| Cell 1998 |
| Title | Subject | Authors |
|---|
| A 9 Angstrom resolution x-ray crystallographic map of a large ribosomal subunit. | Biological sciences | Joachim Frank, Pawel Penczek, Thomas A. Steitz, Peter B. Moore, Robert A. Grassucci, Nenad Ban, Poul Nissen, Betty Freeborn, Robert Sweet |
| Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination. (gamma amino-butyric acid; N-methyl-D-aspartate) | Biological sciences | Shigetada Nakanishi, Ryuichi Shigemoto, Misao Suzuki, Satoshi Kaneko, Robert J. Kreitman, Ira Pastan, Toshiharu Nagatsu, Tomoo Hirano, Masanobu Kano, Kouichi Hashimoto, Dai Watanabe, Hitoshi Inokawa, Norimitsu Suszuki, Keisuke Toyoma, Mineto Yokoi, Koki Moriyoshi, Kazuto Kobayashi |
| A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. | Biological sciences | Eric N. Olson, Jeffrey Robbins, Jeffery D. Molkentin, James (English explorer) Richardson, Jian-Rong Lu, Christopher L. Antos, Bruce Markham, Stephen R. Grant |
| A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. | Biological sciences | Bruce M. Spiegelman, Pere Puigserver, Zhidan Wu, Cheol Won Park, Reed Graves, Margaret Wright |
| A counterdefensive strategy of plant viruses: suppression of posttranscriptional gene silencing. | Biological sciences | James C. Carrington, Kristin D. Kasschau |
| A critical role for amino-terminal glutamine/aspargine repeats in the formation and propagation of a yeast prion. | Biological sciences | Alex Santoso, Jonathan S. Weissman, Angela H. DePace, Paul Hillner |
| A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. | Biological sciences | Stuart H. Orkin, Pieter Dikkes, Yijie Gao, Karen M. Frank, Jayanta Chaudhuri, Roderick T. Bronson, Michael E. Greenberg, Barbara A. Malynn, Laurie Davidson, Frederick W. Alt, Yuko Fujiwara, Roger Ferrini, Yi Sun, Wojciech Swat, Chengming Zhu, Katherine J. Seidl, JoAnn M. Sekiguchi, Gary A. Rathbun, Jiyang Wang, Margaret Bryans, Thomas Stamato |
| Activated RSC-nucleosome complex and persistently altered form of the nucleosome. | Biological sciences | Roger D. Kornberg, Bradley R. Cairns, Yahli Lorch, Mincheng Zhang |
| Activation of SRF-regulated chromosomal templates by Rho-family GTPases requires a signal that also induces H4 hyperacetylation. | Biological sciences | Richard Treisman, Arthur S. Alberts, Oliver Geneste |
| A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. | Biological sciences | Haruo Saito, Mutsuhiro Takekawa |
| A function for the AP3 coat complex in synaptic vesicle formation from endosomes. | Biological sciences | Regis B. Kelly, Victor Faundez, Jim-Tong Horng |
| Aging of C. elegans: Mosaics and mechanisms. | Biological sciences | William B. Wood |
| A homolog of NO APICAL MERISTEM is an immediate target of the floral homeotic genes APETALA3/PISTILLATA. | Biological sciences | Elliot M. Meyerowitz, Robert W.M. Sablowski |
| Aip2, a meiosis-specific protein required for the initiation of chromosome synapsis. | Biological sciences | G. Shirleen Roeder, Penelope R. Chua |
| A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless. | Biological sciences | Jeffrey C. Hall, Michael Rosbash, Ravi Allada, W. Venus So, Neal E. White |
| An anaphase calcium signal controls chromosome disjunction in early sea urchin embryos. | Biological sciences | Laurence Groigno, Michael Whitaker |
| An autoregulatory cascade of EGF receptor signaling patterns the Drosophila egg.(epidermal growth factor) | Biological sciences | Jonathan D. Wasserman, Matthew Freeman |
| An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast. | Biological sciences | Matthias Mann, Kim Nasmyth, Andrej Shevchenko, Wolfgang Zachariae, Christine Michaelis, Rafal Ciosk |
| An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. | Biological sciences | John T. Moore, Steven A. Kliewer, Michael A. Watson, Timothy M. Willson, Stacey A. Jones, Thomas Perlmann, Jurgen M. Lehmann, David D. McKee, Beverly B. Oliver, Rolf H. Zetterstrom, Laura Wade, Jeff L. Stalidinger |
| A Notch affair. (Notch gene in Drosophila, C. elegans and vertebrates) | Biological sciences | Sarah Bray |
| A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts. | Biological sciences | Michael L. Dustin, Paul M. Allen, Jun Li, Andrey S. Shaw, P. Anton van der Merwe, Michael W. Olszowy, Amy D. Holdorf, Shannon Bromley, Naishadh Desai, Patricia Widder, Frederick Rosenberger |
| A novel and ubiquitous system for membrane targeting and secretion of cofactor-containing proteins. | Biological sciences | Raymond J. Turner, Joel H. Weiner, Gavin H. Thomas, Jeff A. Cole, Peter T. Bilous, Gillian M. Shaw, Shannon P. Lubitz, Laura Frost |
| A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. (transactivation response element) | Biological sciences | Ping Wei, Katherine A. Jones, Mitchell E. Garber, Shi-Min Fang, Wolfgang H. Fischer |
| A novel CNS gene required for neuronal migration and involved in x-linked subcortical laminar heterotopia and lissencephaly syndrome. | Biological sciences | Axel Kahn, Pierre Billuart, Antoinette Gelot, Jamel Chelly, Jacques Motte, Vincent des Portes, Jean Marc Pinard, Marie Claude Vinet, Annette Koulakoff, Alain Carrie, Elisabeth Dupuis, Yoheved Berwald-Netter, Martin Catala, Cherif Beldijord |
| A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing. | Biological sciences | Naoyuki Kataoka, Bernard Charroux, Gideon Dreyfuss, Livio Pellizzoni |
| Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. | Biological sciences | Peter Gruss, Francesco Cecconi, Barbara I. Meyer, Gonzalo Alvarex-Bolado, Kevin A. Roth |
| Apaf1 is required for mitochondrial pathways of apoptosis and brain development. | Biological sciences | Young-Yun Kong, Josef Penninger, Andrew J. Elia, Tak W. Mak, Razqallah Hakem, Hiroki Yoshida, Anne Hakem, Ritsuko Yoshida |
| Apoptotic pathways: the roads to ruin. | Biological sciences | Douglas R. Green |
| Arabidopsis LEAFY COTYLEDON1 is sufficient to induce embryo development in vegetative cells. | Biological sciences | Robert L. Fischer, John J. Harada, Robert B. Goldberg, Tamar Lotan, Masa-aki Ohto, Kelly Matsudaira Yee, Marilyn A.L. West, Russell Lo, Raymond W. Kwong, Kazutoshi Yamagishi |
| Architecture of the gammadelta resolvase synaptosome: oriented heterodimers identify interactions essential for synapsis and recombination. | Biological sciences | Nigel D.F. Grindley, Laura Lea Murley |
| A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth. | Biological sciences | Chiara Zurzolo, Filippo G. Giancotti, Kishore K. Wary, Agnese Mariotti |
| A retinal axon fascicle uses Spitz, an EGF receptor ligand, to construct a synaptic cartridge in the brain of Drosophila.(epidermal growth factor) | Biological sciences | Sam Kunes, Ben-Zion Shilo, Zhen Huang |
| ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. | Biological sciences | Yanping Zhang, Yue Xiong, Wendell G. Yarbrough |
| A role for dystroglycan in basement membrane assembly. | Biological sciences | Michael D. Henry, Kevin P. Campbell |
| A serum shock induces circadian gene expression in mammalian tissue culture cells. | Biological sciences | Ueli Schibler, Francesca Damiola, Aurelio Balsalobre |
| Assembly of a tailed bacterial virus and its genome release studied in three dimensions. | Biological sciences | Yizhi Tao, Norman H. Olson, Dwight L. Anderson, Timothy S. Baker, Michael G. Rossmann, Wei Xu |
| A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and elF3. | Biological sciences | Daniel Finley, Victor A. Fried, Wolfgang Baumeister, David M. Rubin, Olivier Coux, Inge Wefes, Michael H. Glickman, Gunter Pfeifer, Zdenka Cjeka |
| A subset of TAF(sub II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation. (TBP-associated factors; Spt-Ada-Gcn5-acetyltransferase) | Biological sciences | Patrick A. Grant, Jerry L. Workman, Joseph C. Reese, John R. Yates III, Marilyn G. Pray-Grant, David Schieltz, David J. Steger |
| A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro. (erythroid Kruppel-like factor) | Biological sciences | Beverly M. Emerson, Jennifer A. Armstrong, James J. Bieker |
| Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice. (spinocerebellar ataxia type 1) | Biological sciences | Harry T. Orr, Huda Y. Zoghbi, Michael D. Kaytor, H. Brent Clark, Pamela J. Skinner, Ivan A. Klement, Steven M. Hersch, Hong Yi |
| Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker. | Biological sciences | Tomas Kirchhausen, Stephen C. Harrison, Andrea Musacchio, Ernst ter Haar |
| A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. | Biological sciences | Thomas C. Sudhof, Masaya Okamoto, Stefan Butz |
| A VSG expression site-associated gene confers resistance to human serum in Trypanosoma rhodesiense.(variant surface glycoprotein) | Biological sciences | Luc Vanhamme, Annette Pays, Etienne Pays, Hoang Van Xong, Mustapha Chamekh, Chibeka Evelyn Chimfwembe, Jan van den Abbeele, Nestor van Meirvenne, Raymond Hamers, Patrick de Baetselier |
| Bacteriophage DNA packaging: RNA gears in a DNA transport machine. | Biological sciences | Roger W. Hendrix |
| Bean dwarf mosaic geminivirus movement proteins recognize DNA in a form- and size-specific manner. | Biological sciences | Robert L. Gilbertson, William J. Lucas, Maria R. Rojas, Amine O. Noueiry |
| Beyond the nucleosome: epigenetic aspects of position-effect variegation in Drosophila. | Biological sciences | Barbara T. Wakimoto |
| Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. | Biological sciences | Xiaodong Wang, Clive Slaughter, Hua Zou, Xu Luo, Imawati Budihardjo |
| BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocon pore before and early in translocation. (endoplasmic reticulum) | Biological sciences | Linda M. Hendershot, Arthur E. Johnson, Brian D. Hamman |
