specificity and metal-dependent catalysis. | Biological sciences | Marcin Nowontny, Sergei A. Gaidamakov, Robert J. Crouch, Wei Yang | |||
| Crystal structures of the ribosome in complex with release factors RF1 and RF2 bound to a cognate stop codon. | Biological sciences | Ditlev E. Brodersen, Sabine Petry, Frank V. Murphy, Christine M. Dunham, Ann C. Kelley, Michael J. Tarry, Maria Selmer, V. Ramkrishnan | |||
| Decoding dopamine signaling. | Biological sciences | James A. Bibb | |||
| Deconstructing the cadherin-catenin-actin complex. | Biological sciences | William I. Weis, W. James Nelson, Soichiro Yamada, Sabine Pokutta, Frauke Drees | |||
| Degradation-mediated protein quality control in the nucleus. | Biological sciences | Richard G. Gardner, Zara W. Nelson, Daniel Gottschling | |||
| Developmental biology takes on a Latin American rhythm.(Latin American Society of Developmental Biology) | Biological sciences | Richard R. Behringer, Jose Xavier-Neto | |||
| Developmental commitment in a bacterium. | Biological sciences | Richard Losick, Jonathan Dworkin | |||
| Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes. | Biological sciences | Jamey D. Marth, Kazuaki Ohtsubo, Shinji Takamatsu, Mari T. Minowa, Aruto Yoshida, Makoto Takeuchi | |||
| Divergence of melanocortin pathways in the control of food intake and energy expenditure. | Biological sciences | Bradford B. Lowell, Olivier Boss, Joel K. Elmquist, Todd Williams, Nina Balthasar, Louise T. Dalgaard, Kathleen Mountjoy, Toshiro Kishi, Charlotte E. Lee, Jia Yu, Hisayuki Funahashi, Manuel Ferreira, Vinsee Tang, Robert A. McGovern, Christopher D. Kenny, Lauryn M. Christiansen, Elizabeth Edelstein, Carl Aschkenasi, Chen-yu Zhang | |||
| DNA repair, genome stability, and aging. | Biological sciences | Raul Mostoslavsky, Katrin F. Chua, Sonia Franco, David B. Lombard, Ferderick W. Alt, Monica Gostissa | |||
| Drosophila DPM neurons form a delayed and branch-specific memory trace after olfactory classical conditioning. | Biological sciences | Ronald L. Davis, Scott Waddell, Dinghui Yu, Alex C. Keene, Anjana Srivatsan | |||
| Drumming up dollars for stem cell research. | Biological sciences | R. John Davenport | |||
| Dynein anchores its mRNA cargo after apical transport in the Drosophila blastoderm Embryo. | Biological sciences | Ilan Davis, Renald Delanoue | |||
| Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila. | Biological sciences | R. Alan B. Ezekowitz, Jules A. Hoffmann, Christine Kocks, Ju hyun Cho, Nadine Nehme, Johanna Ulvila, Alan M. Pearson, Marie Meister, Charles Storm, Stephanie L. Conto, Charles Hetru, Jean-Marc Reichhart, Dominique Ferrandon, mika Ramet | |||
| Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. | Biological sciences | Rudolf Jaenisch, Konrad Hochedlinger, Caroline Beard, Yasuhiro Yamada | |||
| Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice. | Biological sciences | Gang Li, Min Han, Sheng Ding, Xiaohui Wu, Yuan Zhuang, Tian Xu | |||
| Electron transfer between cytochrome c and p66(super Shc) generates reactive oxygen species that trigger mitochondrial apoptosis. | Biological sciences | Saverio Minucci, Pier Giuseppe Pelicci, Marco Giorgio, Enrica Migliaccio, Francesca Orsini, Demis Paolucci, Maurizio Moroni, Cristina Contursi, Giovanni Pelliccia, Massimo Marcaccio, Lucilla Luzi, Paolo Pinton, Rosario Rizzuto, Paolo Bernardi, Francesco Paolucci | |||
| Endogenous siRNAs derived from a pair of natural cis-antisense transcripts regulate salt tolerance in arabidopsis. | Biological sciences | Omar Borsani, Jianhua Zhu, Paul E. Verslues, Ramanjulu Sunkar, Jian-Kang Zhu | |||
| Environmental enrichment reduces A-beta levels and amyloid deposition in transgenic mice. | Biological sciences | John Robinson, Robert M. Sapolsky, Virginia M. Y. Lee, Orly Lazarov, Ya-ping Tang, IIana S. Hariston, Zelka Korade-Mirnics, Louis B. Hersh, Karoly Mirnics, Sangram S. Sisodia | |||
| Equality of the sexes: Found in translation. | Biological sciences | Paul L. Fox, Partho Sarthi Ray | |||
| Escaping the nuclear confines: Signal-dependent pre-mRNA splicing in anucleate platelets. | Biological sciences | Melvin M. Denis, Neal D. Tolley, Michaeline Bunting, Hansjorg Schwertz, Stephan Lindemann, Huimiao Jiang, Christian C. Yost, Frederick J. Rubner, Kurt H. Albertine, Thomas M. McIntyre, Carolyn M. Fratto, Emilysa Tolley, Larry W. Kraiss, Guy A. Zimmerman, Kathryn J. Swoboda, Andrew S. Weyrich | |||
| Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. | Biological sciences | Jonathan S. Weissman, Charles Boone, Nevan J. Krogan, Jack F. Greenblatt, Sean R. Collins, Maya Schuldiner, Natalie J. Thompson, Valdimir Denic, Arunashree Bhamidipati, Thanuja Punna, Jan Ihmel, Brenda Andrew | |||
| Facilitated transport of a Dpp/Scw heterodimer by Sog/Tsg leads to robust patterning of the Drosophila blastoderm embryo. | Biological sciences | Michael O'Connor, Osamu Shimmi, David Umulis, Hans Othmer | |||
| Fanconi anemia (cross)linked to DNA repair. | Biological sciences | Laura J. Niedernhofer, Astrid S. Lalai, Jan H... J. Hoeijmakers | |||
| Feedback loops link odor and pheromone signaling with reproduction. | Biological sciences | Linda B. Buck, Zhihua Zou, Ulrich Boehm | |||
| Fibril conformation as the basis of species- and strain-dependent seeking specificity of mammalian prion amyloids. | Biological sciences | Eric M. Jones, Witold K. Surewicz | |||
| Finding the fittest fold: Using the evolutionary record to design new proteins. | Biological sciences | Lila M. Gierasch, Robet G. Smock | |||
| Folding and quality control of the VHL tumor suppressor proceed through distinct chaperone pathways. | Biological sciences | Judith Frydman, Amie J. McClellan, Melissa D. Scott | |||
| FOS-1 promotes basement-membrane removal during anchor-cell invasion in C.elegans. | Biological sciences | Paul W. Sternberg, James A. Butler, David R. Sherwood, James M. Kramer | |||
| From microbes to prions: The final proof of the prion hypothesis. | Biological sciences | P. Gambetti, W.-Q. Zou | |||
| Fruitless splicing specifies male courtship behavior in Drosophila. | Biological sciences | Barry J. Dickson, Ebru Demir | |||
| General translational repression by activators of mRNA decapping. | Biological sciences | Roy Parker, Jeff Coller | |||
| Gene regulation by histone H1: New links to DNA methylation. | Biological sciences | Peter B. Becker, Ralph A.W. Rupp | |||
| Genetic modulation of senescent phenotypes in Homo sapiens. | Biological sciences | George M. Martin | |||
| Genetics in the age of systems biology. | Biological sciences | Bassem A. Hassan, Peter Robin Hiesinger | |||
| Genome-wide dynamics of Htz1, a histone H2A variant that poises repressed/basal promoters for activation through histone loss. | Biological sciences | Bradley R. Cairns, Haiying Zhang, Douglas N. Robrts | |||
| Genome-wide map of nucleosome acetylation and methylation in yeast. | Biological sciences | Richard A. Young, Julia Zeitlinger, David K. Gifford, Stuart Levine, Nancy M. Hannett, Tong Ihn Lee, P. Alex Rolfe, Dmitry K. Pokholok, Christopher T. Harbinson, Fran Lewitter, Elizabeth Herbolsheimer, Megan Cole, Kimberly Walker, George W. Bell | |||
| Genomic maps and comparative analysis of histone modifications in human and mouse. | Biological sciences | Thomas R. Gingeras, Eric S. Lander, Stuart L. Schreiber, Michael Kamal, Kerstin Lindblad-Toh, Stefan Bekiranov, Bradley E. Bernstein, Dione K. Bailey, Scott McMahon, Dana J. Huebert, Elinor K. Karlsson, Edward J. Kulbokas III | |||
| Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. | Biological sciences | Michelangelo Cordenonsi, Sirio Dupont, Massimo Rugge, Luca Zacchigna, Sandra Soligo, Maddalena Adorno, Piccolo Stefano | |||
| Getting downstream without a Raft. | Biological sciences | Joseph Lin, Andrey S. Shaw | |||
| Glial control of synaptogenesis. | Biological sciences | Marc R. Freeman | |||
| Glial control of synaptogenesis. | Biological sciences | Marc R. Freeman | |||
| Going on a cancer gene hunt. | Biological sciences | Laura Bonetta | |||
| GPCR signaling is required for blood-brain barrier formation in Drosophila. | Biological sciences | Richard D. Fetter, Ulrike Heberlein, Roland J. Bainton, Ulrike Gaul, Tina Schwabe | |||
| G protein beta(sub gamma) subunits and AGS3 control spindle orientation and asymmetric cell fate of cerebral cortical progenitors. | Biological sciences | Kamon Sanada, Li-Huei Tsai | |||
| GroEL1: A dedicated chaperone involved in mycolic acid biosynthesis during biofilm formation in mycobacteria. | Biological sciences | Graham F. Hatfull, Anil Ojha, Mridula Anand, Apoorva Bhatt, Laurent Kremer, William R Jacobs Jr. | |||
| Gross chromosomal rearrangements and elevated recombination at an inducible site-specific replication fork barrier. | Biological sciences | Sarah Lambert, Antony M. Carr, Ben Martin, Adam Watson, Daniel M. Sheedy | |||
| Growth factor regulation of autophagy and cell survival in the absence of apoptosis. | Biological sciences | Tullia Lindsten, Craig B. Thompson, Daniel E. Bauer, Julian J. Lum, Mei Kong, Chi Li, Marian H. Harris | |||
| GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity. | Biological sciences | Takeshi Yoshimura, Kozo Kaibuchi, Yoji Kawano, Nariko Arimura, Akira Kikuchi, Saeko Kawabata | |||
| hDOT1L links histone methylation to leukemogenesis. | Biological sciences | Yi Zhang, Yuki Okada, Qin Feng, Yihui Lin, Yaqiang Li, Qi Jiang, Vernon M. Coffield, Lishan Su, Guoliang Xu | |||
| Heterochromatin silencing and locus repositioning linked to regulation of Virulence genes in Plasmodium falciparum. | Biological sciences | Alan F. Cowman, Brendan S. Crabb, Lucio H. Freitas-Junior, Michael F. Duffy, Manoj T. Duraisingh, JenniferK. Thompson, Till S. Voss, Allison J. Marty, Artur Scherf, Robert T. Good | |||
| Higher-order substrate recognition of elF2alpha by the RNA-dependent protein kinase PKR. | Biological sciences | Thomas E. Dever, Frank Sicheri, Arvin C. Dar | |||
| Him-8 binds to the X chromosome pairing center and mediates chromosome-specific meiotic synapsis. | Biological sciences | Abby F. Dernburg, Philip M. Meneely, Carolyn M. Phillips, Chihunt Wong, Needhi Bhalla, Peter Carlton M., Pinky Weiser | |||
| Histone H1 depletion in mammals alters global chromatin structure but causes specific changes in gene regulation. | Biological sciences | Arthur I. Skoultchi, Yuhong Fan, Tatiana Nikitina, Christopher L. Woodcock, Jie Zhao, Tomara J. Fleury, Eric E. Bouhassira, Riddhi Bhattacharyya | |||
| Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. | Biological sciences | Jerry L. Workman, Scott Anderson, Kenneth K. Lee, John Yates, Michael P. Washburn, Laurence Florens, Selene K. Swanson, Bing Li, Michael J. Carrozza, Wei-Jong Shia, Tamaki Suganuma | |||
| Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin. | Biological sciences | Hiten D. Madhani, Stuart L. Schreiber, Marc D. Meneghini, Ryan M. Raisner, Marie Z. Bao, Oliver J. Rando, Paul D. Hartley, Chih Long Liu | |||
| HnRNP K: An HDM2 target and transcriptional coactivator of p53 in response to DNA damage. | Biological sciences | Stephen P. Jackson, Abdeladim Moumen, Philip Masterson, Mark J. O'Connor | |||
| Homeobox galore: When reproduction goes RHOX and Roll. | Biological sciences | Paolo Sassone-Corsi, Kevin N. Hogeveen | |||
| Homeobox galore: When reproduction goes RHOX and Roll. | Biological sciences | Paolo Sassone-Corsi, Kevin N. Hogeveen | |||
| How do so few control so many? | Biological sciences | Kim Nasmyth | |||
| How the T cell receptor sees antigen - A structural view. | Biological sciences | K. Christopher Garcia, Erin J. Adams | |||
| How the T cell repertoire becomes peptide and MHC specific. | Biological sciences | Philippa Marrack, John W. Kappler, Clemencia Pinilla, Eric S. Huseby, Janice White, Frances Crawford, Tibor Vass, Dean Becker | |||
| Hox genes: The instructors working at motor pools. | Biological sciences | Samuel L. Pfaff, Mi-Ryoung Song | |||
| Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. | Biological sciences | Ramin Shiekhattar, Richard I. Gregory, Neil Cooch, Thimmaiah P. Chendrimada | |||
| Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.(sterol responsive element binding protein) | Biological sciences | Bruce M. Spiegelman, Peter Tontonoz, Christoph Handschin, Paul T. Tarr, Jiandie Lin, Ruojing Yang, Pei-Hsuan-Wu, Wenli Yang, Siming Li, Christopher B. Newguard, Marc Uldry, Liming Pei | |||
| Identification and characterization of MAVS, a mitochondria antiviral signaling protein that activates NF-(sub K)B and IRF3. | Biological sciences | Zhijian J. Chen, Rashu B. Seth, Lijun Sun, Chee-Kwee Ea | |||
| Identification of a multicomponent complex required for outer membrane biogenesis in Escherichia coli. | Biological sciences | Natividad Ruiz, Thomas J. Silhavy, Tao Wu, Juliana Malinverni, Seokhee Kim, Daniel Kahne | |||
| Identification of an intestinal heme transporter. | Biological sciences | Gregory J. Anderson, Majid Shayeghi, Robert C. Hider, David M. Frazer, Gladys O. Latunde-Dada, Fiona E. McCann, Jonathan S. Oakhill, Alice Warley, Christopher D. Vulpe, Abas H. Laftah, Yasmin Khan, Robert J. Simpson, Ken Takeuchi, Neil Halliday, Andrew T. McKie | |||
| Identification of Bronchioalveolar stem cells in normal lung and lung cancer. | Biological sciences | Tyler Jacks, Roderick T. Bronson, Denise Crowley, Carla F. Bender Kim, Erica L. Jackson, Amber E. Woolfenden, Imran Babar, Sinae Vogel, Sharon Lawrence | |||
| Identification of Flt(super 3+) lympho-myeloid stem cells lacking erythro-megakaryocytic potential: A revised road map for adult blood lineage commitment. | Biological sciences | Yutaka Sasaki, Jorgen Adolfsson, Robert Mansson, Natalija Buza-Vidas, Anne Hultquist, Karina Liuba, Christina T. Jensen, David Bryder, Lipang Yang, Ole-Johan Borge, Lina A.M. Thoren, Kristina Anderson, Ewa Sitnicka, Mikael Sigvardsson, Sten Erik W. Jacobsen | |||
| Identification of two proteins required for conjunction and regular segregation of achiasmate homologs in Drosophila male meiosis. | Biological sciences | Peggy Roth, Rainer Dorn, Sharon E. Thomas, Bruce D. McLee, Morvarid Soltani-Bejnood, John M. Logsdon Jr. | |||
| IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. | Biological sciences | Michael Karin, Shin Maeda, Hideaki Kamata, Jun-Li Luo, Hyam Leffert | |||
| Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability. | Biological sciences | James L. Manley, Xialu Li | |||
| Inhibition of bacterial RNA polymerase by streptolydigin: Stabilization of a straight-bridge-helix active-center conformation. | Biological sciences | Jayanta Mukhopadhyay, Sergei Borukhov, v, Steven Tuske, Xinyue Wang, Elena SIneva, Jens J. Birktoft, Arthur D. Clark Jr., Eddy Arnold, Olivier Leroy, Stefan G. Sarafianos, Sajida Ismail, Jookyung Lee, Brian Hudson, Chhaya Dharia, Oleg Laptenko, Andrew Napoli | |||
| Inhibition of RNA polymerase by streptolydigin: No cycling allowed. | Biological sciences | Robert Landick, Scotty Kyzer, Jinwei Zhang | |||
| Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-thomson syndrome. | Biological sciences | Ashok R. Venkitaraman, William G. Dunphy, Mahesh N. Sangrithi, Juan A. Bernal, Mark Madine, Anna Philpott, Joon Lee | |||
| Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. | Biological sciences | Ramin Shiekhattar, Ali Shilatifard, Neil Cooch, David Baillat, Mohamed-Ali Hakimi, Anders M. Naar | |||
| Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. | Biological sciences | Yayoi Toyooka, Janet Rossant, Hitoshi Niwa, Daisuke Shimosato, Dan Strumpf, Kadue Takahashi, Rika Yagi | |||
| Interaction with vesicle luminal protachykinin regulates surface expression of delta-opioid receptors and opioid analgesia. | Biological sciences | Tao Sun, Li-Hua Wang, Andreas Zimmer, Ji-Song Guanz, Zhen-Zhong Xu, Hua Gao, Shao-Qiu He, Guo-Qiang Ma, Lan Bao; Xu Zhang, Gang Pei, Ian Kitchen, Robert Elde, Cheng He, Zhen-Ning Zhang, Isabelle Lena | |||
| Intracellular protein and DNA dynamics in competent Bacillus subtilis cells. | Biological sciences | Peter L. Graumann, Dawit Kidane | |||
| In vitro analysis of Huntingtin-mediated transcriptional repression reveals multiple transcription factor targets. | Biological sciences | Robert Tjian, Dimitri Krainc, Weiguo Zhai, Hyunkyung Jeong, Libin Cui | |||
| In vitro generation of infectious scarpie prions. | Biological sciences | Claudio Soto, Joaquin Castilla, Paula Saa, Claudio Hetz | |||
| Involvement of MicroRNA in Au-rich element-mediated m-RNA instability. | Biological sciences | Qing Jing, Shuang Huang, Sabine Guth, Andrea Motoyama, Jianming Chen, Tyler Zarubin, Franco Di Padova, Sheng-Cai Lin, Hermann Gram, Jiahuai Han | |||
| JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. | Biological sciences | Dirk Bohmann, Mang C. Wang, Heinrich Jasper | |||
| Ku70, a component of DNA-dependent protein kinase, is a mammalian receptor for Rickettsia conorii. | Biological sciences | Pascale Cossart, Juan J. Martinez, Stephanie Seveau, Esteban Veiga, Shigemi Matsuyama | |||
| Life, death, and ubiquitin: Taming the mule. | Biological sciences | Moshe Oren, Ayelet Shmueli | |||
| Longevity and lineages: Toward the integrative biology of degenerative diseases in heart, muscle, and bone. | Biological sciences | Gerard Karsenty, Kenneth R. Chien | |||
| Loops in the central channel of ClpA chaperone mediate protein binding, unfolding, and translocation. | Biological sciences | George W. Farr, Arthur L. Horwich, Wayne A. Fenton, Jorg Hinnerwisch, Krystyna J. Furtak | |||
| Loss of ARNT/HIF1 beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. | Biological sciences | C. Ronald Kahn, Frank J. Gonzalez, Rohit N. Kulkarni, Philip J. O'Connell, Jenny E. Gunton, SunHee Yim, Terumasa Okada, Wayne J. Hawthorne, Yu-Hua Tseng, Russell S. Roberson, Camillo Rocordi | |||
| Machinations of a Maxwellian demon. | Biological sciences | Rui Sousa | |||
| Mammalian staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay. | Biological sciences | Yoon Ki Kim, Furic Luc, Luc DesGroseillers, Lynne E. Maquet | |||
| Maternal Wnt11 activates the canonical Wnt signaling pathway required for axis formation in Xenopus embryos. | Biological sciences | Janet Heasman, Chika Yokota, Qinghua Tao, Helbert Puck, Matt Kofron, Dong Yan, Xinhua Lin | |||
| MCM8 is a MCM2-7-related protein that functions as a DNA helicase during replication elongation and not initiation. | Biological sciences | Domenico Maiorano, Marcel Mechali, Etienne Danis, Olivier Cuvier | |||
| MCM8 is a MCM2-7-related protein that functions as a DNA helicase during replication elongation and not initiation. | Biological sciences | Domenico Maiorano, Marcel Mechali, Etienne Danis, Olivier Cuvier | |||
| MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. | Biological sciences | Manuel Stucki, Stephen P. Jackson, Michael B. Yaffe, Stephen J. Smerdon, Duaa Mohammad, Julie A. Clapperton | |||
| Mechanism of cross-species prion transmission: An infectious conformation compatible with two highly divergent yeast prion proteins. | Biological sciences | Jonathan S. Weissman, Koji Yonekura, Motomasa Tanaka, Peter Chein | |||
| Mechanism of force generation of a viral DNA packaging motor. | Biological sciences | Carlos Bustamante, Paul J. Jardine, Shelley Grimes, Dwight L. Anderson, Yann R. Chemla, K. Aathavan, Jens Michaelis | |||
| Mechanism of Lysine 48-linked ubiquitin-chain synthesis by the cullin-RING ubiquitin-ligase complex SCF-Cdc34. | Biological sciences | Raymond J. Deshaies, Matthew D. Petroski | |||
| Mechanism of nodal flow: A conserved symmetry breaking event in left-right axis determination. | Biological sciences | Yasushi Okada, Nobutaka Hirokawa, Yosuke Tanaka, Sen Takeda, Juan-Carlos Izpisua Belmonte | |||
| Mechanism of transcriptional silencing in yeast. | Biological sciences | Lingyi Chen, Jonathan Widom | |||
| Mechanistic link between PKR dimerization, autophosphorylation, and elF2alpha substrate recognition. | Biological sciences | Chune Cao, Thomas E. Dever, Frank Sicheri, Keiko Ozato, Arvin C. Dar, Madhusudan Dey, Tomohiko Tamura | |||
| Melanocyte stem cell maintenance and hair graying . | Biological sciences | Nancy A. Jenkins, Neal G. Copeland, Eirikur Steingrimsson | |||
| Membrane hemifusion: Crossing a chasm in two leaps. | Biological sciences | Leonid V. Chernomordik, Michael M. Kozlov | |||
| Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. | Biological sciences | William G. Dunphy, Leta K. Nutt, Seth S. Margolis, Mette Jensen, Catherine E. Herman, Jeffrey C. Rathmell, Sally Kornbluth | |||
| microRNA-directed phasing during trans-acting siRNA biogenesis in plants. | Biological sciences | James C. Carrington, Edwards Allen, Zhixin Xie, Adam M. Gustafson | |||
| Microtubule-induced pins/G(alpha)i cortical polarity in Drosophila neuroblasts. | Biological sciences | Chris Q. Doe, Sarah E. Siegrist | |||
| Mitochondrial presequence translocase: Switching between TOM tethering and motor recruitment involves Tim21 and Tim17.(translocase of the outer membrane) | Biological sciences | Bernard Guiard, Albert Sickmann, Helmut E. Meyer, Agnieszka Chacinska, Nikolaus Pfanner, Chris Meisinger, Maria Lind, Ann E. Frazier, Jan Dudek, Peter Rehling, Kaye N. Truscott, Andreas Geissler | |||
| Mitochondria, oxidants, and aging. | Biological sciences | Robert S. Balaban, Toren Finkel, Shino Nemoto | |||
| Mitotic-exit control as an evolved complex system. | Biological sciences | Rong Li, William J. Bosl | |||
| Mitotic remodeling of the replicon and chromosome structure. | Biological sciences | Marcel Mechali, Etienne Danis, Jean-Marc Lemaitre, Philippe Pasero, Yegor Vassetzky | |||
| Mnd2, an essential antagonist of the anaphase-promoting complex during meiotic prophase. | Biological sciences | Franz Klein, Alexandra M. Penkner, Susanne Prinz, Stefan Ferscha | |||
| Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B. | Biological sciences | Marino Zerial, Bianca Habermann, Sebastian Hoepfner, Fedor Severin, Alicia Cabezas, Anja Runge, David Gillooly, Harald Stenmark | |||
| Molecular basis for multiple sulfatase deficiency and mechanism for formylglycine generation of the human formylglycine-generating enzyme. | Biological sciences | Bernhard Schmidt, Thomas Dierks, Malaiyalam Mariappan, Kurt von Figura, Achim Dickmanns, Andrea Preusser-Kunze, Ralf Ficner, Markus Georg Rudolph | |||
| Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. | Biological sciences | Christopher K. Glass, Michael G. Rosenfeld, Michael David, Shankar Subramaniam, Sumito Ogawa, Jean Lozach, Chris Benner, Gabriel Pascual, Alexader Hoffmann, Rajendra K. Tangirala, Stefan Westin | |||