| BRCA1, BRCA2, and DNA damage response: collision or collusion? | Biological sciences | Hongbing Zhang, Barbara L. Weber, Greg Tombline |
| Calmodulin regulates L-selectin adhesion molecule expression and function through a protease-dependent mechanism. | Biological sciences | Bruce Walcheck, Julius Kahn, Takashi Kei Kishimoto, Grace I. Migaki, Mark A. Jutila |
| Candidate adaptor protein CED-6 promotes the engulfment of apoptotic cells in C. elegans. (Caenorhabditis elegans) | Biological sciences | Michael O. Hengartner, Qiong A. Liu |
| Cdc2 kinase directly phosphorylates the cis-Golgi matrix protein GM130 and is required for Golgi fragmentation in mitosis. | Biological sciences | Graham Warren, Catherine Rabouille, Mark Jackman, Martin Lowe, Nobuhiro Nakamura, Rose Watson, Eija Jamsa, Dinah Rahman, Darryl J.C. Pappin |
| Cell nonautonomy of C. elegans daf-2 function in the regulation if diapause and life span. | Biological sciences | Cynthia Kenyon, Javier Apfeld |
| Cells' perception of position in a concentration gradient. | Biological sciences | J.B. Gurdon, Daniel St Johnston, Steven Dyson |
| Centromeres take flight: Alpha satellite and the quest for the human centromere. | Biological sciences | Gary H. Karpen, Terence D. Murphy |
| Centromeric chromatin and epigenetic effects in kinetochore assembly. | Biological sciences | Peter K. Sorger, Garth R. Wiens |
| Cerebellar LTD: a molecular mechanism of behavioral learning? (long-term depression) | Biological sciences | Stephen G. Lisberger |
| Chemokine receptors: keys to AIDS pathogenesis? | Biological sciences | Dan R. Littman |
| Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRalpha. | Biological sciences | Jean-Marc A. Lobaccaro, David J. Mangelsdorf, Robert E. Hammer, Daniel J. Peet, Stephen D. Turley, Wenzhen Ma, Bethany A. Janowski |
| Clathrin coats - threads laid bare. | Biological sciences | Gregory S. Payne, Babak Pishvaee |
| Cleavage of BlD by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. | Biological sciences | Zhu Hong, Junying Yuan, Honglin Li, Chi-jie Xu |
| CNK, a RAF-binding multidomain protein required for RAS signaling.(connector enhancer of kinase suppressor of reticular activating system) | Biological sciences | Gerald M. Rubin, Allan M. Wong, Marc Therrien |
| Coiled coils in both intracellular vesicle and viral membrane fusion. | Biological sciences | Don C. Wiley, John J. Skehel |
| Compartmentalization of bacterial antigens: differential effects on priming of CD8 T cells and protective immunity. | Biological sciences | Rafi Ahmed, Jeff F. Miller, Hao Shen, Xin Fan, David Kolwyck, John T. Harty |
| Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation. (NF-kappaB Essential MOdulator) | Biological sciences | Alain Israel, Gilles Courtois, Robert Weil, Christine Bessia, Shoji Yamaoka, Simon T. Whiteside, Fabrice Agou, Heather E. Kirk, Robert J. Kay |
| Complex formation and functional versatility of Mre11 of budding yeast in recombination. | Biological sciences | Hideyuki Ogawa, Hiroyuki Oshiumi, Tsutomu Ohta, Tomoko Ogawa, Takehiko Usui, Jun-ichi Tomizawa |
| Conservation of structure and mechanism between eukaryotic topoisomerase I and site-specific recombinases. | Biological sciences | Stewart Shuman, Chongui Cheng, Paul Kussie, Nikola Pavletich |
| Conserved themes but novel activities in recombinases and topoisomerases. | Biological sciences | David J. Sherratt, Dale B. Wigley |
| Conspiracy theory: RAS and RAF do not act alone. | Biological sciences | Paul W. Sternberg, Jose Alberola-lla |
| Constitutive expression of the CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) gene disrupts circadian rhythms and suppresses its own expression. | Biological sciences | Zhi-Yong Wang, Elaine M. Tobin |
| Coordination of growth and cell division in the Drosophila wing. | Biological sciences | Bruce A. Edgar, Laura A. Johnston, Thomas P. Neufeld, Aida Flor P. de la Cruz |
| COPII-coated vesicle formation reconstituted with purified coat proteins and chemically defined liposomes. | Biological sciences | Mylene Amherdt, Lelio Orci, Randy Schekman, Susan Hamamoto, Sebastian Y. Bednarek, Ken Matsuoka, Thomas Yeung |
| Cotranslational biogenesis of NF-Kappa-b p50 by the 26S proteasome. | Biological sciences | Warner C. Greene, Li Lin, George N. DeMartino |
| CREB1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation. | Biological sciences | Eric R. Kandel, Dusan Bartsch, Andrea Casadio, Kevin a. Karl, Paulo Serodio |
| CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity. | Biological sciences | Patrick Emery, Jeffrey C. Hall, Michael Rosbash, W. Venus So, Maki Kaneko |
| Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha. | Biological sciences | Gunter Blobel, John Kuriyan, Elena Conti, Marc Uy, Lore Leighton |
| Crystal structure and ATPase activity of MutL: implications for DNA repair and mutagenesis. | Biological sciences | Changill Ban, Wei Yang |
| Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain. | Biological sciences | Min Li, Brian T. Chait, Alice Lee, Roderick Mackinnon, Steven L. Cohen, Joao H. Morais Cabral |
| Crystal structure of a GCN5-related N-acetyltransferase: Serratia marcescens aminoglycoside 3-N-acetyltransferase. | Biological sciences | Stephen K. Burley, Yoshihiro Nakatani, Andrej Sali, Alex Vassilev, Eva Wolf, Yasutaka Makino |
| Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions. | Biological sciences | Josef Jiricny, Laurence H. Pearl, Tom Brown, George Panayotou, Tom Barlow, Renos Savva, Tracey E. Barrett |
| Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: Mechanisms for nucleotide flipping and base excision. | Biological sciences | Gregory L. Verdine, Tom Ellenberger, Albert Y. Lau, Orlando Scharer D., Leona Samson |
| Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-Beta signaling. (transforming growth factors) | Biological sciences | Joan Massague, Nikola P. Pavletich, Yigong Shi, Lata Jayaraman, Yan-Fei Wang, Haijuan Yang |
| Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. | Biological sciences | Yanxiang Zhao, John Kuriyan, David Jeruzalmi, Uwe Vinkemeier, James E. Darnell Jr., Xiaomin Chen |
| Crystal structure of a vertebrate smooth muscle myosin motor domain and its complex with the essential light chain: visualization of the pre-power stroke state. | Biological sciences | Carolyn Cohen, Roberto Dominguez, Kathleen M. Trybus, Yelena Freyzon |
| Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center. | Biological sciences | Vladimir Kral, C.S. Raman, Huiying Li, Pavel Martasek, Bettie Sue S. Masters, Thomas L. Poulos |
| Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A. | Biological sciences | Valerie G. Montana, Helen Piwnica-Worms, William Holmes, Mark A. Saper, Eric B. Fauman, John P. Cogswell, Brett Lovejoy, Warren J. Rocque, Martin J. Rink |
| Crystal structure of the Dbl and Pleckstrin homology domains from the Human Son of Sevenless protein. | Biological sciences | Dafna Bar-Sagi, John Kuriyan, Stephen M. Soisson, Marc Uy, Anjaruwee S. Nimnual |
| Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor. | Biological sciences | Melanie J. Bennett, Jose A. Lebron, Pamela J. Bjorkman, Arthur J. Chirino, Daniel E. Vaughn, Peter M Snow, Gabriel A. Mintier, John N. Feder |
| Crystal structure of the hexamerization domain of N-ethylmaleimide-sensitive fusion protein. | Biological sciences | William I. Weis, Sidney W. Whiteheart, Christian U. Lenzen, Diana Steinmann |
| Crystal structure of the human high-affinity IgE receptor. | Biological sciences | Scott C. Garman, Jean-Pierre Kinet, Theodore S. Jardetzky |
| Crystal structure of the Oxytricha nova Telomere end binding protein complexed with single strand DNA. | Biological sciences | Joanne M. Bevilacqua, Steve C. Schultz, Martin P. Horvath, Viloya L. Schweiker, James A. Ruggles |
| Crystal structure of the signal sequence binding subunit of the signal recognition particle. | Biological sciences | Peter Walter, Robert M. Stroud, Robert J. Keenan, Douglas M. Freymann |
| Crystal structure of the thermosome, the archaeal chaperonin and homolog of CCT. (eukaryotic chaperonin) | Biological sciences | Robert Huber, Jan Lowe, Harald Huber, Lars Ditzel, Daniela Stock, Karl-Otto Stetter, Stefan Steinbacher |
| Crystal structure of the tyrosine phosphatase SHP-2. | Biological sciences | Michael J. Eck, Steven E. Shoelson, Scott Pluskey, Sirano Dhe-Paganon, Peter Hof |
| Cse4p is a component of the core centromere of Saccharomyces cerevisiae. | Biological sciences | M. Mitchell Smith, Douglas Koshland, Pamela B. Meluh, Lynn Glowczewski |
| CTG repeats show bimodal amplification in E. coli. | Biological sciences | Partha S. Sarkar, Haw-Chin Chang, F. Brian Boudi, Sita Reddy |
| CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless. | Biological sciences | Jeffrey C. Hall, Michael Rosbash, W. Venus So, Joan E. Rutila, Vipin Suri, Myai Le |
| Cyclooxygenase regulates angiogenesis induced by colon cancer cells. | Biological sciences | Masatsugu Hori, Raymond N. DuBois, Masahiko Tsujii, Sunao Kawano, Shingo Tsuji, Hitoshi Sawaoka |
| Death-defying yeast identity novel apoptosis genes. | Biological sciences | Ira Herskowitz, Shai Shaham, Marc A. Shuman |
| Decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary. | Biological sciences | Allan C. Spradling, Ting Xie |
| Degradation signal masking by heterodimerization of MAT-alpha-2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway. | Biological sciences | Mark Hochstrasser, Robert Swanson, Phoebe R. Johnson, Larissa Rakhilina |
| De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. | Biological sciences | Elaine Fuchs, Uri Gat, Ramanuj DasGupta, Linda Degenstein |
| Developmentally regulated Xist promoter switch mediates initiation of X inactivation. | Biological sciences | Steven A. Sheardown, Neil Brockdorff, Tatyana B. Nesterova, Colette M. Johnston, Sarah M. Duthie, Alistair E.T. Newall, Emma J. Formstone |
| Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection. | Biological sciences | Doron Melamed, Robert J. Benschop, John C. Cambier, David Nemazee |
| Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells. (major histocompatibility complex) | Biological sciences | Ira Mellman, Philippe Pierre |
| Developmental regulation of vesicle transport in Drosophila embryos: forces and kinetics. | Biological sciences | Steven M. Block, Steven P. Gross, Michael A. Welte, Marya Postner, Eric F. Wieschaus |
| Development of insulin-dependent diabetes mellitus does not depend on specific expression of the human endogenous retrovirus HERV-K. (comments on Conrad et al., 'Cell,' vol 90, p.303, 1997) | Biological sciences | Hermann Wagner, Thomas Miethke, Reinhard Kurth, Joachim Denner, Ralf R. Tonjes, Roswitha Lower, Klaus Boller, Robert C. Phelps, Johannes Lower, Bernd Kaiser, Klaus Baldenhoop, Horst Donner, Klaus Henning Usadel, Matthias Lapatschek |
| Differential requirement for caspase 9 in apoptotic pathways in vivo. | Biological sciences | Scott W. Lowe, Julia Potter, Tak W. Mak, Razqallah Hakem, Gordon S. Duncan, Andrew Elia, Anne Hakem, Jose Luis De la Pompa, Jeffrey T. Henderson, Maria S. Soengas, David Kagi, Wilson Khoo, Stephen A. Kaufman, Mina Woo, Ritsuko Yoshida, Joesf M. Penninger |
| Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. (Jun-N-terminal kinase) | Biological sciences | Marek Mlodzik, Michael Boutros, Nuria Paricio, David I. Strutt |
| Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity. | Biological sciences | David A. Cheresh, Peter C. Brooks, Martin Friedlander, Steve Silletti, Tami L. von Schalscha |
| Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. | Biological sciences | Diane Pennica, J. Michael White, Robert D. Schreiber, Eugene M. Johnson Jr., Scott J. Rodig, Marco A. Meraz, Kathleen C.F. Sheehan, Joan K. Riley, Pat A. Lampe, Cora D. Arthur, Kathleen L. King, Li Yin |
| Dissecting the regulatory circuitry of a eukaryotic genome. | Biological sciences | Tong Ihn Lee, Frank C.P. Holstege, Ezra G. Jennings, Michael R. Green, Richard A. Young, Todd R. Golub, Eric S. Lander, John J. Wyrick, Christoph J. Hengartner |
| DNA binding of the glucocorticoid receptor is not essential for survival. | Biological sciences | Klaus H. Kaestner, Peter Angel, Peter Herrlich, Gunther Schutz, Holger M. Reichardt, Wolfgang Schmid, Peter Gass, Jan Tuckermann, Oliver Kretz, Oliver Wesseley, Rudolf Bock |
| DNA damage and checkpoint pathways: molecular anatomy and interactions with repair. | Biological sciences | Ted Weinert |
| DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations. | Biological sciences | Martin Gellert, Kevin Hiom, Meni Melek |
| Do LCRs open chromatin domains?(locus control region) | Biological sciences | Douglas R. Higgs |
| Doublecortin, a brain-specific gene mutated in human x-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein. | Biological sciences | Jeremy W. Fox, Christopher A. Walsh, William B. Dobyns, Joseph G. Gleeson, Kristina M. Allen, Edward D. Lamperti, Samuel Berkovic, Ingrid Scheffer, Edward C. Cooper, Sharon R. Minnerath, M. Elizabeth Ross |
| Double-time is a novel Drosophila clock gene that regulates period protein accumulation. | Biological sciences | Michael W. Young, Adrian Rothenfluh, Jeffrey L. Price, Justin Blau, Marla Abodeely, Brian Kloss |
| Drosophila ring canal growth requires Src and Tec kinases. | Biological sciences | Lynn Cooley |
| Dying like flies.(apoptosis in the Drosophila) | Biological sciences | Gerard Evan, Pascal Meier |
| Dynamin: a molecular motor with pinchase action. | Biological sciences | Mark A. McNiven |
| Dynamin undergoes a GTP-dependent conformational change causing vesiculation. | Biological sciences | Jenny E. Hinshaw, Sharon M. Sweitzer |
| Endocrine disruptors signal the need for receptor models and mechanisms to inform policy. | Biological sciences | Palmer Taylor, Lee E. Limbird |
| Ethanol intoxication in Drosophila: genetic and pharmacological evidence for regulation by the cAMP signaling pathway. | Biological sciences | Tim Tully, Ulrike Heberlein, Carol M. Singh, Alvin Y. Luk, Monica S. Moore, Jim DeZazzo |
| Ethylene responses are negatively regulated by a receptor gene family in Arabidopsis thaliana. | Biological sciences | Jian Hua, Elliot M. Meyerowitz |
| Eukaryotic transcription: an interlaced network of transcription factors and chromatin-modifying machines. | Biological sciences | James T. Kadonaga |
| Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. | Biological sciences | Richard C. Boucher, Barbara R. Grubb, Robert Tarran, Hirotoshi Matsui, Scott H. Randell, John T. Gatzy, C. William Davis |
| Evolution of simple repeats in DNA and their relation to human disease. | Biological sciences | Philippe Djian |
| Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila. | Biological sciences | Nancy M. Bonini, Kenneth H. Fischbeck, Henry L. Paulson, John M. Warrick, Gladys L. Gray-Board, Quang T. Bui, Randall N. Pittman |
| Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions. (prion protein) | Biological sciences | Marek Fischer, Adriano Aguzzi, Charles Weissmann, Sebastian Brandner, Thomas Rulicke, Antonio Cozzio, Christian von Mering, Thomas Blattler, Eckhard Flechsig, Doron Shmerling, Ivan Hegyi, Jurgen Gotz, Christoph Hangartner |
| Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alphav integrins. | Biological sciences | Richard O. Hynes, Denise Crowley, Helen Rayburn, Bernhard L. Bader |
| F1-ATPase: A rotary motor made of a single molecule. (F1-adenosine triphosphatase)(Minireview.) | Biological sciences | Ryohei Yasuda, Hiroyuki Noji, Masasuke Yoshida, Shin'ichi Ishiwata, Kazuhiko Jr. Kinosita |
| F1 - ATPase is a highly efficient molecular motor that rotates with discrete 120 degree steps. (adenosine triphosphatase) | Biological sciences | Ryohei Yasuda, Hiroyuki Noji, Masasuke Yoshida, Kazuhiko Kinosita Jr. |
| Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body.(phosphatidylinositol 3-kinases) | Biological sciences | Markus Babst, Scott D. Emr, Greg Odorizzi |
| FACT, a factor that facilitates transcript elongation through nucleosomes. (facilitates chromatin transcription) | Biological sciences | George Orphanides, Danny Reinberg, Gary LeRoy, Chun-Hsiang Chang, Donal S. Luse |
| FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. | Biological sciences | John L.R. Rubenstein, Arnon Rosenthal, Kenji Shimamura, Weilan Ye, Mary A. Hynes |
| Floral induction and florigen. | Biological sciences | Milo J. Aukerman, Rick M. Amasino |
| Follow the leader: NK cell receptors for classical and nonclassical MHC class I. (natural killer; major histocompatibility complex) | Biological sciences | Lewis L. Lanier |
| Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. | Biological sciences | Austin Smith, Ian Chambers, Jennifer Nichols, Hitoshi Niwa, Branko Zevnik, Konstantinos Anastassiadis, Daniela Klewe-Nebenius, Hans Scholer |
| frizzled and frizzled 2 play a partially redundant role in wingless signaling and have similar requirements to wingless in neurogenesis. | Biological sciences | Krishna Moorthi Bhat |
| Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice. | Biological sciences | Lennart Mucke, Elizabeth A. Campbell, Martin H. Johnson, Michael V. Sofroniew, Toby G. Bush, Tor C. Savidge, Tom C. Freeman, Hilary J. Cox |
| Functionally related motor neuron pool and muscle sensory afferent subtypes defined by coordinate ETS gene expression. | Biological sciences | David J. Anderson, Thomas M. Jessell, Silvia Arber, Jonathan H. Lin, Cynthia Lance-Jones, Tetsuichiro Saito |
| GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis. | Biological sciences | David Kimelman, Sarah B. Pierce, Cynthia Yost, Gist H. Farr III, Denise M. Ferkey, Michelle Mingzi Chen |
| Geminin, an inhibitor of DNA replication is degraded during mitosis. | Biological sciences | Marc W. Kirschner, Thomas J. McGarry |
| Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. | Biological sciences | En Li, Roderick T. Bronson, Lian-Ee Ch'ng, David M. Livingston, Tso-Pang Yao, Miriam Fuchs, David Newsome, Richard Eckner, Suk P. Oh, Nai-Dong Zhou |
| Generation of coated intermediates of clathrin-mediated endocytosis of protein-free liposomes. | Biological sciences | Kohji Takei, Volker Haucke, Hong Chen, Vladimir Slepnev, Khashayar Farsad, Marco Salazar, Pietro de Camilli |
| Genetic analysis of the mechanisms controlling target selection: complementary and combinatorial function of netrins, semaphorins, and IgCAMs. | Biological sciences | Corey S. Goodman, Kevin J. Mitchell, Margaret L. Winberg |
| Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin. | Biological sciences | Eric R. Kandel, Danny G. Winder, Isabelle M. Mansuy, Mona Osman, Theodore M. Moallem |
| Globin gene expression is reprogrammed in chimeras generated by injecting adult hematopoietic stem cells into mouse blastocysts. | Biological sciences | Constanze Bonifer, Albrecht M. Muller, Hartmut Geiger, Stephanie Sick |
| G protein signaling events are activated at the leading edge of chemotactic cells. | Biological sciences | Carole A. Parent, Peter N. Devreotes, Brenda J. Blacklock, Wendy M. Froehlich, Douglas B. Murphy |
| Hair today, gone tomorrow: transgenic mice with human repair deficient hair disease.(Minireview) | Biological sciences | James E. Cleaver |
| Hedgehog and Spitz: making a match between photoreceptor axons and their targets. | Biological sciences | Thomas R. Clandinin, Iris Salecker, S. Lawrence. Zipursky |