| Moody encodes two GPCRs that regulate cocaine behaviors and blood-brain barrier permeability. | Biological sciences | Ulrike Heberlein, Roland J. Bainton, Ulrike Gaul, Tina Schwabe, Linus T.Y. Tsai, Michael DeSalvo | |||
| Mosaic analysis with double makers in mice. | Biological sciences | Liqun Luo, Hui Zong, Sebastian J. Espinosa, Helen Hong Su, Mandar D. Mazumdar | |||
| MreB actin-mediated segregation of a specific region of a bacterial chromosome. | Biological sciences | Lucy Shapiro, Zemer Gitai, Natalie Anne Dye, Ann Reisenauer, Masaaki Wachi | |||
| MreB actin-mediated segregation of a specific region of a bacterial chromosome. | Biological sciences | Lucy Shapiro, Zemer Gitai, Natalie Anne Dye, Ann Reisenauer, Masaaki Wachi | |||
| mRNA helicase activity of the ribosome. | Biological sciences | Harry F. Noller, Seyedtaghi Takyar, Robyn P. Hickerson | |||
| mTOR and S6K1 mediate assembly of the translation initiation complex through dynamic protein interchange and ordered phosphorylation events. | Biological sciences | Steven P. Gygi, John Blenis, Marina K. Holz, Bryan A. Ballif | |||
| Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. | Biological sciences | Qing Zhong, Wenhua Gao, Fenghe Du, Xiadong Wang | |||
| Multiple mechanisms confining RNA polymerase II ubiquitylation to polymerases undergoing transcriptional arrest. | Biological sciences | Hediye Erdjument-Bromage, Paul Tempst, Baggavalli Somesh, James Reid, Wei-Feng Liu, T. Max M. Sogaard, Jesper Q. Svejstrup | |||
| Mutually exclusive splicing of the insect Dscam Pre-mRNA directed by competing intronic RNA secondary structures. | Biological sciences | Brenton R. Graveley | |||
| Mycobacterial biofilms: A greasy way to hold it together. | Biological sciences | Roberto Kolter, Maria Mercedes Zambrano | |||
| Nanotechnologists seek biological niches. | Biological sciences | Ivan Amato | |||
| Navigating the chaperone network: An integrative mediated by the Hsp90 chaperone. | Biological sciences | Gerard Cagney, Jack Greenblatt, Charles Boone, Andrew Emili, Rongmin Zhao, Ya-Chieh Hsu, Mike Davey, Pia Kaplanek, Amy Tong, Nevan Krogan, Walid A. Houry | |||
| Neural circuitry that governs Drosophila male courtship behavior. | Biological sciences | Barry J. Dickson, Petra Stockinger, Duda Kvitsiani, Shay Rotkopf, Laszlo Tirian | |||
| Nicastrin functions as gamma-secretase-substrate receptor. | Biological sciences | Gang Yu, Sanjiv Shah, Sheu-Fen Lee, Katsuhiko Tabuchi, Yi-Heng Hao, Cong Yu, Haydn Ball, Quincey LaPlant, Charles E. Dann III, Thomas Sudhof | |||
| Nicastrin: Gatekeeper of the gamma-secretase complex. | Biological sciences | Bart De Strooper | |||
| NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry. | Biological sciences | Florian Bassermann, Christine von Klitzing, Silvia Munch, Ren-Yuan Bai, Christian Peschel, Justus Duyster | |||
| No rest for REST: REST/NRSF regulation of neurogenesis. | Biological sciences | Michael G. Rosenfeld, Victoria V. Lunyak | |||
| Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells.(microtubule-organizing center) | Biological sciences | Edgar Gomes R., Shantanu Jani, Gregg G. Gundersen | |||
| Nuclear reprogramming by human embryonic stem cells. | Biological sciences | M. Azim Surani | |||
| Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha. | Biological sciences | Bruce M. Spiegelman, James Rhee, Christoph Handschin, Jiandie Lin, Sherry Chin, Pei-Hsuan Wu, Urs A. Meyer, Anne-Kathrin Peyer | |||
| Olfactory inputs to hypothalamic neurons controlling reproduction and fertility. | Biological sciences | Catherine Dulac, Hayan Yoon, L.W. Enquist | |||
| On regenerating the ovary and generating controversy. | Biological sciences | Roger G. Gosden, Richard Anderson, Anne McLaren, Gerald Schatten, Evelyn E. Telfer, Anne Grete Byskov, Norah Spears, David Albertini, Claus Yding Andersen, Hugh Clarke, Ruth Braw-Tal, Alain Gougeon, Kenneth McNatty, Sherman Silber, Alex Tsafiri, Eileen McLaughlin | |||
| Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood. | Biological sciences | Jonathan L. Tilly, David T. Scadden, John Iacomini, Gregor B. Adams, Joshua Johnson, Jessamyn Bagley, Malgorzata Skaznik-Wikiel, Ho-Joon Lee, Yuichi Niikura, Katherine S. Tschudy, Jacqueline Canning Tilly, Maria L. Cortes, Randolf Forkert, Thomas Spitzer | |||
| Osteoblasts clock in for their day job. | Biological sciences | Benoit de Crombrugghe | |||
| P53 and prognosis: New insights and further complexity. | Biological sciences | Karen H. Vousden, Carol Prives | |||
| PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells. | Biological sciences | Adrienne Boire, Lidija Covic, Anika Agarwal, Suzanne Jacques, Sheida Sherifi, Athan Kuliopulos | |||
| PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells. | Biological sciences | Adrienne Boire, Lidija Covic, Anika Agarwal, Suzanne Jacques, Sheida Sherifi, Athan Kuliopulos | |||
| Par-4 links dopamine signaling and depression. | Biological sciences | El Bachir Affar, Margaret Po-Shan Luke, Li-Huei Tsai, Sang Ki Park, Minh Dang Nguyen, Andre Fischer, Paul Brian Dieffenbach, Huang-Chun Tseng, Yang Shi | |||
| Passenger-strand cleavage facilitates assembly of siRNA into Ago2-cointaning RNAi enzyme complexes. | Biological sciences | David P. Bartel, Yukihide Tomari, Christian Matranga, Chanseok Shin, Philip D. Zamore | |||
| Perp is a p63-regulated gene essential for epithelial integrity. | Biological sciences | Laura D. Attardi, Roderick T. Bronson, Alea A. Mills, Rebecca A. Ihrie, Michelle R. Marques, Bicchau T. Nguyen, Jennifer S. Horner, Cristian Papazoglu | |||
| PGC-1alpha: Looking behind the sweet treat for porphyria. | Biological sciences | Dangsheng Li | |||
| Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. | Biological sciences | Steven Reiken, Andrew R. Marks, Stephan E. Lehnart, Xander H.T. Wehrens, Sunita Warrier, Andriy E. Belevych, Robert D. Harvey, Wito Richter, Catherine S.L. Jin, Marco Conti | |||
| Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis. | Biological sciences | Pier Paolo Pandolfi, Hediye Erdjument-Bromage, Paul Tempst, Li Ma, Zhenbang Chen | |||
| Phylogenetic shadowing and computational identification of human microRNA genes. | Biological sciences | Ronald H.A. Plasterk, Eugene Berezikow, Edwin Cuppen, Victor Guryev, Jose van de Belt, Erno Wienholds | |||
| Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. | Biological sciences | C. David Allis, Brian T. Chait, Robert G. Roeder, Thomas A. Milne, Joanna Wysocka, Yali Dou, Alan J. Tackett, Edwin R. Smith, Jay L. Hess | |||
| Phytochrome-specific type 5 phosphatase controls light signal flux by enhancing phytochrome stability and affinity for a signal transducer. | Biological sciences | Tim Kunkel, Eberhard Schafer, Jose M. Alonso, Pill-Soon Song, Jong Sang Ryu, Jeong-II Kim, Dae Shik Cho, Byung Chul Kim, Sung Hyun Hong, Aurora Pinas Fernandez, Seong-Hee Kim, Yumi Kim, Joseph R. Ecke, Ferenc Nagy, Hong Gil Nam, Pyung Ok Lim | |||
| Phytochrome-specific type 5 phosphatase controls light signal flux by enhancing phytochrome stability and affinity for a signal transducer. | Biological sciences | Tim Kunkel, Eberhard Schafer, Jose M. Alonso, Pill-Soon Song, Jong Sang Ryu, Jeong-II Kim, Dae Shik Cho, Byung Chul Kim, Sung Hyun Hong, Aurora Pinas Fernandez, Seong-Hee Kim, Yumi Kim, Joseph R. Ecke, Hong Gil Nam, Pyung Ok Lim, Ference Nagy | |||