| HERV-K10s and immune-mediated (type 1) diabetes. (comments on Conrad et al., 'Cell,' vol. 90, p. 303, 1997) | Biological sciences | Ricardo Gomez, Noel K. Maclaren, Andrew Mason, Michael S. Lan, Regis Coutant, Qiao-Yi Chen, Alphonso Vargas, Jaysrhee Rao, Stuart Chalew, Robert Garry |
| Histone-like TAFs within the PCAF histone acetylase complex. (TBP-associated factors) | Biological sciences | Jun Qin, Yoshihiro Nakatani, Vasily V. Ogryzko, Xiaolong Zhang, Bruce H. Howard, Xiang-Jiao Yang, R. Louis Schiltz, Tomohiro Kotani, Tazuko Howard |
| HIV-1 auxiliary proteins: making connections in a dying cell. | Biological sciences | Bryan R. Cullen |
| HIV entry and its inhibition. | Biological sciences | Peter S. Kim, David C. Chan |
| Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells. | Biological sciences | Garry P. Nolan, Hideto Kaneshima, Benjamin K. Chen, Shigemi Kinoshita |
| Hsp104, Hsp70, and Hsp40: a novel chaperone system that rescues previously aggregated proteins. (proteins of Saccharomyces cerevisiae) | Biological sciences | Susan Lindquist, John R. Glover |
| HTVL-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation. | Biological sciences | Melanie H. Cobb, Youn-Tae Kwak, Richard B. Gaynor, Min-Jean Yin, Lori B. Christerson, Shuichan Xu, Frank Mercurio, Miguel Barbosa |
| Human SWI/SNF interconverts a nucleosome between its base state and a stable remodeled state. | Biological sciences | Said Sif, Robert E. Kingston, Gavin Schnitzler |
| Human TAF(sub II)28 and TAF(sub II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family. | Biological sciences | Marc Ruff, Olivier Poch, Catherine Birck, Christophe Romier, Gabrielle Mengus, Anne-Claire Lavigne, Irwin Davidson, Dino Mora |
| Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. (mitotic arrest-defective 1) | Biological sciences | Kuan-Teh Jeang, Forrest Spencer, Dong-Yan Jin |
| Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing. (ribonucleic acid-binding proteins) | Biological sciences | James L. Manley, Satoshi Ogawa, Masaya Tohyama, Roland Tacke |
| Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. | Biological sciences | Michael E. Greenberg, Frederic Saudou, Steven Finkbeiner, Didier Devys |
| Identification and characterization of a bacterial chromosome partitioning site. | Biological sciences | Alan D. Grossman, Daniel Chi-Hong Lin |
| Identification and disruption of a plant Shaker-like outward channel involved in K+ release into the xylem sap. | Biological sciences | David Bouchez, Herve Sentenac, Frederic Gaymard, Guillaume Pilot, Benoit Lacombe, Dominique Bruneau, Jossia Boucherez, Nicole Michaux-Ferriere, Jean-Baptiste Thibaud |
| Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. | Biological sciences | Eric R. Kandel, Dusan Bartsch, Bina Santoro, Steven A. Siegelbaum, Gareth R. Tibbs, David T. Liu, Huan Yao |
| Identification of ligands for olfactory receptors by functional expression of a receptor library. | Biological sciences | Randall R. Reed, King-Wai Yau, Dietmar Krautwurst |
| IHF modulation of Tn10 transposition: sensory transduction of supercoiling status via a proposed protein/DNA molecular spring. | Biological sciences | Ronald Chalmers, Nancy Kleckner, Anjan Guhathakurta, Howard Benjamin |
| Immune receptor editing: revise and select. | Biological sciences | Michel C. Nussenzweig |
| Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. | Biological sciences | Gary Rathbun, Frederick W. Alt, Raif S. Geha, Vadim Pivniouk, Erdyni Tsitsikov, Paul Swinton |
| Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. (methyl aspartate) | Biological sciences | Arthur Konnerth, Andrei Rozov, Rolf Sprengel, Peter H. Seeburg, James O. McNamara, Richard F. Thompson, Seth G.N. Grant, Jens Eilers, Jeansok J. Kim, Bettina Suchanek, Carla Amico, Rossella Brusa, Nail Burmashev, Oivind Hvalby, Vidar Jensen, Ole Paulsen, Per Andersen, William Sun, Lorna C. Webster, Jianying Li |
| Imprinting and the initiation of gene silencing in the germ line. | Biological sciences | M. Azim Surani |
| Induced folding in RNA-protein recognition: more than a simple molecular handshake. (response to N. Zheng and L.M. Gierasch, Molecular Cell, vol. 1, p. 79, 1997 and J. Mogridge, et al., Cell, vol. 1, p. 265, 1998) | Biological sciences | Alan D. Frankel, Colin A. Smith |
| Inositol triphosphate mediates a RAS-independent response to LET-23 receptor tyrosine kinase activation in C. elegans. (Caenorhabditis elegans) | Biological sciences | Paul W. Sternberg, Thomas R. Clandinin, John A. DeModena |
| In response to Murphy et al., Lower et. al., and Lan et al. (comments on Vincent J. Murphy et al., Roswitha Lower et al. and Michael S. Lan et al., in this issue, vol. 95, pp. 9, 11, 14) | Biological sciences | Bernard Conrad |
| Interpretation of a BMP activity gradient in Drosophila embryos depends on synergistic signaling by two type I receptors, SAX and TKV. | Biological sciences | Minh Nguyen, Guillermo Marques, Kavita Arora, Sangbin Park |
| Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. | Biological sciences | Kazuaki Takaku, Masanobu Oshima, Makoto M. Taketo, Michael F. Seldin, Hiroyuki Miyoshi, Minoru Matsui |
| Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1. | Biological sciences | Frank McKeon, Gerhard Wagner, Jean-Claude Guillemot, Pascual Ferrara, Futoshi Shibasaki, Volker Dotsch, Jiangyu Zhu, Roydon Price, Takeo Yano |
| Invasion of the nucleotide snatchers: Structural insights into the mechanism of G protein GEFs. | Biological sciences | Stephen R. Sprang, David E. Coleman |
| IP47: a cargo selection device for mannose 6-phosphate receptor trafficking. | Biological sciences | Suzanne R. Pfeffer, Elva Diaz |
| Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. | Biological sciences | Hong Wu, Klaus Pfeffer, Ana Cumano, Hans Neubauer, Mathias Muller, Ulrike Huffstadt |
| Jak2 is essential for signaling through a variety of cytokine receptors. | Biological sciences | Jean-Christophe Marine, James N. Ihle, Elio F. Vanin, Gerard Grosveld, Stephan Teglund, Jan M. van Deursen, Dimitrios Stravopodis, Demin Wang, Sara Bodner, Evan Parganas, David J. Topham, Oscar R. Colamonici |
| Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit. | Biological sciences | Francis J. McNally, Ronald D. Vale, Akihiro Iwamatsu, Susan Thomas, Katsuya Okawa, James J. Hartman, Jeff Mahr, Karen McNally, Sarah Cheesman, John Heuser |
| Kinesin: What gives? (enzyme)(Minireview.) | Biological sciences | Steven M. Block |
| LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. (linker for activation of T cells) | Biological sciences | Weiguo Zhang, Lawrence E. Samelson, Joanne Sloan-Lancaster, Jason Kitchen, Ronald P. Trible |
| lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal. | Biological sciences | Chikara Meno, Yukio Saijoh, Kyoko Mochida, Hiroshi Hamada, Hisato Kondoh, Sumihare Noji, Akihiko Shimono, Kenta Yashiro, Sachiko Ohishi |
| LIM homeodomain factors Lhx3 and Lhx4 assign subtype identifies for motor neurons. | Biological sciences | Heiner Westphal, Samuel L. Pfaff, Kamal Sharma, Karen Lettieri, Hui Z. Sheng, Hung Li, Alexander Karavanov, Steven Potter |
| LIN-10 is a shared component of the polarized protein localization pathways in neurons and epithelia. | Biological sciences | Stuart K. Kim, Joshua M. Kaplan, Christopher Rongo, Charles W. Whitfield, Avital Rodal |
| lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48. | Biological sciences | H. Robert Horvitz, Xiaowei Lu |
| Links in the left/right axial pathway. | Biological sciences | Richard P. Harvey |
| Lipid A acylation and bacterial resistance against vertebrate antimocrobial peptides. | Biological sciences | Samuel I. Miller, Lin Guo, Kheng B. Lim, Christina M. Poduje, Morad Daniel, John S. Gunn, Murray Hackett |
| LMA1 binds to vacuoles at Sec 18p (NSF), transfers upon ATP hydrolysis to a t-SNARE (Vam3p) complex, and is released during fusion. (low Mr activity 1; adenosine triphosphate; soluble N-ethylmaleimide sensitive fusion attachment protein) | Biological sciences | Ken Sato, William Wickner, Zouyu Xu |
| Localized requirements for windbeutel and pipe reveal a dorsoventral prepattern within the follicular epithelium of the Drosophila ovary. | Biological sciences | Trudi Schupbach, Laura A. Nilson |
| Loops, lineage and leukemia. | Biological sciences | Tariq Enver, Mel Greaves |
| Mammalian and Drosophila blood: JAK of all trades? | Biological sciences | Norbert Perrimon, Bernard Mathey-Prevot |
| Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation. | Biological sciences | Tony Pawson, William J. Muller, Robert D. Cardiff, Geraldine Mbamalu, James C. Cross, Alec M. Cheng, Sarang Kulkarni, Ryuichi Sakai, Tracy M. Saxton, Wolfgang Vogel, Christopher G. Tortorice |
| MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction. (membrane-associated protein kinase) | Biological sciences | Stuart K. Kim, Patrick B. Tan, Mark R. Lackner |
| MAP kinases in meiosis. | Biological sciences | Andrew W. Murray |
| Mapping the position of translational elongation factor EF-G in the ribosome by directed hydroxyl radical probing. | Biological sciences | Harry F. Noller, Kevin S. Wilson |
| Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins. | Biological sciences | Stephen J. Weiss, Edward Allen, Nobuaki Hiraoka, Ingrid J. Apel, Margaret R. Gyetko |
| Mechanical devices of the spliceosome: motors, clocks, springs, and things. | Biological sciences | Christine Guthrie, Jonathan P. Staley |
| Meiotic recombination in C. elegans initiates by a conserved mechanism and is dispensable for homologous chromosome synapsis. (Caenorhabditis) | Biological sciences | Abby F. Dernburg, Robert Barstead, Kent McDonald, Gary Moulder, Michael Dresser, Anne M. Villenueve |
| Memory and the brain: what's right and what's left?(Minireview) | Biological sciences | Russell A. Poldrack, D.E. Gabrieli |
| Mesoderm induction: a postmodern view. | Biological sciences | David Kimelman, Kevin J.P. Griffin |
| MIX-1: an essential component of the C. elegans mitotic machinery executes x chromosome dosage compensation. (Caenorhabditis elegans) | Biological sciences | Barbara J. Meyer, Pao-Tien Chuang, Jason D. Lieb, Michael R. Albrecht |
| MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. | Biological sciences | Douglas Hanahan, Thiennu H. Vu, Zena Werb, Steven D. Shapiro, J. Michael Shipley, Robert M. Senior, Gabriele Bergers, Joel E. Berger, Jill A. Helms |
| Molecular basis of lysosomal enzyme recognition: three-dimensional structure of the cation-dependent mannose 6-phosphate receptor. | Biological sciences | David L. Roberts, Daniel J. Weix, Nancy M. Dahms, Jung-Ja P. Kim |
| Molecular dissection of Hox gene induction and maintenance in the hindbrain. | Biological sciences | Claudio D. Stern, Ann C. Foley |
| Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. | Biological sciences | David J. Anderson, Zhou-Feng Chen, Hai U. Wang |
| Molecular movement inside the translational engine. | Biological sciences | Harry F. Noller, Kevin S. Wilson |
| Motor neuron-derived retinoid signaling specifies the subtype identity if spinal motor neurons.(Cover Story) | Biological sciences | Thomas M. Jessell, Shanthini Sockanathan |
| Motors driving mRNA localization: New insights from in vivo imaging. | Biological sciences | Paul M. Macdonald, Eric A. Arn |
| Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICe. (interleukin-1-beta-converting enzyme) | Biological sciences | Zhu Hong, En Li, Junying Yuan, Masayuki Miura, Suyue Wang, Yong-keun Jung |
| Mutations in the ER-Golgi intermediate compartment protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII. (endoplasmic reticulum-Golgi; autosomal recessive bleeding disorder) | Biological sciences | Randal J. Kaufman, Uri Seligsohn, William C. Nichols, Ariella Zivelin, Valeri H. Terry, Colette E. Hertel, Matthew A. Wheatley, Micheline J. Moussalli, Hans-Peter Hauri, Nicola Ciavarella |
| Myogenesis: a view from Drosophila. | Biological sciences | Michael Bate, Mary K. Baylies, Mar Ruiz Gomez |
| Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in C. elegans. | Biological sciences | Cornelia I. Bargmann, Mario De Bono |
| Nef harbors a major determinant of pathogenicity for an AIDs-like disease induced by HIV-1 in transgenic mice. | Biological sciences | Paul Jolicoeur, Serge Jothy, Denis G. Kay, Zaher Hanna, Najet Rebai, Alain Guimond |
| Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. (cytoskeletal protein tensin) | Biological sciences | Josef Penninger, Tak W. Mak, Takehiko Sasaki, Akira Suzuki, David P. Siderovski, Jurgen Ruland, Christine Mirtsos, Vuk Stambolic, Jose Lois de la Pompa, Greg M. Brothers |
| Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. | Biological sciences | Shay Soker, Michael Klagsbrun, Seiji Takashima, Hua Quan Miao, Gera Neufeld |
| New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable? | Biological sciences | Michael Karin |
| Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. | Biological sciences | Richard A. Gatti, Norma J. Nowak, Andre Rosenthal, Richard K. Wilson, Martin Digweed, Andre Reis, Eva Seemanova, Matthias Platzer, Kathrin Saar, Paul R. Cooper, Raymonda Varon, Christine Vissinga, Karen M. Cerosaletti, Krystyna H. Chrzanowska, Georg Beckmann, Markus Stumm, Corry M.R. Weemaes, Karl Sperling, Patrick Concannon |
| NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor trio. | Biological sciences | Stephen W. Fesik, Robert P. Meadows, Hong Wang, Edward T. Olejniczak, John E. Harlan, Matthias Eberstadt, Xiahong Liu, Arndt Schnuchel, Jeff M. Schkeryantz, David A. Janowick, Edith A.S. Harris, Donald Staunton E. |
| NMR structure of the bacteriophage lambda N peptide/boxB RNA complex: recognition of a GNRA fold by an arginine-rich motif. (nuclear magnetic resonance) | Biological sciences | Jack Greenblatt, Jeremy Mogridge, Lewis E. Kay, Joyce Li, Pascale Legault |
| Nuclear access and action of notch in vivo. | Biological sciences | Gary Struhl, Atsuko Adachi |
| Nuclear inclusions in glutamine repeat disorders: are they pernicious, coincidental, or beneficial? | Biological sciences | Sangram S. Sisodia |
| Nucleocytoplasmic transport: the last 200 nanometers. | Biological sciences | Iain W. Mattaj, Mutsuhito Ohno, Maarten Fornerod |
| Obesity and the hypothalamus: novel peptides for new pathways. | Biological sciences | Jeffrey S. Flier, Eleftheria Maratos-Flier |
| Odorant receptor localization to olfactory cilia is mediated by ODR-4, a novel membrane-associated protein. | Biological sciences | Piali Sengupta, Cornelia I. Bargmann, Emily R. Troemel, Noelle D. Dwyer |
| Odorant receptors govern the formation of a precise topographic map. (vertebrate olfactory system) | Biological sciences | Richard Axel, Adriana Nemes, Fan Wang, Monica Mendelsohn |
| Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. | Biological sciences | James A. Richardson, Jonathan R.S. Arch, Roland S. Annan, Steven A. Carr, Masashi Yanagisawa, Takeshi Sakurai, Hirokazu Tanaka, Akira Amemiya, Makoto Ishii, Ichiyo Matsuzaki, Richard M. Chemelli, S. Clay Williams, Gerald P. Kozlowski, Shelagh Wilson, Robin E. Buckingham, Andrea C. Haynes, Dean E. McNulty, Wu-Schyong Liu, Jonathan A. Terett, Nabil A. Elshourbagy, Derk J. Bergsma |
| Organelle membrane fusion: a novel function for the syntaxin homolog Ufe1p in ER membrane fusion. (endoplasmic reticulum) | Biological sciences | Martin Latterich, Sheetal K. Patel, Fred E. Indig, Nicolette Olivieri, Nicole D. Levine |
| Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. | Biological sciences | G. Senaldi, S. Scully, D.L. Lacey, C.R. Dunstan, R. Elliott, A. Colombero, H.-L. Tan, J. Sullivan, E. Davy, W.J. Boyle, E. Timms, M.J. Kelley, T. Burgess, G. Elliott, H. Hsu, N. Hawkins, C. Capparelli, A. Eli, Y.-X. Qian, S. Kaufman, I. Sarosi, V. Shalhoub, J. Guo, J. Delaney |
| Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. (low-density lipoprotein) | Biological sciences | Ronald M. Evans, Laszlo Nagy, Peter Tontonoz, Hongwu Chen, Jacqueline G.A. Alvarez |
| PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization. | Biological sciences | Gary Thomas, Lei Wan, Sean S. Molloy, Laurel Thomas, Gseping Liu, Yang Xiang, Sheree Lyn Rybak |
| Partial V(D)J recombination activity leads to Omenn syndrome. | Biological sciences | Luisa Imberti, Hans D. Ochs, Luigi D. Notarangelo, Annalisa Frattini, Anna Villa, Klaus Schwarz, Silvia Giliani, Eugenia Spanopoulou, Sandro Santagata, Fabio Bozzi, Luisa Benerini Gatta, Paolo Vezzoni |
| Partner of numb colocalizes with numb during mitosis and directs numb asymmetric localization in Drosophila neural and muscle progenitors. | Biological sciences | Yuh Nung Jan, Lily Y. Jan, Bingwei Lu, Michael Rothenberg |
| PDZ proteins organize synaptic signalling pathways. | Biological sciences | David S. Bredt, Sarah E. Craven |
| P. falciparum CG2, linked to chloroquine resistance, does not resemble Na+/H+ exchangers. (Plasmodium) | Biological sciences | David A. Fidock, Thomas E. Wellems, Hisashi Fujioka, Xin-zhuan Su, John C. Wootton, Roland Cooper, Dror Baruch |
| PGL-1, a predicted RNA-binding component of germ granules, is essential for fertility in C. elegans. | Biological sciences | Susan Strome, William B. Wood, Ichiro Kawasaki, Yhong-Hee Shim, Jay Kirchner, Joshua Kaminker |
| Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation. (membrane-associated protein kinase) | Biological sciences | Melanie H. Cobb, Mark Atkinson, Bertram Canagarajah, Andrei V. Khokhlatchev, Julie Wilsbacher, Megan Robinson, Elizabeth Goldsmith |
| PIF3, a phytochrome-interacting factor necessary for normal photoinduced signal transduction, is a novel basic helix-loop-helix protein. | Biological sciences | Peter H. Quail, Min Ni, James M. Tepperman |
| Pinning down positional information: dorsal-ventral polarity in the Drosophila embryo. | Biological sciences | Kathryn V. Anderson |
| Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signalling pathway in determination of left-right asymmetry. | Biological sciences | Chikara Meno, Hiroshi Hamada, Jeffrey C. Murray, Takashi Inoue, Minoru Sugihara, Sumihare Noji, Hideyo Ohuchi, Hidefumi Yoshioka, Kazuko Koshiba, Hiroyuki Itoh, Yoshiyasu Ishimaru, Elena V. Semina |
| Pitx2 participates in the late phase of the pathway controlling left-right asymmetry. | Biological sciences | M. Elisa Piedra, Jose M. Icardo, Marta Albajar, Jose C. Rodriguez-Rey, Maria A. Ros |
| Plexin A is a neuronal semaphorin receptor that controls axon guidance. | Biological sciences | Marc Tessier-Lavigne, Corey S. Goodman, Paolo M. Comoglio, Luca Tamagnone, Margaret L. Winberg, Jasprina N. Noordermeer, Melanie K. Spriggs |
| Polycomb and trithorax group proteins mediate the function of a chromatin insulator. | Biological sciences | Tatiana I. Gerasimova, Victor G. Corces |
| Polycombing the genome: PcG, trxG, and chromatin silencing. | Biological sciences | Vincenzo Pirrotta |
| Polymerases and the replisome: machines within machines. | Biological sciences | Tania A. Baker, Stephen P. Bell |
| POP-1 and anterior-posterior fate decisions in C. elegans embryos. | Biological sciences | Rueyling Lin, Russell J. Hill, James R. Priess |
| Positioning cloning identifies zebrafish one-eyed pinhead as a primitive EGF-related ligand required during gastrulation. (epidermal growth factor) | Biological sciences | Alexander F. Schier, William S. Talbot, Jiaojiao Zhang |