| Phy tunes: Phosphorylation status and phytochrome-mediated signaling. | Biological sciences | Vicente Rubio, Xing Wang Deng | |||
| Phy tunes: Phosphorylation status and phytochrome-mediated signaling. | Biological sciences | Vicente Rubio, Xing Wang Deng | |||
| PIDD: A switch hitter. | Biological sciences | Shigeki Miyamoto, Zhao-Hui Wu, Angela Mabb | |||
| PIDD mediates NF-kappaB activation in response to DNA damage. | Biological sciences | Jurg Tschopp, Sophie Janssens, Antoine Tinel, Saskia Lippens | |||
| PKR and elF2alpha: Integration of kinase dimerization, activation and substrate docking. | Biological sciences | Susan S. Taylor, Gourisankar Ghosh, Nina M. Haste | |||
| Plant nuclear RNA polymerase IV mediates siRNA and DNA methylation-dependent heterochromatin formation. | Biological sciences | Yasunuki Onodera, Jeremy R. Haag, Thomas Ream, Pedro Costa Nunes, Olga Pontes, Craig S. Pikaard | |||
| Plasmodium's sticky fingers. | Biological sciences | Andrew P. Waters | |||
| Playing ping pong with pins: Cortical and microtubule-induced polarity. | Biological sciences | Julie Ahringer | |||
| Polycomb group protein Ezh2 controls actin polymerization and cell signaling. | Biological sciences | Alexander Tarakhovsky, Danny Reinberg, I-hsin Su, Marc-Werner Dobenecker, Ephraim Dickinson, Matthew Oser, Ashwin Basavraj, Raphael Marqueron, Agnes Viale, Christoph Wulfing | |||
| Powered by gas-A ligand for a fruit fly nuclear receptor. | Biological sciences | Carl S. Thummel | |||
| Proapoptotic BID is an ATM effector in the DNA-damage response. | Biological sciences | Atan Gross, Iris Kamer, Rachel Sarig, Yehudit Zaltsman, Hagit Niv, Yaniv Lerenthal, Galia Oberkovltz, Limor Regev, Gal Haimovich, Richard C. Marcellus | |||
| Proteome analysis of separated male and female gametocytes reveals novel sex-specific plasmodium biology. | Biological sciences | Matthias Mann, Chris J. Janse, Andrew P. Waters, Blandine Franke-Fayard, Shahid M. Khan, Gunnar R. Mair, Edwin Lasonder | |||
| Proteome-wide analysis of chaperonin-dependent protein folding in Escherichia coli. | Biological sciences | Matthias Mann, F. Ulrich Hartl, Michael J. Kerner, Dean J. Naylor, Manajit Hayer-Hartl, Costa Georgopoulos, Hung-Chun Chang, Yasushi Ishihama, Tobias Maier, Anna P. Stines, Dmitrij Frishman | |||
| Pursuing cardiac progenitors: Regeneration redux. | Biological sciences | Jonathan A. Epstein, Michael S. Parmacek | |||
| Pursuing cardiac progenitors: Regeneration redux. | Biological sciences | Jonathan A. Epstein, Michael S. Parmacek | |||
| Pushing back the expansion of introns in animal genomes. | Biological sciences | Sudhir Kumar, Blair S. Hedges | |||
| Quantitative and dynamic assessment of the contribution of the ER to phagosome formation. | Biological sciences | Ira Mellman, Sergio Trombetta, James Shaw, Peter J. Peters, Marc Pypaert, Nicolas Touret, Paul Paroutis, Mauricio Terebiznik, Rene E. Harrison, Amy Chow, Aimin Jiang, Christopher Yip, Hsiao-Ping Moore, Nicole van der Wel, Diane Houben, Chantal de Chastellier, Sergio Grinstein | |||
| Rab conversion as a mechanism of progression from early to late endosomes. | Biological sciences | Marino Zerial, Jochen Rink, Eric Ghigo, Yannis Kalaidzidis | |||
| RAS is regulated by the let-7 MicroRNA family. | Biological sciences | Frank J. Slack, Helge Grosshans, Steven M. Johnson, Rolf Myller, Jaclyn Shingara, Mike Byrom, Rich Jarvis, Angie Cheng, Emmanuel Labourier, Kristy L. Reinert | |||
| Reactive oxygen species promote TNF alpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. | Biological sciences | Michael Karin, Lufen Chang, Hideaki Kamata, Shi-chi Honda, Shin Maeda, Hirata Hajime | |||
| Real-time kinetics of gene activity in individual bacteria. | Biological sciences | Johan Paulsson, Edward C. Cox, Ido Golding, Scott M. Zawilski | |||
| Recognition of antimicrobial peptides by a bacterial sensor kinase. | Biological sciences | Samuel I. Miller, Martin W. Bader, Sarah Sanowar, Margaret E. Daley, Anna R. Schneider, Uhnsoo Cho, Rachel E. Klevit, Wenqing Xu, Herve Le Moual | |||
| Reconstitution of 5'-directed human mismatch repair in a purified system. | Biological sciences | Alan E. Tomkinson, Yanbin Zhang, Fenghua Yuan, Steven R. Presnell, Guo-Min Li, Keli Tian, Liya Gu, Yin Gao | |||
| Redoxing calcium from the ER. | Biological sciences | H. Llewelyn Roderick, Martin D. Bootman | |||
| Redox Redux: Revisiting PTPs and the control of cell signaling.(protein tyrosine phosphatase ) | Biological sciences | Nicholas K. Tonks | |||
| Regeneration and transdetermination: New tricks from old cells. | Biological sciences | Laura A. Johnston | |||
| Regeneration and transdetermination: New tricks from old cells. | Biological sciences | Laura A. Johnston | |||
| Regulating gene expression through RNA nuclear retention. | Biological sciences | David L. Spector, Kannanganattu V. Prasanth, Supriya G. Prasanth, Zhenyu Xuan, Stephen Hearn, Susan M. Freier, Frank C. Bennet, Michael Q. Zhang | |||
| Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. | Biological sciences | Amy E. Pasquinelli, Shveta Bagga, John Bracht, Shaun Hunter, Katlin Massirer, Janette Holtz, Rachel Eachus | |||
| Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development. | Biological sciences | Benjamin Abrams, Andrew D. Chisholm, Nakata Katsunori, Xun Huang, Brock Grill, Alexandar Goncharov, Yishi Jin | |||
| Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development. | Biological sciences | Benjamin Abrams, Andrew D. Chisholm, Nakata Katsunori, Xun Huang, Brock Grill, Yishi Jin, Alexandr Goncharov | |||
| Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field. | Biological sciences | E.M. De Robertis, Bruno Reversade | |||
| Regulation of cell proliferation by a morphogen gradient. | Biological sciences | Kenneth D. Irvine, Dragana Rogulja | |||
| Regulation of nuclear proteasome by Rhp6/Ubc2 through ubiquitination and destruction of the sensor and anchor Cut8. | Biological sciences | Mitsuhiro Yanagida, Kojiro Takeda | |||
| Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. | Biological sciences | Michael B. Kastan, Masatoshi Takagi, Michael J. Absalon, Kevin G. McLure | |||
| Remote control of behavior through genetically targeted photostimulation of Neurons. | Biological sciences | Susana Q. Lima, Gero Miesenbock | |||
| REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. | Biological sciences | Gail Mandel, Nurit Ballas, Christopher Grunseich, Diane D. Lu, Joan C. Speh | |||
| Retrospective birth dating of cells in humans. | Biological sciences | Kirsty L. Spalding, Ratan D. Bhardwaj, Bruce A. Buchholz, Henrik Druid, Josan Frisen | |||
| Revealing the molecular determinants of gender in malaria parasites. | Biological sciences | Alan F. Cowman, Brendan S. Crabb | |||
| Reviving the exosome. | Biological sciences | Torben Heick Jensen, Claire Moore | |||
| Rhox: A new homeobox gene cluster. | Biological sciences | Miles F. Wilkinson, James A. MacLean II, Mingang A. Chen, Chad M. Wayne, Carol Macleod, Shirley R. Bruce, Manjeet Rao, Marvin L. Meistrich | |||
| Rhox: A new homeobox gene cluster. | Biological sciences | Miles F. Wilkinson, James A. MacLean II, Mingang A. Chen, Chad M. Wayne, Carol Macleod, Shirley R. Bruce, Manjeet Rao, Marvin L. Meistrich | |||
| Right place, right time, and only once: Replication intitiation in metazoans. | Biological sciences | Anindya Dutta, Joyce L. Hamlin, Yuichi J. Machida | |||