| PPARgamma in monocytes: less pain, any gain? | Biological sciences | Bruce M. Spiegelman |
| PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. (low-density lipoprotein) | Biological sciences | Ronald M. Evans, Laszlo Nagy, Peter Tontonoz, Jacqueline G.A. Alvarez, Vilmos A. Thomazy |
| Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. | Biological sciences | Joel Vandekerckhove, Hannah L. Klein, Heidi Rommelaere, Christophe Ampe, Nicholas J. Cowan, Irina E. Vainberg, Sally A. Lewis |
| Prion protein biology. | Biological sciences | Stanley B. Prusiner, Stephen J. DeArmond, Fred E. Cohen, Michael R. Scott |
| Problems with RHAMM: a new link between surface adhesion and oncogenesis?(includes reply)(response to C.L. Hall et al., Cell, vol. 82, p. 19, 1995)(receptor for hyaluronic acid mediated motility) | Biological sciences | Helmut Ponta, Peter Herrlich, Martin Hofmann, Volker Assmann, Christina Fieber, Jonathan P. Sleeman, Jurgen Moll, Ian R. Hart, E.A. Turley, L. Pilarski, J.I. Nagy |
| Procollagen traverses the Golgi stack without leaving the lumen of cisternae: evidence for cisternal maturation. | Biological sciences | Hans J. Geuze, Alberto Luini, Lidia Bonfanti, Alexander A. Mironov Jr., Jose A. Martinez-Menarguez, Oliviano Martella, Aurora Fusella, Massimiliano Baldassarre, Roberto Buccione, Alexander A. Mironov |
| Prolyl isomerases and nuclear function. | Biological sciences | Tony Hunter |
| Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis. | Biological sciences | Zsolt Bocskei, Vilmos Fulop, Laszlo Polgar |
| Protein chainmail: catenated protein in viral capsids. | Biological sciences | Robert L. Duda |
| Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals. | Biological sciences | Tobias Meyer, Elena Oancea |
| Protein-protein contacts that activate and repress prokaryotic transcription. | Biological sciences | Ann Hochschild, Simon L. Dove |
| Protein splicing of inteins and hedgehog autoproteolysis: structure, function, and evolution. | Biological sciences | Francine B. Perler |
| Protein translocation: tunnel vision. | Biological sciences | Walther Mothes, Tom A. Rapoport, Kent E.S. Matlack |
| Ptdlns-3,4,5-P3: a regulatory nexus between tyrosine kinases and sustained calcium signals. | Biological sciences | Jean-Pierre Kinet, Andrew M. Scharenberg |
| Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein.(kinesin superfamily protein) | Biological sciences | Yasushi Okada, Nobutaka Hirokawa, Yosuke Tanaka, Sen Takeda, Shigenori Nonaka, Akihiro Harada, Yoshimitsu Kanai, Mizuho Kido |
| Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. | Biological sciences | Yutong Xue, Weidong Wang, Ann Kuo, Gerald R. Crabtree, Keji Zhao, Oliver J. Rando, Kristine Swiderek |
| Ras promotes cell survival in Drosophila by downregulating hid expression.(reticular activating system; head involution defective gene) | Biological sciences | Phani Kurada, Kristin White |
| Rb interacts with histone deacetylase to repress transcription. (retinoblastoma protein) | Biological sciences | Douglas C. Dean, Robin X. Luo, Antonio A. Postigo |
| Reactive oxygen intermediates mediate a systemic signal network in the establishment of plant immunity. | Biological sciences | Richard A. Dixon, Maria E. Alvarez, Chris Lamb, Roger I. Pennell, Per-Johan Meijer, Atsushi Ishikawa |
| Reconstitution of an SOS response pathway: derepression of transcription in response to DNA breaks. | Biological sciences | Stephen C. Kowalczykowski, Daniel G. Anderson |
| Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. | Biological sciences | Richard A. Flavell, Keisuke Kuida, Chia-Yi Kuan, Tarik F. Haydar, Pasko Rakic, Choji Taya, Hajime Karasuyama, Yong Gu, Michael S.-S. Su |
| Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development. (adenomatous polyposis coli) | Biological sciences | Arnold Levine, Shigemi Hayashi, Eric Wieschaus, Yashi Ahmed |
| Relocation of the t-SNARE SNAP-23 from lamellipodia-like cell surface projections regulates compound exocytosis in mast cells. | Biological sciences | Zhenheng Guo, Christopher Turner, David Castle |
| Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. (heat shock protein) | Biological sciences | David F. Smith, Jiangying Zou, Yongle Guo, Toumy Guettouche, Richard Voellmy |
| Requirement for specific proteases in cancer cell intravasation as revealed by a novel semiquantitative PCR-based assay. (polymerase chain reaction) | Biological sciences | J. Kim, W. Yu, K. Kovalski, L. Ossowski |
| Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory. | Biological sciences | Eric R. Kandel, Isabelle M. Mansuy, Mark Mayford, Mary Elizabeth Bach, Betsy Jacob |
| Retrohoming of a bacterial group II intron: mobility via complete reverse splicing, independent of homologous DNA recombination. | Biological sciences | Dorie Smith, Marlene Belfort, Alan M. Lambowitz, Benoit Cousineau, Jian Yang, David Mills, Stacey Lawrence-Cavanagh, John E. Mueller, Dawn Manias, Gary Dunny |
| Retroviral superantigens and type 1 diabetes mellitus. (comments on Conrad et al., 'Cell,' vol. 90, p. 303, 1997) | Biological sciences | William A. Rudert, Massimo Trucco, Leonard C. Harrison, Gian Franco Bottazzo, Vincent J. Murphy, Patrizia Luppi, Alessandra Fierabracci, Paul Andrew Biro |
| Reversing time: origin of telomerase. | Biological sciences | Thomas Cech, Toru M. Nakamura |
| RNA and the epigenetic regulation of x chromosome inactivation. | Biological sciences | Rudolf Jaenisch, Barbara Panning |
| RNA-assisted nuclear transport of the meiotic regulator Mei2p in fission yeast. | Biological sciences | Akira Yamashita, Masayuki Yamamoto, Yoshinori Watanabe, Nobuyuki Nukina |
| RNA polymerase as a molecular motor. (ribonucleic acid)(Minireview.) | Biological sciences | Jeff Gelles, Robert Landick |
| Role of the Xist gene in X chromosome choosing. | Biological sciences | Rudolf Jaenisch, York Marahrens, Jan Loring |
| Role of WUSCHEL in regulating stem cell fate in the Arabidopsis shoot meristem.(WUS gene in Arabidopsis) | Biological sciences | Heiko Schoof, Michael Lenhard, Achim Haecker, Klaus F.X. Mayer, Gerd Jurgens, Thomas Laux |
| Roles for proteolysis and trafficking in notch maturation and signal transduction. | Biological sciences | Yuh Nung Jan, Yee-Ming Chan |
| Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionary conserved guidance receptors. (Drosophila) | Biological sciences | Marc Tessier-Lavigne, Thomas Kidd, Corey S. Goodman, Richard D. Fetter, Guy Tear, Kevin J. Mitchell, Katja Brose |
| RuvAB acts at arrested replication forks. | Biological sciences | Benedicte Michel, S. Dusko Ehrlich, Marie Seigneur, Vladimir Bidnenko |
| RuvA gets X-rayed on Holliday. | Biological sciences | Stephen C. West |
| Saccharomyces Ku70, Mre11/Rad50, and RPA proteins regulate adaptation to G2/M arrest after DNA damage. (yeast proteins; second growth and mitotic phases) | Biological sciences | Richard D. Kolodner, James E. Haber, J. Kent Moore, Sang Eun Lee, Allyson Holmes, Keiko Umezu |
| SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor.(Smad anchor for receptor receptor; intracellular signaling mediators) | Biological sciences | Jeffrey L. Wrana, Liliana Attisano, Tomoo Tsukazaki, Theodore A. Chiang, Anne F. Davison |
| Sec3p is a spatial landmark for polarized secretion in budding yeast. | Biological sciences | Thomas E. Hughes, Peter Novick, Fern P. Finger |
| Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells. | Biological sciences | Richard H. Scheller, Enrique Rodriguez-Boulan, W. James Nelson, Charles Yeaman, Kent K. Grindstaff, Niroshana Anandasabapathy, Shu-Chan Hsu |
| Signaling to p53: breaking the MDM2-p53 circuit. | Biological sciences | Carol Prives |
| Signaling via mitogen-activated protein kinase kinase (MEK1) is required for Golgi fragmentation during mitosis. | Biological sciences | Vivek Malhotra, Arrate Mallabiabarrena, Usha Acharya, Jairaj K. Acharya |
| Signal sequence recognition in posttranslational protein transport across the yeast ER membrane. (endoplasmic reticulum) | Biological sciences | Walther Mothes, Tom A. Rapoport, Kathrin Plath, Barrie M. Wilkinson, Colin J. Stirling |
| Simultaneous observation of individual ATPase and mechanical events by a single myosin molecule during interaction with actin. | Biological sciences | Hideo Higuchi, Takashi Funatsu, Akihiko Ishijima, Toshio Yanagida, Hiroaki Kojima, Mako Tokunaga, Hiroto Tanaka |
| Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity in the early mouse embryo. | Biological sciences | Jeffrey L. Wrana, Elizabeth J. Robertson, Pamela A. Hoodless, Elizabeth K. Bikoff, W. Ross Waldrip |
| Smad3 mutant mice develop metastatic colorectal cancer. | Biological sciences | James A. Richardson, Luis F. Parada, Yuan Zhu, Jonathan M. Graff |
| Smads: transcriptional activators of TGF-beta responses.(intracellular signaling mediators; transforming growth factor-beta) | Biological sciences | Rik Derynck, Ying Zhang, Xin-Hua Feng |
| SNAREpins: minimal machinery for membrane fusion. | Biological sciences | Thomas H. Sollner, James E. Rothman, James A. McNew, Francesco Parlati, Thomas Weber, Benedikt Westermann, Boris V. Zemelman, Michael Gmachi |
| Social life and the single nucleotide: foraging behavior in C. elegans. | Biological sciences | James H. Thomas |
| Solution structure of a TBP-TAF(sub II)230 complex: protein mimicry of the minor groove surface of the TATA box unwound by TBP. (TATA box-binding protein, TBP-associated factors) | Biological sciences | Yoshihiro Nakatani, Mitsuhiko Ikura, Lewis E. Kay, Stefan Bagby, Kit I. Tong, Tetsuro Kokubo, Rieko Ishima, Dingjiang Liu, D.R. Muhandiram |
| Solution structure of the core NFATC1/DNA complex. (nuclear factor the activated T cell) | Biological sciences | Gregory L. Verdine, Gerhard Wagner, Pei Zhou, Volker Dotsch, Li Jing Sun |
| Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment. | Biological sciences | Gerhard Wagner, James J. Chou, Hiroshi Matsuo, Hanjun Duan |
| Somatic hypermutation, transcription, and DNA mismatch repair. | Biological sciences | Winfried Edelmann, Matthew D. Scharff, Margrit Wiesendanger |
| Somatic inactivation of Pkd2 results in polycystic kidney disease. | Biological sciences | Harry Hou Jr., Raju Kucherlapati, Winfried Edelmann, Vivette D'Agati, Stefan Somlo, Guanqing Wu, Yiqiang Cai, Glen Markowitz, Jong Hoon Park, David M. Reynolds, Yoshiko Maeda, Thanh C. Le |
| Somite development: constructing the vertebrate body. | Biological sciences | Shahragim Tajbakhsh, Ralf Sporle |
| Sorting out genes that regulate epithelial and neuronal polarity. | Biological sciences | David Bredt |
| Spastic paraplegia and OXPHOS impairment caused by mutations in paraplegin, a nuclear-encoded mitochondrial metalloprotease. | Biological sciences | Marina Mora, Massimo Zeviani, Bertrand Fontaine, Andrea Ballabio, Maurizio De Fusco, Giorgio Casari, Sonia Ciarmaroti, Patricio Fernandez, Guiseppe De Michele, Alessandro Filla, Sergio Cocozza, Roberto Marconi, Alexandre Durr |
| Spatial control of actin filament assembly: lessons from Listeria. | Biological sciences | Mary C. Beckerle |
| Spatially restricted activation of the SAX receptor by SCW modulates DPP/TKV signaling in Drosophila dorsal-ventral patterning. | Biological sciences | Edwin L. Ferguson, Jeffrey L. Neul |
| Spatially restricted expression of pipe in the Drosophila egg chamber defines embryonic dorsal-ventral polarity. | Biological sciences | David Stein, Leslie Stevens, Jonaki Sen, Jason S. Goltz |
| Specification of motor neuron identity by the MNR2 homeodomain protein. (motor neuron homeobox gene) | Biological sciences | Thomas M. Jessell, Yasuto Tanabe, Christopher William |
| Specification of neuronal connectivity: ETS marks the spot. | Biological sciences | Anirvan Ghosh, Alex L. Kolodkin |
| Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow. | Biological sciences | Zaverio M. Ruggeri, Brian Savage, Fanny Amus-Jacobs |
| Splicing regulation in neurons: tinkering with cell-specific control. | Biological sciences | Paula J. Grabowski |
| Splitting hairs: dissecting roles of signaling systems in epidermal development. | Biological sciences | Matthew P. Scott, Anthony E. Oro |
| Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. (fibroblast growth factor) | Biological sciences | Yasushi Hiromi, Mark A. Krasnow, Nir Hacohen, David Sutherland, Susanne Kramer |
| Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. | Biological sciences | Michael Brown, James N. Ihle, Erin Schuetz, Gerard Grosveld, Stephan Teglund, Catriona McKay, Jan M. van Deursen, Dimitrios Stravopodis, Demin Wang, Sara Bodner |
| Staying on track: common features of DNA helicases and microtubule motors.(Minireview.) | Biological sciences | Ronald D. Vale, Timothy M. Lohman, Kurt Thorn |
| Structural basis for activation of ARF GTPase: Mechanisms of guanine nucleotide exchange and GTP-myristoyl switching. | Biological sciences | Jonathan Goldberg |
| Structure and replication of yeast prions. | Biological sciences | Michael D. Ter-Avanesyan, Vitaly V. Kushnirov |
| Structure of an IkappaBalpha/NF-kappaB complex.(inhibitory protein of the transcription factor, NF-kB) | Biological sciences | Stephen C. Harrison, Amrc D. Jacobs |
| Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity. (flap endonuclease; proliferating cell nuclear antigen) | Biological sciences | Clifford D. Mol, John A. Tainer, David J. Hosfield, Binghui Shen |
| Structure of the guanine nucleotide exchange factor Sec7 domain of human arno and analysis of the interaction with ARF GTPase. | Biological sciences | Elena Mossessova, Jacqueline M. Gulbis |
| Structure of the hemagglutinin precursor cleavage site, a determinant of influenza pathogenicity and the origin of the labile conformation. | Biological sciences | David J. Stevens, Don C. Wiley, John J. Skehel, Jue Chen, Kon Ho Lee, David A. Steinhauer |
| Structure of the histone acetyltransferase Hat1: a paradigm for the GCN5-related N-acetyltransferase superfamily. | Biological sciences | Stefan T. Tafrov, Rolf Sternglanz, V. Ramakrishnan, Robert N. Dutnall |
| Structure of type II-beta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation. | Biological sciences | Richard A. Anderson, James H. Hurley, Saurav Misra, Vibha D. Rao, Igor V. Boronenkov |
| S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells. | Biological sciences | Kornel E. Schuebel, Li-Mei Chen, Jorge E. Galan, Wolf-Dietrich Hardt, Xose R. Bustelo |
| SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans. (Caenorhabditis elegans) | Biological sciences | Min Han, Derek S. Sieburth, Qun Sun |
| Switching signals on or off by receptor dimerization. | Biological sciences | Joseph Schlessinger, Arthur Weiss |
| Syntaxin 5 is a common component of the NSF-and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro. | Biological sciences | Graham Warren, Paul Freemont, Catherine Rabouille, Hisao Kondo, Richard Newman, Norman Hui |
| Systemic spread of sequence-specific transgene RNA degradation in plants is initiated by localized introduction of ectopic promoterless DNA. | Biological sciences | Susan Angell, David C. Baulcombe, Olivier Voinnet, Phillippe Vain |
| Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria. | Biological sciences | Yasushi Okada, Nobutaka Hirokawa, Yosuke Tanaka, Sen Takeda, Shigenori Nonaka, Akihiro Harada, Yoshimitsu Kanai |
| TATA box mimicry by TFIID: autoinhibition of pol II transcription. | Biological sciences | Stephen K. Burley, Robert G. Roeder |
| T cell responses and viral escape. | Biological sciences | Andrew McMichael |
| "Tell me where is calcium bred": clarifying the roles of nuclear calcium. | Biological sciences | Anant N. Malviya, Patrick J. Rogue |
| The cadherin superfamily at the synapse: more members, more missions.(Minireview) | Biological sciences | Tadashi Uemura |
| The C. elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters. (Caenorhabditis elegans) | Biological sciences | Yi-Chun Wu, H. Robert Horvitz |
| The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9. (Caenorhabditis elegans) | Biological sciences | H. Robert Horvitz, Barbara Conradt |
| The C. elegans spe-9 gene encodes a sperm transmembrane protein that contains EGF-like repeats and is required for fertilization. (Caenorhabditis elegans; epidermal growth factor) | Biological sciences | Steven W. L'Hernault, Kristina B. Mercer, Andrew Singson |
| The conserved immunoglobulin superfamily member SAX-3/robo directs multiple aspects of axon guidance in C. elegans. (Caenorhabditis elegans) | Biological sciences | Cornelia I. Bargmann, Jennifer A. Zallen, B. Alexander Yi |
| The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation. | Biological sciences | Gourisankar Ghosh, Tom Huxford, De-Bin Huang, Shiva Malek |
| The cry(super b) mutation identifies crytochrome as a Circadian photoreceptor in Drosophila. | Biological sciences | Steve A. Kay, Patrick Emery, Ralf Stanewsky, Jeffrey C. Hall, Michael Rosbash, Maki Kaneko, Bonnie Beretta, Karen Wager-Smith |
| The curious status of the Golgi apparatus. | Biological sciences | Vivek Malhotra, Benjamin S. Glick |
| The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucelosome remodeling activities. | Biological sciences | William S. Lane, Danny Reinberg, Yi Zhang, Gary LeRoy, Hans-Peter Seelig |
| The destinies and destinations of RNAs.(Meeting Review)(third biennial Federation of American Societies on Experimental Biology Summer Research Conference) | Biological sciences | Tulle Hazelrigg |
| The DHR78 nuclear receptor is required for ecdysteroid signalling during the onset of Drosophila metamorphosis. | Biological sciences | Carl S. Thummel, Gregory J. Fisk |
| The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 receptor. | Biological sciences | Stephen J. Elledge, Zheng Zhou, Mingxia Huang |
| The Drosophila clock gene double-time encodes a protein closely related to human casein kinase I epsilon. | Biological sciences | Michael W. Young, Lino Saez, Adrian Rothenfluh, Jeffrey L. Price, Justin Blau, Brian Kloss, Cedric S. Wesley |
| The Drosophila Fab-7 chromosomal element conveys epigenetic inheritance during mitosis and meiosis. | Biological sciences | Renato Paro, Giacomo Cavalli |
| The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling. | Biological sciences | Hermann Steller, Andreas Bergmann, Julie Agapite, Kimberly McCall |
| The enhanceosome and transcriptional synergy. (Escherichia coli) | Biological sciences | Michael Carey |
| The eS-Sense of -SH in the ER. (S-S bond formation in the endoplasmic reticulum) | Biological sciences | Hidde L. Ploegh, Johannes B. Huppa |
| The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus. | Biological sciences | Tsutomu Kume, Douglas B. Gould, Ke-Yu Deng, Virginia Winfrey, Michael A. Walter, Drigid L.M. Hogan |
| The fruit fly: a model organism to study the genetics of alcohol abuse and addiction? | Biological sciences | Hugo J. Bellen |
| The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. | Biological sciences | Richard S. Maser, John H.J. Petrini, James P. Carney, John R. Yates III, Heidi Olivares, Elizabeth M. Davis, Michelle Le Beau, Lara Hays, William F. Morgan |
| The Hsp70 and Hsp60 chaperone machines. | Biological sciences | Arthur L. Horwich, Bernd Bukau |