| RNA degradation by the exosome is promoted but a nuclear polyadenylation complex. | Biological sciences | Elizabeth Thompson, David Tollervey, Elisabeth Petfalski, Alain Jacquier, John LaCava, Jonathan Houseley, Cosmin Saveanu | |||
| RNA interference libraries prove their worth in hunt for Tumor suppressor genes. | Biological sciences | Julian Downward | |||
| RNAi: RISC gets loaded. | Biological sciences | Erik J. Sontheimer, Jonathan B. Preall | |||
| RNAi: The nuts and bolts of the RISC machine. | Biological sciences | Witold Filipowicz | |||
| Role of endocytosis in cellular uptake of sex steroids. | Biological sciences | Annette Hammes, Anders Nykjaer, Thomas E. Willnow, Thomas K. Andreassen, Peter B. Luppa, Robert Spoelgen, Florian J. Schweigert, Jens Raila, Jochen Metzger, Norbert Hubner, Herbert Schulz | |||
| Ro's role in RNA reconnaissance. | Biological sciences | Jennifer A. Doudna, Ian J. MacRae | |||
| Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium. | Biological sciences | Gabriel H. Travis, Hui Sun, Minghao Jin, Songhua Li, Walid N. Moghrabi | |||
| Salmonella's sensor for host defense molecules. | Biological sciences | Robert E.W. Hancock, Joseph B. McPhee | |||
| San1, checking up on nuclear proteins. | Biological sciences | Thomas Sommer, Christian Hirsch | |||
| Sar1p N-terminal helix initiates membrane curvature and completes the fission of a COPII vesicle. | Biological sciences | Mariella Ravazzola, Randy Schekman, Marcus C.S. Lee, Susan Hamamoto, lelio Orci, Eugene Futai | |||
| Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis. | Biological sciences | Robert D. Cardiff, Reginald Hill, Yurong Song, Terry Van Dyke | |||
| Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors. | Biological sciences | Judith Campisi | |||
| Sex and death: What is the connection? | Biological sciences | Linda Partridge, Dominic J. Withers, David Gems | |||
| Sex and the single splice. | Biological sciences | Catherine Dulac | |||
| Shisa promotes head formation through the inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF. | Biological sciences | Akihito Yamamoto, Takashi Nagano, Shoko Takehara, Masahiko Hibi, Shinichi Aizawa | |||
| Short telomeres, even in the presence of telomerase, limit tissue renewal capacity. | Biological sciences | Carol W. Greider, David M. Feldser, Margaret A. Strong, Ling-Yang Hao, Mary Armanios, Baktiar Karim, David Huso | |||
| Silence from within: Endogenous siRNAs and miRNAs. | Biological sciences | Erik J. Sontheimer, Richard W. Carthew | |||
| Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells. | Biological sciences | Ronald D. Vale, Adam D. Douglass | |||
| Sinistral snails and gentlemen scientists. | Biological sciences | J.B. Gurdon | |||
| Sir2 blocks extreme life-span extension. | Biological sciences | Min Wei, Paola Fabrizio, Ksisten McGrew, Cristina Gattazzo, Valter D. Longo, Luisa Battistella, Chao Cheng | |||
| SLAM family receptors distinguish hematopoie. | Biological sciences | Sean J. Morrison, Cox Terhorst, Toshihide Iwashita, Mark J. Kiel, Omer H. Yilmaz, Osman H. Yilmaz | |||
| Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. | Biological sciences | Gerard P. Zambetti, Jerry M. Adams, Wen-Shu Wu, Stefan Heinrichs, Thomas A. Look, Dong Xu, Sean P. Garrison | |||
| Slugging it out: Fine tuning the p53-PUMA death connection. | Biological sciences | Scott W. Lowe, Jack T. Zilfou, Mona S. Spector | |||
| Snaring the function of alpha-synuclein. | Biological sciences | Nancy M. Bonini, Benoit I. Giasson | |||
| Solving mysteries of DNA replication and frog cloning. | Biological sciences | Ron Laskey | |||
| Specific ablation of the apoptotic functions of cytochrome c reveals a differential requirement for cytochrome c and Apaf-1 in apoptosis. | Biological sciences | Andrew Wakeham, Gordon S. Duncan, Andrew Elia, Pamela Ohashi, Zhenyue Hao, Chia-Che Chang, Min Fang, Hitoshi Okada, YingJu Jang, Thomas Calzascia, Annick You-Ten, Wen-Chen Yeh, Wang Xiaodong, Tak W. Mak | |||
| Spiroplasma swim by a processive change in body helicity. | Biological sciences | Joshua W. Shaevitz, Joanna Y. Lee, Daniel A. Fletcher | |||
| Splicing misplaced. | Biological sciences | Tom Misteli, Eran Meshorer | |||
| SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast.(Sterol Regulatory Element-Binding Proteins) | Biological sciences | Peter J. Espenshade, Adam L. Hughes, Bridget L. Todd | |||
| Stathmin, a gene enriched in the amygdala, controls both learned and innate fear. | Biological sciences | Eric R. Kandel, Gael Malleret, Svetlana Vronskaya, Gleb P. Shumyatsky, Evgeny Tsvetkov, Ulrich K. Schubart, Stanislav Zakharenko, Ryong-Moon Shin, Jamie Joseph, Vadim Y. Bolshakov, Shuichi Takizawa, Keith Tully, DeQi Yin | |||
| Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche. | Biological sciences | Terence A. Partridge, Charlotte A. Collins, Irwin Olsen, Peter S. Zammit, Louise Heslop, Aviva Petrie, Jennifer E. Morgan | |||
| Stem cell grand SLAM. | Biological sciences | Amy J. Wagers | |||
| Stem cell research goes underground: The RETINOBLASTOMA-RELATED gene in root development. | Biological sciences | Philip N. Benfey, Jose R. Dinneny | |||
| Stem cells: A plant biology perspective. | Biological sciences | Ben Scheres | |||
| Stem cells are units of natural selection in a colonial ascidian. | Biological sciences | Irving L. Weissman, Diana J. Laird, Anthony W. De Tomaso | |||
| Stem cells for lung cancer? | Biological sciences | Anton Berns | |||
| Sterile 20 kinase phosphorylates histone H2B at serine 10 during hydrogen peroxide-induced apoptosis in S. cerevisiae. | Biological sciences | C. David Allis, M. Mitchell Smith, Wang L. Cheung, Sung-hee Ahn, Jer-Yuan Hsu, Robert L. Diaz | |||
| Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity. | Biological sciences | John C. Burnett, Leor S. Weinberger, Jared E. Toettcher, Adam P. Arkin, David V. Schaffer | |||
| Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. | Biological sciences | Robert A. Weinberg, Dennis C. Sgroi, Akira Orimo, Piyush B. Gupta, Fernando Arenzana-Seisdedos, Thierry Delaunay, Rizwan Naeem, Vincet J. Carey, Andrea L. Richardson | |||
| Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors Sf-1 and LRH-1. | Biological sciences | Elena P. Sablin, Robert J. Fletterick, Timothy M. Willson, Joseph W. Thornton, Irina N. Krylova, Jamie Moore, Robert X. Xu, Gregory M. Waitt, J. Andrew Mackay, Dalia Juzumiene, Lioudmila Lebedeva, Valerie Montana, Kevin Madauss, Jane M. Bynum, Miyuki Suzawa, Holly A. Ingraham, Rodney K. Guy, Shawn P. Williams, Jon D. Williams | |||
| Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors Sf-1 and LRH-1. | Biological sciences | Elena P. Sablin, Irina N. Krylova, Jamie Moore, Gregory M. Waitt, J. Andrew Mackay, Dalia Juzumiene, Lioudmila Lebedeva, Jane M. Bynum, Miyuki Suzawa, Holly A. Ingraham, Rodney K. Guy, Shawn P. Williams, Jon D. Williams, Robert X. Xu, Kevin Madauss, Valerie Montana, Timothy M. Willson, Joseph W. Thornton, Robert J. Fletterick | |||
| Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparum. | Biological sciences | Niraj H. Tolia, Eric J. Enemark, B. Kim Lee Sim, Leemor Joshua-Tor | |||
| Structural basis for the function of the ribosomal L7/12 stalk in factor binding and GTPase activation. | Biological sciences | Holger Stark, Marina V. Rodnina, Mihaela Diaconu, Alexander G. Tonevitsky, Ute Kothe, Frank Schlunzen, Niels Fischer, Markus Wahl C., Jorg M. Harms | |||
| Structural basis of pore formation by the bacterial toxin pneumolysin. | Biological sciences | Helen R. Saibil, Peter W. Andrew, Sarah J. Tilley, Elena V. Oriova, Robert J.C. Gilbert | |||
| Structural insights into RNA quality control: The Ro autoantigen binds misfolded RNAs via its central cavity. | Biological sciences | Karin M. Reinisch, Sandra L. Wolin, Adam J. Stein, Gabriele Fuchs, Chunmei Fu | |||
| Structure of the autoinhibited kinase domain of CaMKll and SAXS analysis of the holoenzyme. | Biological sciences | Angus C. Nairn, Oren S. Rosenberg, Sebastian Deindl, Rou-Jia Sung | |||
| Structure of the Rb C-terminal domain bound to E2F1-DP1: A mechanism for phosphorylation-induced E2F release. | Biological sciences | Nikola P. Pavletich, Seth M. Rubin, Ning Zheng, Anne-Laure Gall | |||
| Structures of MLS(sub B)K antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance. | Biological sciences | Thomas A. Steitz, Peter B. Moore, Daqi Tu, Gregor Blaha | |||
| Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44. | Biological sciences | Takayuki Michikawa, Takayasu Higo, Mitsuharu Hattori, Takeshi Nakamura, Tohru Natsume | |||
| Sumoylation silences the Plasma membrane leak K(super +) channel K2P1. | Biological sciences | Steve A.N. Goldstein, Margaret H. Butler, Sindhu Rajan, Leigh D. Plant, Michael L. Rabin | |||
| Systems biology, integrative biology, predictive biology. | Biological sciences | Edison T. Liu | |||
| Systems biology: Its practice and challenges. | Biological sciences | Alan Aderem | |||
| Systems-level dissection of the cell-cycle oscillator: Bypassing positive feedback produces damped oscillations. | Biological sciences | James E. Ferrell Jr., Sun Young Kim, Joseph R. Pomerening | |||
| Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites. | Biological sciences | Artur Scherf, Luico H. Freitas-Junior, Ana Paola Rojas-Meza, Rosaura Hernandez-Rivas, Liliana Mancio-Silva, Stuart A. Ralph, Ricardo J. Leal-Silverstre, Dvorak Montiel-Condado, Alisson Marques Gontijo, Omar K. Ruvalcaba-Salazar, Spencer Shorte | |||
| Temporal regulation of planar cell polarity: Insights from the Drosophila Eye. | Biological sciences | Francois Schweisguth | |||
| Termination factor-mediated DNA loop between termination and initiation sites drives mithocondrial rRNA synthesis. | Biological sciences | Giuseppe Attardi, Miguel Martin, Jaehyoung Cho, Anthony J. Cesare, Jack D. Griffith | |||
| The apical determinants aPKC and dPatj regulate frizzled-dependent planar cell polarity in the Drosophila eye.(Associated Tight Junction Protein) | Biological sciences | Marek Mlodzik, Alexandre Djiane, Shaul Yogev | |||
| The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/senseless proteins. | Biological sciences | Harry T. Orr, Huda Y. Zoghbi, Hugo J. Bellen, Juan Botas, Hamed Jafar-Nejad, Hirashi Tsuda, Patel Akash J., Yaling Sun, Hung-Kai Chen, Matthew F. Rose, Koen J.T. Venken | |||
| The battlefield of pluripotency. | Biological sciences | Austin Smith | |||
| The biological and chemical basis for tissue-selective amyloid disease. | Biological sciences | William E. Balch, Jeffery W. Kelly, Yoshiki Sekijima, Anu R. Sawkar, Luke R. Wiseman, Jeanne Matteson, Per Hammarstrom, Sean R. Miller | |||
| The birnavirus crystal structure reveals structural relationships among icosahedral viruses. | Biological sciences | Jorge Navaza, Fasseli Coulibaly, Christophe Chevalier, Irina Gutsche, Joan Pous, Rey A. Felix, Bernard Delmas, Stephane Bressanelli | |||
| The blood-brain- barrier: Lessons from moody flies. | Biological sciences | Ben A. Barres, Richard Daneman | |||
| The C2 domain of PKCdelta is a phosphotyrosine binding domain. | Biological sciences | Lewis C. Cantley, Andrew E.H. Elia, Ning Wu, Cyril H. Benes, Tejal Dharia, Stephen P. Soltoff | |||
| The complex cartography of stem cell commitment. | Biological sciences | K. Akashi, D. Traver, L.I. Zon | |||
| The cyro-EM structure of a translation initiation complex from Escherichia coli. | Biological sciences | Joachim Frank, Mans Ehrenberg, Andrey Zavialov, Gregory S. Allen, Richard Gursky | |||
| The Drosophila nuclear receptor E75 contains heme and is gas responsive. | Biological sciences | Keith Pardee, Jeff Reinking, Mandy M.S. Lam, Heidi M. Sampson, Suya Liu, Wendy White, Ping YanG, Gilles Lajoie, Shawn Williams, Aled Edwards, Henery M. Krause | |||
| The ecdysone-induced DHR4 orphan nuclear receptor coordinates growth and maturation in Drosophila. | Biological sciences | Carl S. Thummel, Kirst King-Jones, Jean-Philippe Charles, Geanette Lam | |||
| The enigmatic role of Sir2 in aging. | Biological sciences | Matt Kaeberlein, Brian K. Kennedy, Erica D. Smith | |||
| The European Research Council on the brink. | Biological sciences | Kai Simons, Carol Featherstone | |||
| The F box protein Dsg1/Mdm30 is a transcriptional coactivator that stimulates Gal4 turnover and cotranscriptional mRNA processing . | Biological sciences | Kevan M. Shokat, William P. Tansey, Masafumi Muratani, Charles Kung | |||
| The FK506 protein Fp3 counteracts protein phosphatase 1 to maintain meiotic recombination checkpoint activity. | Biological sciences | Wai-Hong Tham, Angelika Amon, Andreas Hochwagen, Gloria A. Brar | |||
| The future of aging therapies. | Biological sciences | Edward G. Lakatta, Huber R. Warner, Evan C. Hadley, Marcelle Morrison-Bogorad, Richard J. Hodes | |||
| The genesis of a pandemic influenza virus. | Biological sciences | Robert G. Webster, Charles J. Russell | |||
| The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors. | Biological sciences | Stephen Cohen, Aurelio A. Teleman, Claude Desplan, Mathias F. Wernet, Ya-Wen Chen, Tamara Mikeladze-Dvali, Daniela Pistillo, Esteben O. Mazzoni | |||
| The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR. | Biological sciences | Jin Wook Kang, Bum-Joon Park, Sang Won Lee, Young Kee Shin, Yun Hee Choi, Sunghoon Kim, Kwang Soo Lee, Dongho Choi, Young Ha Ahn, So-Jung Choi | |||
| The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP. | Biological sciences | Jianbin Huang, Shian Wu, Jose Barrera, Krista Matthews, Duojia Pan | |||
| The Homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient. | Biological sciences | Charles Antzelevitch, Deepak Srivastava, Alejandra Guerchicoff, Benoit G. Bruneau, Chi-Chung Hui, Danny L. Costantini, Eric P. Arruda, Pooja Agarwal, Yonghong Zhu, Kyoung-han Kim, Wei Zhu, Peter H. Backx, Melanie Lebel, Stephanie A. Pierce, Chi Wa Cheng, Chong Y. Park, Guido D. Pollevick, Toby Y. Chan, M.Golam Kabir, Shuk Han Cheng, Mansoor Husain, Gross Gil J. | |||
| The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling. | Biological sciences | Rene Bernards, Mirjam T. Epping, Liming Wang, Michael J. Edel, Leone Carlee, Maria Hernandez | |||
| The intestinal heme transporter revealed. | Biological sciences | Tracey A. Rouault | |||
| The kinetochore protein Moa1 enables cohesion-mediated monopolar attachment at Meiosis l. | Biological sciences | Yoshinori Watanabe, Shihori Yokobayashi | |||
| The kinky propulsion of Spiroplasma. | Biological sciences | Charles W. Wolgemuth, Nyles W. Charon | |||
| The latest waves in calcium signaling. | Biological sciences | Craig Montell | |||
| The m-AAA protease defective in hereditary spastic paraplegia controls ribosome assembly in mitochondria. | Biological sciences | Thomas Langer, Mark Nolden, Mirko Koppen, Sarah Ehses, Andrea Bernacchia, Elena I. Rugarli | |||
| The many faces of PPAR(gamma).(peroxisome proliferator- activated receptor gamma) | Biological sciences | Mitchell A. Lazar, Michael Lehrke | |||
| The meaning of systems biology. | Biological sciences | Marc W. Kirschner | |||