| The indeterminate gene encodes a zinc finger protein and regulates a leaf-generated signal required for the transition to flowering in maize. | Biological sciences | Venkatesan Sundaresan, Zhuang Yuan, Joseph Colasanti |
| The initiator function of DnaA protein is negatively regulated by the sliding clamp of the E. coli chromosomal replicase. (Escherichia coli) | Biological sciences | Tsutomu Katayama, Elliott Crooke, Toshio Kubota, Kenji Kurokawa, Kazuhisa Sekimizu |
| The Ink4a tumor suppressor gene product, p19(super Arf), interacts with MDM2 and neutralizes MDM2's inhibition of p53. | Biological sciences | Ronald A. DePinho, Lynda Chin, Carlos Cordon-Cardo, Nicole Schreiber-Agus, Ken Chen, Nanette J. Liegeois, Adam Silverman, Jason Potes, Jason Pomerantz, Leila Allan, Irene Orlow, Han-Wong Lee |
| The interpretation of position in a morphogen gradient as revealed by occupancy of activin receptors. | Biological sciences | J.B. Gurdon, Steven Dyson |
| The late elongated hypocotyl mutation of Arabidopsis disrupts circadian rhythms and the photoperiodic control of flowering. | Biological sciences | Robert Schaffer, George Coupland, Nicola Ramsay, Joanna Putterill, Alon Samach, Sally Corden, Isabelle A. Carre |
| The left-right coordinator: the role of Vg1 in organizing left-right axis formation. (asymmetries of internal organs) | Biological sciences | H. Joseph Yost, Brian A. Hyatt |
| The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells. | Biological sciences | Stuart K. Kim, Charles W. Whitfield, Susan Kaech |
| The many interfaces of Mre11. | Biological sciences | James E. Haber |
| The meiosis-specific Hop2 protein of S. cerevisiae ensures synapsis between homologous chromosomes. (Saccharomyces) | Biological sciences | G. Shirleen Roeder, Penelope R. Chua, Jun-Yi Leu |
| The mystique of epigenetics. | Biological sciences | Benjamin Lewin |
| The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. (ataxia-telangiectasia mutated; transformation/transcription domain-associated protein) | Biological sciences | Michael D. Cole, Steven B. Mcmahon, Heather A. Van Buskirk, Kerri A. Dugan, Terry D. Copeland |
| The PHANTASTICA gene encodes a MYB transcription factor involved in growth and dorsoventrality of lateral organs in Antirrhinum. | Biological sciences | Richard Waites, Andrew Hudson, Harinee R.N. Selvadurai, Ian R. Oliver |
| The preprotein translocation channel of the outer membrane of mitochondria. | Biological sciences | Walter Neupert, Roland Benz, Frank E. Nargang, Roland Lill, Stephan Nussberger, Jochen Walz, Klaus-Peter Kunkele, Susanne Heins, Markus Dembowski, Michel Thieffry |
| The proteasome: paradigm of a self-compartmentalizing protease. | Biological sciences | Wolfgang Baumeister, Erika Seemuller, Jochen Walz, Frank Zuhl |
| The role of maternal VegT in establishing the primary germ layers in Xenopus embryos. | Biological sciences | Janet Heasman, Christopher Wylie, Jian Zhang, Christopher Payne, Douglas W. Houston, Mary Lou King |
| The role of TAFs in RNA polymerase II transcription.(TATA-binding protein associated factors) | Biological sciences | Steven Hahn |
| The role of tricorn protease and its aminopeptidase-interacting factors in cellular protein degradation. | Biological sciences | Friedrich Lottspeich, Tomohiro Tamura, Wolfgang Baumeister, Noriko Tamura |
| The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel. | Biological sciences | Ernest G. Peralta, Cachero Teresa G., Anthony D. Morielli |
| The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. | Biological sciences | Geoffrey L. Greene, David A. Agard, Andrew K. Shiau, Peter J. Kushner, Danielle Barstad, Paula M. Loria, Lin Cheng |
| The structural basis of hammerhead ribozyme self-cleavage. | Biological sciences | William G. Scott, James B. Murray, Daniel P. Terwey, Lara Maloney, Alexander Karpeisky, Nassim Usman, Leonid Beigelman |
| The structure of supercoiled intermediates in DNA replication. | Biological sciences | Kenneth J. Marians, Nicholas R. Cozzarelli, Brian J. Peter, Chris Ullsperger, Hiroshi Hiasa |
| The TAFs in the HAT. (ten associated factors) | Biological sciences | Kevin Struhl, Zarmik Moqtaderi |
| The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals. | Biological sciences | Clifford J. Tabin, Malcolm Logan, Sylvia Pagan-Westphal, Devyn M. Smith, Laura Paganessi |
| The transfer of left-right positional information during chick embryogenesis. | Biological sciences | Clifford J. Tabin, Sylvia M. Pagan-Westphal |
| The turn of the screw: the bacterial flagellar motor.(Minireview.) | Biological sciences | David J. DeRosier |
| The unusual active site of Gal6/bleomycin hydrolase can act as a 0 carboxypeptidase, aminopeptidase, and peptide ligase. | Biological sciences | Stephen Albert Johnston, Leemor Joshua-Tor, Wenjin Zheng |
| The VAB-1 Eph receptor tyrosine kinase functions in neural and epithelial morphogenesis in C. elegans. (Caenorhabditis elegans) | Biological sciences | Andrew D. Chisholm, Jeff Hardin, Sean E. George, Kristin Simokat |
| The yin and ynag of evo/devo. (evolutionary developmental biology) | Biological sciences | Michael Akam |
| Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A. | Biological sciences | Josep Rizo, Thomas C. Sudhof, Imma Fernandez, Josep Ubach, Irina Dulubova, Xiangyang Zhang |
| Thrombospondin-1 is a major activator of TGF-beta1 in vivo. (transforming growth factor) | Biological sciences | Noel Bouck, Susan E. Crawford, Richard O. Hynes, Jack Lawler, Joanne E. Murphy-Ullrich, Veronica Stellmach, Solange M. Ribiero, Gregory P. Boivin |
| Through the looking glass: axon guidance at the midline choice point. | Biological sciences | John G. Flanagan, David Van Vactor |
| Tn10 transposition via a DNA hairpin intermediate. (nonreplicative transposon) | Biological sciences | Nancy Kleckner, David B. Haniford, Anjan Guhathakurta, Angela K. Kennedy |
| TRAM regulates the exposure of nascent secretory proteins to the cytosol during translocation in to the endoplasmic reticulum. (translocating chain-associated membrane protein) | Biological sciences | Tom A. Rapoport, Vishwanath R. Lingappa, Ramanujan S. Hedge, Sabine Voigt |
| Transcriptional fidelity and proofreading by RNA polymerase II. | Biological sciences | Matthew J. Thomas, Diane K. Hawley, Angelina A. Platas |
| Transmembrane signaling across the ligand-gated FhuA receptor: crystal structures of free and ferrichrome-bound states reveal allosteric changes. | Biological sciences | Bernard Rees, Dino Moras, Andre Mitschler, Kaspar P. Locher, Jurg P. Rosenbusch, Ralf Koebnik, Luc Moulinier |
| Trans-sensing effects: the ups and downs of being together. | Biological sciences | Steven Henikoff, Luca Comai |
| TRF2 protects human telomeres from end-to-end fusions. | Biological sciences | Titia de Lange, Bas van Steensel, Agata Smorgorzewska |
| Tumor cell intravasation Alu-cidated: the chick embryo opens the window. | Biological sciences | James P. Quigley, Peter B. Armstrong |
| Tumor induction of VEGF promoter activity in stromal cells. (vascular endothelial growth factor) | Biological sciences | Yi Chen, Rakesh K. Jain, Dai Fukumura, Brian Seed, Naifang Lu, Ramnik Xavier, Takeyuki Sugiura, Eun-Chung Park, Martin Selig, Gunnlaugur Nielsen, Tatyana Taksir |
| Tumor suppressing pathways. | Biological sciences | Raymond L. White |
| Twin peaks: Spitz and Argos star in patterning of the Drosophila egg. | Biological sciences | Leslie Stevens |
| Type 2 diabetes: when insulin secretion fails to compensate for insulin resistance. | Biological sciences | Barbara B. Kahn |
| Ump1p is required for proper maturation of the 20S proteasome and becomes its substrate upon completion of the assembly. | Biological sciences | Alexander Varshavsky, Erica S. Johnson, Paula C. Ramos, Jorg Hockendorff, R. Jurgen Dohmen |
| UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans. | Biological sciences | Tony Pawson, Robert Steven, Sarang Kulkarni, Terrance J. Kubiseski, Zheng Hong, Jorge Mancillas, Alberto Ruiz Morales, Chris W.V. Hogue, Joe Culotti |
| Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway. | Biological sciences | Jason R. Kennerdell, Richard W. Carthew |
| Using genetic mutations to study the neural basis of behavior. | Biological sciences | Philip M. Steele, Javier F. Medina, William L. Nores, Michael D. Mauk |
| Vasculogenesis, angiogenesis, and growth factors: ephrins enter the fray at the border. | Biological sciences | George D. Yancopoulos, Judah Folkman, Michael Klagsbrun |
| VDJ recombination: a transposase goes to work. | Biological sciences | David B. Roth, Nancy L. Craig |
| Viral dynamics in HIV-1 infection. | Biological sciences | Robert F. Siliciano, Diana Finzi |
| Wag the tail: structural dynamics of actomyosin. (muscle proteins)(Minireview) | Biological sciences | Yale E. Goldman |
| Wilms' tumor 1 and dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression. | Biological sciences | Holly A. Ingraham, Mark W. Nachtigal, Yoshifumi Hirokawa, Debra L. Enyeart-VanHouten, John N. Flanagan, Gary D. Hammer |
| Wingless repression of Drosophila frizzled 2 expression shapes of wingless morphogen gradient in the wing. | Biological sciences | Matthew P. Fish, Roel Nusse, Eric J. Rulifson, Kenneth M. Cadigan |
| Y do we drink?(role of neuropeptide Y in the regulation of mammalian responses to alcohol) | Biological sciences | Ulrike Heberlein, Laurence H. Tecott |
| Yeast heterochromatin: regulation of its assembly and inheritance by histones. | Biological sciences | Michael Grunstein |
| Yeast retrotransposons: Finding a nice quiet neighborhood.(Minireview) | Biological sciences | Jef D. Boeke |
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