| The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis. | Biological sciences | Michael L. Cleary, Akihiko Yokoyama, Tim C.P. Somervaille, Kevin S. Smith, Orit Rozenblatt-Rosen, Mattthew Meyerson | |||
| The molecular biography of the cell. | Biological sciences | Douglas A. Melton, David A. Shaywitz | |||
| The molecular clock mediates leptin-regulated bone formation. | Biological sciences | Gerard Karsenty, Allan Bradley, Erwin F. Wagner, Millan S. Patel, Loning Fu | |||
| The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation.(mammalian target of Rapamycin) | Biological sciences | Stefano Fumagalli, George Thomas, Jonathan Hall, Heidi A. Lane, Iwan Beuvink, Anne Boulay, Frederic Zilbermann, Stephan Ruetz, Francois Natt, Terence O'Reilly | |||
| The plasticity of aging: Insights from long-lived mutants. | Biological sciences | Cynthia Kenyon | |||
| The polyadendylation factor CPSF-73 is involved in histone-pre-mRNA processing. | Biological sciences | William F. Marzluff, Zbigniew Dominiski, Xiao-cui Yang | |||
| The proteasome: Not just degrading anymore. | Biological sciences | Patrick A. Grant, Stephen P. Baker | |||
| The proteasome regulatory particle alters the SAGA coactivator to enhance its interactions with transcriptional activators. | Biological sciences | Jerry L. Workman, William P. Tansey, Daeyoup Lee, Elena Ezhkova, Bing Li, Samantha G. Pattenden | |||
| The RETINOBLASTOMA-RELATED gene regulates stem cell maintenance in Arabidopsis roots. | Biological sciences | Renze Heidstra, Marjolein Wildwater, Wilhelm Gruissem, Luisa Mariconti, Ikram Blilou, Ana Campilho, Jayanta Chatterjee, Jose Manuel Perez-Perez, Henrie Korthout | |||
| The Rho/Rac-family guanine nucleotide exchange factor VAV-1 regulates rhythmic behaviors in C. elegans.(Caenorhabditis elegans) | Biological sciences | Mary C. Beckerle, Jerry E. Mellem, Kenneth R. Norman, Robert T. Fazzio, Maria V. Espelt, Kevin Strange, Andres V. Maricq | |||
| The role of the RNAi machinery in heterochromatin formation. | Biological sciences | Michael Wassenger | |||
| The set1 methyltransferase opposes Ipl1 aurora kinase functions in chromosome segregation. | Biological sciences | Kelly Tatchell, Sharon Y.R. Dent, Ryuji Kobayashi, Ke Zhang, Wenchu Lin, John A. Latham, David H. Hawke, Gary M. Riefler, Jill M. Schumacher, Clarence Chan | |||
| The Spanish connection: Transcription and mRNA processing get even closer. | Biological sciences | Manuel Ares Jr., Nick J. Proudfoot | |||
| The strength of receptor signaling is centrally controlled through a cooperative loop between Ca(super 2+) and an oxidant signal. | Biological sciences | Dinesh Kumar Singh, Dhiraj Kumar, Zaved Siddiqui, Vikas Kumar, Sandip Kumar Basu, Kanury V.S. Rao | |||
| The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation. | Biological sciences | Federica Marinoni, Kristian Helin, Martin Scheffner, Sovana Adhikary, Andreas Hock, Esther Hulleman, Martin Eillers, Nikita Popov, Rudi Beier, Sandra Bernard, Micaela Quarto, Maria Capra, Stephan Goettig, Ulrike Kogel | |||
| The v-ATPase Vo subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila. | Biological sciences | Hugo J. Bellen, P. Robin Hiesinger, Amir Fayyazuddin, Sunit Q. Mehta, Karen L. Schulze, Tanja Rosenmund, R. Grace Zhai, Yu Cao, Patrik Verstreken, Yi Zhou, Jeznnette Kunz | |||
| The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama 1. | Biological sciences | Andrej Shevchenko, Martin Schwickart, Tobias Oelschlaegel, Joas Matos, Jan Havlis, Alain Camasses, Aliona Bogdanova, Wolfgang Zachariae | |||
| Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis. | Biological sciences | Deane F. Mosher, Johannes W. Hell, Karen S. Christopherson, Erik M. Ullian, Caleb C. A. Stokes, Christine E. Mullowney, Azin Agah, Jack Lawler, Paul Bornstein, Ben A. Barres | |||
| Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis. | Biological sciences | Deane F. Mosher, Johannes W. Hell, Karen S. Christopherson, Erik M. Ullian, Caleb C. A. Stokes, Christine E. Mullowney, Paul Bornstein, Ben A. Barres, Agah, Azin; Lawler, Jack | |||
| Towards Cellular Systems in 4D. | Biological sciences | Luis Serrano, Peer Bork | |||
| Tracking RNA polymerase, one step at a time. | Biological sciences | Dmitry G. Vassylyev, Irina Artsimovitch | |||
| Transcriptional feedback of Neurospora circadian clock gene by phosphorylation-dependent inactivation of its transcription factor. | Biological sciences | Krisztina Kaldi, Michael Brunner, Tobias Schafmeier, Andrea Hasse, Johanna Scholz, Marc Fuchs | |||
| Transition from nonspecific to specific DNA interactions along the substrate-recognition pathway of dam methyltransferase. | Biological sciences | John R. Horton, Kirsten Liebert, Stanley Hattman, Albert Jeltsch, Xiaodong Cheng | |||
| Translational repression by Biocoid: Competition for the cap. | Biological sciences | Paul M. Macdonald | |||
| Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced apoptosis. | Biological sciences | Tim Schedl, Anton Gartner, Bjorn Schumacher, Momoyo Hanazawa, Sudhir Nayak, Min-Ho Lee, Katrin Volkmann, Randall Hofmann, Michael Hengartner | |||
| Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced apoptosis. | Biological sciences | Tim Schedl, Anton Gartner, Bjorn Schumacher, Momoyo Hanazawa, Sudhir Nayak, Min-Ho Lee, Katrin Volkmann, Randall Hofmann, Michael Hengartner | |||
| Transportation proteins and DNA uptake localize to the poles in Bacillus subtilis. | Biological sciences | Michael Sheetz, Jeanette Hahn, Berenike Maier, Bert Jan Haijema, David Dubnau | |||
| Transposons reanimated in mice. | Biological sciences | Timothy H. Bestor | |||
| Trimeric G protein-dependent frizzled signaling in Drosophila. | Biological sciences | Andrew Tomlinson, Vladimir L. Katanaev, Romina Ponzielli, Michel Semeriva | |||
| TTP specifically regulates the internalization of the transferrin receptor. | Biological sciences | Pietro De Camilli, Daniela Tosoni, Anna Elisabetta Salcini, Carlo Tacchetti, Pier Paolo Di Fiore, Claudia Puri, Stefano Confalonieri | |||
| Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. | Biological sciences | Stephen B. Baylin, Wei Gu, Wen Yong Chen, David H. Wang, Raywhay Chiu Yen, Jianyuan Luo | |||
| TWEAK attenuates the transition from innate to adaptive immunity. | Biological sciences | David Lawrence, Avi Ashkenazi, Jun Li, Heather Maecker, Eugene Varfolomeev, Frank Kischkel, Wyne Lee, Heidi LeBlanc, Stephen Hurst, Dimitry Danilenko, Ellen Filvaroff, Becky Yang, Dylan Daniel | |||
| Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective. | Biological sciences | Rudolph E. Tanzi, Lars Bertram | |||
| Two birds with one stone- Dealing with nuclear transport and spindle assembly. | Biological sciences | H. Funabiki | |||
| Two Pseudomonas syringae type III effectors inhibit RIN4-regulated basal defense in Arabidopsis. | Biological sciences | David Mackey, Min Gab Kim, Luis da Cunha, Aidan J. McFall, Youssef Belkhardir, Sruti DebRoy, Jeffrey L. Dangl | |||
| Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. | Biological sciences | Motozo Yamashita, Sai-Xia Ying, Gen-mu Zhang, Cuiling Li, Steven Y. Cheng, Chu-xia Deng, Ying E. Zhang | |||
| Under pressure: Stormal fibroblasts change their ways. | Biological sciences | Harold L. Moses, Brian Bierie | |||
| Understanding the odd science of aging. | Biological sciences | Thomas B.L. Kirkwood | |||
| UPS shipping and handling.(ubiquitin-proteasome system) | Biological sciences | Jon M. Huibregtse | |||
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